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Description: In This Issue: EFAs: This is No Fish Story, Healthy Blood Sugar, Supply Innovation, and Fiber

w w w. NI W Visi eb t O Em si u ag te r az in e.c om A VRM Media Publication www.niemagazine.com November December 2015 Go to www.niemagazine.com sabinsa for info about this advertiser Go to www.niemagazine.com nowpl for info about this advertiser TableofContents Proud Supporter of VOLUME 20 NO. 9 NOVEMBER DECEMBER2015 F E A T U R E S 32 EFAs This is No Fish Story Omega-3s have weathered storms and are still full speed ahead. 36 Glucose Support Blood sugar health and weight management are becoming even more important as a whole in the journey toward a healthier future. A L S O I N S I D E 12 21 27 28 29 30 30 31 55 55 55 56 Industry News Ingredient News SupplySide West Wrap-up UNPA Summit Wrap-up AHPA Update Association News Conventions & Meetings Science Update Equipment & Packaging Advertiser Index Industry Events Supplier of the Month 47 Supply Innovation NIE has given companies a chance to highlight their latest most innovative offerings. C O L U M N S 4 First Word 6 Condition Specific 10 Legalities 40 Production Line 42 Marketing Innovation 44 Food Technology FREE Subscription (Print Digital or BOTH) & E-newsletter Available www.NieMagazine.com Copyright 2015. Nutrition Industry Executive (ISSN 2331-2602) Volume 20 Number 9 November December 2015. Nutrition Industry Executive is published monthly (except for bimonthly January February and July August and November December) by VRM Media 431 Cranbury Road Suite C East Brunswick NJ 08816 USA Phone (732) 432-9600 Fax (732) 432-9288. All rights reserved including the right to reproduce in whole or in part. Not responsible for unsolicited material. Opinions expressed in by-lined articles or advertisements are not necessarily those of Nutrition Industry Executive or its owners. Publisher is not liable for advertiser product claims or representations. Advertisers assume total responsibility for the contents of their advertisements. Printed in U.S.A. Basic annual subscription rate is 50.00. Application to Mail at Periodicals Postage Prices is Pending at East Brunswick NJ 08816 and additional mailing offices. POSTMASTER Send address changes to Nutrition Industry Executive P.O. Box 15026 North Hollywood CA 91615-5026. Subscription Customer Service Nutrition Industry Executive P.O. Box 15026 North Hollywood CA 91615-5026 USA Phone (818) 286-3170 Fax (800) 869-0040 niecs magserv.com www.niemagazine.com. Back Issues & Single Copies For order information contact (732) 432-9600 or info niemagazine.com. March issue is 25.00. All other issues are 8.00 each. 2 Nutrition Industry Executive Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 Go to www.niemagazine.com plt for info about this advertiser FirstWord Visions in Blue aybe it s because of my brother who lost most of his eyesight due to detached retinas and is considered legally blind that I have a special interest in vision health. But my concern is certainly not unique. A national public opinion poll commissioned by Research America and the Alliance for Eye and Vision Research (AEVR) found that Americans across racial and ethnic groups describe losing eyesight as potentially having the greatest impact on their day-to-day life-- more so than other conditions including loss of memory hearing and speech. An especially alarming reality is ubiquitous blue light exposure and its consequences--most notably age-related macular degeneration (AMD). While at October s SupplySide West show in Las Vegas NV I discussed the issue of blue light s effect on the eyes with Brian Appell the marketing manager of New Jersey-based Omni Active Health Technologies. (See more Supplyside West show coverage on page 27). More than ever before our eyes are being bombarded by high-energy blue light sources including electronic devices such as televisions tablets smartphones and computers as well as indoor lighting (CFL or LED) and even LED car headlights Appell explained. High-energy blue light reaches deep into the eye and can harm the macula the region of the eye responsible for the highest visual acuity and sharpness he added. Lutein and the zeaxanthin isomers are known as the macular carotenoids and support eye health by acting as powerful antioxidants and filtering high-energy blue light. The company recently launched What s Your B.L.U.E. (Blue Light User Exposure). An extension of the company s Lutein For Every Age campaign What s Your B.L.U.E. is a new initiative to educate consumers on M high-energy blue light its sources and ways to help protect healthy vision from its effects with the support of the macular carotenoids--lutein and zeaxanthin isomers (RR-zeaxanthin and RS [meso]-zeaxanthin). The company s core products products are spice plant extracts specialty functional ingredients and carotenoids. However not all blue light is bad. The labeled blue-turquoise light range is essential to vision the function of the pupillary reflex and in general to human health. It also helps to regulate the circadian sleep wake cycle. So blue light in general can have healthy affects on vision as well as the body and it is this blue-turquoise light that tends to have these beneficial effects. As for the harmful blue rays researchers are looking for ways to block them but allow the helpful blue rays of light to penetrate through and get into the eye. Traditional blue blockers distort color and you want your colors to be natural. Optical companies that currently offer blue-blocking technology include Nikon (SeeCoat Blue) Essilor (Crizal Prevencia) PFO Global (iBlu coat) HOYA (Recharge) VSP (UNITY BluTech) and Spy Optic Inc. (Happy Lens). Who needs the most protection Those who have high exposure to white LED or fluorescent light bulbs in offices and homes frequent users of LED computer monitors tablets or smartphones (or almost everyone I know and especially the young people who have been exposed to this type of light since early childhood and will continue to be) and those at risk for AMD particularly those at high risk (those with family history smokers etc.). Eye doctors have been made aware of the dangers of blue light and are asking patients if there is a family history of macular degeneration how much time they spend in front of a digital device or computer and if they currently protect their eyes on a daily basis. They would be wise to also suggest good vision health supplements. Publisher Daniel McSweeney Editorial Director DanM VRMmedia.com Associate Russ Fields Publisher RussF VRMmedia.com Advertising Roy Kieffer Sales Manager RoyK VRMmedia.com Advertising Gary Pfaff Sales Associate GaryP VRMmedia.com Editor-in-Chief Janet Poveromo JanetP VRMmedia.com Managing Editor Shari Barbanel ShariB VRMmedia.com Assistant Editor Corinne Anderson CorinneA VRMmedia.com Contributing Writers Ronald C. Deis PhD James J. Gormley Todd Pauli Lisa Schofield Ivan J. Wasserman Art Director Robert Certo Production Manager RobertC VRMmedia.com Production Assistant Bryan Zak Graphic Designer BryanZ VRMmedia.com Circulation Manager Rosie Brodsky Rosie StarkServices.com A PUBLICATION OF VRM MEDIA President Daniel McSweeney VRM Media 431 Cranbury Road Ste. C East Brunswick NJ 08816 Phone (732) 432-9600 Fax (732) 432-9288 Email info VRMmedia.com Website www.niemagazine.com VRM Media publishes Nutrition Industry Executive Vitamin Retailer Gluten Free Retailer Natural Practitioner and FitnessTrainer magazines. Subscription Customer Service To order a subscription or manage your account please contact us at Nutrition Industry Executive P.O. Box 15026 North Hollywood CA 91615-5026 USA Phone (818) 286-3170 Fax (800) 869-0040 niecs magserv.com www.niemagazine.com Back Issues See the Table of Contents page for price and order information. Connect With Us www.twitter.com www.facebook.com www.linkedin.com www.instagram.com www.pinterest.com vitaminretailer vitaminretailermagazine company vrm-media vitaminretailermagazine vrm_media 4 Nutrition Industry Executive Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 Go to www.niemagazine.com jiaherb for info about this advertiser ConditionSpecific Fiber Innovative dietary fibers help achieve consumer goals of good taste convenience plus wide-spectrum health benefits. B Y J ANET P OVEROMO Focusing on he dietary fiber market is driven by three main innovation trends natural origin efficiency and taste according to Mathieu Dondain director of business development with Francebased natural ingredient supplier Nexira. We can notice that the nutritional and functional food market sees a high level of consumer awareness of dietary fibers for a healthy and balanced diet he noted. In fact John Peters president of New Jersey-based ingredient supplier BENEO Inc. said following consumer research commissioned by BENEO a clear 67 percent of the 1 000 consumers interviewed found high in natural fiber as a very appealing fiber claim for food and beverage products. The research also shows a clear preference for natural products--with as many as 47 percent of respondents actively seeking natural fibers--and 45 percent considering non-GMO (genetically modified organism) products as better. This research shows that natural non- T GMO ingredients such as chicory root fibers are of growing interest to consumers as well as fibers that can deliver credible health benefits with scientific claims to help consumers feel comfortable with their purchase decisions. One of the innovation goals is thus to offer all-natural fiber obtained without any chemical or enzymatic treatment with origin and quality guarantees in particular the non-GMO certification Dondain added. Numerous scientific studies also confirm the nutritional importance of dietary fiber. Now the health benefits of dietary fiber are becoming more specific digestive comfort intestinal transit feeling of satiety weight control and improvement of the intestinal flora prebiotic well-being from inside blood sugar regulation etc. Dondain added. Today he continued research goes further and highlights that dietary fibers could be involved in reducing the risk of inflammatory disease like obesity diabetes and cardiovascular diseases. To exist dietary fibers need to be supported by serious and complex scientific studies. The latest innovation trends concern the necessity of fibers to be incorporated in food and beverage formulations without negative impacts on taste and organoleptic properties of finished products in order to benefit from the fiber-related claims. Peters pointed out that while fiber is popular for a wide variety of products ranging from dairy to confectionary-- and even chocolate--a growing category is gummies. By incorporating the natural health benefits of fiber into the new class of products it becomes a convenient and tasty way to supplement fiber intake for adults and children. We indeed expect to see more products in this area he said. Types of Fiber In the current market there are more than 50 different types of fiber-containing ingredients according to Peters. 6 Nutrition Industry Executive Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 Go to www.niemagazine.com olcott for info about this advertiser ConditionSpecific These include inulin oligofructose resistant starches polydextrose resistant dextrin resistant corn syrup among others. Though being classified as fibers they differ significantly in their beneficial characteristics. He noted that only very few are classified as prebiotic for Dietary fibers are non-digestible and therefore reach the large intestine unaltered he explained. Depending on type they are either excreted or fermented to short-chain fatty acids by the large intestine s microflora. While dietary fibers in general play such a role some substrates can have more specific and qualitative functions. Fibers that are designated as prebiotics are substrates for the microflora and enhance growth of bifidobacteria which are considered the good bacteria in the large intestine because they support the development of a strong digestive system. Inulin-type fructans (i.e. chicory root fiber inulin and oligofructose) galactans and lactulose (a non-digestible sugar mainly used as a laxative) are the only ingredients that satisfy the classification criteria of a given food constituent as prebiotic and thus are considered confirmed prebiotics Peters continued. For other ingredients the evidence is currently not convincing mainly due to the lack of human intervention studies (Gibson et al. 2010). In fact chicory root fibers inulin and oligofructose are among the best-researched prebiotics worldwide. Their health benefits have been confirmed in 157 human intervention studies during the past 20 years. Last but not least not all fibers can be claimed natural. While the prebiotic fibers inulin and oligofructose are gained via a gentle hot water extraction method some other fibers are artificially or chemically treated. And chemical free is preferred. The demand from consumers to increase the natural dietary fiber content in food and beverages is expected to fuel all categories of food products Dondain added. Cereal products and bakery products are certainly the leading users of fibers and fiber-related claims and their growth will still go on. However he said adding fibers to food products means that industrials will face new formulation challenges in terms of taste texture stability shelf life and digestive comfort. Fibregum developed by Nexira which has a U.S. office in New Jersey 8 Nutrition Industry Executive offers technical and functional benefits odorless colorless and flavorless. This all-natural source of soluble dietary fiber obtained from acacia gum has low viscosity and low hygroscopicity enabling high fiber claims Dondain said. With its high solubility and a great stability to extreme process Fibregum has already been successfully formulated in a wide selection of food and beverage applications. Consumers are not willing to sacrifice taste and texture in the foods they choose to eat even when looking for healthier and more nutritious options. -- John Peters President of BENEO Gaining Ground Fibers that meet consumer demand for naturalness cleaner label and health benefits such as digestive health and weight management are the fibers that are gaining traction in the market today. Consumers are not willing to sacrifice taste and texture in the foods they choose to eat even when looking for healthier and more nutritious options Peters said. Chicory root fibers for example are soluble and have a mild sweet taste. Thus manufacturers are able to develop products with less sugar but with the same smooth texture and taste of the commonly known alternatives. Chicory root fiber also reduces or even replaces fat in dairy products while maintaining the desired creamy mouth feel. Along with health benefits and taste convenience is also important to consumers Peters added. While they are aware of the need to increase fiber in their diet they struggle to meet the recommended daily amount of fiber intake. Fibers that can easily be incorporated into food and beverage products (chocolate confectionary or dairy) are therefore attractive to consumers and the industry as they make food and beverages more nutritious and provide more balanced options. The global dietary fiber market is witnessing tremendous growth due to the increasing demand for healthy and natural food products from health-conscious consumers agreed Dondain. Sources of natural fibers with quality and origin certifications are thus more and more preferred. He explained that Nexira s GMO-free Fibregum offers a minimum of 90 percent fiber and is associated with proven health benefits. Fibregum offers additional clean label values--highly appealing to consumers organic certified vegan friendly (100 percent vegetable) and very recently approved by the Non-GMO Project. Fibregum is the first and only acacia fiber approved by this NGO (non-governmental organization) which is the only organization offering independent verification of testing and GMO controls for products in the U.S. and Canada Dondain noted. Digestive or gut health is still the main key focus for product activity in functional and healthy foods but some consumers ask for more scientific results he added. That is why Nexira constantly invests in scientific studies to highlight the health and nutritional benefits of Fibregum. More recently Nexira has conducted a new study to reinforce and demonstrate all the scientific background of Fibregum offering new natural alternative to protect the gut barrier. Science & Fiber With the worldwide growth of bowel pathologies such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) the overall interest in gut health and more specifically the intestinal barrier has grown. The gut barrier is one of the most important components of the innate immune system Dondain said. Its main role is to absorb nutrients and to serve as one of our body s most important barrier[s]. Based on the preliminary positive results of Fibregum on digestive health with a prebiotic effect and the production of beneficial SCFA (short chain fatty acids) Nexira recently conducted new experiments which demonstrated (Continued on page 39) Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 Go to www.niemagazine.com pinnaclelabs for info about this advertiser Legalities What to Bear in Mind From the Bayer Decision By Ivan J. Wasserman Manatt Phelps & Phillips A s you likely know by now in September a New Jersey district court issued a decision in United States (FTC) v. Bayer. Indeed as the headlines read the FTC (Federal Trade Commission) did lose the case and they lost it big. However does that loss mean that the FTC will change its approach to evaluating what constitutes adequate substantiation for dietary supplement claims Let s see ... does a bear use a public restroom By way of brief background the case involved whether claims for Bayer s Phillips Colon Health (PCH) probiotic supplement violated its existing FTC consent order that requires Bayer to possess competent and reliable scientific evidence (CARSE) for dietary advertising claims. The claims at issue were relatively common structure function claims for probiotic supplements including claims that the product can defend against occasional constipation diarrhea and gas and bloating. The FTC argued in part that Bayer was in violation because it did not possess randomized clinical trials (RCTs) on the exact combination of the exact probiotic strains to support its advertising claims. Instead Bayer relied on numerous studies on the three individual probiotics in the product. In deciding for Bayer the judge relied heavily on two things that are unique to the facts of this case and that are not relevant to a typical review of advertising claims. First this was a civil contempt action and the court held that to be found in contempt the FTC would have to prove by clear and convincing 10 Nutrition Industry Executive evidence that Bayer had violated a clear and unambiguous provision of the consent decree. The court found that the CARSE standard is far from clear and unambiguous. Second it is clear from the 38-page decision that in the judge s mind Bayer handily won the battle of the experts that these cases can often become. Bayer s experts were highly qualified specifically on probiotic dietary supplements whereas the government s experts did not have that specific expertise. Clearly the case stands for the point that in the right circumstances structure function claims for dietary supplements can be supported by something other than RCTs on the exact product formula. It also supports an argument that by enacting DSHEA (The Dietary Supplement Health and Education Act of 1994) Congress intended that the regulation of dietary supplements be different from the regulation of drugs. It is also a reminder of the importance of having qualified scientific experts review substantiation for claims. Finally it demonstrated that companies should continue to take the FTC to court in the right circumstances. However the fact is that when analyzing the adequacy of the substantiation for a claim it is still a claim-by-claim ingredient-by-ingredient product-byproduct analysis. For example in this case Bayer s experts successfully convinced the court that despite the FTC s contention individual probiotics cannot be antagonistic and therefore combining them could not negate their effects. Of course that may not be the case with other types of ingredients which may somehow counteract each other. Also unlike some ingredients that may be the subject of just one or two studies Bayer was able to show the court the large body of evidence on the effects of probiotics on digestive health. Finally the court stressed that these were structure function claims. Had the court found that the claims were drug claims either expressly or by implication in the context in which they appear the case could have come out very differently. It is also important to note that the FTC may appeal the decision. In sum this case was a great win for Bayer and provides some interesting tips on how to litigate future cases. However caution must be used not to take it as a significant change in how the FTC will evaluate advertising claims in the future. Claims must still be made like Goldilocks found Baby Bear s porridge just right. NIE Ivan J. Wasserman is a partner in the advertising marketing and media division of law firm Manatt Phelps & Phillips. He counsels clients on the advertising and marketing of products subject to the overlapping jurisdiction of the FDA (U.S. Food and Drug Administration) and FTC including dietary supplements drugs and foods. Wasserman can be reached at (202) 585-6529 or iwasserman manatt.com. Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 Go to www.niemagazine.com alkemistlabs for info about this advertiser IndustryNews USP Launches New GMP Audit Certification T he U.S. Pharmacopeial Convention (USP) has announced it is expanding its verification services to include a new good manufacturing practice (GMP) audit program for dietary supplement and dietary ingredient manufacturers. Officially launched on October 22 during a reception at the Council for Responsible Nutrition s (CRN) annual conference for the dietary supplement industry in Palm Springs CA the program will help to ensure that manufacturers have good quality systems and may help mitigate regulatory risks by preparing manufacturers for U.S. Food and Drug Administration (FDA) GMP inspection. The USP GMP audit program will complement other USP Verification programs and can serve as a steppingstone toward achieving USP s acclaimed dietary supplement product verification mark. USP has created the GMP audit program in response to overwhelming demand from industry and manufacturers said John Atwater senior director of verification services for USP. Although we continue to believe Dietary Ingredient and Dietary Supplement Verification Programs are the most comprehensive ways to ensure the quality of a given ingredient or supplement we believe the GMP audit program is an important addition. It supports USP s mission by encouraging greater adoption of public standards designed to increase product quality and thereby promotes public health. USP s GMP facility audit program provides assurance that manufacturers not only meet FDA cGMPs but also exceed them. That s because USP s GMP audit program is the only program that will require manufacturers to comply with both FDA and USP GMPs. USP GMPs include requirements of particular interest to retailers such as recall procedures expiration dating supported by stability data and identity testing for all ingredients--not just dietary ingredients. Although separate from the USP Verification Program participation in the new GMP facility audit program is recommended for companies consider- ing having their products quality verified by USP. Manufacturers can apply the results of a successful GMP audit to the USP Verification Program with no additional fee for up to a year. In recognition of CRN s support and the launch of the program at the CRN meeting--USP is offering CRN members a 25 percent discount for participation in the GMP audit program until April 2016. We welcome efforts by organizations such as USP a global leader in quality standards to help dietary supplement companies improve accountability to consumers said Steve Mister CRN president and CEO. We hope companies will take a serious look at this new initiative and that more and more companies in our industry will seek out ways to promote transparency and demonstrate their commitment to manufacturing and marketing quality products. We re proud that USP is an Associate CRN member and pleased that the organization chose to unveil the new program at the conference. For more information visit www.usp.org. NPA Challenges New Study On Supplements and ER Visits he Natural Products Association (NPA) has challenged the methodology and findings of a study published in the New England Journal of Medicine that claimed dietary supplements are responsible for approximately 23 000 hospital visits each year. The study Emergency Department Visits for Adverse Events Related to Dietary Supplements based its findings on data from 63 emergency departments from 2004 through 2013 instead of relying on the official U.S. Food and Drug Administration s (FDA) Serious Adverse Event Reporting database for dietary supplements. The laws that regulate supplements require official reporting of adverse events so that the regulators the health care community and others can review the data and make informed public policy decisions. This so-called study excludes that very data which is more than puzzling because it was written in part by FDA T officials who know this said Dan Fabricant PhD NPA executive director and CEO. The facts are that adverse events from supplements are extremely low given their widespread usage and most of these are the result of three factors accidents people not consulting with their doctor or misuse of a product combined with other health factors Fabricant continued Supplements are safe which is why millions of Americans use them every day. According to the FDA s website (www.fda.gov food dietarysupplements reportadverseevent ) the Safety and Reporting Portal is a convenient secure and efficient method for letting FDA know when industry or consumers finds a problem with a dietary supplement. Further government data reported that there were 3 249 adverse event reports for 2012 a far smaller number than the 23 000 annual average cited in the author s report. Even if the study estimates are accurate the number of hospital visits suggested to relate to dietary supplements would represent 0.0001687 percent of the 136.3 million hospital visits each year according to data from the Centers for Disease Control (CDC). The study authors concede that their figures could be an over or under-representation and that more than 90 percent of the patients who went to an emergency room were discharged. For more information visit www.npainfo.org. 12 Nutrition Industry Executive Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 THE NUTRITION INDUSTRY S NEWS & INFORMATION RESOURCE 1995 20 Y ars Celebratingellence e of Exc 2015 NIE s Upcoming 2016 Issue Highlights Jan. Feb. March April May June 12 16 15 ad closing Industry Forecast 2016 NIE Supplier Sourcebook Sourcing and Ingredient Purity & Ingredient Marketplace Show Issue 2 5 16 ad closing 3 22 16 ad closing 4 11 16 ad closing Science of Ingredients Food Safety 5 16 16 ad closing Our 2016 Media Planner Is Now Available At NIEmagazine.com 2016-Media-Planner Contact One of Our Ad Specialists Today Russ Fields at 732-432-9600 ext. 102 or e-Mail RussF VRMmedia.com Gary Pfaff at 732-432-9600 ext. 103 or e-Mail GaryP VRMmedia.com IndustryNews CRN Asks State AG to Help FDA and Industry Stop Criminals from Marketing Illegal Drugs as Dietary Supplements he Council for Responsible Nutrition s (CRN) Regulatory Counsel Rend Al-Mondhiry asked an audience of approximately 80 assistant state Attorneys General (AG) to help support efforts to rid the marketplace of the most serious issue facing the dietary supplement industry and its consumers--by prosecuting companies that spike products with illegal drugs and market them as dietary supplements. She advised These types of activities clearly violate the law and present real risks to public health. This is where state AGs can be most effective in protecting consumers and can coordinate with FDA (U.S. Food and Drug Administration) to target these illegal products. Al-Mondhiry made her remarks as a panelist at the National Association of Attorneys General (NAAG) Fall Consumer Protection Meeting in St. Louis MO. Al-Mondhiry was invited by NAAG to share the dietary supplement industry s perspectives as part of a panel that included Pieter Cohen MD assistant professor of medicine Harvard Medical School and Maia Kats director of litigation Center for Science in the Public Interest. Al-Mondhiry observed that the biggest problem facing the dietary supplement industry comes from criminals who flout the laws and regulations governing dietary supplements and their ingredients and put consumers at T risk while also unfairly giving responsible industry a black eye. During the panel presentation AlMondhiry explained what the industry is currently doing to help ensure that products that reach consumers are safe and have truthful accurate labeling. She explained the important role of FDA and federal regulation including extensive good manufacturing practices (GMPs) that mandate 100 percent identity testing for raw materials and specifications for purity and strength among other requirements. The federal legal framework for dietary supplements also provides FDA with various enforcement tools to take action against illegal ingredients and illegal claims from seizures and mandatory recalls to civil and criminal penalties. Another key piece contributing to consumer safety is mandatory postmarket surveillance--a law the dietary supplement industry helped to pass Al-Mondhiry said. The 2006 Dietary Supplement and Non-Prescription Drug Consumer Protection Act requires reporting of all serious adverse events to the FDA and recordkeeping of all adverse event reports a company receives about its products. These reports provide important information to regulators regarding potential safety issues in the supplement marketplace allowing the agency to respond quickly to protect consumers. Al-Mondhiry also focused on some of CRN s educational and self-regulatory initiatives to help promote compliance within the industry. CRN and its members proactively developed science-based guidelines as part of its self-regulatory initiatives. Al-Mondhiry advised that despite these self-policing efforts the industry doesn t have an enforcement hammer to bring down on companies that actively ignore the laws. FDA working with state agencies can target the intentional wrongdoers who introduce illegal products and pass them off as dietary supplements. As the chief law enforcement officers in their states state AGs can use their powers to target clear violations of the law such as illegal spiking of products. CRN wants to continue working with FDA and also with the state AGs to help address this issue Al-Mondhiry said. For more information visit www.crnusa.org. Sabinsa Honored With Two Pharmexcil Awards ami Labs (India) the manufacturing arm of Sabinsa Corporation (East Windsor NJ) has received two Pharmexcil Awards for 2014-2015 in the Herbals category the Silver Award for Patents and the Outstanding Export Performance Award. Pharmexcil a ministry set up by the Government of India as a gateway to global pharma trade bestows annual awards to acknowledge those companies that excel in developing proprietary products granted patents throughout the world. The awards were presented during the Pharma CEOs Conclave organized by the Pharmaceuticals Export Promotion S Council (Pharmexcil) and sponsored by Department of Commerce & Industry Government of India. We re honored to be once again recognized by Pharmexcil for our deep commitment to Innovation and science that results in successfully marketing the products we develop worldwide said Dr. Muhammed Majeed founder of Sabinsa and Sami Labs. Sami Labs also received the top Pharmexcil Patent Award for 2010-2011 in the Herbals Ayurveda & Nutraceuticals category and two Pharmexcil Awards for 2012-2013 in the Herbals Ayurveda & Nutraceuticals category the Gold Award for Patents and the Silver Award for Exports in Herbals. Since the company s founding Sabinsa Corporation Sami Labs has secured more than 95 patents globally. For more information visit www.sabinsa.com. Gokaraju Gangaraju (in white shirt) member of Parliament to the 16th Lok Sabha presents award to Madhavi T Sr. Manager--Business Development Sami 14 Nutrition Industry Executive Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 Alkemist Labs to Offer Next Generation Sequencing DNA Testing eginning in early 2016 Alkemist Labs (Costa Mesa CA) will include Next Generation DNA Sequencing in the arsenal of testing capabilities the company offers clients. Adding DNA analysis to our testing capabilities once the technology evolved more has been in the plans since my father and I started building our herbarium almost 20 years ago said Elan Sudberg CEO of Alkemist Labs. Our clients want us to offer this service and with recent events as well as advancement in technology we felt it finally the right time to bring it in house. However this is a very new technology as applied to botanical identity in industry and fit for purpose methods still need to be developed. The scientists at Alkemst believe that needs to be done collaboratively and transparently and intend to encourage trade associations and other companies in the industry to join forces in developing the groundwork required to make NGS a useful tool rather than a source of confusion. We look forward to launching this new testing platform to add additional data points and increase confidence in the realm of botanical identity said Holly Johnson PhD Alkemist Labs director. It is in everyone s best interest for industry stakeholders and technical experts to work in collaboration on developing a database of verified sequences from authenticated specimens and also in building consensus with appropriate standardized methods and validating procedures with full transparency in testing. NGS equipment is the newest and most powerful tool available for speciation in plant based products it goes deeper than anything else said Sudberg. However that depth can reveal nearly anything that was gathered with the herb in inconsequential quantities such as pine pollen for example and an occasional piece of grass from the field. We plan to work with the industry to help establish how much pine pollen constitutes contamination rather than just a negligible component of a natural product to be expected and accepted. The events of this year have made it clear that we as an industry must make absolutely cer- B tain our product contents match our product labels and this technology when used correctly and appropriately may help us ensure that. NGS technology has become simpler to use and more affordable. The latest innovation in benchtop sequencing is the ThermoFisher Ion S5 Next Generation Sequencing System for tar- geted sequencing which Alkemist is in the process of installing in its facility. For more information visit www.alkemist.com. Go to www.niemagazine.com fenchem for info about this advertiser Celebrating 20 Years of Excellence 1995-2015 Nutrition Industry Executive 15 November December 2015 www.niemagazine.com IndustryNews Industry Responds to Oregon AG Lawsuit Against GNC he natural products industry is responding to a lawsuit filed by Oregon Attorney General (AG) Ellen Rosenblum alleging that supplement retailer GNC (Pittsburgh PA) violated the state s Unlawful Trade Practices Act. The lawsuit accuses GNC of selling workout supplements containing picamilon a prescription drug used to treat neurological conditions. Acting Deputy Director of the Dietary Supplement Programs at the U.S. Food and Drug Administration (FDA) Cara Welch wrote in a signed affidavit on September 28 that picamilon does not fit any of the dietary ingredient categories under the law. Despite this assertion the FDA has yet to use its enforcement power to restrict the ingredient. Both the Natural Products Association (NPA) and GNC have responded to the lawsuit. NPA strongly criticized the FDA for its failure to take action in this case and for its decision to delegate authority to the state level. The FDA has both the authorities T and tools in place to take action against harmful ingredients said Dan Fabricant PhD executive director and CEO of NPA. It is concerning to us that the FDA is delegating its responsibilities to the states instead of using its own enforcement authority. If the FDA finds an ingredient to violate the law then it should take immediate administrative action not use taxpayer dollars to fund a state priority. The AG s lawsuit also accuses the retailer of selling BMPEA which the FDA did in fact take action to remove from store shelves earlier this year. In the case of BMPEA the agency took the necessary steps to shield consumers against a product that it has found to contain an illegal adulterated dietary ingredient said Fabricant. NPA encourages this type of action in response to picamilon instead of delegating its regulatory and enforcement authority to states. On October 23 GNC filed a motion to move the lawsuit filed against it by the Oregon AG to a federal court. Regrettably despite our best efforts we were unable to reach an agreement with the Oregon Attorney General said GNC in an issued statement. As a next step the company filed today to have the action moved to Federal court. Products sold by GNC are regulated by the U.S. Food and Drug Administration. GNC s vendors certify that they are in full compliance with the Food Drug and Cosmetic Act (FDC Act) and to guarantee that their products meet all applicable Federal and state laws. Consistent with retail standard practice GNC has appropriately relied on the guarantees of suppliers that their products are lawful the statement continued. This is a basic tenet of retail sales and is recognized in federal law in the FDC Act and what is known nationally as the FDA Guarantee. GNC is contractually entitled to indemnification by its third-party vendors related to these guarantees and requires appropriate levels of third party vendor insurance. For more information visit www.gnc.com or www.npainfo.org. PLT Health Solutions Launches Transparency & Trust Building Initiative P LT Health Solutions Inc. (Morristown NJ) has launched a formal transparency and trustbuilding initiative for its ingredient portfolio. The initiative is designed to support emerging opportunities for food beverage and supplement companies that can deliver assured ingredient quality demonstrable efficacy and clean labels in consumer products. Called PLT360 the initiative has a major quality assurance component that focuses on ingredient integrity and quality compliance. It also includes programs that focus on sustainability and efficacy. The process framework of PLT360 is designed to build value into PLT s ingredients that can be transferred by consumer products companies through their own products into the market-- building trust and also responding to important and emerging consumer preferences. PLT started the ingredient review process with some of its flagship brands this summer and will continue the review through 2016. According to Devin Stagg vice president of strategy and business devel16 Nutrition Industry Executive opment changing markets create new opportunities for forward-thinking companies. The natural ingredients market is very active right now--with consumers demanding ingredients they can trust in cleaner simpler healthier formulations and increased scrutiny on quality and claims. PLT360 is a recognition that best-in-class ingredient solutions go beyond the demands for traceability ingredient identification and quality compliance. They must also be efficacious and sustainable he said. PLT360 examines every aspect of an ingredient that we supply in an effort to provide transparency with our operations build trust with the health and well-being community and together with them support healthier happier lives for the con- sumers we serve. The program is designed to create a new type of value for consumers and as a way to differentiate ingredients that build brands and win market share. The four main pillars or activity areas of PLT360 are Integrity Quality Sustainability and Efficacy. According to Seth Flowerman executive vice president of PLT PLT360 while a major initiative for the organization is in keeping with the company s core principles of delivering market-ready science-backed ingredients that help its customers build strong brands. The PLT360 Program is a formalization of many of the things we currently do to provide value and confidence for our customers. It is also a roadmap to how we plan to improve our company our manufacturing network and our ingredient offerings in the future. Finally it is part of a dialogue we want to have with our customers to ensure that--together--we are always looking to serve the best interests of consumers he said. For more information visit www.plthealth.com plt360. Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 Branch Out and Join VRM Media s FAMILY OF PUBLICATIONS NIEmagazine.com VitaminRetailer.com FitnessTrainerMag.com NaturalPractitionerMag.com Our 2016 Media Planner Is Now Available At NIEmagazine.com 2016-Media-Planner Contact One of Our Ad Specialists Today Russ Fields at 732-432-9600 ext. 102 or e-Mail RussF VRMmedia.com Gary Pfaff at 732-432-9600 ext. 103 or e-Mail GaryP VRMmedia.com IndustryNews NSF International Launches Suite of GMO Transparency Services R esponding to industry and consumer demand for non-GMO (genetically modified organism) certification options NSF International has launched NSF NonGMO True North. NSF International s newest certification offering expands its suite of GMO transparency services for retailers manufacturers suppliers and producers. The new nonGMO certification available through NSF International s Consumer Values Verified Program is offered in addition to Non-GMO Project verification. NSF Non-GMO True North certification utilizes elements of global and domestic GMO labeling regulations including E.U. and Vermont GMO labeling requirements. The certification gives credit for food safety quality system best practices including segregation traceability and supplier approval and monitoring programs. Additionally to ensure consumer confidence and transparency NSF Non- GMO True North requires risk assessment-based unannounced audits unannounced chain of custody sampling and independent testing. It also requires manufacturers to perform routine testing. NSF Non-GMO True North provides manufacturers an additional certification for sourcing and production claims on packaging and in marketing materials at a time when non-verified and never inspected claims for Non-GMO or GMO-Free are increasingly commonplace in the absence of federal oversight. Research reveals a gap between what American consumers report they want in GMO transparency and how U.S. manufacturers and the supply chain are keeping pace. According to a recent Consumer Reports study ...GMO labeling isn t required in the U.S. Yet our survey found that 92 percent of Americans want genetically modified foods to be labeled. NSF NonGMO True North is an expansion in non-GMO cer- tification services that will help consumers make an informed decision about the food they eat as more products in the marketplace are able to be independently certified by a trusted thirdparty certifier said Jaclyn Bowen director of NSF International s Consumer Values Verified Program. As consumer demands for non-GMO products grow NSF Non-GMO True North offers producers (including ranchers and farmers) processors and manufacturers a solution that utilizes fundamentals of other current and emerging regulatory and food safety requirements. The conversation around GMO labeling continues to grow in relevance as the U.S. government considers the Safe and Accurate Food Labeling Act. Additionally the state of Vermont GMO regulation requires the labeling of food products containing genetically engineered ingredients effective July 2016. NSF Non-GMO True North is part of the NSF Consumer Values Verified Program which can harmonize multiple certifications and inspections including its GMO transparency services into one fluid process. This increases efficiency for companies trying to reach and inform today s increasingly health- and environmentally conscious consumers. For more information visit www.valuesverified.org. Go to www.niemagazine.com nutritional 18 Nutrition Industry Executive Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 Capsugel Acid-resistant DRcaps N ew Jersey-based Capsugel announced that it developed a technology that makes its vegetarian acid-resistant DRcaps hard capsules suitable for liquid-fill applications. As a result Capsugel s customers can now bring the benefits of DRcaps capsules--including resistance to stomach acid and taste odor-masking--to liquidbased dietary supplements. Capsugel s DRcaps capsules are made of a vegetarian polymer that slows down capsule opening after swallowing effectively masks the unpleasant tastes and odors of certain ingredients and reduces the aftertaste caused by such ingredients as garlic--all without the need for shellac coatings the company said. Since their launch in 2011 DRcaps capsules have been a winwin for customers and consumers alike which is why we are so excited to extend the platform beyond powder-filled capsules to now benefit our customers liquid-filled products as well said Peter Zambetti Capsugel s director of global business development health and nutrition. As a vegetari- an solution our DRcaps capsules can now help even more of our customers meet the demands of today s health-conscious consumers who are increasingly seeking cleanlabel options. Because of their acid-resistant properties DRcaps capsules are ideally suited for highly acid-sensitive supplements--including probiotics enzymes and certain sports nutrition ingredients--which work best in the intestines. This capability will initially be available to Capsugel s global customers through the company s Dosage Form Solutions facility in Greenwood SC. For more information visit www.capsugel.com. Deerland Enzymes Joins NASC eerland Enzymes (Kennesaw GA) has announced the company s acceptance into membership of the National Animal Supplement Council (NASC) as a Preferred Supplier. Founded in 2001 NASC is a non-profit trade organization dedicated to protecting and enhancing the health of companion animals and horses throughout the United States. Deerland Enzymes joins a membership that includes manufacturers of finished products as well as raw material suppliers distributors veterinarians and retailers. NASC s Preferred Supplier program ensures that suppliers of raw materials meet comprehensive standards for testing and other specifications to ensure its members can buy from trusted companies. Digestive health is one of the fastest-growing segments in the animal supplement market and the popularity of formulating with ingredients such as probiotics prebiotics and digestive enzymes is on the rise. Deerland s status as a preferred supplier in the NASC streamlines the sourcing process for our customers who display the NASC Quality Seal on their finished products said Scott Ravech CEO of Deerland Enzymes. For more information call (800) 697-8179 or visit www.deerlandenzymes.com. D Go to www.niemagazine.com somalabs Nutrition Industry Executive 19 November December 2015 www.niemagazine.com Celebrating 20 Years of Excellence 1995-2015 IndustryNews DDW Opens New Natural Food Color Operation DW (Louisville KY) The Color House has announced the opening of its second site in Louisville for manufacturing food ingredients. Located next to the company s global support center on Spring Street and near its caramel color operation and U.S. subsidiary on Payne Street the facility will produce specialty colorings for leading food and beverage companies in North America. Greg Fischer mayor of Louisville joined DDW associates and guests in a recent ribboncutting ceremony to celebrate the occasion. The new state-of-the-art facility will D produce DDW s new EmulsiTech color emulsions. Using cutting-edge emulsion technology DDW converts oil soluble sources such as beta-carotene and paprika into water dispersible form making them suitable for coloring beverages soup ice cream yogurt confections baked goods and more. With EmulsiTech product developers can formulate with easy-to-use natural colorings for clear or opaque applications. In addition to manufacturing the facility also houses a pilot plant cold storage and offices. The new site enables DDW to produce an even broader portfolio of food coloring in the yellow orange and red spectrum for customers said Elaine Gravatte DDW s president and chief operating officer. The opening of a natural color manufacturing site in Ireland back in April also speaks to our continued momentum as we celebrate our company s 150-year anniversary. For more information visit www.ddwcolor.com. Kerry Aquires Wellmune from Biothera Inc. erry Group plc Tralee Ireland a global taste and nutrition company has acquired Wellmune from Minnesota-based Biothera Inc. a natural food beverage and supplement ingredient that is clinically proven to help strengthen the immune system. Wellmune is a 100 percent natural food beverage and supplement ingredient that strengthens the immune system making it easier for consumers to be well and stay well the company stated. At Kerry cutting-edge science and technology informs everything we help shape and create. The addition of Wellmune to our portfolio offers Kerry tremendous growth opportunities globally said Michael O Neill nutrition president Kerry. This natural immunity enhancer strengthens our nutrition and general wellness capabilities and complements our taste solutions for applications in food beverages and supplements. The combination of Biothera s technology and Kerry s leadership in R&D nutritional science and forward looking market insights will advance the science of immune health and help create new and innovative food beverages and supplements said Richard G. Mueller chief executive officer of Biothera. Wellmune is a great fit for Kerry s portfolio of science-based nutritional ingredients. Backed by more than 10 clinical studies this proprietary yeast beta 1 3 1 6 glucan has regulatory approval in major markets around the world. Wellmune is patented kosher halal non-allergenic GMO (genetically modified organism)-free gluten free and Informed-Sport Certified and available in products from more than 60 countries. For more information visit www.wellmune.com. K Sabinsa (East Windsor NJ) Marketing Director Shaheen Majeed has been appointed to the Board of Directors of the Sami Labs Group Sabinsa s sister company responsible for manufacturing and R&D in India. He is also a board Shaheen member of Sabinsa Corporation and of Majeed Sami Direct the Group s multi-level marketing company in India. Aker BioMarine (Norway) has appointed Trond Atle Smedsrud as vice president of the company s new product marketing department. The newly established department will focus on enhancing the value of the company s existing and new products. As part of the management team Smedsrud s main goal will be to strengthen the company s commercial focus. Qualitas Health (Jerusalem Israel) has announced that Dr. Rebecca White has been appointed as its Texas site manager. Prior to joining Qualitas she was director of cultivation at Sapphire Energy overseeing the growing and processing of microalgae. BENEO (Morris Plains NJ) has named Ginger Schilling regional sales manager Ginger responsible for the Midwestern Region of Schilling the U.S. In her position she will support the food and beverage manufacturers in the region in improving existing and developing new products--both nutritionally and functionally. MJS Packaging (Livonia MI) recently welcomed Matthew McDonnell as the company s new director of business development. In this role McDonnell will focus on developing and implementing plans to increase existing business and capture Matthew new opportunities and will be an active McDonnell member of the sales team. In addition he will continue to serve as a member of the Board of Directors of MJS Packaging a position he has held since late 2010. www.niemagazine.com November December 2015 You reHired 20 Nutrition Industry Executive Celebrating 20 Years of Excellence 1995-2015 IngredientNews Ingredion Submits Health Claim to FDA ngredion Incorporated (Weschester IL) submitted a health claim petition to the FDA (U.S. Food and Drug Administration) for the reduction of risk for type 2 diabetes with resistant starch from high-amylose corn. HI-MAIZE resistant starch is a type of dietary fiber derived from a variety of corn that is high in amylose starch. This type of starch is resistant to digestion and acts like fiber in the human digestive tract the company said. It is a white powder with a mild taste that is easily incorporated into everyday foods such as pasta smoothies bread muffins and other baked goods. We believe that there is consistent scientific evidence showing a clear I link between consumption of resistant starch from high-amylose corn and reduction of risk for type 2 diabetes. Ingredion collaborated with external scientific and regulatory experts who indicated that these findings provide a strong basis for a health claim petition for reducing the risk for this disease said Christine Pelkman PhD senior nutrition scientist and clinical research manager at Ingredion. Eight well-controlled clinical trials showed HI-MAIZE resistant starch from high-amylose corn improved insulin sensitivity or other biomarkers accepted by the FDA as evidence for reduced risk for type 2 diabetes the company said. The petition underwent an initial review by the FDA and was accepted for filing on July 8 2015. After going through a public comment period the petition is now under review as a qualified health claim. A final decision is expected in the first quarter of 2016 or later. For more information visit www.ingredion.com. AlaskOmega Launches MSCCertified Omega-7 Concentrate hio-based Organic Technologies producer of AlaskaOmega omega-3 fish oil concentrates and natural oils announced the addition of AlaskOmega marine ingredient product line Omega-7. AlaskOmega Omega-7 Palmitoleic 500 allows formulators to achieve higher omega-7 label claims and use smaller capsule sizes versus other traditional omega-7 sources such as sea buckthorn oil at a more competitive price the company said. We see the omega-7 category growing as customers search for new clinically documented products and formulation ideas within the omega space said Dan Wiley vice president of nutrition and health at Organic Technologies. Organic Technologies is positioning our AlaskOmega Omega7 Palmitoleic 500 concentrate as a high strength omega-7 alternative Wiley continued. We think our tasteless and odorless MSC (marine stewardship council) certified omega-7 concentrate will be a welcome addition to the omega 3 6 9 category as formulators look to leverage the many health applications of this unique potent omega-7 ingredient and to provide a broader spectrum of omegas added Steve Dillingham global director for AlaskOmega Ingredients. For more information visit www.alaskomega.com. BiovaFlex Reduces Back Pain After Five Days iovaFlex a water soluble egg membrane (WSEM) ingredient by Iowabased Biova LLC was associated with improved joint function increased comfort in daily activities and elevated physical activity according to a just-published peerreviewed research study article the company said. Specific results could be seen in as few as five days. The article Support of Joint Function Range of Motion and Physical Activity Levels by Consumption of a Water-Soluble Egg Membrane Hydrolyzate in the September issue of Journal of Medicinal Food is based on research conducted by NIS Labs Klamath Falls OR. The randomized double-blind placebo-controlled crossover study showed consuming 450 mg of BiovaFlex daily was associated with improved joint range of motion (ROM) in multiple areas including the neck back hips shoulders and knees. Increased physical energy and activity levels were observed. Subgroup analysis showed reduction of back pain after just five days. Research demonstrating quantitative ROM and pain improvements is significant but the real takeaway is that people feel better when taking BiovaFlex said Matt Stegenga Biova president. Exercise everyday life can cause discomfort. The ability to do the daily activities one wants or needs to accomplish is what people value. Showing rapid improvement in back pain after just five days is exceptional in the current natural ingredients marketplace. For more information visit www.biova.com. O B November December 2015 www.niemagazine.com Celebrating 20 Years of Excellence 1995-2015 Nutrition Industry Executive 21 IngredientNews Viva 5 Corporation and Mitsubishi Ingredients Partner lorida-based Viva 5 Corporation is partnering with Mitsubishi International Food Ingredients a specialty ingredients company to develop and help commercialize the proprietary Immuno-LP20 ingredient in gummy delivery forms. Originally isolated from a traditional Asian food Immuno-LP20 is specially processed Lactobacillus plantarum L-137 probiotic strain also known as an immunobitoic super potentiated for its balanced immune F benefits with a five-year shelf life the company said. We are very excited to team up with Mitsubishi Ingredients and are equally impressed with their commitment to high-quality science-based products said Brian Baer president of Viva 5. With the growth of probiotic sales in dietary supplements as well as gummy delivery forms we expect to see high demand for Immuno-LP20 Gummy applications. We believe the Immuno-LP20 strain is an ideal candidate for such a product in the marketplace due to its scientific support and superior stability over traditional commercial probiotic products. For more information visit www.viva5corp.com. PureCircle to be Granted Patent ureCircle a producer of highpurity stevia ingredients based in Illinois announced that it will receive a U.S. Patent Application for the use of rebaudioside M (Reb M) in beverage applications. Dr. Avetik Markosyan vice president R&D and process development of PureCircle Limited stated Our new Reb M product patent is the latest of more than 60 other granted patents across our portfolio of stevia ingredients. Our expanding list of patents reinforces our customers confidence in working with us as the industry leader in high-purity stevia. For more information visit www.purecircle.com. BASF Human Nutrition Launches Ultra-high Omega-3 Concentrate ew Jerseybased BASF launched an ultra-high omega3 concentrate (approximately 90 percent) PronovaPure 46 38 EPA DHA. We carefully concentrate the beneficial omega-3s to a high level of 90 percent to ensure optimal delivery of the healthy components EPA and DHA said Anne van Gastel business director BASF Human Nutrition. Research shows that omega-3 products support health platforms including cognitive function and heart health depending on the ratio of EPA to DHA. BASF s PronovaPure has a minimal fishy taste and is perfect for small easy-to-swallow soft gels. For more information visit www.basf.com. P N Egg Protein Demonstrates Unique Benefits tudies with a new protein hydrolysate from egg whites revealed benefits for cardiovascular health and metabolic syndrome pre-diabetes. NWT-03 the trade name NewtriFlow is a natural ingredient from egg white produced through a proprietary enzymatic hydrolysis process. According to the studies NewtriFlow has been shown to be beneficial to decrease triglycerides reduce blood glucose levels increase of insulin sensitivity reduce blood pressure realization of blood vessels and increase low S HDL cholesterol. NewtriFlow was developed specifically to prevent health complications in the pre-diabetes population. The Netherlands-based Newtricious is seeking a strategic partner for the marketing and distribution and co-development of NewtriFlow and will be available as an ingredient than can be utilized in nutritional supplements and food applications. The results of NewtriFlow for metabolic syndrome and cardiovascular health are very impressive said Dr. Luc Sterkman COO Newtricious. Newtricious has high expectations from this product for the benefit of the ever-increasing number of people with pre-diabetes. For more information visit www.newtricious.com. 22 Nutrition Industry Executive Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 PLT Health Solutions Teams Up With DolCas Biotech ew Jersey-based PLT Health Solutions Inc. announced that it is partnering with DolCas Biotech LLC (Chester NJ) to bring OXYSTORM Standardized Nitrate to the U.S. market. OXYSTORM is an extract of red spinach (Amaranthus dubius) one of the richest sources of nitrate in nature. The patent-pending production process delivers 9 000 mg 100 g with more than five times the amount of nitrate at beetroot powder and 50 times of beet juice. OXTYSROM is offered as a powder is nutrient dense 100 percent water-soluble sugar-free and has a neutral pH making it ideal for any formulation type. N We have seen some interesting research demonstrating the use of nitrate in the form of beet juice or beetroot powder in positively impacting vascular and muscle function via nitric oxide (NO) production during workouts or athletic competition said Sid Hulse director of new product development at PLT Health Solutions. What we see with beetroot powder and beet juice is that they have relatively low levels of nitrate in a typical serving and that these levels can vary widely based on where and how the plants were harvested and processed he continued. We call OXYSTORM an optimized form of nitrate for sports nutrition applications. It is a concentrated form of nitrate standardized to a minimum 9 percent nitrate content. But almost as important is what isn t in it. OXYSTORM does not contain oxalate which is often found in spinach and beet greens. It also does not contain sugar--which many beetbased products do in relatively high amounts. We re very excited to be teaming up with DolCas Biotech to bring this ingredient to our customers he added. For more information visit www.plthealth.com. PrimaVie Study Increases Testosterone Levels atreon s (New Brunswick NJ) PrimaVie a clinically proven and high-quality purified shilajit from the Himalayas significantly increased free and total testosterone levels in healthy volunteers in a new study published in Andrologia. In a random double-blind placebo-controlled study 75 healthy volunteers between the ages of 45 and 55 received either 250 mg doses of PrimaVie or identical placebo twice daily for 90 consecutive days. Results from the study showed that supplementation with PrimaVie led to a 20 percent increase in total testosterone levels and a 19 percent increase in free testosterone levels. The results suggest that the supplement would be an ideal ingredient for male sexual health products. PrimaVie consists of dibenzo-apyrones (DBPs) DBP-chromoproteins (DCPs) fulvic acid 40 different trace minerals and very low levels of heavy metals the company said. It can be utilized in beverages including ready-to-drink beverages is more than 90 percent soluble and stable in solution and is pre-DSHEA (The Dietary Supplement Health and Education Act of 1994) kosher and halal certified and has achieved GRAS (generally recognized as safe) status. In conjunction with increasing testosterone levels clinical studies have shown that PrimaVie increases exercise endurance overall fitness and up-regulates genes in skeletal N muscle coding for synthesis of collagen and related extracellular matrix proteins by several fold making it ideal for sports nutrition beauty from within and anti-aging products as well. For more information visit www.natreoninc.com. Go to www.niemagazine.com herballyyours for info about this advertiser Celebrating 20 Years of Excellence 1995-2015 Nutrition Industry Executive 23 November December 2015 www.niemagazine.com IngredientNews Isolated Soy Protein Offers Superior Dispersibility for Beverages D uPont Nutrition & Health (Denmark) announced the introduction of a new product innovation for dry blended nutritional beverage powders SUPRO XT 221D Isolated Soy Protein. SUPRO XT 221D is a plant-based high-quality protein that disperses completely in water in only nine seconds the company said. Consumer complaints such as hard to stir in and lumps are commonly heard in the dry blended beverage industry said Jean Heggie marketing strategy lead DuPont Nutrition & Health. Based on what we ve seen in the marketplace we believe SUPRO XT 221D disperses faster than any other isolated soy protein on the market today. This latest innovation from DuPont Nutrition & Health offers the potential to create a much better experience for the consumer and drive brand preference. According to the company in sensory studies with consumers DuPont Nutrition & Health compared a 20 g protein supplement formulation with SUPRO XT 221D with similar formulas made with other isolated soy proteins. Consumers rated the SUPRO XT 221D formula significantly higher in flavor dispersibility mouth-feel and overall liking. The study also confirmed significantly higher purchase intent scores for the SUPRO XT 221D formula. SUPRO XT 221D Isolated Soy Protein also demonstrates flow characteristics which has the potential to improve plant efficiencies by improving can-fill speed and accuracy. The flow characteristics of SUPRO XT 221D provides a 50 percent improvement overall compared to DuPont s previous best flowing technology. For more information visit www.dupont.com. Natural Alternatives Expands Commitment to CarnoSyn Brand alifornia-based Natural Alternatives International (NAI) announced its expanded commitment to CarnoSyn a patent-protected beta-alanine ingredient for supporting an increase in muscle C carnosine and athletic performance. NAI began to directly oversee the sales and distribution of CarnoSyn in the U.S. and abroad in April 2015 as well as showcased CarnoSyn and previewed SR Carnosyn a new sustained release beta-alanine powder at SupplySide West Las Vegas NV in October. CarnoSyn beta-alanine is an ingredient in sports nutrition formulations supporting the synthese of muscle carnosine which acts as a buffer delaying the onset of muscle fatigue and failure. SR CarnoSyn provides flexibility via a sustained release profile extending the benefits of betaalanine to a much broader group of active lifestyles it releases much higher dosage levels than instant release CarnoSyn the company said. NAI is investing significant resources towards building promoting and protecting the CarnoSyn brand as well as supporting the upcoming launch of our new SR CarnoSyn sustained release beta-alanine powder Mark A. LeDoux NAI CEO and board chairman said. We re very excited to expand the CarnoSyn portfolio of products and to work in partnership with both current and prospective partners to help drive business opportunities. For more information visit www.nai-online.com. 24 Nutrition Industry Executive Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 PlusBiotic Ingredients Introduced to Nutraceutical Market CI Nutrients USA Inc. a California-based company has developed a line of PlusBiotic ingredients that support the regrowth of the intestines. These ingredients are specialized nutrients that target the rebuilding of the intestinal mucosa. The first of these PlusBiotic ingredients are protected under the PrebioSure Brand the only clinically proven ingredient to greatly enrich epithelium enterocytes of the small intestine mucosa and enable reconstruction of healthy uniform villi lining that is responsible for optimal absorption of macro- mirco- and G trace elements. PrebioSure is based on several years of research and development of a proprietary enzymatic extraction of biologically active compounds such as benzoquinone from non-GMO (genetically modified organism) and organic food grade wheat germ. Its synergistic and symbiotic effect combat harmful bacteria and nourish beneficial bacteria aiding in many metabolic processes and prevent side-effects such as flatulence bloating diarrhea caused by Inulin IMO FOS GOS XOS. For more information visit www.gcinutrients.com. KD-Kap Omega-3 Dispersion D Omega Health a Germany-based company announced the launch of its new KD-Kap encapsulated omega-3 products. Offering high omega-3 loading KDKap products offer a shelf stable solution for water-based applications in pharmaceuticals dietary supplements food and beverages. K KD Omega Health s flexible patented MicroJet Reactor technology creates KD-Kap Omega 3 that is both protected from oxidation and easily mixable in water. KD-Kap double encapsulated omega-3 is odorless and tasteless and made to suit your specific needs the company stated. For more information visit www.kd-pharma.com. MenaQ7 Vitamin K2 Featured in PreNatal Blend C alifornia-based SuperNutrition has reformulated its best-selling PreNatal Blend multivitamin adding Norway-based NattoPharma s MenaQ7 as its source of vitamin K2 (MK-7). This decision comes on the heels of the growing scientific research demonstrating how vitamin K2 (MK-7) cannot only have a significant impact on heart and bone health but also has an essential role in craniofacial and skeletal devel- opment of the fetus the company stated. We are fortunate to partner with NattoPharma of Norway. We selected their MenaQ7 the only clinically validated form of K2 as MK7 specifically because of its superiority and the growing scientific research supporting it said Kathy Mooney CEO SuperNutrition. For more information visit www.supernutritionusa.com or www.nattopharma.com. Celebrating 20 Years of Excellence 1995-2015 Nutrition Industry Executive 25 November December 2015 www.niemagazine.com IngredientNews Valensa Awarded U.S. Patents on Omega-3 Perilla Seed Compositions V alensa International (Eustis FL) announced that it received a series of patents covering the composition and application of nutraceutical formulations featuring Perilla seed oil as a major component. The most important patent covers the use of Perilla seed oil alone or in combination with other omega-3 sources such as krill oil algae oils fish oils and other seed oils for cardiovascular health support. Perilla seed oil is an ideal way to address the omega-6 omega-3 imbalance which is common to Western diets but which is also a feature of vegan and vegetarian diets because of the difficulty these groups have in consuming adequate amounts of omega-3 from food sources. For more information visit www.valensa.com. Study Confirms Neuravena Efficacy on Cognitive Performance A placebo-controlled doubleblind randomized cross-over study investigated the effects of 800 mg Neuravena produced by Israel-based Frutarom on cognitive performance. The study used the computerized mental performance assessment system (COMPASS)--a battery of tests selected to allow assessments across the major cognitive domains including global func- tioning (speed accuracy) attention working and episodic memory and executive function. Neuravena is an extract of a proprietary variety of green oat (Avena sativa). Frutarom s EFLA HyperPure patented technology used to pro- duce Neuravena ensures good solubility stability purity and removal of contaminants. Neuravena is a natural safe and effective ingredient suitable for multiple supplements and food and beverage formats such as energy drinks cereal bars cookies and dairy products the company said. For more information visit www.neuravena.com. Albion Launches Powdered Drink Applications for Sports Nutrition tah-based Albion Human Nutrition a manufacturer of patented organic mineral amino acid chelates announced the launch of two magnesium applications optimal energy MLG (magnesium lysinate glycinate) powdered drink and Albion s MGG (magnesium glycinate glutamine) powder drink for sports recovery both targeted at the sports nutrition market. Magnesium is critical to more than 300 functions in the body including heart rhythm blood pressure sleep energy production and muscle health the company said. Albion s MLG binds magnesium with lysine an essential amino acid that is a building block for all protein. Together magnesium and lysine support magnesium absorption and aid in muscle recovery. Albion s MGG chelate binds to both glycine and glutamine enhancing molecule stability and nutritional functionality. Glutamine is the most abundant free amino acid in the body and helps support optimal recover when the body undergoes physical stressors and challenges. According to Albion both ingredients have other excellent applications including capsules tablets foods and other beverages. For more information visit www.albionminerals.com. U 26 Nutrition Industry Executive Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 SupplySideWestWrapUp Supply Side West 2015 Breaks Records T his year s SupplySide West event held at the Mandalay Bay in Las Vegas NV saw a 9 percent increase in attendance over last year and approximately 45 percent were first time attendees. With more than 1 200 exhibiting companies on the show floor and a total of 14 000 people who came out to the five-day event this was another record-breaking event according to show organizers. The American Institute for Biosocial and Medical Research (AIBMR) was one of the exhibitors in attendance this year and every other year since the first show in 1996. In AIBMR s opinion SupplySide West is the most important natural products suppliermanufacturer trade show in the world today said Alexander G. Schauss PhD FACN CFS president and CEO of AIBMR Life Sciences Inc. However the growth of the show in recent years has created a challenge--how can exhibitors attend presentations during the show AIBMR feels it s worth Informa Exhibitions considering the value of making it possible for exhibitors to attend presentations currently held during show floor hours. (L to R) Jon Benninger VP Health & Nutrition Network Informa moderating panel Dan Fabricant PhD CEO and executive director NPA Karen Howard CEO and executive director Organic & Natural Loren Israelsen president UNPA Mark LeDoux founder chairman and CEO NAI Michael McGuffin president AHPA Steve M. Mister Esq. CEO and president CRN and Mark Ullman Esq. Rivkin Radlet. Education The show featured a panel moderated by Jon Benninger vice president Health & Nutrition Network Informa and Heather Granato vice president of content Health & Nutrition Network Informa. The discussion focused on the safety and regulation of supplements DNA barcoding and the shifting landscape of the industry. Panelist participants included Dan Fabricant PhD CEO and executive director of the Natural Products Association (NPA) Karen Howard CEO and executive director of Organic and Natural Health Association (Organic & Natural) Loren Israelsen president of the United Natural Products Alliance (UNPA) Mark LeDoux founder chairman and CEO of Natural Alternatives International (NAI) Michael McGuffin president of the American Herbal Products Association (AHPA) Steve M. Mister Esq. CEO and president of the Council for Responsible Nutrition (CRN) and Mark Ullman Esq. of counsel Rivkin Radler. Along with the panel the show featured workshops vendor briefs and other discussions covering a range of topics from functional foods and dietary adulteration to product development and clean labeling. The show floor was filled with attendees browsing the exhibitor booths which covered the dietary supplement food beverage animal nutrition personal care cosmetic pharmaceutical packaging and sports nutrition marketplaces. Trends at this year s show included pet health omegas eye health and sports nutrition. Movember Kicking off the Men s Health Movember campaign early SelenoExcell by Cypress Systems used its booth to raise awareness and money for men s health. Cypress Systems set up a moustache photo booth at its location on the show floor. For each photo taken the company donated 5. Participants accounted for 1 500 in donations and Cypress matched the donations from its nonprofit JPW3 for a total of 3 000 raised. My personal mission is to reduce disease and suffering said Paul Willis CEO of Cypress and founder of the 501C-3 JPW3. We were thrilled that so many SupplySide West attendees and exhibitors joined us in such a worthy cause as Movember. The show ended with a 17 028 donation to Vitamin Angels through the SupplySide Cares program. This program donated 3 from each paid registration in support of bringing vitamin supplementation to at-risk populations. SupplySide West 2016 will return to Mandalay Bay October 4-8. For more information visit www.supplysideshow.com. Nutrition Industry Executive 27 Companies displayed their packaging capabilities on the show floor at SupplySide West. November December 2015 www.niemagazine.com Celebrating 20 Years of Excellence 1995-2015 UNPASummitWrapUp UNPA Turns Up the Heat on Industry Standards Post NY AG Summit stresses importance of identity testing and industry cooperation. By Janet Poveromo T he United Natural Products Alliance (UNPA) Dietary Supplement Analytical Summit held in November in Salt Lake City UT kicked off with a warning from UNPA President Loren Israelsen actions by attorneys general (AG) are not going away. He described a recent NAAG (National Association of Attorneys General) conference (see news item on page 14) which featured a panel discussion that included Maia Kats from Center for Science in the Public Interest as well as Harvard MD and perennial supplement critic Pieter Cohen. The Council for Responsible Nutrition (CRN) was represented by the organization s regulatory counsel Rend Al-Mondhiry Israelsen said. Their meeting was a very painful 60 minutes he noted adding that AGs are arguing that herbal products are not supplements but drugs. the eight common allergens and offer consumer education in store and on website about raw material and finished product testing. The two suggested an outline for an industry stakeholder groups to elevate standards. The plan includes a coordinated media approach to define a strategy and roadmap to change the narrative of erroneous stories. They also suggested a raw material GMP action group that would require suppliers meet industry standards based on U.S. GMP regulations Australia s Therapeutic Goods Administration Health Canada among other examples. Lastly the two suggested a finished product notification database. We want to consider as a group a product notification database. We want to test sample database for ease of notification and effectiveness of data collection identify third-party providers and costs per product they noted. GNC s AG Settlement During the summit Jim Sander GNC s senior vice president chief legal officer and Guru Ramanathan PhD GNC s senior vice president and chief innovation officer explained the company s settlement with the New York AG. According to Sander the company first received news of the AG s letter regarding the impure marketing of five products from a New York Times reporter on deadline. They received the call at 4 o clock and were given one hour to respond. Regarding the testing on finished goods Sander said We knew it was inappropriate right away. The company submitted to an information request. We gave them everything he said noting that the company supplied 70 000 pages of information. Ultimately the AGs findings were that GNCs products were consistent with GMPs (good manufacturing practices) and labeling laws. So why did they settle GNC said they agreed to a settlement because the alternative was tedious litigation and concerns regarding consumer confidence. The perception was that consumer protection laws are inadequate Sanders explained. A drawn-out investigation would keep these erroneous statements on people s mind. The company agreed to DNA-based testing to authenticate plants where it s feasible in addition to standard testing techniques. They also agreed to test for 28 Nutrition Industry Executive of DNA can be amplified small difference in DNA cause negative results and that the degree of certainty in the method is 53 to 85 percent. Failure to detect DNA does not mean it doesn t exist. She stressed that DNA barcoding must be fit for purpose. DNA isn t magic it s just another chemical test. Danica T. Harbaugh Reynaud PhD CEO of AuthenTechnologies LLS and a botanical geneticist clarified that DNA barcoding is not DNA sequencing. It s a process not a technology. She argued that such testing works is accurate and can be used on old things. She noted that false negative results and detection of cross-contaminants can occur if used on degraded DNA such as extracts or if not tested under well-controlled conditions. There are numerous ways to conduct DNA-based authentication. Each method must be validated. Currently AuthenTechnologies is the only full-servcie DNA contract testing laboratory for natural products industries. She explained that when the NY AG targeted supplements in February she called the test scientist. They did not call me back she said. Afterward she co-authored a white paper refuting the AG s findings. Expert Guidance Offering his advice Ikhlas Khan PhD associate director National Center for Natural Products Research University of Mississippi noted that the industry is 21 now (since the passage of DSHEA) and has grown. Post NY AG what are we dealing with he said. Small companies probably don t need to do DNA testing since they are not being watched he said. The bigger players do. We have to know what we are dealing with before we take an approach he noted adding media bashing is an excuse. His suggestions for industry solutions Creating Institution s for the dietary supplement industry Create a public reference library of authentic reference material Compounds reference markers (specific) Clearing house for methods of analysis and reference method Represent the current status of science Be the liaison for scientific issues DNA Testing Exchange Susan Murch PhD professor and Canada research chair natural product chemistry University of British Columbia said DNA barcoding is easy cheap fast technology adding that these tests have been made much faster. The capacity is now massive. She added we don t have a grip on diversity. There are sources of error the same primers don t work for all species. She added that small amounts Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 AHPAUpdate Leading Industry Association Speaks Directly to Nutrition Industry Executive Readers Perspective on Emergency Room Visits Purportedly Associated With Supplements n article recently published in the New England Journal of Medicine (NEJM) presented a review of emergency room (ER) visits to 63 hospitals between 2004 and 2013 reportedly associated with dietary supplements and other products such as over-the-counter drugs and skin creams (Geller AI et al. 2015) ( Emergency Department Visits for Adverse Events Related to Dietary Supplements October 15 2015). Extrapolating from this data the authors estimate an average of 23 005 ER visits for adverse events associated with dietary supplements annually and calculate that about 9 percent of these would actually result in hospitalizations. Marketers of dietary supplements are committed to providing safe products for our millions of consumers as is required under federal law commented Michael McGuffin president of the American Herbal Products Association (AHPA). This study when placed into the context of the U.S. population of supplement users and compared to other product categories demonstrates the relative safety of this product class. The authors of the dietary supplement study include four employees of the Center for Disease Control and Prevention (CDC) and three employees of the U.S. Food and Drug Administration (FDA). Some of these same authors have conducted similar analyses on unsupervised pediatric medication exposures (estimating 54 000-76 000 ER visits annually between 2004 and 2013) (Lovegrove MC et al. 2015) and on insulinrelated hypoglycemia and errors (estimating 98 000 ER visits each year primarily in elderly persons (80 years or older) with more than one-third resulting in hospitalization) (Geller AI et al. 2014). A Article Includes Drugs Cosmetics and Other Non-supplement Products In the NEJM article Geller et al. incorporate several products that do not meet the federal definition of dietary supplements. These include products that are regulated and lawfully marketed as drugs including eye drops ear drops and homeopathic products topical treatments like skin cream and at least two misbranded drugs found by FDA to contain undeclared active pharmaceutical ingredients. The authors confirm that these are also included in the analysis in spite of the implication of the article s title (and the resulting media emphasis) as relevant only to dietary supplements. Because no perproduct information is provided on the number of reported hospital visits there is no way to know what portion of these visits were associated with products that are not dietary supplements. ciated with prescription drugs (taken as a doctor prescribed) (CDC 2015) 775 000 of the 30 million children participating in organized sports visit an ER annually (Johns Hopkins Medicine 2015) More than 1.2 million ER visits every year for first-listed alcohol-related diagnoses for persons ages 12 years and older (NIH 2013) Roughly 2.3 million people visit an ER each year in association with a headache (CDC 2015) Approximately 136 million total ER visits took place in 2011 (CDC 2015) A Fraction of Supplement Users Visit the ER Due to Supplement Use Roughly 166 million Americans use supplements each year (CDC 2011). According to Geller et al. approximately 23 000 would be expected to have an ER visit associated with their consumption representing less than 0.014 percent of all supplement users. As already noted many of the products included in the article s numbers are actually drugs (lawful or otherwise) or topical products rather than supplements so the number estimated for supplement-associated ER visits would be lower if these products were excluded from the data. The authors also identify several possible limitations of their analysis noting that the number of estimated ER visits is probably an underestimation but also acknowledging their data gathering methods could lead to overestimation. A Fraction of ER Visits are Associated With Supplements Every year roughly 136 million people visit the ER in the U.S. The just over 23 000 visits estimated by Geller et al. as associated with supplements (and some nonsupplement products) represents about 0.017 percent of these ER visits. Health agencies such as the CDC and National Institutes of Health (NIH) have for many years compiled information on the numbers and causes of emergency department visits and hospitalizations in the U.S. A sampling of some of this data is provided below to provide some perspective on the supplement numbers in this article 731 000 hospital ER visits every year are asso- Unsupervised Ingestion by Small Children More than 20 percent of the ER visits in the Geller report were attributed to unsupervised ingestion by children under the age of four representing approximately 4 900 expected ER visits annually. While this is a serious matter it does not indicate concern over the safety of dietary supplement use but instead suggests a need to ensure that adults supervise children s access to supplements. This same parental responsibility is also relevant to the 54 000 to 76 000 estimated annual ER visits over the last decade associated Nutrition Industry Executive 29 November December 2015 www.niemagazine.com Celebrating 20 Years of Excellence 1995-2015 AHPAUpdate with all unsupervised pediatric medical exposures as reported in the current issue of the journal Pediatrics by some of the same authors of the article on supplement-associated ER visits (Lovegrove MC 2015) though without the same media fanfare. In addition AHPA adopted a recommendation in 2001 that consumers of herbal supplements inform their health care providers of such use. In the interest of seeing this recommendation broadly accepted by consumers AHPA also encourages health care providers to receive such communication with respect for the consumers health care choices and to seek out accurate and truthful information about herbs. Injury Statistics. Retrieved from Johns Hopkins Medicine website www.hopkinsmedicine.org healthlibrary conditions pediatrics sports_injury_statistics_90 p02787 Lovegrove MC Weidle NJ Budnitz DS (2015). Trends in Emergency Department Visits for Unsupervised Pediatric Medication Exposures 2004-2013. Pediatrics 136(4) 821-829. National Institutes of Health. (2013 September). Alcohol-related emergency department visits and hospitalizations and their co-occurring drugrelated mental health and injury conditions in the United States Findings from the 2006-2010 Nationwide emergency department sample (NEDS) etc. Supplement Marketers Must Inform FDA of Serious Adverse Event Reports AHPA Recommends Informing Physicians of Supplement Use Reflecting its uncompromising commitment to ensuring supplement products are safe AHPA petitioned FDA in 2003 to require dietary supplement marketers to submit all serious adverse event reports received from their customers to the agency. When FDA responded that it did not have the authority to establish this responsible requirement the supplement industry worked cooperatively to get a law passed in 2006 to grant this new power to the FDA. References CDC. (2011 April). NCHS Data Brief Dietary Supplement Use Among U.S. Adults Has Increased Since NHANES III (1988-1994). CDC. (2015 April 29). National Hospital Ambulatory Medical Care Survey 2011 Emergency Department Summary Tables. Geller AI et al. (2015). Emergency Department Visits for Adverse Events Related to Dietary Supplements. New England Journal of Medicine 373(16) 1531-1540. Geller AI et al. (2014). National estimates of insulinrelated hypoglycemia and errors leading to emergency department visits and hospitalizations. JAMA Internal Medicine 174(5) 678-686. Johns Hopkins Medicine. (2015 Oct. 16). Sports Michael McGuffin President and Board of Trustees American Herbal Products Association (AHPA) AssociationNews NPA Hires New Director of Government Affairs he Natural Products Association (NPA) has announced that Michael Kelley will join the association as director government affairs. In his new role Kelley will be responsible overseeing the association s interaction with the U.S. Congress and management of its PAC. Kelley joins the NPA from Mayer Brown LLP where he was a government affairs specialist in the firm s Washington D.C. office. He has extensive experience in analyzing legislation and developing strategies for T engaging the U.S. Congress. Kelley has worked extensively with government officials ambassadors and embassy staff from the governments of Kenya Egypt Malawi and Morocco in order to convey their interests on Capitol Hill the think tank community non-governmental organizations and academia. We are thrilled to welcome Michael as the newest member of our talented staff here in Washington D.C. said Daniel Fabricant PhD executive director and CEO of the NPA. I m confident that Michael s background and experience will make him an excellent addition to NPA and further solidify our position as the premier association representing the natural products industry. For more information visit www.npainfo.org. Conventions&Meetings GOED Exchange 2016 T he GOED (Global Organization EPA and DHA Omega-3s) Exchange Conference is designed to bring together those in the industry to discuss challenges faced and talk about how to shape the future together. As the omega-3 industry expands it faces new opportunities and issues at this conference the focus is to exhange ideas learn from the experts and implement new concepts in the business immediately. 30 Nutrition Industry Executive The conference will be held February 2-4 2016 at the Ritz Carlton Abama in Tenerife Canary Islands. Presentations include topics such as Authenticity Testing for Marine Oils How to Ensure Your Supply Chain s Integrity presented by Svein Erik Haugmo OmegaVeritas and Oliver Kromer IOI Maris Omega-3 From Supplement to Drug Discovering the Optimal Regulatory Pathway for Your Omega-3 Product presented by Rodney Butt MSc MBA Vice President programs Nutrasource keynote speaker Rohit Bhargava Influential Marketing Group on reputation building and consumer trust Omega-3 Case Studies facilitated by Tom Clough HSC and more. For more information visit www.goedexchange.com. Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 ScienceUpdate Study Sheds Light on Vitamin D and Improved Blood Sugar Control N ew research published in Diabetologia shows that people carrying a certain genetic variant relating to vitamin D metabolism are more likely to benefit from a high-protein weight loss diet than those without it. Previous research has shown that low levels of circulating vitamin D are associated with obesity insulin resistance and an increased risk of type 2 diabetes. Other genetic studies have identified several genes involved in vitamin D metabolism. In this study the authors analyzed whether diets high in fat or protein--both good sources of vitamin D--interact with these genetic variants in a way that improves weight loss and metabolic outcomes such as blood sugar control. They analyzed interactions with three gene variants 1. DHCR7 involved in the synthesis of cholesterol which is itself an essential component for making vitamin D 2. CYP2R1 this converts vitamin D into 25-hydroxyvitamin D which is the major circulatory form of vitamin D 3. GC vital for vitamin D storage and transport The authors analyzed overweight obese participants from a two-year weight-loss trial conducted in the U.S. (POUNDS Lost study). They assessed genotype effects on changes in body weight fasting levels of glucose and insulin and insulin resistance at both six months (656 participants) and two years (596 participants) in response to low-protein versus high-protein diets and low-fat versus high-fat diets. They found significant interactions between DHCR7 and diets varying in protein but not in fat which brought about changes in insulin and insulin resistance at both six months and 2 years. People with the DHCR7 variant which leads to increased vitamin D showed greater decreases in fasting insulin levels and insulin resistance in response to highprotein diets while there was no significant genotype effect on changes in these traits in the low-protein diet group. There was no significant interaction found between the other two genetic variants and dietary protein or any of the three variants with dietary fat. Regarding weight loss there was no significant interaction between vitamin D genetic variants and dietary protein or fat on weight loss. The amount of weight loss was similar between the low- and high-protein diet groups and between the low- and high-fat diet groups (meaning all the diets worked for weight loss but there were no differences between people with different genotypes). We speculate that vitamin D and or other nutrients from protein-rich foods may interact with DHCR7 to influence DHCR7 function thereby affecting blood vitamin D levels and eventually modifying the effects on changes in insulin resistance ... our findings provide new insight into the utility of using knowledge of vitamin-D-related genetic variation to improve personalized dietary interventions the authors said. Our findings of gene-protein dietary interaction are biologically plausible provide additional evidence for the roles of vitamin D in insulin resistance and suggest new insights into effective strategies for type 2 diabetes prevention and intervention. For more information visit www.diabetologia-journal.org. Nutritional Needs for Skeletal Health Changes With Age hether you re young or old the right nutrition can make a difference to your bone health and influence your ability to live an independent mobile fracture-free life into your more senior years. That s the key message of a new scientific review published in the journal Osteoporosis International. The review summarizes the latest evidence relating to the nutritional needs of mothers children and adolescents adults and seniors in relation to developing and maintaining a healthy skeleton. Placing particular emphasis on calcium vitamin D and protein it shows how adequate nutritional intake of these and other micronutrients can support the primary objectives for good bone health 1. Achieving genetic potential for peak bone mass in children and adolescents 2. Avoiding premature bone loss and maintaining a healthy skeleton in adults 3. Preventing and treating osteoporosis in seniors. Findings from international studies and W trials are summarized as well as current dietary guidelines. The report also underlines how lifestyle trends which lead to poor diet and nutrient deficiencies are a growing cause of concern in people of all ages and particularly in children. Milk and dairy products comprise the main stay of calcium intake for most children yet a decline in milk consumption has been observed across the world during the last few decades. Furthermore vitamin D insufficiency is widespread among youth which has led to recommendations in several countries for vitamin D supplements to be given to infants and young children. In adults and seniors studies have shown that calcium intakes are often considerably below those recommended by national guidelines. Similarly alarmingly low levels of vitamin D have been found in populations around the world. Lifestyle factors such as excessive alcohol consumption smoking and a very high or low body mass index (BMI) also ele- vate fracture risk for a substantial number of people. The impact of nutrition on falls and fracture prevention in seniors who are a growing segment of the population and most affected by osteoporosis is discussed. The review shows how deficits in protein intake as well as malnutrition can negatively affect their bone and muscle health. It also highlights how together with appropriate exercise adequate nutritional intake in those at high risk of fracture plays an important complementary role to pharmacotherapy. For more information visit www.worldosteoporosisday.org resources 2015 th ematic-report. November December 2015 www.niemagazine.com Celebrating 20 Years of Excellence 1995-2015 Nutrition Industry Executive 31 By James J. Gormley E ssential fatty acids (EFAs) are today among the most popular and widely used ingredients for finished products and food fortification in the U.S. and globally. They enjoy broad support by consumers public health agencies and medical bodies. In 1929 the essentiality of alpha linolenic acid (ALA)--the precursor of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)--was established by Burr and Burr at the University of Minnesota Medical School. In 1982 the first reported instance of omega-3 deficiency in humans was unveiled although earlier reports in infants and adults dating back to 1969 laid the foundation for this discovery. And in that 1982 medical case published by Ralph Holman and colleagues from Illinois Carle Foundation Hospital visual complications and sensory loss in a six-year-old girl on total parenteral nutrition were reversed after ALA was added to her nutritional regimen. Since EPA and DHA can be synthesized by the body from ALA these two 32 Nutrition Industry Executive omega-3 polyunsaturated fatty acids (PUFAs) do not strictly meet the definition of essential. Nevertheless since the dietary levels of omega-3s in the modern era are inadequate and due to the fact that ALA conversion is not efficient enough to satisfy health requirements EPA and DHA are considered conditionally essential. As to studies backing up EFAs an exhaustive 2015 review of animal in vivo and clinical research studies over the last 40 years by Karsten Weylandt and colleagues published in BioMed Research International noted as follows Our review of the omega-3 PUFA research literature prompts us to conclude that the animal and in vitro data have been remarkably consistent in showing health benefits particularly through mechanisms dampening inflammation and proliferation in different tissues which have established the protective effects of omega-3s in diseases ranging from cardiac arrhythmia and inflammatory conditions --such as atherosclerosis and arthritis--to cancer. In fact Duffy MacKay PhD senior vice president of scientific and regulatory affairs for the Council for Responsible Nutrition (CRN) noted The numerous benefits of omega-3 fatty acids from foods like salmon and sardines and dietary supplements are well-established for men and women for all stages of life. Hundreds of studies over the past two decades have shown omega-3 fatty acids to have positive effects associated with cardiovascular health perinatal health inflammation cognitive function and cancer added MacKay. So it is with dismay that the industry is challenged by commentaries in the mainstream media dismissing the established benefits of dietary omega-3s such as the recent New York Times headline Fish Oil Claims Not Supported by Research. In a response to the Times piece William Harris PhD CEO of OmegaQuant Analytics in South Dakota found a number of problems repeated in meta-analyses and studies Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 that are often the focal point of such articles one of which involves the statistical methodologies used. In referring to a meta-analysis by Rizos and colleagues in 2012 Harris said They concluded that fish oil capsules offer no benefit for heart patients. Unfortunately Rizos used a highly controversial statistical maneuver. In their actual data there was a highly statistically significant reduction in cardiac death associated with fish oil use (p 0.01 for the stat-savvy). So fish oils did reduce risk for cardiac death. Why the no effect conclusion Harris asked. The researchers decided to set the statistical bar higher than I ve ever seen it in meta-analyses. They defined a significant p-value as 0.006 instead of the universally accepted p 0.05. This trick changed a positive finding into a negative one and generated a media storm of fish oils don t work. Other issues with some of the recent studies noted Harris is that they are plagued with such problems as using too low a dose supplementing for too short a period and selecting very sick patients who are already being treated with very powerful medications. To this we can add that for populations and study groups already consuming a great deal of fish in their diets supplemental omega-3s might not show a very significant added benefit. Doctors--the top gatekeepers of health information continue to recommend omega-3s to their patients. In research sponsored by Aker BioMarine in 2014 90 percent of physicians said they continue to recommend omega-3s to their patients despite the negative media coverage. In fact added Wright 30 percent of physicians are recommending them more since the first of several negative studies and stories surfaced in mid-2013. Gunilla Traberg marketing and communications manager health and nutrition for Pennsylvania-based FMC Corporation the maker of Epax omega3 concentrates said that Essential fatty acids is still one of the strongest supplement categories we believe this is due to both the strong science supporting EFAs and also to the unique traditiondriven place occupied by omega-3s in the minds of many customers. The State of the EFA Market In terms of the EFA omega-3 market on the one hand there is heavy market saturation and commoditization of traditional fish oil products with added value segments (such as algae- or krillsourced products) on the other hand unique delivery forms combination products and unique processing technologies offer disruptive innovation and differentiation in an otherwise crowded category. Becky Wright marketing director for Norway-based Aker BioMarine AS believes that The marine omega-3 market--here in North America and abroad--is rebounding from a perception problem one that severely impacted sales over the past couple of years especially for fish oil. Wright said that there is a lot of encouraging news too some of which came out of a physician-focused study sponsored by Aker BioMarine in 2014. The marine omega-3 market--here in North America and abroad-- is rebounding from a perception problem one that severely impacted sales over the past couple of years especially for fish oil. -- Becky Wright Marketing Director Aker BioMarine AS Traberg added that The drive to develop even more forms of healthy omega-3 fatty acids through new sources and technologies proves to us that the industry is still experiencing strong demand from consumers around the globe. David Hart vice president of marketing for Texas-based Qualitas Health also points to category growth however with some changes. The omega-3 market has experienced some major shifts since 2013-- the overall market has shrunk but consumers are shifting toward more valueadded omega-3s especially algal sources krill oil and highly concentrated fish oils. Other industry experts see market changes driven by demographic differences. Tiffany Huenefeldt corporate development manager at KD Pharma in Germany observed In the U.S. and Europe we see educated consumers who recognize the importance of higher concentrations and potency in the omega-3s they consume. In other countries the market is primarily lower grade fish oils but growing steadily although we do expect a shift to higher-potency concentrates in these markets as consumers become more savvy. She attributed bumps in growth in the U.S. and China to misguided press coverage in the U.S. and infant formula scandals in China. Sabrina Di Blasio marketing director for Neptune Technologies & Bioressources in Canada said the omega-3 slow-down is itself decelerating. The decline of omega-3 retail sales in the U.S. seems to be slowing down she noted. According to the latest IRI (Information Resources Inc.) data retail sales of omega-3s for the last 12 months are declining at a rate of -2.5 percent whereas they were declining at -7 percent in the previous year. The Good Seed (and Plants) While marine-sourced omega-3s (fish krill or algal oils) offer the highest levels levels of EPA and DHA there are also land-based seed oils with respectable levels of omega-3 fats such as flax (58 percent omega-3s) chia (30 percent omega-3s) hemp (20 percent omega-3s) and pumpkin (up to 15 percent omega-3s). Aker BioMarine s Wright said We are definitely seeing what some are calling The rise of the super seeds like flax and hemp--these omega-3 options are a good choice for consumers who are vegetarian or who have a shellfish allergy. She added however that many consumers do not realize that not all omega-3s are created equally. Some seed omega-3s are trying to ride the coattails of health benefits tied directly to marine-source EPA and DHA Wright explained. While ALA has its own health benefits and does eventually convert to EPA and DHA in the body the conversion rate is very low around 1 percent which means you would need a lot of it Nutrition Industry Executive 33 November December 2015 www.niemagazine.com Celebrating 20 Years of Excellence 1995-2015 As to seed and marine-plant omega3s KD Pharma s Huenefeldt noted that Algae has certainly become an interesting source in recent years especially for DHA. Obviously concerns about sustainability may drive some consumers to plant sources for their EFAs but marine sources remain the best sources for omega-3 EPA and DHA. Qualitas Health takes a unique approach to its algae-based Almega PL ingredient. Algae are the original source of long-chain omega-3s in the marine ecosystem--fish and krill get their omega-3s directly from their diet ultimately algae according to David Hart vice president of marketing. Qualitas Health s Farm-grown algae do not impact fragile marine ecosystems and are a truly renewable and sustainable source of omega-3s. and beyond traditional sustainability requirements she said. Some firms aim to exceed standard practices in terms of quality and purity. KD Pharma s Huenefeldt explained that As markets mature there is an increasing demand for higher potency and purity in concentrates. You certainly can t handle 95 percent omega-3 oils in the same manner as you handle 18 12 or low fish oil concentrates added Huenefeldt. For example we may be the only manufacturer that flushes our systems and drums with argon gas rather than nitrogen thus ensuring the best quality product. Algae are the original source of long-chain omega-3s in the marine ecosystem--fish and krill get their omega-3s directly from their diet ultimately algae. -- David Hart VP of Marketing Qualitas Health Other firms develop or implement novel methods of analysis to assess the stability purity and efficacy of its products which is what Israel-based Enzymotec aimed to do for its K Real krill oil brand. Normally the quality of krill oil is measured by chemical markers that are tested during shelf life however these parameters do not reflect changes in krill oil s biological activity after consumption. By using a simulation model for measuring the biochemical quality of the krill oil in the digestive system Enzymotec has established [new] biological quality parameters the company noted. According to Jeffrey Blumberg PhD of Tufts University Utilizing a validated in vitro gastric model K Real krill oil proved more resistant to oxidation reactions and to degradation of its DHA and EPA content than other krill oil samples tested. KD Pharma s Huenefeldt noted that since its founding 25 years ago the Innovate or Fade Away Facing that crowded marketplace one marked by proliferation of me-too brands and by some products that do not offer a compelling reason to buy in the minds of either finished product manufacturers or end-user consumers ingredient companies that have powerful and innovative brand stories attempt to focus on what sets them apart from an ocean of choices. When asked What do you do differently or better than other brands -- Aker BioMarine s Wright pointed out that Aker developed eco-friendly harvesting technology (i.e. Eco-Harvesting) which helps protect the integrity of krill as well as minimize environmental impacts and eliminate by-catch. According to Wright what helps is that Aker BioMarine is the only vertically integrated krill supplier meaning that we have full control of the supply chain from sea to shelf. Wright explained that Aker BioMarine partners with several outside institutions to research and monitor the krill biomass in the Southern Ocean and to check on the animal populations that depend on krill as a food source. The company maintains close relationships with the World Wildlife Fund for Nature (WWF-Norway) which helps Aker to establish best practices that go above 34 Nutrition Industry Executive company has specialized in what it refers to as kd-pur Technology a combination of supercritical CO2 fluid extraction (SFE) and supercritical fluid chromatography (SFC) in order to produce its ultra-high fish oil concentrates. Today we still continue to be at the forefront of innovation in separation technologies Huenefeldt added. The benefits of ultra-high concentrates for our customers and end users are immense--smaller soft gel size fewer sof gels per serving higher omega-3 daily dose less pro-inflammatory molecules less gelatin etc.--and we are happy to provide cutting-edge solutions to this exciting market. Qualitas Health s Hart said that sustainability and the unique algal product itself sets them apart. By definition Almega PL and our nutrition ingredients from farm-grown algae are sustainable--in addition to using sunlight for photosynthesis as the main energy source we have purchased renewable energy credits so that our Texas algae farm is complexly powered by renewable energy. Hart added Almega-PL is the only omega-3 with both glycolipids and phospholipids--a unique molecular structure that provides improved bioavailability and digestibility. Innovation is critical to the FMC Corporation according to Traberg. Purity quality and innovation form the basis for everything we do with the Epax brand which has been proven again and again over the years explained Traberg. Our continued innovation is key to maintaining our market leadership and our new EPAX 4535 TGN omega-3 triglyceride oil which we debuted in September is a testament to that as it is to our knowledge the highest concentration of EPA and DHA fatty acids in a 90 percent triglyceride form on the market today. In addition to innovation FMC attempts to focus on purity and quality as well starting at the fishing ground level. FMC requires that all crude fish oil suppliers to Epax omega-3 concentrates adhere to strict FMC procurement standards and unalterable specification requirements in order to be a business partner Traberg added. FMC only receives human-grade-certified Epax raw materials from Friend of the Seacertified strategic partners and exercises strict quality control over the entire process from the fishing ground Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 through ingredient manufacturing. Quality depends on multiple factors which all need to be satisfied before a product can be released observed Neptune s Di Blasio. Neptune s unique extraction process allows for the company to have the purest krill oil product on the market-- our krill oil has 98 percent fat content compared to competitors krill oils which have around 92 percent Di Blasio added. Neptune s products also have less than 0.001 percent solvent residue compared to 3 percent in other krill products. Impurities are the main cause of oil degradation--our krill oil contains more fat less residual solvent no protein a bright red color and a better odor superior levels of EPA and DHA and seven times more antioxidant astaxanthin. More bang for the buck is important to BASF (Florham Park NJ) as well in its recent roll-out of an ultra-high EPADHA omega-3 concentrate and other innovations. We carefully concentrate the beneficial omega-3s to a high level of 90 percent to ensure optimal delivery of EPA and DHA said Anne van Gastel business director of BASF Human Nutrition. The new 46 38 EPA DHA product composition is the most clinically studied so it gives our customers a solid foundation to market their products. The Future of EFAs So what does the future hold for this category The Baby Boomers are no longer babies said Qualitas Health s Hart. They are living longer and more active lives may have chronic health issues and have more discretionary income. The well-proven health benefits of EFAs especially the cardiovascular benefits make these an important component of do-it-yourself nutrition and health care--the combination of an aging population which seeks its own solutions to maintain a healthy lifestyle will fuel future demand for EFAs. FMC Corporation s Huenefeldt sees growth and market change on the immediate horizon. EFA supplementation will continue to grow in 2016 and beyond albeit with some regional markets slowing--immature markets will gradually shift to higher concentrates of omega-3s as consumers and health care providers become more educated on the benefits and are provided alternatives to traditional fish oil. Aker BioMarine s Wright also predicts that knowledgeable end-users will drive market changes and product offerings. Consumers are becoming more savvy and educated and that will help dictate how companies evolve to meet those needs she said. Sustainability will also become a prerequisite for companies operating in the marine omega-3 market--third-party certification will be deemed necessary to help ensure that everyone is taking the appropriate steps to protect our world s oceans and species. Some experts such as FMC Corporation s Traberg see particularly robust growth ahead for conditionfocused formulations. We see strong growth in conditionspecific omega-3 formulas for both sports nutrition and healthy aging Traberg noted. Additionally recent U.S. market research showed doubledigit omega-3 growth in what we call ultra concentrates meaning 700-plus mg g of EPA DHA suggesting that consumers are looking for more convenient more potent products. Neptune s Di Blasio also forecasts increased consumer interest in condition-oriented products. As more and more unique benefits are clinically proven and accepted consumers will continue to look for omega-3 products for overall health and for antioxidant properties but they also will become increasingly interested in targeted specific formulas to meet their individual health needs. Other omega-3 market watchers such as BASF s van Gastel believe that improved and more varied delivery options will open up untapped market potential. Form and function will increasingly drive demand for dietary supplements predicted van Gastel. While consumers are increasingly wellness-oriented we do know that about 30 percent do not regularly take their supplements so there s a tremendous opportunity to reach this group with products that better fit their lifestyle and are more pleasant to take. NIE Extra Extra Visit www.niemagazine.com for more information about the future of the omega-3 category. FORMOREINFORMATION Aker BioMarine AS www.akerbiomarine.com BASF Human Nutrition (800) 527-9881 Enzymotec 972 74 717 7177 FMC Corporation 47 70 13 59 60 KD Pharma 49 (0) 6826 979700 Neptune Technologies & Bioressources (450) 687-2262 OmegaOne Analytics (800) 949-0632 Qualitas Health www.qualitas-health.com November December 2015 www.niemagazine.com Celebrating 20 Years of Excellence 1995-2015 Nutrition Industry Executive 35 Glucose Support Blood sugar health and weight management are becoming even more important as a whole in the journey toward a healthier future. By Corinne Anderson aintaining healthy blood sugar levels is a continuous struggle for many Americans and with the number of people dealing with poor blood sugar increasing over the years the demand for healthy solutions is also growing. Insulin is one of the most actively studied hormones in modern medicine said Pete Maletto president and senior scientist for PTM Food Consulting in New Jersey. According to the Centers for Disease Control (CDC) in 2014 there were a total of 29.1 million people (approximately 9.3 percent of the population) with diabetes in America. On top of those staggering numbers the American Diabetes Association said that approximately 8.1 million diabetics in the U.S. don t even know they have diabetes. Additionally in 2014 the International Diabetes Federation reported that there were 387 million people world wide living with diabetes and 39 million of those people live in 36 Nutrition Industry Executive M North America and the Caribbean an 11.4 percent prevalence. According to Maletto because of the spike in diabetes the healthy blood sugar supplements that have been utilized for years by the life extension crowd have made their way into mainstream public. Blood sugar levels can be a rough aspect of health for people to monitor considering the average American diet includes about 20 teaspoons of sugar each day according to a report from the 2005-10 NHANES (National Health and Nutrition Examination Survey) database. The American Heart Association reported that teens and men consume the most added sugars men 335 calories women 230 calories boys 362 calories and girls 282 calories. These extra sugars can be hard to avoid if consumers aren t aware of the unhealthy sugars in juices drinks and snacks that they are ingesting. According to BENEO Fiber Research 2013 consumers are increasingly looking for more natural and non-GMO (genetically modified organism) products 65 percent consider natural products as better 47 percent actively look for natural products and 45 percent consider non-GMO as better. They are searching for product information that helps them to feel comfortable with their purchase decision so it is important for manufacturers to be proactive with the information about origin said Jon Peters president of New Jersey-based BENEO Inc. Even though consumers may be paying more attention to what they are ingesting the fast-paced setting of today s world leads consumers to graband-go often times making poor choices and selecting products that are sweet carbohydrates or fats with high calories that can lead to high blood glucose levels. That doesn t mean consumers should avoid carbohydrates altogether. Carbohydrates are an essential food within daily diets and are recommended by the European Food Safety Authority (EFSA) and World Health Organization Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 (WHO) to provide 40-55 percent of the total energy intake by each individual while the Dietary Guidelines for Americans recommends between 45 and 65 percent. Carbohydrates are initially seen as bad particularly by dieters however not all carbs are the same. Fiber-rich fruit and vegetables whole grains lowfat dairy products beans and legumes and limiting the amount of added sugar to a diet can help keep the body balanced according to the Mayo Clinic. Consumers are becoming more and more aware of the negative impact of high glycemic carbohydrates and sugars on their health and well-being and start to differentiate between good and bad carbohydrates Peters said. Consumer research commissioned by BENEO (BENEO Fiber Research 2013) shows that 53 percent of the U.S. population is concerned about healthy blood sugar levels and 55 percent about preventing diabetes. These results have been confirmed by insights from the International Food Information Council Foundation in 2014 saying that Americans are considering less sugar and or high quality carbs as part of a healthy lifestyle in order to prevent a future health condition Peters said. Between 2013 and 2014 the low glycemic product launches worldwide grew 51 percent according to Innova Market Insights. Mintel revealed that in the U.S. one in five product launches carried low glycemic claims in 2014. Ingredient manufacturer Sensus based in The Netherlands said there is a distinct opportunity for products programs and services to target and help the growing population of diabetics cope with and manage their condition. steak in the kitchen Maletto continued. These reactions are very dangerous in human tissues where AGEs produce powerfully destructive oxidative stress and inflammatory conditions that lead to atherosclerosis [plaque buildup in the arteries] and fatal diseases. By cross-linking with collagen and other tissue proteins in the body AGEs oxidative effects reduce the elasticity of all tissues particularly blood vessels where these proteins reside as a result the reactions induced by AGEs also damage DNA which besides diabetes and together with inflammation can promote the development of cancer Maletto elaborated. Between 2013 and 2014 the low glycemic product launches worldwide grew 51 percent according to Innova Market Insights. Mintel revealed that in the U.S. one in five product launches carried low glycemic claims in 2014. People with diabetes have lower than normal antioxidant levels due to the stress of the insulin blood sugar management. As general management of health and life extension specific antioxidants should be an important part of everyone s supplement program to prevent AGE. Marie Peytavy-Izard product manager at France-based Dialpha said there are several natural options to help maintain healthy blood sugar levels. Starch blockers are beneficial for anyone wishing to control both blood glucose and body weight. They are particularly recommended for people consuming excess starch which is known to have a profound impact on blood glucose response she said. Natural Options For those not following carbohydraterestricted diets supplementation of clinically studied herbal extracts and natural compounds that can easily prevent deadly advanced glycation end products (AGEs) associated with an aging endocrine system that cause cellular damage has been bigger than ever Maletto said. AGEs are created through the Maillard reaction the interaction of glucose and the unfolding proteins through a specific kind of chemical reaction that is similar to overcooking According to the University of California San Francisco s Diabetes Teaching Center starch blockers lower blood sugar by delaying how fast starch and carbohydrates (CHO) are absorbed from the intestines. Starch blockers can be used as supplements in capsule table sachet or stick formats as well as incorporated into both functional food and beverage form Peytavy-Izard said. Supplementation with antioxidants is a strong aid in maintaining healthy blood sugar. R alpha lipoic acid has been well documented in preventing and treating diabetes Maeltto said. Another antioxidant is alpha lipoic acid which studies suggest helps lower blood sugar levels. Its ability to kill free radicals may help people with diabetic peripheral neuropathy who have pain burning itching tingling and numbness in arms and legs from nerve damage. Researchers have also seen that it helps improve insulin sensitivity which can bring sugar levels down a notch or two he continued. Other supplementation can be found in EGCG (epigallocatechin gallate) from green tea a phenol that is an antioxidant that can help the body to prevent damage from AGEs benofotiamine a fat soluble version of B1 which blocks three of the major AGE producing biochemical pathways through which high blood sugar promotes tissue damage without known side effects and MHCP (methylhydroxychalcone polymer) a critical compound of cinnamon that can mimic the effects of insulin according to Maletto. MCHP also increases the sensitivity of aging insulin receptors making insulin work better and thereby lowering blood sugar. MCHP stimulates glycogen synthesis just like insulin does as it shows the two substances work similarly with blood sugar reactions it has been found to lower blood pressure in lab animals and it has antioxidant properties Maletto explained. The preferred type of cinnamon extract is Cinnulin PF a patented water-soluble extract of cinnamon that contains Type-A MHCP polymers that have clinically proven to provide a significant 8 percent decrease in fasting blood sugar after just consuming 500 mg a day. Other ways to reduce the impact of food on the glycemic response includes replacing flour by resistant starch or Nutrition Industry Executive 37 November December 2015 www.niemagazine.com Celebrating 20 Years of Excellence 1995-2015 Glucose Support fibers replacing sugar with stevia or adding proteins to foods as well as products that aid in the uptake of glucose and increase insulin production. Chromium has been shown to increase blood sugar uptake and decrease insulin levels and insulin resistance Peytavy-Izard said. Sensus manufactures Frutafit Inulin and Frutalose oligofructose soluble dietary fibers that are well suited for replacing sugar in a range of food products the company said. By using products like this food manufacturers can lower the glycemic response of the food. Carbohydrates that are not broken down or digested into simple sugars by the upper human digestive tract will not affect the blood glucose level Sensus said. Inulin and oligofructose are such types of carbohydrates which instead reach the large intestinal tract where they are fermented by the gut microbiota meaning their building blocks of mainly fructose is not released into the blood stream like sugar. Because they don t release the fructose they do not affect the glucose level and only trigger a minimal glycemic response. 1 Seaweed extracts also have health benefits according to clinical studies. One particular extract InSea2 produced by Canadian nutraceutical company InnovActiv has been shown to block the action of glucosidase and amylase which are enzymes your body uses to break down carbs into glucose and facilitate its transport into the blood stream Maletto revealed. Derived from brown seaweed and bladderwrack a single 500 mg dose of this proprietary compound triggered a 48.3 percent decline in after-meal blood sugar spikes in a recent doubleblind placebo controlled trial Maletto explained. clinical results Peytavy-Izard said. A scientific evaluation was done from an expert group looking at carbohydrate quality on the outcome of blood sugar management and reduced glycemia in health with some important and relevant results Peters said. Leading scientists and academics in the field of GI GL and GR research worldwide concluded in their consensus statement that convincing evidence exists that reducing the postprandial glycemic response has health benefits in the management and prevention of diabetes mellitus coronary heart disease and with probable evidence also in weight management.2 In addition to in vitro and in vivo data research and development departments of suppliers and manufacturers need to evaluate the protocols and end points form human clinical studies. -- Marie Peytavy-Izard Product Manager Dialpha In addition to in vitro and in vivo data research and development departments of suppliers and manufacturers need to evaluate the protocols and end points form human clinical studies Peytavy-Izard said. More specifically when the ingredient is marketed for a chronic treatment targeting blood glucose data on fasting glycemia fasting insulinemia and HbA1c should be analyzed. Additionally data on postprandial glycemia and insulinemia should be analyzed for any active ingredient claiming a reduction of blood glucose response to meals such as carb blockers she continued. BENEO noted several human intervention studies supporting the beneficial effect of chicory root fibers and functional carbohydrates from beet sugar (isomaltulose and isomalt) Peters revealed. Isomalt s very low blood glucose response has been tested and verified in at least 10 human intervention studies with healthy as well as type 1 and type 2 diabetes populations.3 The low blood glucose response of Palatinose was also assessed and verified in more than 30 trials in various population groups4 and chicory root fibers were verified in six studies within a total of nine trials to have a blood glucose response-lowering effect as a sugar replacement.5 In the U.S. claims referring to the low reduced glycemic properties of foods are considered structure function claims. In Europe the European Food Safety Authority (EFSA) also acknowledged the comprehensive scientific body BENEO s chicory root fibers inulin and oligofructise and their scientific substantiation to reduce the blood glucose response of foods Peters said. In January 2014 the EFSA released an evaluation confirming that inulin and oligofructose reduce the post-prandial glycemic response of foods when it replaces sugar. The Replacements There are two options to minimize a food s glycemic effect. First is to modify the glucose supply by choosing a fully available low-glycemic and slow release carbohydrate such as Palatinose. The second Peters continued is to reduce the glucose supply by replacing fully available carbohydrates by prebiotic fibers such as oligofructose and inulin or sugar replacers (polyols) such as ISOMALT. BENEO offers a range of functional ingredients from natural sources with nutritional and technological benefits. With its functional carbohydrates from beet sugar ISOMALT and Palatinose and its chicory root fibers inulin and oligofructose the company provides ingredients that allow for the production of great-tasting products with a reduced blood glucose response. Palatinose is the only fully yet slowly digestible and low-glycemic carbohydrate that provides balanced and sustained energy. It is derived from beet sugar and has a very mild sugarlike taste and according to the company is also tooth friendly. It can be utilized in options such as sports nutrition functional and wellness foods and The Science While generic plant extracts like green coffee bean gymnema sylvestre and fenugreek bring limited scientific data to substantiate their efficacy other products standout with their significant 38 Nutrition Industry Executive Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 beverages because of the slower steady and sustained energy supply. It also increases fat oxidation and can be used in applications such as chocolate dairy and baked goods. ISOMALT is another one of BENEO s products it is the only sugar replacer made from pure beet sugar which gives it a natural taste and sweetness. It has half the calories of sucrose and offers a very low glycemic response. It is the global leader in sugar replacement for sugar-free hard candies and is also famous for its positive effects in chewing gum coatings or centers Peters said. Additionally it serves as a sugar replacer in chocolate cereals and baked goods. MealShape distributed by HORN is a next generation starch blocker clinically proven to instantly reduce carb absorption by more than 20 percent. By inhibiting enzymatic digestion of dietary starch MealShape helps prevent glycemic spikes and sugar crashes thus aiding the body to reduce conversion of excess sugar into fat Peytavy-Izard said. The Global Diabetes Community said that more than 90 percent of newly diagnosed type 2 diabetics are classified as being above their ideal weight. MealShape is the first and only cinnamon extract Cinnamomum zeylanicum working as a starch blocker and is suitable in any nutraceutical applications from dietary supplements and functional foods beverages and pet food Peytavy-Izard said. The market for managing healthy blood sugar continues to grow aggressively highlighting the ballooning diabetes epidemic Peytavy-Izard concluded. Nutraceutical products targeting healthy blood glucose will not only address this market but also the market for weight loss. NIE 25(9) 795-815. www.nmcd-journal.com article S09394753(15)00127-1 abstract. 3 Holub et al (2009) Improved Metabolic Control After 12-Week Dietary Intervention with Low Glycemic Isomalt in Patients with Type 2 Diabetes Mellitus. www.thieme-connect.com products ejournals abstract 10.1055 s-0029-1234107. 4 Holub et al (2010) Novel findings on the metabolic effects of the low glycemic carbohydrate isomaltulose (Palatinose). http journals.cambridge.org action displayabstract frompage online&aid 7807683&fileld S0 007114509993874. 5 Kellow et al. (2013) Metabolic benefits of dietary prebiotics in human subjects a systematic review of randomized controlled trials. http journals.cambridge.org action displayabstract frompage online&aid 9205035 &fileld S0007114513003607. Extra Extra Visit www.niemagazine.com to read about the positive effects of sugar reduction on obese children s health. References 1 Meyer (2007). Inulins for product development of low GI products to support weight management p. 257270 In Dietary fibre components and functions (Salovaara et al. eds.) Wageningen Academic Publishers Wageningen the Netherlands. 2 Augustin et al (2015) Glycemic index glycemic load and glycemic response An International Scientific Consensus Summit from the International Carboyhrdrate Quality Consortium (ICQC). Nutr Metab Cardiovasc Dis FORMOREINFORMATION BENEO Inc. (973) 867-2141 Dialpha 33 (0)4 67 40 44 19 PTM Foods (888) 736-6339 Sensus 31 165 582 500 ConditionSpecific (Continued from page 8) the innovative physiological properties of Fibregum on gut permeability and microbiota using the Simulator of the Human Intestinal Ecosystem (SHIME). The SHIME is a device that has been used for experiments to mimic the entire gastrointestinal tract including the stomach small intestine and the three regions of the large intestine (ascending transverse and descending). These experiments showed that Fibregum fermentation in the distal part of the colon could modulate the composition of the gut microbiota and induce the production of beneficial SCFA. Moreover Fibregum showed an anti-inflammatory effect and an improvement of the gut permeability. Results of this study will be soon published in scientific publications and a patent procedure is ongoing in order to protect these new acacia gum properties. At BENEO a study conducted by the research team of Professor Raylene Reimer from the University of Calgary in Canada shows that the company s prebiotic chicory root fiber Orafti Synergy1 (oligofructose-enriched inulin) improves appetite regulation and decreases food intake in overweight and obese children helping those children to eat less naturally. Reimer and her team concluded that prebiotic chicory root fiber is a potential tool for the prevention and treatment of pediatric obesity. The study results released in May of this year strengthen the findings of previous studies addressing the topic of weight-management support by chicory root fibers in adults and children. Additionally BENEO gained a positive EFSA (European Food Safety Authority) evaluation for the prebiotic fiber inulin improving the effect on bowel function by increasing stool frequency. The application included new and proprietary scientific research. EFSA s positive evaluation allows the approval by the Commission the Member States and the European Parliament with the health claim procedure which opened new opportunities for food and drink applications to benefit the industry and consumers. Understand Your Fiber Ingredient Only few people around the world actually reach the recommended daily intake of fibers which could explain the increasing rate of some diseases and health troubles Dondain concluded. To be able to consume the 25 to 30 g day of dietary fibers a high tolerability is required. If not the flip side of the coin could be a rejection of the fibers. That is why the right fiber should be easy to use comfortable to digest highly tolerable and to present healthy properties. Peters concurred. With the amount of different fiber ingredients being available on the market and their significantly varying benefits he said it is even more essential for food manufacturers to have a clear understanding of their ingredients in order to have the most healthful impact on the products they are formulating. NIE FORMOREINFORMATION BENEO Inc. (973) 539-6644 Nexira (908) 707-9400 Nutrition Industry Executive 39 November December 2015 www.niemagazine.com Celebrating 20 Years of Excellence 1995-2015 ProductionLine Eco-friendly Practices Fifty Shades of Green By Lisa Schofield oing green not too long ago was a bit rudimentary like one shade say jade recycling glass plastic and cardboard using energy-saving lights even carpooling with co-workers. But now it s morphed from just jade into 50 shades of green--which encompasses use of multiple new technologies to conserve resources while simultaneously being allowed to maximize growth and output. Many quality suppliers are global in nature whether concentrating on one key nutraceutical or providing a widerange of materials of natural origin. Good sustainable practices filter down to the consumer who now more than ever places more trust and loyalty in the supplements and functional foods beverages they choose to use and exemplify their own commitment to a healthier planet. Here are several suppliers on the cutting edge of using novel sustainable practices to ensure longevity of output with minimal environmental harm. G BI NUTRACEUTICALS (Long Beach CA) Eco-Forward Practices Our industry has a global footprint unlike any other BI alone sources from over 40 countries commented Rikka Cornelia product manager. Due to this extensive supply chain BI believes sourcing is the point where the company can make the greatest impact when it comes to the environment. BI s ecofriendly and sustainable practices are embedded in our supply chain required by our quality program. Rupa Das BI s vice president of global quality and compliance manages the company s worldwide vendor surveillance program. This strict vendor quality management system ensures all materials meet stringent specification standards and adhere to GMP (good manufacturing practice) and regulatory requirements. The program provides clear guidelines on specifications test methods and product quality to suppli- ers regular audits of the manufacturing and lab facilities to assure compliance with GMP and GLP (good laboratory practice) random audits of traceability to assure usage of correct raw materials random sampling and testing to ensure compliance with specifications and oversight of the supplier s entire QA QC (quality assurance quality control) program. Vendors are first qualified based on paper documents and samples. After clearing this initial pre-screening the second step is an on-site visit. This allows for two-way education to take place. BI can learn about harvesting practices and processes directly from the vendors as well as educate them about GMP GLP GAP (good agricultural practice) HACCP (hazard analysis critical control point) etc. It also allows BI to look at long-term product sustainability and any economic compliance issues. Lastly BI conducts ongoing monitoring of each vendor to ensure continued compliance and consistency of material received. 40 Nutrition Industry Executive Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 Motivation BI s quality program has always been the foundation of our business said Cornelia adding that outside factors can sometimes drive BI to make better changes. For instance with California facing one of the most severe droughts on record this year BI was motivated to evaluate its water usage and discover ways to reduce consumption. Last year Cornelia reported BI significantly reduced its annual water consumption and saved nearly 2.5 million gallons of water year-over-year. This significant reduction in water usage was attributed to several factors both big and small including the addition of a more efficient steam sterilization unit retrofitting existing steam units to make them greener and adjustments to BI s irrigation schedule. Benefits Cornelia expressed that these practices are part of our quality program not only to ensure current product is of high quality but also to guarantee that future product is as well. For our customers it can be utilized as a marketing tool with the increased consumer demand for ethically sourced quality ingredients. But most significantly it means peace of mind for our customers. Plans As of right now according to Cornelia BI plans to continue to uphold our strict vendor qualification requirements developing our sophisticated supply chain even more so. than one percent oxygen to preserve the phytonutrients. Water Water is essential to Nutrex Hawaii s continual production. The supplier uses local fresh water from Hawaii Island s pristine aquifer. To minimize water waste and return essential nutrients back into its growing ponds the majority of the fresh water used is recycled and returned to the pond for the next growing cycle. Sustainable Crop Spirulina is one of the world s most environmentally efficient crops Johansen pointed out. Spirulina produces 20 times more protein per acre than common crops such as beef corn and even soybeans while using 10 times less water to produce it. Efficiency is assured through Nutrex Hawaii s patented process which converts spirulina from the pond to the bottle in under 30 minutes. Reduced Carbon Footprint Nutrex Hawaii Johansen reported recently added a 2 280 solar array panel that s run by Neighborhood Power Company to produce 1 147 000 kilowatt hours of electricity each year. The energy production is sufficient to power the farm s production during daylight hours and is projected to reduce the company s greenhouse gas emissions by 791 metric tons of carbon dioxide per year--that s equivalent to the annual greenhouse gas emissions of 167 passenger vehicles. Aker Biomarine (Oslo Norway) Eco-Forward Practices Aker BioMarine the largest vertically integrated supplier of krill-derived products to the nutrition markets has built what it believes is the most appropriate infrastructure for the harvest of krill and addresses sustainability on several different fronts from third-party research to environmental partnerships to technological developments described Marte Haabeth Grindaker sustainability director. Aker BioMarine was the first krill supplier to obtain MSC (Marine Stewardship Council) certification and was recently recertified for the sustainability and 100 percent traceability of its krill products for another five years. The company uses a unique patented technology called Eco-Harvesting which brings live krill aboard the ship. This reduces the waste incurred by traditional methods when a proportion of the catch at the bottom of the net is rendered unusable through pressure from the rest as it is hauled aboard. This technology also successfully prevents birds marine mammals and fish from consuming any of the catch. Aside from implementing cutting edge technology Aker adheres to strict regulations developed by the Commission for the Conservation of Antarctic Marine Living Resource (CCAMLR)--the authority that regulates krill harvesting. Beyond that Aker voluntary works with the World Wild Fund for Nature and other environmental non-government organizations (NGOs). Earlier this year Aker Biomarine was instrumental in forming the Antarctic Wildlife Fund (AWR) a first-of-its-kind partnership between industry academia and NGOs operating in Antarctica focused on better understanding of the marine ecosystem and krill s vital role as a keystone species. Aker also recently achieved an A rating in the 2015 Reduction Fisheries Sustainability Overview from the Sustainable Fisheries Partnership (SFP) a grade no other fishery in this report earned Grindaker reported. Motivation Malama Aina which translates to respect the land is our motivation Johansen asserted. Nutrex Hawaii s corporate philosophy is to leave the land and environment in better condition than when we started. Some of these measures such as the solar array panels also result in cost savings making it a win-win. CYANOTECH CORP. NUTREX HAWAII (Kailua-Kona HI) Eco-Forward Practices Jen Johansen vice president of quality and regulatory affairs explained that Nutrex Hawaii s microalgae farm located on the pristine Kona coast of Hawaii Island was carved out of land that had been a barren lava flow. In addition the company has taken the following steps Green Operations The active and very efficient photosynthesis of our microalgae sequesters carbon dioxide and produces oxygen--the main byproduct of its microalgae production she described. Nutrex Hawaii s patented Ocean Chill Drying system dries its spirulina in just three to seven seconds relies on very cold deep ocean water to provide de-humidification and uses less Benefits The solar array panel installation reduces Nutrex Hawaii s greenhouse emissions and costs which Johansen said creates a win-win for our bottom line and the environment. These efforts also help build trust with Nutrex Hawaii s consumers and partners. Motivation Plans We continue to look at ways to improve our operations to reduce our environmental impact and cut cost Johansen related. Aker BioMarine s commitment to sustainability was established from inception and has continued for nearly a (Continued on page 46) Nutrition Industry Executive 41 November December 2015 www.niemagazine.com Celebrating 20 Years of Excellence 1995-2015 MarketingInnovations By Todd Pauli ay back in 2001 well before the practice of providing content to potential customers had a name I was fortunate enough to work for a company whose marketing program still stands as one of the finest examples of growing sales with content. What type of cutting edge company arrived so early to the content party Tractor sales. No not the big green company but another tractor manufacturer that owned ag brands reaching back to the turn of the century. As much of the natural products industry turns toward content for the purpose of reaching new customers and reinforcing relationships with all customers it s important to note that regardless of the renewed focus on this age-old tactic the effectiveness of a content marketing strategy still depends on a few tried and true practices. The tractor manufacturer s secret content weapon was a printed 12-page newsletter sent to each of its 1 500 or so independently owned dealerships. Each quarter the newsletter made its rounds from the manager s office W through the parts and service department with many dealerships requesting multiple copies. As the editor I had the opportunity to write stories about generations of American farmers who stayed loyal to their tractor brand. Our little company newsletter mixed these brand loyalty stories with articles on the latest agriculture parts and accessories to produce a publication that grew an active audience and drove sales while solidifying the brand for a new generation of family farmers. My favorite day on the job was climbing to the top of a silo to get a photo of more than 30 pieces of farm machinery a 78-year-old farmer had assembled in his field. To experience how important the story was to this lifelong brand customer and later to the thousands of tractor dealership employees who read it illuminated the power of using content to connect customers with brands. This experience has stayed with me all these years and underlies much of the work we do today. The newsletter we produced worked as an effective content marketing piece because it connected with our audience in an engaging and useful way that ultimately led to increased sales. Content works the same way today whether it s used to sell machinery or to communicate the benefits of the latest breakthrough in natural ingredients. For our industry it s also an extremely effective way to answer questions allay concerns illustrate transparency and reinforce customer trust. Branding vs. Lead Generation The first step in building a content marketing program that increases sales is to design the program that delivers leads instead of producing content for the sake of producing content. Good ad campaigns build your brand while also delivering sales leads to your organization and successful content marketing programs are no different. Producing great content that gets read and shared is always the initial goal but it s just as important to have a solid strategy in place that ultimately prompts a potential customer to share their contact information with your marketing or sales team. Prompting prospects to give up their contact information is tough but 42 Nutrition Industry Executive Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 the right content makes it possible. Gathering leads from a content marketing program typically takes several visitor interactions. From the point someone first reads a blog post or clicks on a piece of content you shared on Facebook it may take several interactions before they register for more information or decide to contact your sales reps directly. The content marketing plan you create will define clear paths to converting content consumers to sales leads for your business. Content that s meant to initially attract an audience s interest should first and foremost be genuine. It should address a reader s interest or need regarding a particular topic that is also related to your business or industry. For example if you are a chondroitin supplier you might provide a simple PDF checklist to help manufacturers assess chondroitin quality. The content piece should be branded and readers should be invited to your website to learn more but the checklist content itself should be supplier agnostic so it serves as a genuine tool the manufacturer could use to assess any chondroitin supplier. If the checklist is set up to merely rule out other chondroitin suppliers it s not really true content but rather an underhanded advertisement. one further along in the purchasing process where they are more open to hearing about your company s individual expertise. Unlike an ad campaign this process of engaging an individual through a search for Chondroitin Quality can be repeated every time a new prospect begins to look for a chondroitin supplier. Where ad campaigns rely heavily on timing to communicate a message content marketing campaigns use search engine optimization to connect with a buyer at the moment he or she becomes interested in a product. Involving sales in the content creation process is important to ensure success. Sales reps usually know the specific content pieces customers will find helpful because they are asked questions every day by prospects at various points along the purchase path. What Constitutes a Lead Working closely with your sales team to determine at what point in the content consumption process an individual becomes an actionable lead is important. Sending your sales team lists of people who downloaded a simple PDF and expecting them to reach out individually probably won t be the best use of sales resources. In fact it s likely to turn your entire sales team against your marketing strategy. Instead it s smart to rely on analytics to help determine when a prospect warrants direct outreach from a sales team member. The definition of a qualified sales lead can vary widely depending on your industry the product you sell and the sales resources available. For some the fact that a prospect downloaded a report and has visited your company website twice in a 14-day period to check out a particular product page is enough to reach out directly. For other companies it may take a sample request or another more direct On-demand Marketing Successful content marketing plans meet a potential customer at his or her point in the buying process. Instead of traditional ad campaigns that run over a period of weeks or months content programs can have a much longer life because prospects engage with them individually. If a buyer searches for Chondroitin Quality and finds a recent blog post in which you offer the chondroitin quality checklist for download she is also likely to be interested in a more in-depth report on the current state of chondroitin quality. A report on chondroitin quality written as a genuine investigative piece with references and industry expert input represents the next piece of content in your plan. This report will go into more detail about the measures necessary to ensure pure chondroitin supply and it will detail your company s process by telling the story of how you source and test to ensure and confirm purity. This type of longer form content piece provides a deeper look into a topic and is more likely to be consumed by some- communication from a prospect to justify contact. The best way to determine what level of content consumption qualifies as a sales lead for your organization is to work directly with members of your sales team. Involving sales in the content creation process is important to ensure success. Sales reps usually know the specific content pieces customers will find helpful because they are asked questions every day by prospects at various points along the purchase path. Further qualifying a lead before it s handed off to sales can easily be done through email. Just as potential customers will encounter your content marketing pieces in an individual manner email can also be used in the same way to reach customers who have shown interest in your brand by engaging with the content you created. Numerous email services allow you to set up automated campaigns that are triggered by content consumption events on your website. The key to using these services is to not craft awkwardly worded follow-up emails that sound automated. Instead keep it simple. Good follow-up emails are casual direct and sent from a specific salesperson s email. The goal is simply to check in to see if the prospect would like more information or if he or she would be interested in a quick introductory call. Measuring Success and Evolving Another great advantage of a good content marketing program compared to more traditional campaigns is that every component is measurable. You ll easily be able to compare different content pieces you create to determine which pieces were read which led to more site visits and ultimately which helped move prospects along the path to becoming a qualified sales lead. While metrics can be interesting to review it s important to take action on the metrics you gather. If a content piece isn t working it s time to refine and adjust to help it reach your audience or scrap the piece altogether if subsequent iterations prove the target audience just isn t engaging. Most marketers like to create but the process of tinkering to make improvements isn t always as exciting. However when you consider how much underwhelming content costs (Continued on page 46) Nutrition Industry Executive 43 November December 2015 www.niemagazine.com Celebrating 20 Years of Excellence 1995-2015 FoodTechnology Recipe for Change Clean Labels B Y R O N A L D C . D E I S P H D D I R E C TO R G L O B A L S W E E T E N E R D E V E L O P M E N T I N G R E D I O N hat was described as a trend only a few years ago has now become a major focus area for many consumer packaged goods (CPG) R&D groups. In consumer research conducted by MMR Research Worldwide and Ingredion Incorporated it was found that nearly 80 percent of consumers across 11 countries surveyed (France Germany Italy Spain U.K. U.S.A. China Japan Australia Mexico the Netherlands) think a short simple ingredients listing is important or very important and they also want to be able to recognize the ingredients listed. This movement--no longer a simple trend--has been described as Clean Label. It is linked loosely to natural and organic but generally refers to minimal processing no synthetic or artificial additives including sweeteners colors flavors and preservatives--or anything which could be regarded as non-natural. The movement is governed primarily by consumer perception as there is no regulatory definition for clean label or natural. The FDA (U.S. Food and Drug Administration) does not have a definition for natural but states the agency has not objected to the use of the term if the food does not contain added color artificial flavors or synthetic substances. Consumer research has shown a dra44 Nutrition Industry Executive W matic rise in the number of consumers who read claims and front of pack descriptions as well as an up-tick in the number who would switch brands for a minimal processing claim. Clean Label and Non-GM Initial developments of this clean label migration emerged in Europe as a movement to eliminate anything modified or ingredients assigned an E-number. This has included modified starches bleached flours artificial sweeteners and artificial colors flavors emulsifiers and preservatives--replacing them with simpler more consumerrecognizable ingredients. One over-riding theme to this which has now gone global is the issue of genetic modification (GM). This issue again is driven totally by consumer perception. In a 2015 Penn State Ag Science article The Science of GMOs (genetically modified organisms) the dilemma of science vs. consumer perception is laid out perfectly. GM crops were first introduced in 1996 and were rapidly adopted worldwide--18 million farmers in 28 countries planted biotech crops last year (2014). Most of these crops are fed to livestock so most of the GM concentration on crops has been to increase yield. Corn canola soybeans sugar beets papaya alfalfa and cotton are heavily planted so this trickles down to a wide array of food ingredients which must be considered if a non-GM product is the focus. These ingredients include corn starches and syrups high fructose corn syrup amino acids aspartame sucrose xanthan gum ascorbic acid citric acid lactic acid ethanol flavors molasses and maltodextrin to name a few. Should consumers be concerned According to the Penn State article the E.U. has invested about 300 million for more than 130 research studies (25 years of research) with the conclusion that there is no notable difference in food safety or environmental impact between GM and non-GM products and a separate review reported the same result in terms of animal health. Regardless of the science behind these statements it is obvious that consumers have not bought into this. This is the basis for the need to develop non-GM-based products. This is part of the must have requirements of all clean label products. While some non-GM corn is available in the U.S. for production of non-GM starches R&D groups have looked to sourcing starches glucose syrups dextrose maltodextrins and other ingredients from other sources such as tapioca potato rice wheat and sago--sources that are ensured to be Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 non-GM. Due to the predominance of corn and soybean as crops in the U.S. most of these non-GM ingredients are being sourced initially from other regions. This increases shipping costs for ingredients as demand for these products increases. Keeping It Simple Since the wholesome or better-foryou initiative began in Europe several years ago it has now fully evolved into a global clean label initiative. Actually the Trends Research Institute used the word clean foods in 1996 in a New York Times article to describe a new standard for health and reliability and included within it foods free of artificial preservatives coloring irradiation synthetic pesticides fungicides ripening agents fumigants drug residues and growth hormones and those that are processed packaged transported and stored to retain maximum nutritional value. Retailers in Europe called for the removal of artificial colors flavors and preservatives-- movement away from ingredients with E-numbers a number of years ago and this has been followed in the U.S. by a number of grocery chains restaurant chains and CPG companies many of which have published lists of unacceptable ingredients. Research conducted in the U.S. U.K. and Germany by Ingredion Incorporated (focus groups expert interviews and accompanied shopping visits) demonstrated a clear consumer dislike for chemicalsounding and unpronounceable ingredients. The results clearly showed that consumers preferred labels that were 1) free from chemical additives 2) contain simple ingredient listings that consumers understand and 3) indicate foods that are minimally processed or processed using traditional techniques. According to Mintel GNPD the percentage of new clean label food products among all launches in North America (U.S. Canada) grew from 22 percent to 29 percent between 2012 and 2014 and only 38 percent of U.S. consumers say they trust what companies say on their labels. Clean Label Texture So what do consumers feel comfortable with on ingredient listings Ingredion research asked the question when you are buying a food or drink product which of the following ingredients are acceptable to you This resulted in a list of ingredients that appeared to be acceptable some that were borderline and some ingredients that definitely need to be replaced in a clean label product. The unacceptable list contains a number of ingredients that provide viscosity and shelf life stability to foods including bleached flours modified starches gelatin and a number of food gums--xanthan gum CMC HPMC and MCC included. In terms of modified flours and starches this initially presented a problem. For example native starches have narrow peak viscosity ranges and very limited process tolerance as well as undesirable textures and shelf-life stability. Physically modified starches were first developed by Ingredion more than 20 years ago with subsequent improvements to replace the viscosity and shelf life stability of modified starches especially in Europe as the market evolved. For clean label products this has now become part of the requirement-- starch is definitely a clean-label option. Starch does not have an E-number and can be used in products labeled additive-free or simple. In addition a number of functional native flours are also now available initially developed to improve gluten-free products but adaptable to a much wider range of food products and these are available in cook-up or instant versions. Pectin maltodextrin and guar gum also have some level of acceptability depending on region product claims and other factors. Another texturizing category of products which has emerged following the rise of glutenfree and clean-label products has been proteins and functional flours derived from pulses primarily green peas yellow peas red lentil yellow lentil fava beans and chickpeas. These pulse proteins provide 55-60 percent protein and the flours generally 10-25 percent protein another important factor in today s marketplace. These functional proteins and flours are natural non-GM gluten- and grain free hypoallergenic and come from sustainable crops. They also provide dietary fiber and are low glycemic. From a functional view they can provide texture gelation emulsification adhesion film-forming and waterholding characteristics and advantages to a wide range of products. Clean Label Sweetness In terms of sweeteners many formulators have turned to the non-GM sources previously discussed as well as honey agave nectar maple syrup brown rice syrup and other sources of sweeteners familiar to the consumer. Naturally derived fruit and vegetable concentrates purees and essences extracted from fruits including strawberry blueberry cranberry raspberry and peach and vegetable concentrates purees and essences include pumpkin red beet carrot and celery should see much greater use in natural and clean-label applications. These products are a great starting point to provide natural colors flavors sweetness and texture to clean label products. On top of clean label considerations consumers are also asking for sugar and calorie reduction. Since many clean label options are still based on fully caloric sugars and well-known high potency sweeteners such as aspartame and sucralose do not fit the criteria of clean label formulators have moved to natural sweeteners known for many years but available commercially only recently. Included in this are stevia leaf extracts--steviol glycosides extracted from the leaves of the plant Stevia rebaudiana. The primary stevia leaf extract marketed now is based on rebaudioside A 250-300 time sweeter than sucrose and stable under most temperature and pH conditions. This market is rapidly developing to include mixtures with other steviol glycosides. Another clean label option is monk fruit extract a sweetener 150 to 200 times sweeter than sugar based on the high mogroside content in a sub-tropical melon harvested in China. Natural high potency sweeteners are usually formulated with sugar or other bulk sweeteners for the best sweetness profile and mouthfeel. It is clear that demand is increasing for food labels containing simple ingredients that are recognizable by the consumer and the ingredient list should be relatively short. Ingredients should be natural or recognized as such with the absence of artificial ingredients including sweeteners preservatives colors and flavors. Replacing functional ingredients in gluten-free and clean-label food products has not been an easy task and the demand for sugar and calorie reduction has added to this challenge. It is evident however that the food industry is rising to the challenge--the portfolio of functional clean label ingredients is increasing with many more changes on the horizon. NIE Nutrition Industry Executive 45 November December 2015 www.niemagazine.com Celebrating 20 Years of Excellence 1995-2015 MarketingInnovations (Continued from page 43) both in terms of hard dollars to get the content distributed or time to create it and get it noticed organically the importance of improving lackluster content becomes clear. message. Renting audiences through media purchases is a valuable tactic to reach new prospects but once they ve opted-in to your email list you are able to deliver messages repeatedly to them without paying for access. Whether you launch a content marketing program in-house or hire an agency to help the ability to convert your audience to qualified sales leads will ultimately depend on the quality of content and the level of effort put forth to connect that content to your target customers path-to-purchase. So to answer the question yes content marketing can really grow sales but just like most other things the amount of effort you put into your content efforts will determine the success you experience. NIE The Shelton Group is a boutique public relations and marketing agency working exclusively in the dietary supplements and natural products industry since 1990. Todd Pauli works with clients to develop comprehensive marketing strategies that integrate social media advertising and content marketing. Prior to joining The Shelton Group Pauli led marketing communications efforts for several well-known businesses including NOW Foods one of the largest supplement manufacturers in the natural channel. Does Content Marketing Really Grow Sales A content marketing program s success depends largely on the size and value of the audience it builds for your organization. Every time you create content useful enough that someone is prompted to register his or her email to download it you ve grown your audience. Your email list or audience is valuable because it s an audience you own. When you pay to place an ad you are essentially renting an audience in order to communicate a ProductionLine (Continued from page 41) decade Grindaker explained. Since Antarctica is a vulnerable place Aker s team was determined to create a fishery that would last. The effort we put behind sustainability allows us to be seen as a role model for other fisheries. What we do impacts the wider ecosystem and that cannot be overlooked or ignored. guins and krill) were chosen to receive research grants this year Grindaker reported. The AWR is leading the way to uncover data that will help determine the impact of the krill fishing industry on the Antarctic marine ecosystem as well as fill in any knowledge gaps related to this area she said. Benefits Grindaker asserted that krill (and other marine based omega-3 businesses) will thrive only if they are sustainable. Sustainability shouldn t be considered a bonus she emphasized it should be a prerequisite for doing business in the omega-3 market because consumers are more educated and are paying closer attention to product certifications. Consumers are demanding to know where and how products are made. And consumers aren t the only ones asking. Every part of the supply chain--and even brand marketers--are interested in tracing products back to their original sources she said. AVOCA EXTRACTION PHARMACHEM LABORATORIES INC. (Kearny NJ) Eco-Forward Practices According to David Peele president in late 2011 two biomass boilers became operational to supply the steam for the facility. The biomass boilers replaced three diesel-fired boilers. The biomass boilers use hardwood chips as fuel. This represents a major shift in our energy needs to a renewable sustainable source he comments. The clary sage biomass that remains after extraction is being land applied as a green fertilizer. From an agronomic viewpoint Peele said the clary sage biomass provides a source of phosphorus and potassium. In addition the organic matter content of the soil is increased providing for improved soil conditions and better water retention. Clary sage biomass being spread on local farmer s fields as a green fertilizer. cost of energy Peele explained. The land application of the clary sage biomass is the best alternative for the environment. It is not the least expensive alternative however it is the best practical disposal option. Benefits These practices Peele pointed out have a direct effect on the cost of production for its products by lowering Avoca s energy costs. Plans According to Peele Avoca Inc. s continuing quality improvement optimization programs are looking to reduce water consumption and switch to LED lights. NIE Plans According to Grindaker Aker BioMarine will continue its commitment to protecting Antarctica s ecosystem on many levels. Currently the company is excited about the various research projects funded through the Antarctic Wildlife Fund (AWR) three unique projects (studying whales pen46 Nutrition Industry Executive Motivation The biomass boilers were installed both to meet our internal renewable sustainable goals and to reduce the FORMOREINFORMATION Aker Biomarine (U.S.) (206) 855-6736 Avoca Inc. (252) 482-2133 BI Nutraceuticals (310) 669-2100 Nutrex Hawaii (800) 395-1353 Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 Supply Innovation F or more than a decade Nutrition Industry Executive (NIE) has tried to cultivate relationships between ingre- Following is the list of companies participating in this year s Supply Innovation section Alkemist Labs.................................................48 dient suppliers and finished product manufacturers by providing Science of Supplements sections to highlight the research supporting ingredients that can help finished products stand out. In the interest of furthering that cause and providing greater insight into suppliers efforts NIE offers its Supply Innovation section. Biova LLC ......................................................49 Fenchem Inc..................................................54 Jiaherb Inc.....................................................50 Pinnacle Labs International............................51 PLT Health Solutions ......................................52 NIE has given companies a chance to highlight their latest most innovative offerings. NIE has also provided ample company information to foster immediate connections with parties interested in learning more. November December 2015 www.niemagazine.com Sabinsa Corporation ......................................53 Celebrating 20 Years of Excellence 1995-2015 Nutrition Industry Executive 47 Supply Innovations Axiom Foods Alkemist Labs 1260 Logan Ave. B2 Costa Mesa CA 92626 Telephone (714) 754-4372 x210 Fax (714) 668-9972 Email sales alkemist.com Website www.alkemist.com Bringing Transparency to All Areas of Natural Products Industry Testing s a pioneer in natural products testing Alkemist Labs helps companies achieve and maintain quality products and cGMP (current good manufacturing practice) compliance. Alkemist Labs an industry recognized leader established in 1997 is a contract testing laboratory that renders comprehensive analytical testing solutions to its clients in the food and beverage nutraceutical and cosmeceutical industries to meet their product safety transportation and quality guidelines. Testing natural products is all the company does and it does it extraordinarily well. The company s mission to bring transparency to all areas of natural products industry testing includes education tools designed to demystify testing and help companies obtain accurate results to support regulatory compliance and illustrate their quality commitment to consumers. Alkemist Labs specializes in routine QC Compendial testing method development and validation verification services and dedicated research services. Alkemist Labs offers high throughput HPTLC analysis for botanical ingredient identity testing of whole herbs and plant extracts with a standard 5-business day turn-around time. In combination with HPLC microscopy and the company s on-site berbarium Alkemist offers the most reliable technical support and the highest quality services. Specific services include A Identify botanical microscopy HPTLC MS and HPLC fingerprinting composite reference botanicals (CRBs) Analyze HPLC GC UV-Vis UPLC MS & wet chemistry Verify The FDA (U.S. Food and Drug Administration) requires brands to be able to prove their label claims using scientifically valid methods. Alkemist Labs offers custom verification and validation services for their clients unique finished products and their ingredients. New Technology Launching in early 2016 Alkemist Labs will offer nextgeneration DNA sequencing services a powerful tool available for speciation in plant-based products. Because this technology has often been misapplied and standard methods are not yet developed Alkemist Labs will be using this platform alongside more established and accepted testing methods in order to accelerate understanding of this technology and help make it one of the useful testing tools for dietary supplements and ingredients. Phytochemical Reference Standards Alkemist Labs reference material offerings include phytochemical reference standards manufactured by Extrasynthese Lyon France and Botanical Reference Materials developed by the American Herbal Pharmacopoeia (AHP). Reference Standards are used in the measurement of content or for the presence of the many phytochemi- cals contained in natural products which have direct impact on the ability to assess safety quality and potency of both raw materials and finished products. Herbal products contain many phytochemicals that are responsible for their activities. It is of tremendous importance to be able to accurately measure the presence and or content of these substances in herbal products in order to assess safety quality and potency. Currently a concern in the industry is assessing the herbal products supply chain traceability and to detect adulteration. To address these concerns analytical methods have been developed using phytochemical standards to assist in the quality process. Phytochemical standards are pure substances existing in and mostly derived from plants for which chemical structure has been determined and for which purity has been accurately measured. They can be made by extraction and or chemical synthesis. As they can be complex and fragile materials their production needs advanced skills in extraction organic chemistry and purification techniques the main set of purification techniques being preparative chromatography. Alkemist Labs holds memberships and is active in multiple trade associations and industry groups ABC (American Botanical Council) AHPA (American Herbal Products Association) CRN (Council of Responsible Nutrition) NPA (Natural Products Association) and the UNPA (United Natural Products Alliance). 48 Nutrition Industry Executive Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 Supply Innovations Axiom Foods Biova LLC Kansas Bioscience Authority Bldg. 10900 S. Clay Blair Blvd. Ste. 1000 Olathe KS 66061 Phone (877) OVACORE (913) 815-4049 Email clear biova.com Website www.biova.com What s New on the Joint Horizon Egg membrane is making a strong case for being the next go-to ingredient. T he market for joint health supplements continues to grow as an aging and more active population seeks natural support and pain relief. Growing demand combined with market research showing slowing interest in traditional glucosamine and chondroitin formulas translates into plenty of opportunities in the joint health ingredient marketplace.1 Although glucosamine and chondroitin have been the requisite joint health combo for years they re starting to show their age said Matt Stegenga president of Biova the U.S. company that manufactures BiovaFlex water-soluble egg membrane (WSEM). We re finding that consumers are not only looking for something new they want products with demonstrated fast results-- BiovaFlex is just such an ingredient. And the scientific efficacy research is there to support BiovaFlex s continued market growth. A recently published study shows taking a daily 450 mg dose of BiovaFlex was associated with improved joint range of motion (ROM) in multiple areas including the neck back hips shoulders and knees. Study participants reported increased physical energy and activity levels. And subgroup analysis showed reduction of back pain--as one might experience from exercise and or daily activity--after just five days.2 The article Support of Joint Function Range of Motion and Physical Activity Levels by Consumption of a Water-Soluble Egg Membrane Hydrolyzate is based on the randomized double-blind placebo-controlled crossover study conducted by NIS Labs Klamath Falls OR. It was published in the September 2015 Journal of Medicinal Food. This research is compelling for several reasons but what s most powerful is that people say they feel better when taking BiovaFlex said Stegenga. Everyone wants to enjoy their daily activities whether it s exercise or chores or just day to day living. The empirical data collected during this study are important. We love that our product demonstrated fast five-day relief to back pain. And we re happy that people report being able to be more active enjoy life with BiovaFlex. Another important aspect of the most recent BiovaFlex research is that it focused on a study population with no diagnosis of joint diseases. The study reflects broad improvements independent of a person s identified chronic joint and mobility problems Stegenga said. The article concluded that with more research WSEM might hold future promise as a natural support for the joints of older populations athletes and patients recovering from joint and muscle injuries. The research article can be found online at biova.com research or at the Journal of Medicinal Food. Stegenga also points out that relief doesn t have to come in a pill. Biova s patented-process WSEM ingredients allow for expanded delivery options for consumer products far beyond traditional tablets and capsules. Research shows 40 to 70 percent of adults report issues3 with swallowing pills or tablets said Stegenga. Why not formulate a consumer product that dissolves completely in water Or create a gummy that can be chewed and easily swallowed BiovaFlex delivers these options to formulators. We want to help our customers innovate to look at what s new to be unconventional and more successful with consumers. With a uniform ingredient profile including standardized 88 percent protein Biova s Hydro5 patented process makes egg membrane water soluble while maintaining the natural ratio of complex proteins including glycosaminoglycans collagen elastin desmosine and isodesmosine. Our Hydro5 and OvaPure processes allows us to produce very uniform and pure low-ash high-protein water soluble egg membrane ingredients every time said Stegenga. And offering water solubility we re an innovative alternative delivery solution for formulators. Founded in 2005 Biova is the market leader for water soluble egg membrane (WSEM) ingredients offering proven health benefits BiovaFlex for joint health BiovaDerm for skin care and BiovaPlex for animal health. We knew from the very beginning that our WSEM ingredients would offer formulators something unique said Stegenga. We re providing new exciting ingredients that can be used in new exciting ways. Biova s patented water soluble process creates expanded delivery options for consumer products including functional foods beverages lotions and more. A focus on sustainable production anchored by vertical integration with some of the largest U.S.-domestic egg producing and processing partners assures Biova unmatched raw material supply--the right combination of access and capability to drive opportunity and growth worldwide. We ve dedicated years of investment scientific research and leadingedge technology bringing these ingredients to market said Stegenga. Based on the reception we ve seen-- around the world--it s really starting to pay off. References 1 Nutrition Business Journal--Global Supplement Nutrition Industry Report 2014 figure 4-16 section 4.2.1 2014 Penton Media Inc. 2 Jensen Gitte S. Miki R. Lenninger Joni L. Beaman Robert Taylor and Kathleen F. Benson. Support of Joint Function Range of Motion and Physical Activity Levels by Consumption of a Water-Soluble Egg Membrane Hydrolyzate Journal of Medicinal Food September 2015 18(9) 1042-1048. doi 10.1089 jmf.2015.0041. 3 Hermes Pharma. A Hard Truth to Swallow. Accessed October 19 2015. www.swallowingtablets.com. Nutrition Industry Executive 49 November December 2015 www.niemagazine.com Celebrating 20 Years of Excellence 1995-2015 Supply Innovations Jiaherb Inc. U.S. Headquarters 1 Chapin Rd. Unit 1 Pine Brook NJ 07058 California Office 1204 N. Miller St. Ste. D Anaheim CA 92806 Highest Quality Standard s the largest NSF-GMP (good manufacturing practice) certified natural ingredient manufacturer in China Jiaherb Inc. offers more than 600 ingredients regularly stocked in both of the company s more than 50 000-square-foot New Jersey and California locations. Using a comprehensive and diverse sourcing program Jiaherb s dedicated sourcing team travels the world to find the top raw materials allowing its customers full product traceability. To guarantee the highest quality standards the company works closely with the premier growers and pickers using stringent quality control practices and examining each batch of raw material in our state of the art laboratory for identity potency and purity. The experience and reliability of Jiaherb s production team allows the company to produce thousands of metric tons of natural ingredients per year resulting in short lead times on orders. Along with Jiaherb s USDA (U.S. Department of Agriculture) Organic and Orthodox Union Kosher products Jiaherb offers a number of Non-GMO (genetically modified organism) Project Verified products. The company is dedicated to complying with their extensive verification process testing and traceability practices to assure that its customers are receiving the best quality product on the market. Jiaherb s Quality Control and Assurance team uses the most advanced equipment for analytical testing certifying the transparency and safety of all its products. Run by skilled scientist and technicians the company s in-house laboratories are equipped with extensive systematic instrumentation including but not limited to HPLC UPLC GC UV ICP-MS HPTLC FTIR PPSL as well as pesticide and microbiology testing. Research and development work to identify current and future market demands combining their proficiency with the latest technological innovations to develop unique products keeping Jiaherb s customers one step ahead of the rest. 50 Nutrition Industry Executive A To guarantee the highest quality standards the company works closely with the premier growers and pickers using stringent quality control practices and examining each batch of raw material in our state of the art laboratory for identity potency and purity. Jiaherbs U.S. Headquarters Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 Supply Innovations Pinnacle Labs International 284 Industry Way Upland CA 91786 Phone (800) 600-4634 (909) 946-1017 Fax (909) 920-6631 Website www.pinnaclelabs.net Providing High-quality Innovative and Cost-effective Products F or more than 12 years Pinnacle Labs Int l. has been in the business of developing and producing nutraceutical products. Since 2000 Pinnacle Labs International has expanded its focus to provide its customers with high-quality innovative and cost-effective products. Pinnacle Labs is recognized as cGMP (current good manufacturing practice) compliant privately owned and operated and a successful leader in the production of private labeling nutritional supplements and vitamins. Now with absolute emphasis on cGMP manufacturing and satisfying all FDA (U.S. Food and Drug Administration) standards the company is now doubtless at the forefront of the industry. Pinnacle Labs is committed to providing its customers with products that not only meet but also exceed quality and efficacy standards. This leaves its customers with more time to concentrate on growing their business to the next level. At Pinnacle Labs the company s partnerships are based on a promise its approach to that promise is to treat its customer s product as if it were Pinnacle s own and to translate our customer s innovation and passion into the company s passion to deliver the quality and services they deserve from a reputable partner. Pinnacle Labs produces gelatin and veggie capsule formulations based on our customers specific requirements. Furthermore the company can produce private label formulations in a variety of sizes and configurations based on the target audience. The company has been in this business for more than 15 years and has built its reputation on excellent customer service and performance under tight deadlines. At Pinnacle Labs the company is proficient at problem solving innovation and discovery. Whether it is creating unique formulations or resolving custom manufacturing challenges and process issues Pinnacle Labs talented staff will investigate the problems Since 2000 Pinnacle Labs International has expanded its focus to provide its customers with high-quality innovative and cost-effective products. Pinnacle Labs is recognized as cGMP (current good manufacturing practice) compliant privately owned and operated and a successful leader in the production of private labeling nutritional supplements and vitamins. test new theories and deliver inspired solutions. Pinnacle Labs offers prompt quote turnaround times on all requests submitted via the website or through its team of product advisers and the company continues to strive to turn products around faster than any other manufacturer. Pinnacle also employs the most knowledgeable and experienced customer service team who is ready and able to answer any type of nutraceutical manufacturing question. Pinnacle Labs business understands that customers have many contract manufacturers to choose from ... and that is why Pinnacle Labs is determined to deliver smart solutions form a strong relationship and make a secure commitment to a promise our customers can count on. A cGMP-certified facility Free--no obligation quotes Quick quote turnaround time Prompt product turnaround time Knowledgeable product advisers Friendly and professional customer service Quality control and quality assurance Nutrition Industry Executive 51 November December 2015 www.niemagazine.com Celebrating 20 Years of Excellence 1995-2015 Supply Innovations PLT Health Solutions 119 Headquarters Plaza Morristown NJ 07960 Phone (973) 984-0900 Email info plthealth.com Website www.plthealth.com OXYSTORM Standardized Nitrate A food-based standardized form of nitrate that can help sports nutrition formulations rise to the challenge. T he use of nitrate for improving human health and enhancing sports performance has been the subject of numerous scientific publications of late. As a result increasing media attention has been given to this topic as well. The story is actually very interesting and centers around nitric oxide (NO). This signaling molecule plays a variety of critical roles in normal functioning of the body including neurotransmission vascular control mitochondrial respiration and muscle contraction--many of the processes that are critical to exercise performance. Until the past decade or so it was thought that NO was generated solely through oxidation of the amino acid larginine via NO synthase enzymes with nitrite (NO2-) and nitrate (NO3-) being inert metabolites in the process. However recent evidence has demonstrated nitrate and nitrite reduction to NO via bacterial and mammalian enzymes occurs and that dietary nitrate ingestion increases plasma and tissue concentrations of nitrate and nitrite. Subsequently it has been shown that dietary consumption of sodium nitrate or nitrate-rich vegetables (e.g. beet) elevates plasma nitrite and NO concentrations that are associated with several benefits. Indeed research has demonstrated that short-term dietary intervention with nitrate improved exercise efficiency and potentially performance (Larsen 2007) A patent-pending production process for OXYSTORM delivers the highest nitrate content ingredient from the leaves of red spinach-- 9 percent or 90 mg gram of product. the efficiency of muscular work (Bailey 2009) and exercise tolerance during high-intensity exercise (Baily 2009 Bailey 2010 Lansley 2011 Vanhatalo 2010 Vanhatalo 2011). Most of these studies have focused on supplementing nitrate in the 350-500 mg range to achieve these results--although lower levels of nitrate or dose-response studies to determine more precisely an effective level of nitrate consumption need to be conducted. As example achieving the 350-500 mg level could require 500 mL (about two cups) of beet juice to achieve these levels-- which has the potential to cause digestive distress and lacks convenience. In addition to this the nitrate content of vegetables can vary considerably dependent on factors such as soil conditions season water availability and storage conditions. These reasons make current sources of dietary nitrate challenging to use. New OXYSTORM Standardized Nitrate is an extract of red spinach (Amaranthus dubius)--one of the richest sources of nitrate in nature. A patentpending production process for OXYSTORM delivers the highest nitrate content ingredient from the leaves of red spinach--9 percent or 90 mg gram of product. This level is conservatively five times the nitrate found in beetroot powder and 50 times that found in beet juice--two commonly discussed sources of nitrate for sports nutrition. The levels of nitrate in OXYSTORM are standardized while the levels found in natural sources such as beetroot powder and beet juice are highly variable based on a variety of phytochemical harvesting and processing conditions. Offered as a powder OXYSTORM is highly water soluble. OXYSTORM does not contain oxalate which is often found in spinach and beet greens and which has been found to contribute to kidney stones. It also does not contain sugar--which many beet-based products do in relatively high amounts. Along with its neutral pH and mild flavor these factors make OXYSTORM an ideal ingredient for a wide variety of sports nutrition formulations--including bars beverage powders chewables nutrition powders as well as sports and energy drinks. As one of the only standardized forms of nitrate available on the market OXYSTORM offers sports nutrition formulators the ability to deliver nitrate content with precision. 52 Nutrition Industry Executive Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 Supply Innovations Sabinsa Corporation 20 Lake Dr. East Windsor NJ 08520 Phone (732) 777-1111 Fax (732) 777-1443 Email info sabinsa.com Website www.sabinsa.com uC3 CLEAR Raise a Glass to Curcuminoids C urcuminoids the versatile cascading and long-lasting pronutrient is undoubtedly the most important and precious gifts to mankind from nature. A common spice used in South Asian cooking turmeric and more appropriately the component curcuminoids have been preclinically and clinically validated for their beneficial role in maintaining health and wellness. They offer antioxidant support anti-inflammatory support support for a healthy immune system and the potential to prevent connective tissue break down through inhibiting destructive enzymes with benefits in healthy aging. At the molecular level curcuminoids have been shown to inhibit nuclear factor kappaB (NFkB) a transcription factor that triggers inflammatory mediators. NFkB is implicated in a variety of chronic disease conditions ranging from cardiovascular diseases to cancer. While more than 45 human clinical studies have been published and continue to emphasize the relevance and importance of curcuminoids in general health and wellness more than 50 pre-clinical studies have also been carried out for a range of applications unraveling the mechanisms at the cellular level. Sabinsa has more than 26 years experience in the field of standardized extracts and with the chemistry and properties of turmeric. The team of scientists at Sabinsa while working on this traditional herb turmeric derived an optimized composition of curcuminoids from rhizomes of turmeric to provide the maximum antioxidant or bioprotectant activity. This composition was later patented by Sabinsa. This unique and patented composition of curcuminoids is available under the brand name Curcumin C3 Complex. Curcumin C3 Complex achieved a major landmark in 2013 when it received no comment letter from the FDA (U.S. Food and Drug Administration) which meant that Sabinsa s Curcumin C3 Complex achieved GRAS (generally recognized as safe) status and now could be used in food categories as well. With all the above benefits delivery of curcumin in the form of a drink has always been a challenge due to poor solubility resulting in sedimentation. Several methodologies have been attempted by many to improve the solubility such as use of polymeric substances nano particle synthesis lipophilic formulations and so on. The safety of these forms of curcumin and their excipients to increase the solubility has always been an issue of concern. uC3 CLEAR is an improved convenient delivery system for curcumin that overcomes the basic challenges and limitations that can be present with solid dosage delivery systems such as poor disintegration slow dissolution or difficulty swallowing thus enhancing the uptake of curcumin. Sabinsa s uC3 CLEAR is Water soluble A compatible form of curcuminoids in beverages Free from nano-technology Visually appealing The use of standardized extracts in different dosage forms such as tablets capsules and soft gels is well known. However their incorporation in functional foods and beverages is in recent times more widely accepted and preferred. The challenge is to solubilize plant based extracts that are safe effective and compatible in beverages. With this background the development of uC3 CLEAR is the culmination of a wide range of experiments that have gone into formulating a water soluble form of curcumin. With equal and vast knowledge on scientifically validated natural extracts and the formulation of functional foods using these ingredients Sabinsa has delivered its water soluble curcumin extract--uC3 CLEAR. uC3 CLEAR is standardized for 10 percent curcuminoids and forms clear solution with water. Curcumin with its multifaceted biochemical mechanisms and in its water-soluble form remains the unparalleled natural molecule of interest--in the past present and future. With all the health and wellness benefits of natural curcuminoids packed in a compatible form uC3 CLEAR is here to deliver one of the most powerful natural extracts of the century. Nutrition Industry Executive 53 November December 2015 www.niemagazine.com Celebrating 20 Years of Excellence 1995-2015 Supply Innovations Fenchem Inc. 15308 El Prado Rd. Chino CA 91710 Phone (909) 597-8880 Fax (909) 597-1113 Email fenghq fenchem.com Website www.fenchem.com Fenchem Inc. Broadens its HyaMax Branded Hyaluronic Acid Portfolio H yaMax Sodium Hyaluronate (hyaluronic acid) available from Fenchem Inc.--a wholly owned subsidiary of Fenchem Biotek Ltd.--is now available in a variety of specific molecular weight fractions for optimizing formulations across food beverage and nutraceutical supple- ments to personal care lotions cosmetics and topical applications. Hyaluronic acid (HA) is well characterized in the treatment of degenerative joint conditions and more recently is credited and utilized in increasing and maintaining moisture and fullness in a broad spectrum of dermal and aesthetic products. HyaMax HA has been demonstrated in published controlled clinical experiments to be effectively absorbed in a variety of tissues with uptake in as soon as 15 minutes and retention in excess of 48 hours.1 The referenced study analyzed oral administration of our 1.0--1.5 million Dalton molecular weight fraction material. Fenchem Inc. s HyaMax HA product portfolio can accommodate specific molecular weight needs from as low as 1 500 Da up to 2.5 million Da. Contact Fenchem Inc. of Chino CA to learn which molecular weight fraction may be ideal for your application and formulation goals. Pack size and minimum order quantity are 1Kg. HyaMax HA is a pure food-grade non-GMO (genetically modified organism) 80 mesh powder and is both kosher and halal certified. Reference 1 Balogh L. Bucci L. R. et al. Absorption Uptake and Tissue Affinity of High-Molecular-Weight Hyaluronan after Oral Administration in Rats and Dogs. J. Agric. Food Chem. 2008 56 10582-10593. 54 Nutrition Industry Executive Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 Equipment&Packaging TriVex SL Sli Fulfills Retail-ready Market Needs Douglas Machine Inc. (Alexandria MN) debuted the robotic TriVex SL SLi top load case packer. This top load packs bags pouches and cartons in a standup configuration into retail-ready cases with one or two product facings. With speeds up to 150 products per minute the dual Scara robots combine the functionality of product infeed pack pattern collation and case loading functions into one mechanism. For more information call (320) 763-6587 or visit www.douglas-machine.com. Added Benefits to PharmaFlex iSeries Deduster Pharma Technology Inc. (PTI Piscataway NJ) is offering value-added benefits to its enhanced PharmaFlex iSeries Deduster for its introduction into the North American market. The new deduster features dust-tight Level 3 occupation exposure banding (OEB) standard execution for all machines as well as modular contraction with bolts on high-containment and WIP modules (both OEB Level 5 rated). The iSeries also comes with interchangeable clear polymer or stainless steel with clear polymer hood segmented spirals and is compatible with PTI s 2-parameter in process tablet tester. The iSeries offers an output increased by up to 20 percent more efficient dedusting process and enhanced resistance to alcohol heat and industrial detergents exposure. For more information call (973) 668-3197 or visit www.pharmatec-inc.com. Miniature Rotary Batch Mixer New York-based Munson Machinery released the new Miniature Rotary Batch Mixer model MX-1SS which blends up to 1 cu ft. of dry bulk ingredients with or without additions in ratios down to one part per million with total uniformity in two to three minutes regardless of disparities in the bulk densities particle sizes or flow characteristics of batch ingredients. For more information call (800) 944-6644 or visit www.munsonmachinery.com. Advertiser Index Alkemist Labs Biova LLC Fenchem Inc. Herbally Yours Jiaherb Inc. Now Foods PL Nutritional Engineering Inc. Olcott Plastics Pinnacle Labs International Inc. PLT Health Solutions Inc. Sabinsa Corporation Soma Labs Inc. United States Pharmaceopea 11 C3 15 23 5 1 18 7 9 3 C2 19 C4 (714) 754-4372 (877) 682-2673 (909) 597-8880 (480) 892-8220 (888) 542-4372 (800) 999-8069 (760) 599-5200 (630) 584-0555 (800) 600-4634 (973) 984-0900 (732) 777-1111 (732) 271-3444 (301) 230-6361 www.niemagazine.com alkemistlabs www.niemagazine.com biova www.niemagazine.com fenchem www.niemagazine.com herballyyours www.niemagazine.com jiaherb www.niemagazine.com nowpl www.niemagazine.com nutritional www.niemagazine.com olcott www.niemagazine.com pinnaclelabs www.niemagazine.com plt www.niemagazine.com sabinsa www.niemagazine.com somalabs www.niemagazine.com usp Industry Events February 2-4 GOED Exchange 2016 Ritz Carlton Abama Tenerife Canary Islands (800) 746-1413 www.goedexchange.com February 9-11 West Pack Anaheim Convention Center Anaheim CA (310) 445-4200 www.westpack.packagingdigest.com March 9-13 Engredea at Natural Products Expo West Anaheim Convention Center Anaheim CA (303) 998-9329 www.engredea.com or www.expowest.com April 27-29 Ingredient Marketplace Orlando World Center Marriott Orlando FL www.marketplace.supplysideshow.com May 10-12 VitaFoods 2016 Geneva Palexpo Geneva Switerland www.vitafoods.eu.com November December 2015 www.niemagazine.com Celebrating 20 Years of Excellence 1995-2015 Nutrition Industry Executive 55 SupplieroftheMonth Dr. Paul Stevens Global Research & Application Rousselot Kanaaldijk Noord 20-21 5691 NM SON The Netherlands Email gelatin rousselot.com peptan rousselot.com Websites www.rousselot.com www.peptan.com Rousselot and Peptan are both brands of Darling Ingredients Inc. Rousselot is the leading manufacturer of gelatin and collagen peptides to the food nutrition and pharmaceutical industries. Rousselot benefits Director from a global sales and production network of 13 plants and 10 sales offices located in Europe North America South America and Asia. Peptan produced at Rousselot is globally recognized as the leading brand in its category. Dr. Paul Stevens is Rousselot s global research and application director. In 1988 Stevens joined the Rousselot gelatin industry in process development and a few months later became responsible for quality control quality assurance and production. Since 2005 Stevens has been responsible for technical support for Rousselot s customers worldwide. Since 2010 he has also been in charge of the four Rousselot application laboratories worldwide as well as R&D activity. Stevens has wide experience in the functionality of gelatin and its different applications in food including confectionery dairy and pharmaceutical applications such as soft and hard capsules. NIE Rousselot recently released a skin study that highlights the unique efficacy of collagen peptides intake on the restructuring of deep skin layers. Please discuss the study. Stevens This new publication 1 which appeared in the September issue of the J. of Cosmetic Dermatology highlighted the efficacy of Peptan on skin anti-aging parameters including restructuring of the collagen network in deeper layers of skin. The paper presents data showing a skin restructuring effect (it is the first clinical data ever published on this). The results demonstrate the underlying mechanism of how Peptan helps to strengthen and rejuvenate the deeper skin layers and maintain a cohesive and dense collagen network. This is key to the prevention of wrinkles and sagging. For skin hydration a statistically significant effect was seen across different skin types in the clinical study. Maintaining well-hydrated skin is essential for smooth and plump skin and helps prevent the formation of micro relief wrinkles. The ability of Peptan to restructure the collagen network and promote a healthy dense and moist skin foundation is the explanation for the visible improvement in skin appearance and the attractive youthful look achievable after intake of collagen peptides. positioning. And Peptan collagen peptides can also deliver important health benefits. Several in-vitro in-vivo and clinical studies suggest their ability to promote healthier bones and joints as well as younger and vibrant skin. Both gelatin and collagen peptides are neutral in taste and odor. As a result they are easy to integrate into many applications. They are also food ingredients do not contain any additives or e-numbers and are not subject to specific authorizations or safety evaluations. This means that both of them can easily be incorporated into clean label products and tap into wider consumer concerns. with E.U. Regulation 1169 2011. NIE Rousselot and Fortified Food Coatings have developed a ready meal concept to address the nutritional requirements of the aging population. How will the meal concept help aging consumers Stevens Rousselot and Fortified Food Coatings have developed a revolutionary ready meal concept to facilitate the inclusion of vital nutrients in senior consumers diets. This new fortifying technology uses a food printer to spray a thin gelatin-based layer enriched with Peptan collagen peptides calcium and vitamin D over restaurant-quality ready meals. Thanks to this high-quality clean gelatin-based layer it boosts a food s dietary profile enhances its presentation and prevents it from shifting on the plate during transport and delivery. As senior people tend to cook less and less this new concept enables them to ensure their daily meals contain the right amount of nutrients increasing their vitality and quality of life. The thin gelatin layer has the unique characteristics to fortify the food with no impact on the taste and texture and to improve the presentation on the plate. This innovative delivery format can replace pills or other delivery formats that are not always acceptable for seniors the intake of essential nutrients is therefore easier to achieve. NIE How can gelatin and collagen peptides be used in a variety of formulations to elevate protein levels deliver health benefits and preserve organic labeling Stevens Gelatin and more specifically hydrolyzed gelatin and collagen peptides provide an effective method of incorporating additional protein into end products--they are pure proteins boasting more than 90 percent protein content. For example ProTake can be easily mixed with other proteins in order to achieve a high in protein product 56 Nutrition Industry Executive NIE What is ProTake-P How can it be incorporated into functional food products Stevens A fully digestible protein of low calorific value (17 kJ g or 4 kcal g) ProTake-P contains 18 different amino acids including eight out of the nine essential amino acids with the exception being tryptophan. Unlike other protein sources used in the food industry such as soy whey and pea protein gelatin is particularly rich in hydroxyproline. ProTake can also be easily blended with other protein to achieve an optimal amino acid profile and offers neutral organoleptic characteristics. ProTake-P is simple to integrate into many applications in a cost effective way. These applications include powder blends nutritional bars meat replacements soups and ready-to-eat products to name just a few. As an entire protein ProTake-P can help achieve high levels of protein in a variety of food and drinks while also acting as a texturizing agent if required. It is also GMO (genetically modified organism)- and allergen-free and complies References 1 Assarin J. et al. 2015. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network evidence from an ex vivo model and randomized placebo-controlled clinical trials. Journal of Cosmetic Dermatology 0 1-11. Grand View Research Gelatin Market Analysis and Segments Forecasts to 2024 2014. Celebrating 20 Years of Excellence 1995-2015 www.niemagazine.com November December 2015 Go to www.niemagazine.com biova for info about this advertiser Go to www.niemagazine.com usp for info about this advertiser