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Description: In This Issue: The State of Sourcing and Ingredient Purity, Memory & Cognition, Women's Health, and Keeping Websites Fresh

VI M ING SIT BO ARK RED US OT ET IE AT H PL NT M AC A VRM Media Publication 44 E www.niemagazine.com April 2016 Go to www.niemagazine.com sabinsa for info about this advertiser Go to www.niemagazine.com nowpl for info about this advertiser TableofContents Proud Supporter of VOLUME 21 NO. 3 APRIL2016 F E A T U R E S 26 Remember Natural Easy and Proven The cognitive health market is seeing a surge in consumer demand for products that are portable reliable and edible. 32 The State of Sourcing and Ingredient Purity Industry leaders discuss the recent advances as well as the challenges to meet the demand for pure safe and efficacious natural ingredients. 26 A L S O I N S I D E 38 Female Focus Ingredients and Products for Women 8 The women s health category isn t only about calcium and iron a broader focus on ingredient application emerges. C O L U M N S Industry News Ingredient News Association News AHPA Update Conventions & Meetings Science Update Ingredient Marketplace Booth Preview Equipment & Packaging Advertiser Index Industry Events Testing Lab of the Month 18 23 24 25 48 49 50 51 51 52 4 First Word 6 Condition Specific 42 Marketing Innovation 45 Functional Foods 41 Research & Development 45 FREE Subscription (Print Digital or BOTH) & E-newsletter Available www.niemagazine.com Copyright 2016. Nutrition Industry Executive (ISSN 2331-2602) Volume 21 Number 3 April 2016. Nutrition Industry Executive is published monthly (except for bimonthly January February and July August and November December) by VRM Media 431 Cranbury Road Suite C East Brunswick NJ 08816 USA Phone (732) 432-9600 Fax (732) 4329288. All rights reserved including the right to reproduce in whole or in part. Not responsible for unsolicited material. Opinions expressed in by-lined articles or advertisements are not necessarily those of Nutrition Industry Executive or its owners. Publisher is not liable for advertiser product claims or representations. Advertisers assume total responsibility for the contents of their advertisements. Printed in U.S.A. Basic annual subscription rate is 50.00. Periodicals Postage Paid at East Brunswick NJ 08816 and additional mailing offices. POSTMASTER Send address changes to Nutrition Industry Executive P.O. Box 15026 North Hollywood CA 91615-5026. Subscription Customer Service Nutrition Industry Executive P.O. Box 15026 North Hollywood CA 91615-5026 USA Phone (818) 286-3170 Fax (800) 869-0040 niecs magserv.com www.niemagazine.com. Back Issues & Single Copies For order information contact (732) 432-9600 or info niemagazine.com. March issue is 25.00. All other issues are 8.00 each. 2 Nutrition Industry Executive www.niemagazine.com April 2016 Go to www.niemagazine.com plt for info about this advertiser FirstWord Onwards and Upwards hat a difference a year makes. At this time last year I reported on my trip to Natural Products Expo West and Engredea for Nutrition Industry Executive in my editor s column titled Expo Unrest. I wrote about the underlying anxiety permeating the Expo Engredea show floors due to the news of the New York attorney general herbal supplement debacle. This year though certainly not forgotten it seems that members of the supplement industry are moving ahead confidently despite the past news headlines. For example number increases show the strength of the industry Expo West saw 6.9 percent growth and hosted more than 77 000 attendees the largest attendance ever according to the trade show organizers. (See the Expo West wrap-up article on page 25.) Also according to Nutrition Business Journal (NBJ) supplement sales are forecasted to grow at 5.8 per year through 2020--although not as strong as in previous years still impressive figures. NBJ reported that the anticipated growth would be from consumers who are expected to continue to focus on conditions in this order Sleep issues Lack of energy Skin or hair issues Frequent joint soreness Menopause Frequent muscle soreness Others Frequent digestive issues Respiratory issues Blood sugar issues Vision problems Though supplements that are condition specific may be the industry s strength let s not forget the value of W good multivitamin mineral supplements. Dr. Tieraona Low Dog an internationally recognized expert in the fields of dietary supplements herbal medicine women s health and natural medicine was at Expo West to remind the industry of their importance. During a conversation she and I had she stressed that nutrient deficiencies such as with choline vitamin D and magnesium are common and the often-heard advice that we ought to meet our nutritional needs from the foods we eat is nearly impossible. In her new book Fortify Your Life Your Guide to Vitamins Minerals and More Low Dog said that it is time for a broader rational discussion on the topic of supplements that goes beyond the confusing sound bites and outdated fragmented distorted information about vitamins minerals and other important nutrients that the media is bombarding us with today. And no matter what an attorney general may say regarding nutritional supplements consumers are still focusing on natural solutions for health. It s up to the industry to help foster the best outcome. Shaheen Majeed marketing director with Sabinsa Corp said he is also feeling positive about that. In the issue highlight feature article The State of Sourcing and Ingredient Purity he stated We re pleased to see so much industry focus on ingredient quality in the past year because we have been talking about this literally for years. Buying by price alone has contributed to the industry s vulnerabilities with identity potency and scientific verification of safety and efficacy an afterthought. Consumers expect and deserve to get the benefits of safe and effective products and we are optimistic that the industry will improve on delivering that. Good to keep in mind going forward. Publisher Daniel McSweeney Editorial Director DanM VRMmedia.com Associate Russ Fields Publisher RussF VRMmedia.com Advertising Gary Pfaff Sales Associate GaryP VRMmedia.com Editor-in-Chief Janet Poveromo JanetP VRMmedia.com Managing Editor Shari Barbanel ShariB VRMmedia.com Assistant Editor Corinne Anderson CorinneA VRMmedia.com Contributing Writers James J. Gormley Todd Pauli Lisa Schofield Art Director Robert Certo Production Manager RobertC VRMmedia.com Production Assistant Bryan Zak Graphic Designer BryanZ VRMmedia.com Circulation Manager Rosie Brodsky Rosie StarkServices.com A PUBLICATION OF VRM MEDIA President Daniel McSweeney VRM Media 431 Cranbury Road Ste. C East Brunswick NJ 08816 Phone (732) 432-9600 Fax (732) 432-9288 Email info VRMmedia.com Website www.niemagazine.com VRM Media publishes Nutrition Industry Executive Vitamin Retailer Natural Practitioner and FitnessTrainer magazines. Subscription Customer Service To order a subscription or manage your account please contact us at Nutrition Industry Executive P.O. Box 15026 North Hollywood CA 91615-5026 USA Phone (818) 286-3170 Fax (800) 869-0040 niecs magserv.com www.niemagazine.com Back Issues See the Table of Contents page for price and order information. Connect With Us www.twitter.com www.facebook.com www.linkedin.com www.instagram.com www.pinterest.com vitaminretailer vitaminretailermagazine company vrm-media vitaminretailermagazine vrm_media 4 Nutrition Industry Executive www.niemagazine.com April 2016 Go to www.niemagazine.com jiaherb for info about this advertiser ConditionSpecific Becoming Allergy Friendly Suppliers and manufacturers are taking precautions to ensure that products are safe for those with food allergies and or intolerances. B Y S HARI B ARBANEL O ver the past couple of years the number of people with food allergies intolerances or sensitivities seems to have grown significantly. And while it may be trendy for some to follow a gluten- dairy or [insert other allergen here]-free diet others must do so because of an allergy or food intolerance. Known as The Big 8 peanuts tree nuts milk eggs wheat soy fish and shellfish account for 90 percent of food allergic reactions in the United States. According to Food Allergy Research and Education (FARE) researchers estimate that up to 15 million Americans have a food allergy or intolerance and that one in every 13 children under the age of 13 suffer from food allergies. Further the number of people who have a food allergy or sensitivity is growing worldwide and researchers are still looking for a clear answer as to why. Current labeling guidelines from the U.S. Food and Drug Administration (FDA) state that food products must contain less than 20 ppm (parts per million) to bear a gluten-free claim. And while the labeling of food products is often the focus for food allergies and intolerances it is just as important that supplements are labeled for The Big 8 and other allergens as well. Labeling of allergens has been taking place at least since the introduction of the Food Allergen Labeling and Consumer Protection Act of 2004 (Public Law 108-282 Title II) said Mark Thurston president of AIDP Inc. in California. For those with allergic reactions to peanuts or tree nuts or people with celiac disease it is not only important to create and label products that are allergen-free but it is also vital to their health that allergen-containing ingredients and products be kept separate from the ingredients and products that are allergen-free to ensure that there is 6 Nutrition Industry Executive no cross-contamination. According to Thurston AIDP ensures that all allergens are stored separately from non-allergens. Illinois-based FutureCeuticals has allergenfree manufacturing facilities. In addition the company does not manufacture any products that contain milk eggs fish crustacean shellfish peanuts tree nuts or wheat. Further products containing gluten are segregated. Taking Action Ingredient suppliers and manufacturers are making strides in ensuring that their ingredients and finished products are available for those with a food sensitivity or allergy. Companies are also on a constant search for ingredients available that can act as an equal replacement for their allergen-containing counterparts. There have been changes in formulations to minimize contact with allergen groups--in the world of protein we have seen an increased interest in allergenfree sources such as rice and pea protein AIDP s Thurston explained. In sports bars again gluten-free requests are growing. We continue to search for healthy non-allergen alternatives. Andrew H. Wheeler director of marketing for FutureCeuticals also noted that customers were looking for allergenfriendly replacements. Over the past two years our gluten-free Nutrim beverageready oat product has experienced substantial growth in the RTM protein space he said. Customers were looking for healthy hydrocolloid clean-label gum replacements and our gluten-free grains have superior functionality in this space. Wisconsin-based ingredient innovator Glanbia Nutritionals recently announced the U.S. launch of its OatPure gluten-free oats. Guaranteeing fewer than 10 ppm gluten OatPure gluten-free oats exceed industry specifications and offer complete gluten free integrity. The company s fully owned NSF certified 14-step OatSecure closed loop supply chain process guarantees a remarkably high level of protection from seed to end product providing manufacturers with peace of mind and absolute assurance of the provenance of the ingredient the company stated. To ensure complete food safety the oats are dried within three days of harvest and heat-treated using an independently validated 4.6 log kill step which eliminate pathogens and mycotoxin growth. These processes also help extend the shelf life of the oats to 18 months--a significant increase compared to standard oats. Our rigorous carefully monitored OatSecure closed loop supply chain enables Glanbia agronomists to follow the crop at every step of the production process through growing harvesting processing and storage said Danielle Black product manager Glanbia Nutritionals. It seems that the demand for allergenfriendly products and ingredients that can be used as replacements will only grow. A study released in 2013 by the Centers for Disease Control and Prevention food allergies among children increased approximately 50 percent between 1997 and 2011. And because celiac disease and many allergies are lifelong raw material suppliers and manufacturers will be creating allergen-friendly alternatives for a long time to come. NIE FORMOREINFORMATION AIDP Inc. (866) 262-6699 FutureCeuticals (888) 452-6853 Glanbia Nutritionals (800) 336-2183 www.niemagazine.com April 2016 Go to www.niemagazine.com onceagain for info about this advertiser IndustryNews U.S. Senate Declines Advancement of DARK Act n March 16 the Senate voted to defeat the Deny Americans the Right to Know (DARK) Act introduced by Sen. Pat Roberts (R-KS). Gary Ruskin co-director of the U.S. Right to Know stated The Senate vote is a victory for consumers and everyone who wants the right to know what s in our food. The bill would have prevented states from requiring companies to label GMO (genetically modified organism) foods. In addition it would have also stopped the pending laws in states that will require this type of labeling to go into affect. The Roberts measure backed by the O food industry shows the contempt of our nation s large food companies for their own customers who overwhelmingly support labeling of genetically engineered food said Ruskin. According to EcoWatch Many Senators properly noted that this bill fails to solve the problem it claims to fix. Instead by blocking state laws from going into effect and replacing them with voluntary measures and impractical alternatives to labeling it would have ensured that big food processing companies and the biotechnology industry continue to profit by misleading consumers. The industry campaign for the DARK Act will only accelerate consumer distrust of large food companies and their processed food. In other words the bill s proponents will reap what they have sown Ruskin continued. EcoWatch stated that nine out of 10 Americans want GMO foods to be labeled. The majority of Americans support labeling for GMOs and will hold their elected officials accountable if they vote to strip away transparency about how their food is produced. We urge the Senate to continue to reject bills that would block state labeling laws EcoWatch concluded. For more information visit www.usrtk.org or www.ecowatch.com. FDA Appoints New Commissioner R obert M. Califf MD MACC was confirmed as the new U.S. Food and Drug Administration s (FDA) commissioner of food and drugs in February. As the top official of the FDA Califf is committed to strengthening programs and policies that enable the agency to carry out its mission to protect and promote the public health the FDA said. Dr. Califf has demonstrated a long and deep commitment to advancing the public health throughout his distinguished career as a physician researcher and leader in the fields of science and medicine Stephen Ostroff acting FDA commissioner said in a statement. He understands well the critical role that the FDA plays in responding to the changes in our society while protecting and promoting the health of the public across the many areas we regulate--and I am confident that our public health and scientific contributions will further grow under his exceptional leadership. Previously Califf served as the FDA s deputy commissioner for medical products and tobacco from February 2015 until his appointment as commissioner in February 2016. In that capacity he provided executive leadership to the Center for Drug Evaluation and Research the Center for Biologics Evaluation and Research the Center for Devices and Radiological Health and the Center for Tobacco Products. He also oversaw the Office of Special Medical Programs and provided direction for cross-cutting clinical scientific 8 Nutrition Industry Executive Takasago Acquires Centre Ingredient Technology akasago International Corporation (Rockleigh NJ) has announced the expansion of its natural material portfolio through the acquisition of Centre Ingredient Technology Inc. (CIT Rockingham NC) on January 20 2016. CIT produces natural flavor and fragrance ingredients using their unique biotechnology manufacturing processes. In addition CIT also supplies specialty ingredients for the food beverage and cosmetics industry. Developing unique and superior technologies continues to be a Takasago focus and priority. This is a core strategy of Takasago s medium term growth plan said Satoshi Masumura president and CEO of Takasago. With the highly advanced manufacturing technologies and capabilities of CIT and Takasago s unique and patented fermentation technologies we expect significant quality cost and efficiency improvements. The acquisition will also enable Takasago to address the ever increasing consumer demands for natural ingredients and to become a key player in the Natural Ingredients arena. Additionally it is anticipated that CIT will also contribute to the future of the Takasago Group as it will be designated as the development center for new natural ingredients. For more information call (914) 747-1400. T and regulatory initiatives including precision medicine combination products orphan drugs pediatric therapeutics and the advisory committee system. Prior to joining the FDA Califf was a professor of medicine and vice chancellor for clinical and translational research at Duke University. He also served as director of the Duke Translational Medicine Institute and founding director of the Duke Clinical Research Institute. A nationally and internationally recognized expert in cardiovascular medicine health outcomes research health care quality and clinical research Califf has led many landmark clinical trials and is one of the most frequently cited authors in biomedical science with more than 1 200 publications in the peerreviewed literature. Califf is a graduate of Duke University School of Medicine. He completed a residency in internal medicine at the University of California San Francisco and a fellowship in cardiology at Duke. For more information visit www.fda.gov. www.niemagazine.com April 2016 Go to www.niemagazine.com gencor for info about this advertiser IndustryNews AHP Publishes Revision for Cranberry Fruit n 2002 The American Herbal Pharmacopoeia (AHP) released its Standards of Analysis Quality Control and Therapeutic Compendium for the botanical dietary supplement Cranberry Fruit (Vaccinium macrocarpon). This was one of the first monographs and therapeutic reviews of its kind for cranberry which is one of the most popular selling botanicals in the United States. It was recently updated and expanded from 28 pages to 96 pages. I It represents the most comprehensive review of cranberry ever developed and then reviewed by some of the world s leading authorities on all things cranberry. The monograph also reveals findings regarding adulteration of cranberry products predominantly extracts what those adulterants are and how they can be detected. Newer studies have also looked at putative cranberry-drug interactions most specifically with blood thinners which previously caused FDA (U.S. Food and Drug Administration) to issue a warning regarding cranberry use. Together the AHP Monograph and Therapeutic Compendium provides comprehensive and reliable information regarding the therapeutic potential and safety of cranberry and its quality control requirements. This allows consumers and health professionals make the most educated decisions about its use and guides manufacturers in the manufacture of cranberry preparations that will deliver the benefits that are expected. Since the first release of the cranberry monograph numerous clinical studies meta-analyses mechanistic reviews and interaction studies have been performed and have been included in the revision. For more information visit www.herbal-ahp.org. TSI Group Invests in Transparent Botanical Production Platform ong Kong-based TSI Group Co. Ltd. (TSI) recently announced the creation of a new botanical products growing and manufacturing platform located in Yancheng Jiangsu Province China. The new venture elevates TSI s manufacturing capabilities into a completely integrated farm-to-product growing and production platform that addresses today s pressing market demands for authenticated botanical products produced in a transparent custody secure completely integrated supply chain. According to TSI CEO Joe Zhou the first phase of our expanded operation is the acquisition of 1 000 acres of farmland dedicated exclusively for Ginkgo tree cultivation. Ginkgo is a very strategic ingredient for TSI and with this acquisition we are able to extend our chain of custody controls up stream to the ginkgo trees and the farm they grow on. Located adjacent to TSI s farm is a new state-of-the art cGMP (current good manufacturing practice) botanical extraction facility that is scheduled to open the summer of 2016. The facility significantly expands TSI s botanical extraction production capacity and it is designed to operate in accordance with global food dietary supplement and pharmaceutical cGMPs. For more information visit www.tsiinc.com. H Go to www.niemagazine.com kml for info about this advertiser 10 Nutrition Industry Executive www.niemagazine.com April 2016 Go to www.niemagazine.com texasbestorganics for info about this advertiser IndustryNews AHPA Advocacy Spurs Correction of FDA s Dietary Supplement Labeling Guide he U.S. Food and Drug Administration (FDA) has corrected its Dietary Supplement Labeling Guide after the American Herbal Products Association (AHPA) notified the agency of inaccurate information posted online. AHPA notified FDA in September 2015 that its guidance for industry titled A Dietary Supplement Labeling Guide included one detail that contradicted cur- T rent law and FDA regulations. Specifically the answer to the third question in Chapter II titled Identity Statement inaccurately stated that the term dietary supplement by itself could not be considered the statement of identity for dietary supplement products. FDA posted a Federal Register notice on March 7 to alert the industry that it has revised its guidance to state that the term dietary supplement may be used as the entire statement of identity for a dietary supplement and to explain the basis for that change. FDA also revised questions 1 2 and 3 for clarity and consistency with current regulations and FDA s guidance on statements of identity for conventional foods in A Food Labeling Guide Guidance for Industry. AHPA and the supplement industry greatly appreciate FDA correcting this guidance said AHPA President Michael McGuffin. Many dietary supplement products are labeled with Dietary Supplement as the only statement of identity in accordance with FDA regulations. Correcting this guidance will help eliminate any confusion that could lead to unsubstantiated allegations of misbranding and appreciates FDA s attention to our request. AHPA was alerted to the issue through a blog post by Wes Siegner a director at Hyman Phelps & McNamara PC. For more information visit www.ahpa.org. White Paper Instructs on Bar Formulation With Clean-Label Sweeteners utrition bars have come a long way since hitting the food scene in the late 1970s. Considered the ultimate healthy food many of the first bars to market were made from granola corn syrup nuts and fruit. Today s consumers demand more nutrition reduced sugar and minimal processing--all of which pose unique challenges to experts in research and development. To assist manufacturers in formulating bars that contain more naturally nutritionally and texturally rich ingredients-- which bring a variety of stability humectancy binding browning and flavor-profile issues--Steviva Ingredients (Portland OR) has developed a white paper Clean Label--Sugar Reduction in Bars. To download the free white paper visit www.stevivaingredients.com press cleanlabelsugarreduction bars.pdf. For more information visit www.stevivaingredients.com. N Go to www.niemagazine.com nutraceutix for info about this advertiser 12 Nutrition Industry Executive www.niemagazine.com April 2016 Go to www.niemagazine.com alkemistlabs for info about this advertiser IndustryNews Naturex & Mazza Innovation Sign Processing Agreement T he Naturex Group (Avignon France) a leader in specialty plant-based natural ingredients and Mazza Innovation Ltd. (Delta BC Canada) a provider of premium-quality solvent-free botanical extracts have signed an exclusive agreement for use of Mazza s patented pressurized low-polarity water (PLPW) technology to extract phytochemicals from cranberries. As part of the agreement Mazza will use its PhytoClean extraction process to produce cranberry extracts exclusively for Naturex in its newly opened facility in British Columbia. The PhytoClean Method is an earthfriendly way to extract bioactives from plants using only water and produces clean non-solvent-derived ingredients. The green technology efficiently extracts bioactive compounds including polyphenols alkaloids glycosides and specialty carbohydrates that can be used as ingredi- ents for functional foods dietary supvarious sources. The collaboration plements and beauty products. with Mazza Ltd. is one of the first This open innovation partnership steps in our recently-launched global with Mazza Ltd. is a great opportunity Open Innovation program. to bring the global market new natuFor more information visit ral clean-label ingredients using enviwww.naturex.com or ronmental friendly technologies said www.mazzainnovation.com. Olivier Rigaud CEO of Naturex. As one of the foremost companies in the field of natural health care solutions Naturex is fully aware of the abinsa Corporation (East Windsor NJ) founder importance of Muhammed Majeed PhD was honored with the supporting innoNIB Global Innovation & Excellence Award at a vative ideas and ceremony organized by the Public Relations Council of processes from India (PRCI) and the Press Club of India on February 20 Sabinsa Founder Honored With Global Innovation & Excellence Award S 2016. The award was largely in recognition of the intellectual property portfolio attained by the Sami-Sabinsa Group now encompassing 110 U.S. and international patents. Innovation is a key driver for successful companies said Majeed in his speech accepting the award. When you establish a dedication to research and innovation as a corporate culture incredible discoveries can happen as evidenced by obtaining 15 new patents in recent months. The recent patents were comprised of ingredients such as calebinoids stilbenoids peptides 3-hydroxypterostilbene boswellic acids and garcinol along with several others in countries ranging from China and New Zealand to the U.S. Canada and Mexico. The categories ranged from hypercholesterolemia weight management treating skin aging inhibiting and preventing adipogenesis protecting articular cartilage and a hepatoprotectant molecule. For more information visit www.sabinsa.com. Go to www.niemagazine.com somalabs 14 Nutrition Industry Executive Majeed (center) accepts award from K.V. Thomas chairman of the Public Accounts Committee of Parliament www.niemagazine.com April 2016 Iichiroh Ohhira PhD Probiotic Pioneer Dies at 80 n March 1 Iichiroh Ohhira PhD developer of worldrenowned Dr. Ohhira s Probiotic Formulations (known as OM-X in Japan) passed away after a brief illness. He was 80 years old. This is extremely sad news for everyone at Essential Formulas. I had the privilege of working with Dr. Ohhira for many years and considered him not only a brilliant scientist but also a friend. He was a visionary in the field of microbiology and biochemistry and his pioneering research developed the first clinically controlled natural fermentation process thus setting the gold standard for probiotic supplementation worldwide said Michael Schoor CEO and president of Essential Formulas Incorporated. Dr. Ohhira was a true humanitarian who made it his life s work to positively impact O the health of millions of people thus becoming a champion for a generation who were seeking naturally viable health alternatives. In 1974 Ohhira founded Bio Activity Research & Development Center in Okayama Japan later known as BioBank. Through his research he discovered Enterococcus faecalis TH-10 a strain whose proteolytic power is 6.25 stronger than other lactic acid bacteria (LAB) known to science. This strain became the foundation of Ohhira s award-winning formulations. This discovery along with his research in lactic acid bacteria earned Ohhira a series of prestigious awards. He received the Presidential Citation from Philippine Medical Association and was named a GUSI Peace Prize winner often referred to as the Philippine s version of the Nobel Peace Prize. Ohhira once stated Each capsule is filled with our passion and hope for bringing health and long life to all seven billion people on the earth. We make our product with not only proven scientific protocol but tender care through the power of fermentation inspired through nature s blessings and the mighty lactic acid bacteria. Continuing to lead the company is CEO Masumi Ohhira lead research scientist and Ohhira s prot g Muneaki Takahata PhD and his team of researchers and Hiroaki Takahata who oversees marketing operations in Japan and other regions. For a full list of Dr. Ohhira s accomplishments visit www.essentialformulas.com efi.cgim template beta-dr._ohhira. Go to www.niemagazine.com vit-best for info about this advertiser April 2016 www.niemagazine.com Nutrition Industry Executive 15 IndustryNews ADM Opens New Flavor Creation and Customer Innovation Facility A rcher Daniels Midland Company (ADM Chicago IL) recently opened a new stateof-the-art flavor creation application and customer service facility in Cranbury NJ. The 15 700-square-foot site is designed to provide customers with a creative and innovative environment for their product development. The space features a beverage bar dedicated to presentations tastings and development a dedicated lab for mint and oral care products and state-of-the-art facilities including a pilot plant to enable the creative development of sweet and savory flavor creations for a wide range of other applications. The innovation center is supported by a team of flavorists mint specialists and application technologists. The space is designed to allow customers to be actively involved in the process of developing new products and applications complete with a comfortable work area so customers can stay connected to their offices throughout the process. ADM has long been known in the industry as a reliable ingredient provider and our recent acquisitions of WILD Flavors Specialty Commodities Harvest Innovations and Eatem Foods give us a whole new range of ingredients and flavors that allow us to provide fully integrated applications and solutions for our customers said Vince Macciocchi president of ADM s WILD Flavors & Specialty Ingredients business unit. This facility provides a great way for us to work side-by-side with our customers to develop on-trend solutions to meet the unique demands of their consumers. For more information visit www.adm.com. Omya Opens New Lab Offers Enhanced R&D Services mya s new pharmaceutical and nutraceutical laboratory is now operational. The facility at the company s Swiss headquarters in Oftringen comprises a wet lab for product development a dry lab for granulation tableting and performance analysis as well as storage and office space. Cutting-edge equipment--including fluid-bed technology a roller compactor and a rotary tablet press--allows for high-quality mineral research development and technical customer support. Until now Omya has done pharmaceutical and nutraceutical product development with external partners through third-party agreements. However securing intellectual property rights in collaborations such as these can be challenging. With its own lab Omya can react to market O needs much faster now and ensures legal certainty for both itself and its customers which is a prerequisite for the company to be able to sell its products without restrictions. Of paramount importance for the new laboratory will be developing innovative applications and maintaining ongoing natural minerals research projects. These include the award-winning Omyapharm a functionalized calcium carbonate and ideal excipient that allows granules and tablets with high levels of mechanical strength and fast disintegration times to be produced. Owing to its outstanding properties Omyapharm was selected from 20 shortlisted substances and presented with the 2015 CPhI Pharma Award for most innovative excipient. For more information visit www.omya.com. www.niemagazine.com April 2016 16 Nutrition Industry Executive Steve Fink has joined PLT Health Solutions (Morristown NJ) as its new director of marketing. Fink will represent the marketing function on PLT s New Product Development team oversee new product launch efforts support PLT s innovation partners with marketing strategies and work closely with PLT customers in developing concepts for consumer products. Aker BioMarine has hired two new employees at its company headquarters in Norway. Cilia Holmes Indahl the company s new director of sustainability will further develop and implement the company s sustainability strategy while working with key stakeholders and non-government organizations (NGO s) interested in krill and Antarctica. Katrin Berntsen Aker BioMarine s new director of communications will be responsible for managing and directing the company s internal and external communications. Nutralliance (Yorba Linda CA) has You reHired hired Tim Intfen as one of its regional account executives. Intfen brings more than 10 years of industry knowledge and ingredient sales expertise to Nutralliance and will play an instrumental role in managing the company s continued growth and expansion. In addition the company has also hired Felipe Chaluppe as its new director of sales--Midwest region. Chaluppe will help expand the company s service to customers through Midwest food and pharmaceutical channels. Archer Daniels Midland Company (ADM Chicago IL) has named Erik Heggen president North American Refined Oils. Heggen joined ADM in 2001 and has held key roles in the North American Refined Oils group since 2008. In his new role Heggen will be responsible for overseeing ADM s North American vegetable oil refineries and ADM s oils and fats product portfolio in the region. Heggen replaces Ray Bradbury who was recently appointed president risk management for ADM s corn business unit. The U.S. Pharmacopeial Convention (USP) announced that Todd Abraham PhD has been appointed as an At Large Trustee of USP s Board of Trustees. An expert in food science innovation and knowledge management Abraham is senior vice president of research and nutrition at Mondel z International a leading multinational food and beverage company. Biova LLC (Johnson IA) has announced new personnel and expansion at its Olathe KS sales and marketing offices Kathy Hockla has been promoted to channel manager. Merriam Vater sales representative will focus on expanding domestic sales opportunities for Biova s water soluble egg membrane (WSEM) ingredients in the natural products market. Ella Sue Roche inside sales support will carry out a number of support functions that assist Biova s global sales and marketing teams. THE NUTRITION INDUSTRY S NEWS & INFORMATION RESOURCE NIE s Upcoming Issue Highlights June July August 5 16 16 ad closing 6 28 16 ad closing Food Safety Company Profiles September October 8 11 16 ad closing 9 7 16 ad closing SupplySide West Show Issue Washington and the Natural Industry Our 2016 Media Planner Is Available At NIEmagazine.com 2016-Media-Planner Contact One of Our Ad Specialists Today Russ Fields at 732-432-9600 ext. 102 or e-Mail RussF VRMmedia.com Gary Pfaff at 732-432-9600 ext. 103 or e-Mail GaryP VRMmedia.com April 2016 www.niemagazine.com Nutrition Industry Executive 17 IngredientNews Algatechnologies Non-GMO Project Verified srael-based Algatechnologies Ltd. announced its verification by the Non-GMO (genetically modified organism) Project (NGP). The Certification of Compliance together with the NGP seal was received January 2016. Verification by the NGP ensures that AstaPure natural astaxanthin products are produced in compliance with the NGP Standard including ongoing testing of high-risk ingredients. AstaPure astaxanthin is sourced from the Haematococcus pluvialis microalgae cultivated at Algatech s Arava desert facility in a closed tubular environmentally protected system utilizing 12 Astaxanthin is extracted from the microalgae biomass using supercritical CO2 technology without any solvents. I This controlled sustainable process guarantees the highest quality of natural bioactive ingredients and complete traceability. The Non-GMO Project Verification is an important recognition of Algatech s strong commitment to North American and global customers said Efrat Kat marketing and sales director for Algatech. The AstaPure brand includes a wide range of natural Astaxanthin oleoresin beadlets and powder solutions. AstaPure is among the first Astaxanthin ingredients to be verified by the NGP. In addition Algatechnolgoies has established a new distribution arrangement that will enable its AstaPure natural astaxanthin to be sold in Mexico for the first time. Ingredients from the AstaPure range are now available to businesses in Mexico s thriving dietary supplements sector through local company NaturaExtracta a subsidiary of the Arancia Group which specializes in marketing natural extracts. For more information visit www.algatech.com. Curry Powder to Clinical Significance ew Jersey-based Sabinsa Corporation announced the availability of Curry Powder to Clinical Significance by NutriScience Publishers LLC 1st Edition. This comprehensive hardcover book captures the robust body of science on curcumin in the clinical setting and goes on to cover the history of Sabinsa s Curcumin C3 Complex. Curry Powder to Clinical Significance delves into curcumin chemistry and the many health benefits curcumin provides which have been verified by numerous human clinical studies. It gives an overview of clinical studies on C3 Complex for a variety of medical conditions ranging from cardiovascular to radiation dermatitis. Edited by Sabinsa founder Muhammed Majeed PhD and Anju Majeed MS the book is dedicated to India s 11th President Dr. APJ Abdul Kalam a scientist who visited Sami Sabinsa shortly before he passed away. For more information visit www.sabinsa.com. Ganeden Partners with FlapJacked unctional pancake and muffin company Colorado-based FlapJacked and Ohio-based Ganeden the makers of the patented probiotic GanedenBC30 partnered to launch Mighty Muffins protein and probiotic muffins for mindful eaters. Mighty Muffins are certified gluten-free protein packed and high-fiber muffins developed with balanced nutrition and convenience in mind. Mighty Muffins are under 230 calories and packs 20 grams of protein as well as the benefits of the patented probiotic GanedenBC30 into each container. Our growth is driven by quality products and fueled by consumer demand for convenient better for you foods said Jennifer Bacon co-founder of FlapJacked. Mighty Muffins were developed under the promise to deliver high quality healthy and convenient foods that cater to today s on-the-go lifestyles. Being a functional protein-packed and convenient product positions FlapJacked to partner with retailers who are focused on providing functional foods to deliver on growing consumer demands. For more information visit www.ganedenprobiotics.com or www.flapjacked.com. N F ZyCal Bioceuticals Announces Self-Affirmed GRAS ew Jersey-based ZyCal Bioceuticals Healthcare Inc. announced that its Cyplexinol bioactive protein-complex for bone and joint health has obtained self-affirmed GRAS (generally recognized as safe) status for use as an ingredient in food and dietary supplement applications. N Under provisions of the Federal Food Drug and Cosmetic Act administered by the U.S. Food and Drug Administration (FDA) ZyCal s Cyplexinol was submitted for an extensive review by a panel of experts to thoroughly examine all aspects of process and production. After a comprehensive evaluation of toxicology data and research studies the panel concluded that Cyplexinol is safe for use as an ingredient in a variety of products including dietary supplements confections and nutritional bars. For more information visit www.zycalbio.com. www.niemagazine.com April 2016 18 Nutrition Industry Executive BENEO Authorized 13.5 Health Claim Translucent Gum Coating unctional ingredients manufacturer New Jersey-based BENEO announced that the E.U. Commission authorized a 13.5 health claim with proprietary use for its chicory root fiber inulin promoting digestive health. The official wording for the claim is chicory inulin contributes to normal bowel function by increasing stool frequency. From January 1 2016 this proprietary claim is available for use by BENEO s customers. By incorporating the company s inulin into any food and beverage applications in combination with the health claim manufacturers can help consumers to understand and benefit from the positive effect chicory inulin has on bowel function. In addition to the authorized 13.5 F proprietary health claim general health-related well-being claims under article 10.3 are also possible. Manufacturers that want to use the claim should consider that the beneficial effect is achieved with a daily intake of 12 g chicory inulin and the consumer should be informed accordingly. The amount of 12 g can be split up into several servings per day. BENEO also showcased its new ISOMALT translucent gum coating technology for the first time at ISM 2016 in Cologne Germany. This innovative coating process enables chewing gum manufacturers to create attractive products that deliver translucence and shine while also maintaining stability throughout product shelf life. The new coating has been made possible by incorporating BENEO s ISOMALT the only sugar replacer that crystallizes translucently. This characteristic makes it the coating of choice for producers looking to create shiny pellets with innovative visual effects. The ISOMALT translucent coating technology now offers new ways to create appealing gum products on existing production equipment. Gum coated with ISOMALT has a fine delicate crunch excellent flavor release and is not prone to chipping or cracking during production or transport. For more information visit www.beneo.com. Viva 5 Demonstrates Long-term Stability of Probiotic Gummies lorida-based Viva 5 Corporation a probiotic specialist announced that they have demonstrated 18 months of real-time stability with its Bacillus coagulans probiotic gummies. Viva 5 has developed a proprietary manufacturing process which allows for the addition of the probiotic into the gummy matrix rather than as a component of the sugar coating allowing high recovery after manufacture and robust stability over an extended period of 18 months. F dietary supplements as well as gummy delivery forms we expect to see continued high demand for our shelf stable probiotic gummies worldwide. For more information visit www.viva5corp.com. Accelerated testing further indicates probiotic stability over a 24-month period making Viva 5 Corporation the only known manufacturer worldwide to offer an active probiotic gummy with such compelling shelf life. This highly stable probiotic can tolerate higher temperatures during manufacturing than traditional lactic acid bacteria thereby conferring superior shelf-life stability in gummies and other finished products containing this strain. Probiotic stability is a big challenge in the industry and we are very pleased to see that our accelerated stability trend has been substantiated by extended real time shelf life studies said Brian Baer president of Viva 5. With the growth of probiotic sales in April 2016 www.niemagazine.com Go to www.niemagazine.com hsus for info about this advertiser Nutrition Industry Executive 19 IngredientNews Stevia Ingredients Partners With Farmers in Brazil n response to increased consumer interest in health and environmental consciousness Stevia Ingredients (Portland OR) a global supplier of all-natural highintensity sweeteners and custom sweetening solutions partnered with farmers in Brazil to produce BraziliaSweet RA95 and BraziliaSweet 95-60 stevia extracts. The newest additions to the company s portfolio of clean label sugar reduction products are harvested from ethically sourced identity-preserved stevia plants that are cultivated in a single location in Brazil. The farming agreement by which Steviva invests time and capital to support the involved farmers builds upon Steviva s mission of environmental sustainability and provides full traceability--as well as a reliable ready supply of the premium stevia leaves that produce the most sought-after stevioside Rebaudioside A (Reb A) the company said. Because concentration and purity of sweetening glycosides can vary immensely when stevia leaves are sourced globally Steviva s single-location sourcing ensures dependable consistent flavor. For more information visit www.stevivaingredients.com. MSM Supports Immune Health ergstrom Nutrition based in Washington released a new report titled MSM Immune Health Science Brief to summarize the varying research pointing to how methylsulfonylmethane (MSM) benefits the innate immune system. The company s product OptiMSM is known for its positive effects on inflammation and conditions of oxidative stress (such as arthritis) and is now building a reputation for immune health support. The report can be viewed online. This is our way of organizing the collective evidence regarding MSM s affects on the immune system said Tim Hammond vice president of sales and marketing for Bergstrom Nutrition. In summary if the immune system is producing too much of an inflammatory response OptiMSM can mitigate it lessening the damage. And conversely when the immune system is suppressed OptiMSM can boost its response to fight infections. Key take-aways from the report include MSM mitigates inflammation by reducing inflammatory markers MSM modulates a healthy immune response MSM reduces oxidative stress and improves oxidative status and MSM may reduce seasonal allergies. For more information visit www.optimsm.com wp-content uploads Immune-science-brief.pdf. I B Proprietary C. Forskohlii Awarded Certification in Japan io Actives Japan and American Medical Holdings NY have announced that based on proprietary analytical and research data on Coleus forskohlii a component of its proprietary researched FB3 fatabsorption inhibition formula Japan Bio Actives obtained the High Quality Certification from Japan Health Food and Supplement Association for its FB3 Coleus forskohlii extract. Vladimir Badmaev MD PhD CEO of American Medical Holdings and formulator of FB3 commented This certificate was awarded after evaluation of the FB3 C. forskohlii safety data green-solvents extraction technology and the peer review published clinical efficacy data. The regulatory evaluation process took over 1.5 years to complete and attests to high quality of the FB3 formula. For more information visit www.bioactives.co.jp english . B Go to www.niemagazine.com herballyyours for info about this advertiser 20 Nutrition Industry Executive www.niemagazine.com April 2016 Mazza Innovation Opens Commercial Extraction Processing Facility C anada-based Mazza Innovation Ltd. a provider of premium-quality solvent-free botanical extracts announced the opening of its first largescale commercial extraction processing facility to produce PhytoClean Cranberry Green Tea and Blueberry extracts as well as other clean label ingredients for its customers. The 38 000-square-foot facility received its GMP (good manufacturing practice) certification and is fully compliant with the quality requirements of dietary supplements and natural health product manufacturers including with organic customers in the near future. Since the Mazza PhytoClean process only uses water as its solvent no costly solvent-handling environmental safety permits or explosion-proof equipment were needed in its construction. This translates into competitive pricing for its quality ingredients or contract manufacturing services offered to its customers the company said. Opening and initiating large-scale production is an exciting and important milestone for Mazza as we enter commercial production of our advanced premium extracts for the customers who have placed orders said Benjamin Lightburn president of Mazza Innovation. We now have significant processing capability to fulfill demand. Our extraction technology can be applied to source many different botanical ingredients with higher purity than is typically available. For more information visit www.mazzainnovation.com. Bacillus subtilis Health Benefits Recognized rance-based Lesaffre Human Care supplier of quality ingredients from yeast and bacteria fermentation for the global human care markets reported that Bacillus subtilis CU1 health benefits were recognized by the scientific community in a newly published peerreviewed paper written by a team of researchers from the University of Bordeaux Biofortis-M rieux NutriSciences Paris 7 University and Lesaffre Human Care. Bacillus subtilis CU1 is made of an exclusive and patented strain of Bacillus subtilis registered with the French National Collection of Microorganism Cultures as CNCM I-2745. It is a spore forming bacteria that helps support immune health especially in people with weakened natural defenses. Researchers recruited 100 healthy volunteers aged between 60 and 74 years old and with a history of winter infections to participate in a randomized double-blind placebo-controlled study. The purpose of this trial conducted in collaboration with Pr. Philippe Marteau--independent expert in the area of gastroenterology--was to investigate the effect of Bacillus subtilis CU1 on winter respiratory and gastrointestinal infectious episodes in elderly people. Thanks to its ability to form spores Bacillus subtilis CU1 is different from many other bacteria which are often vulnerable to manufacturing processes or gastric acid and intestinal bile. Bacillus subtilis CU1 is indeed highly stable and able to survive exposure to the human gastrointestinal tract as well as extreme conditions. It can thus be incorporated into a diverse range of food F and beverage applications (e.g. hot tea cereal bar etc.) and deliver its health benefits no matter how harsh the environmental conditions may be. In addition Bacillus subtilis CU1 is compatible with all kinds of dietary restrictions. It is gluten and lactose free non-GMO (genetically modified organism) as well as halal and kosher certified and therefore suited for virtually any healthy individual that wants to boost their natural defenses the company said. For more information visit www.esaffrehumancare.com. April 2016 www.niemagazine.com Nutrition Industry Executive 21 IngredientNews Xsto Announces Cuvitus for Muscle & Joint Health ew Jersey-based Xsto Solutions announced the addition of Cuvitus a new ingredient to its specialty lineup. As a whole fruit extract from cucumbers Cuvitus is a new condition specific ingredient for relief of muscle and joint pain from temporary over exercise. After a successful launch in Europe Naturelea SA of Switzerland recently partnered with N Xsto to bring this exciting new ingredient to North America. Working metabolically to reduce TNF alpha and other cytokines Cuvitus can be used in pre- and post-workout supplements as well as joint health products to support active healthy lifestyles. It s exciting to launch Cuvitus a truly novel ingredient sourced from cucumbers a healthy and completely untapped fruit source stated Francis Foley president of Xsto Solutions. People know cucumbers are healthy and delicious and we often see images related to relaxing and rejuvenating spa visits so we believe consumers will easily relate to the benefits of Cuvitus. For more information visit www.xstosolutions.com. innoVactic Unveils New Study GELITA at VitaFoods Europe ermany-based GELITA a manufacturer of collagenous proteins returns to Vitafoods Europe in Geneva Switzerland on May 10 12 to showcase the latest science in Bioactive Collagen Peptide supplementation. Being the official collagen peptide sponsor of the show and a market-leading contributor to clinical collagen peptide research the company will highlight its latest findings in the areas of sarcopenia and cellulite treatment during the exhibition (Verisol and BodyBalance). Moreover GELITA will present the future of soft capsule production with reduced cross-linking characteristics. To further increase the application range of soft gelatine capsules GELITA highlights GELITA RXL ADVANCED at this year s Vitafoods. Providing decreased cross-linking and reduced drying times the pharmaceutical gelatine guarantees reliable fill release and more efficient capsule production. Protected by U.S. and other international patents this gelatine grade improves dissolution and capsule shelf-life and provides significant benefits for the development of OTC products with faster fill release characteristics even at high humidity and very warm temperatures. For more information visit www.gelita.com. i nnoVactiv a Canadian company dedicated to the development of science-based specialty ingredients announced new study results demonstrating for the first time the superior potency of InSea2 against free radicals. InSea2 is a non-GMO (genetically modified organism) organic-certified brown seaweed extract that is well-established for its best-in-class ability to optimize post-meal carbohydrate absorption and assimilation. Since it contains mostly phlorotannins a polyphenol found exclusively in brown seaweeds InSea2 was always expected to show antioxidant benefits. Free radicals are a driving force behind aging processes and their production is stimulated when blood glucose and insulin levels are high such as after a meal said Jocelyn B rub executive and scientific director at innoVactiv. Our new study found that not only InSea2 phlorotannins exerts protective action against free radicals but they are also among the most potent antioxidants available to the dietary supplement industry outperforming well-known antioxidants such as green tea blueberry cranberry and grape seed extracts. For more information visit www.innovactiv.com. G HP Ingredients Receives Safety Confirmation lorida-based HP Ingredients a manufacturer and supplier of organic non-GMO (genetically modified organism) and sustainably wildharvested patented herbal extracts announced two significant regulatory and safety reviews that will greatly help marketers of its LJ100 Ingredient for sports performance maintaining high free testosterone levels enhancing sexual function and promoting overall wellbeing mood state and hormonal health. Barry Lynch director Food and Nutrition Group Intertek Scientific & Regulatory Consultancy (Intertek) reviewed a total of 56 studies (human clinicals and animal studies) encompassing safety mechanism of action and efficacy in a range of sexual and reproductive support issues and concluded The available information supports the safety of LJ100 at the intake level of 200 mg per day. In his written review (dated February F 16 2016) Lynch asserted The components of this extract are consistent with the specifications established in the Malaysian Standard. Emphasis was placed on assessing the safety of incorporation of this specific aqueous extract of tongkat ali root into dietary supplement products and further to determine a dose not likely to cause significant adverse effects. Specifically Intertek evaluated the safety of a proposed dosage of 200 mg day in healthy adults. Lynch concluded that based on an exhaustive review of the available data that show a lack of serious adverse effects at doses of 200 to 600 mg day there is no indication that consumption of 200 mg day of LJ100 would be associated with adverse effects. This review by Intertek further supports the safety of LJ100 brand of standardized aqueous Eurycoma longifolia extract specifically and does not encom- pass generic tongkat ali alternatives said Annie Eng founder and president of HP Ingredients. In addition Health Canada has recently concluded that HP Ingredients application for its proprietary Eurycoma longifolia ingredient known as LJ100 is in compliance pursuant to section 7 of the Natural Health Products Regulations (NHPR) and has thus issued product license NPN 80067049 for LJ100 capsules. Further the following claims are now allowed to be made for Canadian LJ100 products (100 mg and 200 mg) Eurycoma longifolia helps support healthy sexual interest. Eurycoma longifolia helps promote testosterone production. Eurycoma longifolia supports testosterone production. Eurycoma longifolia is a source of provides antioxidants. For more information visit www.hpingredients.com. www.niemagazine.com April 2016 22 Nutrition Industry Executive AstaReal Earns Halal Certificate ew Jersey-based AstaReal Inc. announced that its parent company Fuji Chemical Industries Co. Ltd. has gained another quality certification. Fuji received its halal certificate from the certifying body NPO Japan Halal Association which listed AstaReal P2AF (2 percent cold water dispersible N powder) as one of the certified products. AstaReal P2AF is ideal for tableting two piece hard capsules and powder premixes for beverage formats. Achieving Halal approval for AstaReal P2AF is yet another measurement of our commitment to providing superior quality assured astaxanthin especially for those consumers who need to follow strict dietary compliance said Joe Kuncewitch national sales manager for AstaReal Inc. AstaReal is truly the most certified and accepted natural astaxanthin on the global market. For more information visit www.astarealusa.com. AssociationNews AHPA and UNPA Launch Campaign to Educate State AGs he American Herbal Products Association (AHPA) and the United Natural Products Alliance (UNPA) have launched a joint campaign to develop working relationships with state attorneys general (AG) and educate state AGs about the herbal supplement industry. This is the latest effort by AHPA and UNPA to ensure state AGs have an accurate understanding of the industry. Roughly one year ago New York AG Eric Schneiderman initiated the first of two still-unresolved regulatory actions against dietary supplement retailers and manufacturers. AG Schneiderman subsequently secured support from 13 other state AGs and issued a letter to Congress requesting an inquiry into the botanical supplements industry. Most recently Oregon AG Ellen Rosenblum sued a supplement retailer for including picamilon in its supplement products. While the state AGs actions may be well intentioned an accurate and detailed depiction of the industry has yet to be conveyed. AHPA and UNPA s campaign provides an opportunity for industry to offer expertise on the comprehensive regulations herbal supplements must comply with and the nuances unique to herbal supplement products. A balanced portrayal will ensure state AGs actions yield the intended result of protecting consumer interests without causing unnecessary alarm in the absence of a complete understanding of the laws under which supplements are marketed. T The associations have hired the Washington D.C.-based law firm BuckleySandler and attorney Douglas Gansler to help deliver information and expertise about the industry to state AGs. Gansler was the AG of Maryland from 2006-2014 and is the most recent past president of the National Association of Attorneys General. The campaign has the following objectives Build positive collaborative relationships with state AGs their office and staffs Provide resources for state AGs in support of responsible industry and to create industry advocates Shift the focus of state AG regulatory efforts toward unsafe and adulterated products that are falsely labeled as supplements Educate state AGs about responsible industry and the economic significance of dietary supplement companies on state economies Rebut inaccurate media accusations Provide timely information educa- tion and resources regarding state AG activity to AHPA and UNPA member companies AHPA fully supports regulators efforts to ensure consumers have informed access to safe and highquality herbal products including dietary supplements said AHPA President Michael McGuffin. This campaign is a unique opportunity to partner with state AGs to ensure such efforts are based on accurate information. UNPA sees this joint state AG project as a logical extension of the regulatory work both organizations already do at the federal level added UNPA President Loren Israelsen. It is our expectation that with Mr. Gansler s assistance we will be able to create positive collaborative working relationships with state attorneys general in support of the responsible dietary supplement industry. The joint AHPA UNPA state AG representation campaign has been initially funded by the generous support from the following companies Emerson Ecologics Essential Formulas Herb Pharm Indena NOW Foods Pharmavite PLT Health Solutions Thorne Research Additional funding for the project is actively being solicited by the two trade organizations. For more information visit www.ahpa.org or www.unpa.com. Nutrition Industry Executive 23 April 2016 www.niemagazine.com AHPAUpdate Leading Industry Association Speaks Directly to Nutrition Industry Executive Readers The Herbal Supplement Industry s Winning Record T he ongoing and persistent attacks against the herbal supplement industry by our career critics and a uniformed media can make it easy to lose perspective and forget our long history of success in protecting informed consumer access to a wide variety of herbal products. Despite all the negative publicity and the best efforts of those who oppose inclusion of herbs in our health care choices the industry continually emerges victorious. Speakers at the American Herbal Products Association s (AHPA s) Annual Member Meeting in March reminded industry leaders about their many victories and helped explain why the industry continues to come out on top. The industry won in 2014 by working together to defeat legislation that would have required supplement manufacturers to register their products and ingredients with FDA without any consideration for other changes to the law that would provide benefits to people that use herbs and supplements This industry gets beat up all the time Harkin said. It can be hard to remember that we ve come a long way with herbal supplements in the United States even with all the fierce opposition. Factors That Contribute to Success Molyneaux s presentation highlighted one of the many reasons why the supplement industry keeps winning consumer support. The industry has always had the support of consumers who demand access to safe products. Whenever there is an attack on supplement access the industry is strongly supported by consumers. Harkin stressed another reason the herbal supplement industry keeps winning. On Capitol Hill if you re not at the table you re on the menu Harkin said. AHPA has always been at the table. The industry continues to fight on behalf of consumers to preserve their choices in health care and wellness. At the same time industry advocacy efforts are bolstered by strong consumer support. At AHPA s Annual Meeting an award was presented posthumously to Bob Ullman one of the supplement industry s biggest advocates with a long history of victories against individuals and organizations seeking to restrict consumer access to supplements. Ullman won cases that no other lawyers would take and helped protect the industry against efforts by the federal government to hinder consumers access to supplements. The award was presented to Bob s son Marc Ullman counsel at the Rivkin Radler law firm. In accepting the award Marc outlined two additional reasons that help explain his father s success and why the herbal supplement industry has a long history of winning. The reasons we always win are because we have common sense on our side and we put in the hard work Ullman said. Growing Consumer Support While recent negative press may concern the industry it may have helped increase consumers awareness of supplements according to Maryellen Molyneaux president of Natural Marketing Institute (NMI). Molyneaux provided AHPA members with an overview of consumer trends that demonstrate the growing popularity of supplements. Nearly one in three consumers (31 percent) believe in the importance of herbal supplements for health maintenance an increase of 80 percent since 2011. The percentage of supplement users indicating herbals botanical products are very safe has increased from 21 percent in 2009 to 30 percent in 2015 a 41 percent increase. Over the same time the percentage of supplement users that think prescription drugs are very safe has dropped to 24 percent a 17 percent decline. At the same time a growing number of supplement users believe in the effectiveness of these products and increasingly doubt the effectiveness of prescription drugs. Between 2011 and 2015 the percentage of supplement users who indicated that they feel the herbal supplements are very effective for health issues and or medical conditions grew to 17 percent in 2015 up from 12 percent in 2011. The percentage of supplement users who indicated they thought prescription drugs are very effective dropped from 59 percent in 2011 to 51 percent in 2015. These numbers provide additional evidence of the industry s ability to weather significant (even if unfounded) attacks. History of Congressional Victories Recently retired Iowa Senator Tom Harkin provided AHPA Member Meeting attendees with a review of the dietary supplement industry s many legislative victories in the U.S. Congress beginning with the Dietary Supplement Health and Education Act (DSHEA) amendments to the Federal Food Drug and Cosmetic Act. Harkin said there is no doubt that DSHEA has been an overwhelming success and noted that the bipartisan support garnered for the bill is unimaginable today. We didn t give in. We fought hard. And we won Harkin said. DSHEA passed the House and Senate by unanimous consent. Harkin also reviewed how the industry has succeeded in defending and improving DSHEA over the years. He provided examples of these victories including The industry won in 2005 when it advocated to institute adverse event reporting (AER) system for supplements and over-the-counter drugs The industry won in 2010 by working together to defeat legislation that would have limited consumer choice to a list of dietary ingredients to be approved by the U.S. Food and Drug Admistration (FDA) The industry won in 2011 by stopping FDA s attempt to issue draft guidance on new dietary ingredients and overstep its authority by rewriting DSHEA 24 Nutrition Industry Executive Michael McGuffin President and Board of Trustees American Herbal Products Association (AHPA) www.niemagazine.com April 2016 Conventions&Meetings 36th Expo West Engredea Sees More Growth T Convention Center campus. In addihe 36th annual Natural Products tion to traditional exhibit halls new Expo West & Engredea the exhibitors showcased hot products at world s largest natural organic the Hilton Hotel Anaheim. and healthy products event experiThe NEXT Forecast 2016 projects enced another record-setting year with strong growth for the nat6.9 percent growth playural products industry. ing host to more than U.S. consumer sales of 77 000 attendees. The natural organic and event brought together an healthy products are foreinspired community of casted to expand 64 perindustry members and cent from 153B in 2013 more than 3 000 exhibitto 252B by 2019 including companies including Speaker Dr. Tieraona Low ing growth of 9 percent more than 600 first-time Dog discussed the case per year driven in part by exhibitors. The show held for dietary supplements. new and emerging March 9-13 at the brands. Anaheim Convention Center in Natural Products Expo West serves California is produced by the recently as a launching pad for innovation from re-branded New Hope Network. entrepreneurial brands to more estabFor the second year in a row the lished companies looking to keep up event s exhibit space was expanded to with shifts in consumer demand said encompass the entire Anaheim Carlotta Mast executive director of Content and Insights New Hope Network. Evolving shopper tastes and values have positioned the natural products industry as a major force in what products end up on shelves from natural stores to more conventional supermarkets. The education program offered Keynote speaker Samuel Kass former keynote presentations from Sam Kass White House personal chef. former White House personal chef Erik Weihenmayer author adventurer and activist and Martha Rogers acclaimed author and business strategist. Next up for Natural Products Expo is the East Coast event at the Baltimore Convention Center September 21-24 in Baltimore MD. Natural Products Expo West 2017 is scheduled to take place March 8-12 at the Anaheim Convention Center. Keynote speaker Erik Weihenmayer author adventurer and activist spoke about facing fears and reaching higher. Functional Food Myanmar 2016 M yanmar Functional Food 2016 will he held May 20-22 at the Rose Garden Hotel in Yangon Myanmar (Burma). The Functional Food Myanmar 2016 is a place where products and services in food supplement industry biomedicine for health and beauty laboratory equipment research and development ideas processes and methods of treatment raw materials vegetables and clean food as well as food and healthrelated service are brought from all around the world to entrepreneurs. The event will also be a platform for trade negotiation for entrepreneurs in the food industry in the Asian region said Romain Marselli business development director and conference organizer. For more information visit www.functionalfood-myanmar.com. April 2016 www.niemagazine.com Nutrition Industry Executive 25 The cognitive health market is seeing a surge in consumer demand for products that are portable reliable and edible. By Corinne Anderson T he unprecedented declines in mortality and fertility have resulted in a rapid population aging process in most developing countries said the National Center for Biotechnology Information. Dementia has emerged as a public health problem as it is one of the most common diseases in the elderly and a major cause of disability and mortality. According to the Alzheimer s Association an estimated 5.3 million Americans of all ages had Alzheimer s in 2015. This number includes an estimated 5.1 million people age 65 and older and approximately 200 000 individuals under age 65 who have younger-onset Alzheimer s. And those numbers will continue to rise as the population continues to live longer. The projected number of people with Alzheimer s in 2050 has been approximated at 959 000 a 110 per26 Nutrition Industry Executive cent increase from 2010 according to the Alzheimer s Association. Upgrade Your Brain As Baby Boomers reach retirement age the number of Americans experiencing decreased brain health and focus is on the rise. But declining cognitive function is not just age related. Chronic stress associated with modern lifestyles can also result in difficulty focusing and remembering things. For example just think how difficult it is to remember where the car keys are when pressed for time or feeling overwhelmed said Bruce Abedon PhD director of scientific affairs for Nutragenesis in Vermont. Recently we have seen a large number of startup companies driven by entrepreneurs with backgrounds outside of the dietary supplement industry added Chase Hagerman brand director of Texas-based Chemi Nutra. These enthusiastic business owners with backgrounds in the highstress tech industry are drawn in by the nootropic category and the seeming appeal to hack-their-brains --a term reminiscent of technology. The idea is you can swap your smartphone tablet or laptop for an upgraded model so why not try and improve your own central processing unit Go Natural Or Go Home The increased awareness of the burden and cost of contracting neurodegenerative diseases like Alzheimer s in addition to the potential adverse effects associated with pharmaceutical agents for treatment has led to both older and younger consumers to demand natural and clinically researched ingredients to be used in cognitive health supplements said www.niemagazine.com April 2016 Bryan See regional product manager with New Jersey-based ExcelVite Inc. Ingredients addressing different aspects of memory health are being introduced to brain formulations including brain signaling anti-oxidative stress membrane integrity anti-toxicity anti-brain aging and more explained Jennifer Gu PhD chief science officer with California-based AIDP. The benefits of omega-3 fatty acid DHA and vitamin E tocopherols in supporting brain health are already widely known. However a form of vitamin E called tocotrienols is gaining market attention with strong research evidence shown in supporting brain cell survival in the event of stroke See shared. The tocotrienol ingredient used in the brain clinical studies is in the form of self-emulsifying delivery or bioenhanced system called EVNol SupraBio he said. Unlike regular tocotrienol or vitamin E (oil extract) this self-emulsifying tocotrienol formula doesn t rely on a high fat meal for absorption. According to Abedon consumers are moving beyond traditional use of whole herbs vitamins and minerals in the category of memory and cognitive health. They are purchasing with increasing frequency standardized extracts of botanicals that have been clinically tested to significantly enhance memory and cognitive benefits. Branded patented ingredients are particularly important due to their superior quality and excellent safety profiles he said. Besides proven clinical studies (being scientifically substantiated) the market is moving toward clean label and non-GMO (genetically modified organism) See added. (Magtein) on cognitive ability was evaluated in four cognitive domains executive function working memory attention and episodic memory by administration of the Trail Making Digit Span Flanker and Face-Name tests respectively as Baseline Week 6 and Week 12 the company stated. These cognitive tests represent the best science available based on the current consensus that multiple domains of cognitive should be evaluated to determine cognitive impairment. The cognitive domains selected were similar to those included in major cognitive studies. They are considered reliable for testing cognitive deficits and improvements. As consumers both young and old are reaching out for supplements to support cognitive health they are also looking for simple convenient and on-the-go type of nutrient delivery formats to enhance cognitive health -- Bryan See regional product manager ExcelVite Inc. Magtein is shown to effectively cross the blood-brain barrier and increase brain synaptic density by rejuvenating neural cells attributing to its ability to improve memory and other cognitive functions Gu added. Due to its clean taste odorless and high-solubility qualities it can be in both the nutraceutical and food beverage markets Gu continued. Bluenesse by Maypro is also watersoluble. A fine beige powder it is a proprietary Melissa officinalis leaf extract commonly known as lemon balm. Human clinical research shows that lemon balm supports a calm positive mood and can reduce the effects of occasional stress said Dan Lifton president Proprietary Branded Ingredients Group from New Yorkbased Maypro. Unlike other mood support ingredients Bluenesse does not cause drowsiness in fact research Cognitive Food & Beverages In addition to clean botanicals consumers are turning to beverages for cognitive health said Gu. This particular trend resulted in AIDP s response in the form of Magtein magnesium threonate which has been studied for its effectiveness at reversing cognitive impairment and returning cognitive function almost back to normal ability relative to age the company said. The gold standard randomized controlled double-blind study was published in the Journal of Alzheimer s Disease. The effect of magnesium threonate April 2016 www.niemagazine.com indicates that it improves indicators of alertness focus memory and learning. With the food and beverage trend taking off ExcelVite Inc. also launched their R&D teams to develop two forms of bio-enhanced tocotrienol ingredients to cater to the food and beverage market as well as dietary supplement application. EVNolMax is a water dispersible natural full-spectrum palm tocotrienol complex powder. EVNol SupraBio is a patented and bio-enhanced natural full-spectrum palm tocotrienol complex liquid solution. Both of these products are bio-enhanced tocotrienol which the bio-enhanced system ensures a consistent and increased absorption of tocotrienol (bioavailability) See explained. The SupraBio system has been shown in human studies to improve oral bioavailability of individual tocotrienol isoform by up to 300 percent. In addition a recent human tissue distribution study has conclusively proved that tocotrienol via oral supplementation of EVNol SupraBio is wellabsorbed into the human plasma and is transported to vital human organs including the brain. A human clinical trial published in the American Heart Association s journal STROKE reported that EVNol SupraBio supplementation for two years at 200 mg daily slows down the development of white matter lesions (WMLs) in the human brain.1 WMLs are closely related to vascular events of the brain and are indications of fragile brain vascular network. As consumers both young and old are reaching out for supplements to support cognitive health they are also looking for simple convenient and on-the-go type of nutrient delivery formats to enhance cognitive health See said. This has prompted the rise of brain health beverages and foods. We collaborated with 3i Solutions from Wooster OH a leader in ingredient nanodispersion technology to come up with a solution to a formulation challenge for a couple phospholipid ingredients we produce [Mediator Phosphatidic Acid (PA) and SerinAid PhosphatidylSerine (PS)] said Hagerman. Both of the ingredients are fat soluble rather than water-soluble. When customers would ask if they could use them in a beverage we had to tell them they don t mix well since oil and water don t mix. 3i Solution s Nutrition Industry Executive 27 nanotechnology allows us to have a raw material that can be added successfully to a beverage he continued. More Than Memory When consumers hear of cognitive health many think of memory and fear a future where cognitive impairment becomes a factor in their ability to live quality lives. However long-term memory is not the only concern. There are some consumers who are looking for products that help with attention and stress in addition to memory benefits. Cognitive health encompasses mood stress and focus as well as memory. In 2012 the American Psychological Association released a collective report Stress in America Our Health at Risk that compared stress levels and emotional tolls that Go to www.niemagazine.com comar for info about this advertiser 28 Nutrition Industry Executive stress has on individuals over a course of a few years. One such comparison compared the emotional and physical toll of stress to each other. Americans report irritability or anger (42 percent) fatigue (37 percent) lack of interest motivation or energy (35 percent) headaches (32 percent) and upset stomachs (24 percent) due to stress. A smaller percentage report having a change in appetite (17 percent) and sex drive (11 percent) the report revealed. NutraGenesis offers Sensoril a nutraceutical extract that works synergistically to not only enhance cognitive function but also to help reduce stress and enhance mood based on the superior properties of the glycowithanolide bioactives it contains Abedon said. Stress plays a major role in how our brain and body react to our environment. It is important to make sure that when we supplement for cognitive health we keep in mind that our brain does more than remember the past it affects our present and future state of being as well. Sensoril not only helps with memory and mental clarity consumers really feel the difference in mood which helps them cope with life in general Abedon said. It has been evaluated in multiple randomized double-blind placebo-controlled human clinical trials that have demonstrated benefits in healthy subjects. In these trials researchers utilized validated cognitive health tests that were both objective in nature and measured working memory reaction time and the ability to process and store information as well as being subjective in nature. Other products for overall cognitive health from Maypro include ETAS a proprietary ingredient derived from the tough lower portion of asparagus stalks which has been shown to increase quality of sleep alleviate occasional stress raise cognitive performance reduce fatigue and improve stress response and MicroPQQ a specially formulated PQQ (pyrroloquinoline) preparation that combines a bioadhesive polymer natural wax and J3cyclodextrin to enhance dissolution and absorption in the human body leading to higher levels of availability. Research suggests that PQQ protects nerve cells improves cognitive function and alleviates occasional stress www.niemagazine.com April 2016 Go to www.niemagazine.com natreon for info about this advertiser and sleeplessness. In addition Maypro offers Venetron a patented purified extract of Apocynum venetum which has some of the same active constituents of St. John s wort. It has been shown in human clinical trials to promote a positive outlook alleviate occasional stress and improve sleep quality. Chemi Nutra makes two ingredients that aid in cognitive function that benefit more than just memory SerinAid PhosphatidylSerine (PS) and AlphaSize Alpha-Glyceryl Phosphoryl Choline (AGPC). AlphaSize A-GPC derived from high phosphatidylcholine (PC) soy phospholipids is a nutrient that occurs naturally in the human body where it is involved in a multitude of very crucial biochemical functions Hagerman explained. Phosphorylcholine formed from AGPC migrates to the synaptic nerve endings found throughout the entire central nervous system and in turn increases the synthesis and release of acetylcholine (AC). AC is a vastly important neurotransmitter present in both brain and muscle tissue. In the brain AC plays a key role in basically every cognitive function while in muscle it is vitally involved in muscle contraction. On the other hand Hagerman said SerinAid PS helps proteins that manage membrane functions that are involved in transmission of molecular messages from cell to cell helps nutrients enter into cells and helps harmful stress-related waste products to exit the cells. PS is so effective the U.S. Food and Drug Administration (FDA) granted two health claims for it indicating that it may reduce the risk of cognitive dysfunction and dementia in the elderly. This is especially notable since it is the only ingredient to have a qualified health claim for cognitive health Hagerman said. ical characteristics and interaction with other ingredients. When a product is supported by studies published in top journals it shows strong science and quality and the significance it makes in the field Gu added. See agreed. He noted that manufacturers should opt for ingredients with long histories of research across invitro in-vivo and human studies in short scientifically substantiated. They should also note ingredients with pharmacokinetic studies like proven absorption and tissue distribution data in humans. Efficacy Matters When selecting ingredients and formulating new products Gu said there are six things to keep in mind safety efficacy science regulation novelty phys30 Nutrition Industry Executive Of course cGMP (current good manufacturing practice)-cerfitications nonGMO and other safety certifications like kosher and halal are also signs of quality ingredients. And if the demand from consumers is any hint safe natural and proven ingredients are being sought after by purchasers across all categories and cognitive health is no exception. Like the rest of the dietary supplement industry one of the challenges associated with ingredients in this category is in the area of transparency quality and ID testing which is increasingly required for regulatory purposes and to satisfy consumer concerns about what is in their dietary supplement products Abedon said. Sensoril is manufactured according to strict guidelines that maintain the highest level of quality and purity. Prior to sale all raw materials are ID tested and the finished nutraceutical is evaluated for levels of bioactives heavy metals and microbial analysis via validated test methods Abedon explained. With watchful eyes dead set on the cognitive health category it is more important now than ever to make sure your health product is in compliance with the rules and regulations of the nutrition industry. Thus compliance influences research and development at the very basic level. Ingredients have to be approved for use in the health industry before you should even consider them for your formulation Hagerman said. According to Hagerman 2015 will go down in history for the health industry. It was a hallmark year he said with numerous high-profile case studies that made it into mainstream media s negative limelight. One such case was U.S. Senator Clair McCaskill s (D-MO) threepronged examination of dietary supplements that specifically market to seniors using claims about improving memory and treating dementia and Alzheimer s disease. Her investigation was into the products themselves the regulatory standing and retailer vetting policies Hagerman explained. Branded ingredients that are backed up by published clinical research not just animal data or experimental research alone is key Lifton said. By using human research-supported ingredients in this way consumers will be able to achieve optimal results and your product will be a big part of the reason why. NIE Resource 1 Gopalan Y Shuaib IL Magosso E Ansari MA Abu Bakar MR Wong JW Karim Khan NA Liong WC Sundram J Ng BH Karuthan C Yuen KH. Clinical Investigation of the Protective Effects of Palm Vitamin E Tocotrienols on Brain White Matter. Stroke 45 no. 5 (2014) 1422-8. Extra Extra Visit www.niemagazine.com to read more about the aging brain. FORMOREINFORMATION AIDP (866) 262-6699 Chemi Nutra (866) 907-0400 ExcelVite Inc. 60 (05) 2014192 Maypro (914) 251-0701 NutraGenesis (802) 257-5345 www.niemagazine.com April 2016 Go to www.niemagazine.com nutragenesis for info about this advertiser The participants are Rikka Cornelia Product Manager BI Nutraceuticals Rancho Dominguez CA (310) 669-2162 Deanne Dolnick Science Director TR Nutritionals Alpharetta GA (404) 935-5761 Dr. Cheryl Luther General Manager Dietary Supplements and Beverage Quality NSF International Ann Arbor MI (734) 769-8010 Shaheen Majeed Marketing Director Sabinsa Corp. Payson UT (801) 465-8400 Michael OHara General Manager UL Global Nutraceuticals Northbrook IL (847) 664-2642 Jon Peters President BENEO Inc. Morris Plains NJ (973) 867-2141 Matt Stegenga President Biova Olathe KS (877) OVACORE Elan M. Sudberg CEO Alkemist Labs Costa Mesa CA (714) 754-4372 Sherry Wang Founder and President ingredientsonline.com La Mirada CA (562) 207-9770 32 Nutrition Industry Executive Industry leaders discuss the recent advances as well as the challenges to meet the demand for pure safe and efficacious natural ingredients. By Janet Poveromo N IE The biggest challenges facing the natural products industry last year were actions by New York and state attorneys generals regarding ingredient purity. How have suppliers and manufacturers responded Cornelia For most of our existing clients transparency has always been highly valued and not much has changed. For some its priority has increased and we have experienced a rise in document requests. However the most notable change since the actions by the New York attorney general (NYAG) is the requirement of DNA testing from some of our customers. Identity authentication and testing has always been on the forefront of BI s quality efforts. In 1996 we introduced our Identilok program in order to guarantee the highest levels of purity authenticity and cleanliness. It encompasses identity authentication and testing on the Genus Species level from all angles macroscopic taxonomy microscopic taxonomy organoleptic tests TLC fingerprint FTIR fingerprint HPLC chromatogram HPTLC chromatogram. As of right now BI s Identilok program is 95 percent correlated to DNA testing and in April we plan to further strengthen our identity authentication and testing efforts as well as meet customer demand by installing DNA testing technology in our new Reno NV facility. Dolnick TR Nutritionals has made a number of changes to accommodate our customers responses to NYAG actions. Several customers are now requiring samples of raw biomass to be included with shipments of ingredients or for the biomass to undergo additional ID testing at U.S. labs with reports supplied prior to order delivery. It requires some extra legwork on the part of TR and our manufacturers but we are happy to facilitate and promote our quality ingredients. TR Nutritionals has been working with most of our key manufacturers for over a decade and without reservation stand behind our ingredients. Luther As a result of the NYAG s actions this past year dietary supplement companies are striving to restore and maintain brand integrity by demonstrating their commitment to producing safer products for their customers. Because of this action retailers and consumers want to know that they can trust the safety and quality of their supplements. One important role that NSF International plays in this industry is helping to educate consumers about how they can find supplements that have been analytically tested to confirm the contents in the supplement match the label claims. Suppliers www.niemagazine.com April 2016 and manufacturers who understand the importance of brand integrity invest in quality control and risk management many choosing third-party certification of their ingredients and products. NSF International has seen an increase in certification of dietary supplements which may come from consumer demands that manufacturers and suppliers have a responsibility to demonstrate the contents of their products are true to their label claims and not harmful to consumers. We have also seen an increase in supply chain management integrity. The GMP (good manufacturing practice) audit is a critical step in providing and proving quality within the manufacturing process. Majeed As an ingredient supplier we have not seen anything in particular that all or most of our customers (from contract manufacturing to marketing companies) are asking but that may be because with our ingredients there is never a question as to identity or fear of adulteration. If anything they now repeatedly ask if they can come audit us but other than asking this question very few are spending the money to do this. The focal point today seems to be on ingredient purity but let s not forget where this started--from tainted products to products that did not contain the adeApril 2016 www.niemagazine.com quate amounts that were stated on their labels. Very little had to do with the legitimate ingredient suppliers. However now this seems to the target of the industry because it is a deficiency in industry GMP compliance. Part of the problem is commoditization of ingredients that is ingredients aggregated by brokers making the source murky and adulteration more likely. With increasing knowledge and awareness of the benefits of natural products there is exponential increase in their demand. To meet this demand there are a few foul players in the industry who indulge in adulteration of authentic natural extracts. With continuous innovation by the genuine suppliers in the industry several techniques have evolved to identify adulterants. Right from the first step of raw material sourcing adulteration is a concern. Parts of plants are normally supplied in dried form and hence until authenticated tend to pose a challenge. Since the chemical profile and in turn activity of the plant extract is dependent on the authentic raw material identity screening is critical. Simple and quick techniques such as anatomical sectioning of plant parts microscopic techniques to study the sections and powdered material are popular and accepted methods of identification of raw materials and perhaps in the near future high-end DNA finger printing could be something suppliers can look into. Chemical fingerprints of raw materials are also a preferred method of authentication. A common form of adulteration of natural extracts is by addition of synthetic versions of the same. Radiolabelling techniques are able to analyze and curb this practice. A very common example in the industry is the adulteration of natural curcuminoids with synthetic curcumin which has on several occasions been identified using this technology. Another form of adulteration is fortification of natural extracts with other plant extracts. However using chemical fingerprints using HPLC and LC-MS chromatographic techniques this form of adulteration can also be effectively identified. We need companies to test audit and learn about how to do them smartly and effectively. While a positive trend has been observed in the innovation of such techniques it is primarily the ethical responsibility of manufacturers to curb such practices that would be the most ideal way to bring to a halt the practice of adulteration. O Hara UL has seen a big push for greater visibility and transparency in the industry. Our customers want greater and Nutrition Industry Executive 33 greater assurance that the products they are receiving and or producing have the purity and potency as advertised. Also testing methodology and validation of protocols is a question we receive from our customers as well. They want to make sure the analytical chemistry methods UL uses in our FDA (U.S Food and Drug Administration) registered lab will produce the correct results. The industry has worked very hard to ensure finished product manufacturing facilities meet the cGMP requirements set by the FDA but we have seen more and more focus on the ingredient or raw material supplier. Manufacturers want more information and assurance about the ingredients they are receiving. Peters Organic natural non-GMO (genetically modified organism) and clean label are very important trends in food innovation. We do see a strong consumer demand for products that in their perspective contain easy-to-recognize natural ingredients no unwanted chemical additives label transparency and ingredients that provide natural or intrinsic health benefits. Still BENEO feels that consumers are making purchase decisions based on their own personal definitions when it comes to clean label natural etc. Consumer research commissioned by BENEO in the U.S. and announced in January 2015 showed that 65 percent of respondents consider that natural products are better and 47 percent are actively seeking natural products including foods and beverages that contain the healthy benefit of fiber. BENEO is seeing a number of trends with clean-label foods and beverages. However there is a challenge to make sure that products with fewer additives are still pleasing to consumers when it comes to taste. They also need to appeal to consumers visually and in terms of texture. By carefully selecting natural ingredient combinations and working with an experienced partner manufacturers can master the art of balancing technological issues with a cleaner label taste and texture. For example there is a trend in meat production of replacing modified cornstarch in the U.S. with clean label non34 Nutrition Industry Executive GMO rice starch for poultry. Stegenga Truthfully the vast majority of our customers and prospects that inquire about our ingredients don t appear to have changed much they ve always been concerned with ingredient quality and safety. It s just sound business. That said if we ve noticed anything is a greater industry awareness that ingredient sourcing matters ... while there is a heightened awareness as to formulator accountability there is also clear demand for high integrity ingredient sourcing. And we welcome this level of scrutiny. Sudberg In my experience suppliers and manufacturers are paying closer attention to ingredient purity now than ever before. Quality has never been a choice but rather an obligation that is enforced more and more each day. So now where suppliers might have trusted a C of A (certificate of analysis) yesterday today they verify and where manufacturers might have trusted and then sometimes verified they are now verifying first and then trusting. NIE There are other issues that now impact the industry--FSMA (FDA Food Safety & Modernization Act) defining natural GMO labeling etc. Are they affecting your company Cornelia I wouldn t call them issues. All of the above will have a positive impact on the industry as well as BI. Our products and procedures already address them--our ingredients are plant-based non-GMO and minimally processed and our global supplier qualification program is one of the industry s most stringent quality programs that verifies and validates all stages of the supply chain from the farm to our shipping docks. In the past year we have experienced an increase in new clients looking for a more transparent quality focused supplier base. Transparency has always played a role in the development of our company s in-house procedures and we are experiencing the benefits of it now more than ever. As manufacturers start implementing much stricter requirements we will see supplier bases become smaller as those without the infrastructure to support the new requirements are weeded out. The above are elements professional suppliers have in place to protect their customers not issues. Dolnick Documenting non-GMO compliance continues to be a growing concern. Just a short time ago a simple statement that material was non-GMO was sufficient. Today many of our customers are requiring analysis to document and or more detailed surveys about individual products solvents etc. FSMA compliance dates are coming up later this year for large companies and we are getting increased inquiries from customers regarding steps TR is taking to comply. Our compliance date will be August 2017 but we are already working to ensure complete compliance ahead of schedule. Luther Many of these issues have made a positive impact on the industry. To assist the industry with these issues NSF International has developed several new services this year including FSMA Training--NSF International will begin offering training courses in May for the dietary supplement industry around the new FSMA rules. NSF International is also working to incorporate FSMA rules into the NSF GMP audits. GMO Labeling--NSF International is updating Non-GMO True North to include an additional criteria for dietary supplements in mid-2016. NSF is currently working with the industry for feedback on this new annex that defines the requirements for testing and auditing in this area. DNA Testing--NSF International offers both chemical and DNA testing for both dietary ingredients as well as finished products. Majeed Right from the introduction of natural products in the market there have been challenges that the industry has had to face. At Sabinsa there is always a conscious effort to abide by regulatory guidelines that are both valid and relevant including evaluating and www.niemagazine.com April 2016 Go to www.niemagazine.com biova for info about this advertiser material comes from egg production facilities that meet or exceed all USDA (U.S. Department of Agriculture) FDA regulations. We have further proprietary internal operational standards that must be met these are continuously monitored and 100 percent compliance ensured. analyzing our products to adhere to the guidelines laid by the various regulatory bodies. Most of the raw materials used by Sabinsa are cultivated either on our own lands or through contract farming to prevent and control any contamination. A hot issue for us is non-GMO ingredients because of the pressure our customers face from consumers on their finished products. Also while there is no official definition of natural we ve come out strongly against substituting synthetic versions of botanical products without labeling them as such. Since we control the harvesting of our major crops we know exactly what the materials are and how they are handled from the seed to extraction and beyond. O Hara As a certification audit and testing company our customers come to UL to better understand how these changes affect them and their products. FSMA s impact on supplement ingredient suppliers is very significant. Based on all the questions from our customers UL has developed a program that helps customers understand the changes that FSMA will introduce. Regarding GMO evaluation and labeling UL has recently been approved as a testing vendor for the Non-GMO Project and chose to do this as GMO and GMO labeling is and will continue to be an important topic for the industry. UL is able to conduct qualitative screening and quantitative testing using real-time PCR which is a highly sensitive and reliable method for the detection and quantification of nucleic acids in our ISO 17025 Certified lab. Sudberg Identity and potency are the major concerns our customers have. As of now I don t see any major affects of FSMA or GMO labeling in my lab but won t be surprised if we see more business as a result. Stegenga We don t see these as issues so much as standard operating procedure principles we ve embraced from day one. Biova has always considered issues of safety and quality as paramount--everything we do is tied to creating efficacious safe ingredients of exceptional unmatched quality. By definition our natural egg membrane based ingredients come from very regulated highly scrutinized producers--all of our raw 36 Nutrition Industry Executive A hot issue for us is non-GMO ingredients because of the pressure our customers face from consumers on their finished products. -- Shaheen Majeed Marketing Director Sabinsa Corp. NIE How does your company define transparency What are the best methods to achieve it Cornelia Transparency is receiving the exact product requested with a complete chain of custody. Transparency starts before the raw materials enter our facility with our strict vendor quality management system. The program provides clear guidelines on specifications test methods and product quality to suppliers regular audits of the manufacturing and lab facilities to assure compliance with GMP and GLP (good laboratory practice) random audits of traceability to assure usage of correct raw materials random sampling and testing to ensure compliance with specifications and oversight of the suppliers entire QA QC program. Once raw materials enter our facility the product is tested before during and after production. Dolnick Transparency has become one of those industry buzz words but when every company uses it it loses its meaning. At TR Nutritionals transparency is simply the way we have always worked to ensure that our customers are buying the highest quality raw materials available. We work with manufacturers with whom we have long-established relationships. We supply samples for all of our products. For our botanical extracts we offer raw biomass as needed. We supply requested documents. We do all of this with full disclosure never trying to obfuscate the manufacturers from whom we purchase our ingredients. Luther NSF International s dietary supplement certification program offers assurance of transparency to consumers in a three step process 1. Manufacturers seeking certification of dietary supplements first must demonstrate compliance with good manufacturing practices (GMP) of the manufacturing facility as specified by the FDA in 21 CFR Part 111. Compliance to GMP begins with twice annual audits and only after any findings that do not comply are addressed will the facility become NSF GMP registered. 2. The next step in the process is NSF Dietary Supplement Certification. Fourteen years ago NSF developed the only American National Standard for dietary supplements (NSF ANSI 173). This certification produces transparency of label claims and content verification including contaminant testing which verifies there are no harmful levels of specific contaminants in the product. As part of the demand for transparency and safer products by consumers the number of NSF certified products has doubled in the past year to over 800 certified dietary supplements. 3. Transparency of a dietary supplement product can go an additional step via the NSF Certified for Sport Certification. Certification to this program means that the product has been screened for more than 200 athletic banned substances from the World AntiDoping Agency (WADA) NSF Annex B NFL and MLB prohibited substance lists. NSF Certified for Sport dietary supplements are the only recognized supplements allowed for use by the NFL NHL MLB PGA LPGA Canadian Center for Ethics in Sport (CCES) and the New York City Police Department. Majeed Sabinsa believes in complete transparency in terms of educating the consumer about details of products and we provide quite a bit of information to our customers to help them do that. Details provided in the specification of individual products encompass physical and chemical parameters along with 2632 other parameters. For each product the customer is also provided with a set of documents that include manufacturing process details free from statements a certificate of composition technical data sheet and most importantly a safety www.niemagazine.com April 2016 data sheet. The company is also audited and certified by several bodies such as NSF and inspected by US-FDA. Individual company audits are also not unusual although we d like to see more customers audit us in person. Product related websites brochures white papers and both scientific and popular articles from the Sami--Sabinsa Group gives information regarding the source chemistry and preclinical and clinical studies conducted for individual products in order to educate the formulator and consumer. O Hara We believe information management and availability of information drive transparency. This is the main reason UL developed ClearView and are now working with industry stakeholders like Natural Products Association (NPA) GNC Council for Responsible Nutrition (CRN) and others to evolve ClearView into the product registry. It may be easy to say you want more transparency but there has to be commitment and focus to develop the tools necessary to truly deliver transparency. We believe a common industry platform can offer manufacturers a new mechanism to differentiate themselves from other branded firms that may not be building in the same level of quality into their products. The goal is to have a platform where manufacturers can increase their visibility in the industry to ultimately ensure only the highest quality products are available to consumers. UL firmly believes in transparency and that is a main driver into why we have the UL and NPA GMP Certification program accredited by ANAB. Peters BENEO is keenly aware of its nutritional responsibility to constantly ensure top quality. This occurs through a laser focus on selected natural sources state-of-the-art production facilities and comprehensive services to meet very high standards along the entire supply chain. Additionally we provide valuable up-to-date insights on nutrition legislation markets and application technology. Our supply chain is consistently evaluated to ensure delivery of the highest quality ingredients. As a 100 percent subsidiary of the German company S dzucker an organization deeply rooted for more than 100 years in the highest agricultural quality it is in the genes of BENEO and part of its policy to be constantly committed to natural raw material sources of highest quality. Sudberg We have defined transparency since the day we sold our first test in the terms of full method disclosure at no extra cost. Our C of A s have always April 2016 www.niemagazine.com shown the entire method which is not standard in the industry but we feel is what makes an Alkemist Labs C of A the gold standard. You can essentially come to Alkemist Labs for as long as it takes to test each botanical you sell set up an HPTLC lab hire some chemists and reproduce the work we do. The fact is only a few of our customers have done that in the 20 years we have been testing in this industry. It s actually a lot harder than one might think to replicate what we do however it is possible and with our full disclosure C of A s you will never wonder how did they come to that conclusion To take the transparency definition further it means that our customers have everything they need to demonstrate to FDA auditors that they know what is in their products. Transparency should mean honest and open easy to see through and easy to understand. Suppliers must be able to provide transparency on price factory of origin inventory and QA QC documentation-- just to name a few. -- Sherry Wang Founder and President ingredientsonline.com Stegenga Complete and open exchange of information. We re seeing more requests tied to ingredient specificity from our customers and we welcome it. Biova is uniquely qualified among egg membrane ingredient suppliers to be transparent--our vertical integration with some of the world s largest egg producers gives us unmatched control over our raw source material. While we have patents and other proprietary intellectual property that are not open to the public all data concerning ingredient quality and safety is shared with our mfg. formulator CPG customers and they re free to share with their customers. Wang Transparency should mean honest and open easy to see through and easy to understand. Suppliers must be able to provide transparency on price factory of origin inventory and QA QC documentation--just to name a few. Ingredientsonline.com is an online platform providing raw materials for the dietary supplement food beverage cosmetic and pharmaceutical industries. The cutting-edge technology equips buyers with knowledge and information that is just a click away. Knowing the factory of origin is critical in today s environment. Ingredientsonline.com provides factory information on all ingredients. Having QA QC documentation at your fingertips for any ingredient you are sourcing is critical. Online technology provides a fast and efficient method to download documentations and it s very transparent. Seeing the price for each and every ingredient and seeing tiered pricing for volume discounts can save a huge amount of time for purchasing agents. Inventory levels are also clearly displayed on ingredientsonline.com for both our California and New Jersey warehouse locations empowers purchasing agents with the information needed to keep their production schedules on track. NIE Other comments Majeed We re pleased to see so much industry focus on ingredient quality in the past year because we have been talking about this literally for years. Buying by price alone has contributed to the industry s vulnerabilities with identity potency and scientific verification of safety and efficacy an afterthought. Consumers expect and deserve to get the benefits of safe and effective products and we are optimistic that the industry will improve on delivering that. Stegenga Ensuring ingredient purity isn t an activity that s done once and considered achieved. Providing pure safe efficacious ingredients (and making sure one formulates with these types of ingredients) is more a mindset an ongoing commitment to SOPs that address changes in the market space and stay one step ahead one level above expectation requirement or regulation. Safe. Pure. Natural. This is how Biova approaches the production of our ingredients every day all the time. Our families consume our ingredients. We are committed to quality. NIE Extra Extra Visit www.niemagazine.com to read the continuation of this article which includes information on preparing to meet consumer trends. Nutrition Industry Executive 37 FEMALE FOCUS INGREDIENTS AND PRODUCTS FOR WOMEN The women s health category isn t just about calcium and iron a broader focus on ingredient application emerges. By James J. Gormley H eart disease is the leading cause of death for women in the United States killing 292 188 women in 2009--that s one in every four female deaths. Although heart disease was previously thought of as a man s disease about the same number of women and men die each year of heart disease in the U.S. Despite increases in awareness over the past decade only 54 percent of women recognize that heart disease is their No. 1 killer. Heart disease is the leading cause of death for African American and white women in the U.S. Among Hispanic women heart disease and cancer cause roughly the same number of deaths each year. For American Indian or Alaska Native and Asian or Pacific Islander women heart disease is second only to cancer. After heart disease and cancer chronic lower respiratory disease is the third-leading cause of death for women overall. Regarding heart disease about 5.8 percent of all white women 7.6 percent of black women and 5.6 percent of Mexican American women have coronary heart disease. In fact nearly two-thirds 38 Nutrition Industry Executive (64 percent) of women who die suddenly of coronary heart disease had no previously reported symptoms. High blood pressure high LDL cholesterol and smoking are key risk factors for heart disease. Several other medical conditions and lifestyle choices can also put people at a higher risk for heart disease including diabetes obesity poor diet physical inactivity and excessive alcohol use. Bone health is another area of great concern for women. According to the World Health Organization (WHO) poor bone metabolism currently impacts about 200 million people globally. Approximately 54 million Americans-- of whom 68 percent are women--have low bone mass putting them at risk for osteoporosis. Studies suggest that about one in two women and up to one in four men age 50 and older will break a bone due to osteoporosis according to the National Osteoporosis Foundation. While one in three men are expected to experience a bone fracture at some point the lifetime risk of bone fracture for women is nearly one in two. Women are more vulnerable due to two factors noted Eric Anderson senior vice president of global sales and marketing for New Jersey-based supplier NattoPharma. First women in general have less bone mass than men and secondly the annual loss of bone mass in women accelerates after menopause. Public health stats are one thing but what health issues women care about the most is arguably more important. According to research firm Mintel in an August 2015 report titled Marketing Health to Women U.S. 2015 the top 13 health concerns of women over age 18 are 1. Stress 2. Arthritis 3. Anxiety 4. Obesity 5. Diabetes 6. Heart disease 7. Depression 8. Breast cancer 9. Chronic pain 10. Alzheimer s disease dementia 11. Osteoporosis 12. Skin cancer 13. Menopause In the same report barriers to women achieving what they consider ideal health include a number of factors such as www.niemagazine.com April 2016 cost lack of results and confusing health information. It would seem that natural product suppliers and marketers are uniquely positioned to tackle those obstacles head on. Boning Up on Mineral Health It is becoming increasingly clear that optimal consumption of macro-minerals (such as calcium magnesium and potassium) and micro-minerals (such as iron and zinc) is critical to heart health and bone health. Magnesium alone is needed in more than 300 functions in the body including blood pressure energy production muscle health heart rhythm and sleep. Given the proper nutrients the body can repair bone damage at any age noted Todd Johnson director of marketing for Albion Minerals a supplier based in Utah. It is never too late but the earlier women recognize the essential need for adequate nutrient consumption particularly calcium and magnesium the more osteoporosis can be prevented. Albion s Johnson pointed out that Magnesium deficiency is a frequently occurring disorder that leads to loss of bone mass abnormal bone growth and skeletal weakness. A 2013 study by M.M. Bellucci et al. aimed to learn more about whether low levels of magnesium affects the formation or activity of osteoclasts which are large bone cells instrumental in controlling the amount of bone tissue. Bone marrow cells were studied in medium containing different concentrations of magnesium Johnson explained. Magnesium deficiency resulted in increased numbers of osteoclast-like cells and increased development of osteoclasts due to magnesium deficiency was reflected in higher expression of osteoclast-related genes. The data suggest said Johnson that altered osteoclast numbers and activity may contribute to the unhealthy skeletal characteristics seen in people who are magnesium-deficient. The Albion TRAACS brand of magnesium chelates have demonstrated high bioavailability noted Johnson and are offered for dietary supplement food fortification and pharma applications. Albion also offers Calcium Bisglycinate Chelate and DimaCal for supplement formulations and Calcium Citrate Malate (CCM) and Calci-K food and beverage applications. As a complement to calcium vitamin K2 has come to the fore in recent years for its ability to activate K-dependent April 2016 www.niemagazine.com proteins which helps the body to properly use calcium. NattoPharma s Anderson pointed to a three-year study of MenaQ7 and 244 healthy postmenopausal women which was said to show statistically significant protection of the vertebrae and hip against bone loss with 180 mcg daily. As mentioned iron is also vital for women s health in general and bone health as one example. Sufficient although not excessive levels of dietary iron intake are now believed to be associated with proper bone mineralization. The Heart of the Matter A number of nutrients are vital for health health including L-carnitine vitamin K2 and magnesium. Aouatef Bellamine PhD scientific manager for ingredient supplier Lonza in New Jersey said that By breaking down fatty acids to smaller molecules used by the Krebs cycle L-carnitine promotes energy production in the form of ATP [adenosine triphosphate]. Carnipure L-Carnitine is the nutrient needed to help support conversion of fat into metabolic energy she added which is important for consumers weightmanagement and healthy heart goals. While it used to be believed that arterial calcification--hardening of the arteries--was an inevitable consequence of aging recent research has made it clear that there are many things we can do to fend off this process. For example noted NattoPharma s Anderson Healthy arterial tissues have been shown to contain 100 times more vitamin K2 than calcified arteries meaning that simply supplementing with K2 can actively protect the cardiovascular system. While observational data have suggested a connection between vitamin K2 intake and heart health intervention trials with cardiovascular endpoints had been lacking until recently added Anderson. Researchers at the R&D Group VitaK of Maastricht University in the Netherlands monitored 244 healthy post-menopausal women for three years using pulse-wave velocity and ultrasound techniques. The participants who ranged in age from 55 to 65 years were randomly assigned to receive a nutritional dose (180 mcg) of vitamin K2 as MK-7 (as MenaQ7) daily for three years or placebo capsules. After three years of supplementation an important measurement of arterial stiffness in the MK-7 group the Stiffness Index Beta had decreased significantly after compared to the slight increase in the placebo group. Results confirmed that vitamin K2 as MK-7 not only inhibited age-related stiffening of the artery walls but also yielded a statistically significant improvement in vascular elasticity Anderson explained. This study published in Thrombosis and Haemostasis in 2015 is a breakthrough because it is the first intervention trial whose results confirm the association made by previous population-based studies that low vitamin K2 intake is linked to cardiovascular risk said Anderson. According to the researchers the data demonstrated that a nutritional Nutrition Industry Executive 39 A recognition of this--along with known benefits in the areas of immunity cardiovascular health and cognition--has led to widespread proliferation of supplements featuring iron which does not always yield the intended benefits. In fact inorganic iron supplements such as ferrous sulfate still have low bioavailability and typically produce undesirable side effects such as gastric upset and nausea observed Albion s Johnson who pointed to clinical research comparing inorganic iron to Ferrochel [Ferrous Bisglycinate Chelate] a significant number of study participants [. . . ] reported fewer instances of gastrointestinal (GI) upset than with ferrous sulfate which is typically associated with side effects such as constipation and nausea. Johnson added that Ferrochel has been the subject of approximately 70 clinical studies that are said to support its superior efficacy and tolerability as compared to iron salt ingredients like ferrous sulfate. FEMALE FOCUS INGREDIENTS AND PRODUCTS FOR WOMEN dose of vitamin K2 in fact promotes cardiovascular health. As mentioned earlier magnesium is needed by the body in cardiovascular health including healthy blood pressure and healthy cholesterol levels. The mechanisms by which magnesium asserts its effect in these areas are quite varied noted Albion s Johnson. Magnesium has been seen to have a major positive influence on cardiac arrhythmias Johnson added. The mechanisms of action through which magnesium can promote healthy heart rhythm explained Johnson include maintaining the heart s muscle electrolyte balance complementing calcium s effects and supporting a healthy (lower) release of neurotransmitters and stimulating mediators (e.g. noradrenaline adrenaline). Albion offers Magnesium Bisglycinate Chelate Magnesium Lysinate Glycinate Magnesium Glycinate Glutamine Chelate Magnesium Aspartate Dimagnesium Malate and Creatine MagnaPower with Magnesium Lysinate Glycinate Chelate Magnesium Glycinate Glutamine Chelate and Creatine MagnaPower geared more to exercise and recovery. essentially indicates higher levels of stress. Dan Lifton president of the Proprietary Ingredients Group at the New York-based supplier Maypro pointed out that mood related to premenstrual syndrome (PMS) is an area that has been shown particularly amenable to nutritional support. Magnesium has been seen to have a major positive influence on cardiac arrhythmias. -- Todd Johnson director of marketing Albion Minerals Venetron a patented purified powdered extract of Apocynum venetum is standardized to contain at least 4 percent hyperoside and isoquercitrin and has been shown noted Lifton in several placebo-controlled human clinical trials to promote a positive outlook alleviate occasional stress and improve sleep quality all areas that important to female consumers. Case studies have shown results in patients with depressive PMS disorders and in younger and older depressed patients (unpublished data) Lifton said. In one 29-year-old woman 50 mg of Venetron a day for one month reduced melancholy and overeating associated with PMS in a 39-year-old with PMS 25 mg of Venetron taken for two weeks before menstruation over three months improved emotional symptoms such as irritability and depression and a 55-yearold woman given 50 mg a day showed a decrease in fatigue and grief. prised of three blended botanical root extracts that was scientifically developed for the purpose of providing relief from the symptoms of menopause. EstroG-100 is derived from the roots of three botanical extracts that are endemic to South Korea Phlomis umbrosa Cynanchum wilfordii and Angelica gigas Nakai (Korean angelica). According to Helios Corp research supports EstroG-100 s benefits in the areas of night sweats sleeplessness vaginal dryness joint discomfort mood swings nervousness and fatigue. According to Helios Corp s Jeffers the ingredient complex is supported by three double-blind placebo-controlled human clinical studies and nine supportive studies. Backed by an U.S. Food and Drug Administration (FDA) non-objection to its new dietary ingredient (NDI) submission and approval from Health Canada. Women have very few choices in terms of menopause relief options because the products are estrogenic are linked to liver toxicity or take six to eight weeks to work Jeffers observed. EstroG-100 is the first option since the Estrogen-Plus-Progestin Study which was stopped in 2002 found to be natural effective safe non-estrogenic and fast-acting--working in as few as seven to 10 days. Take-Away The key to creating a successful product --in women s health and in any category--comes down to ingredient selection NattoPharma s Anderson advised. Manufacturers need to partner with suppliers offering clinically validated ingredients with this validation often comes patents approved structure-function claims and proof of efficacy that manufacturers can use to create a clear message for the consumer. NIE Mood Anxiety and Stress In the Mintel survey cited before mood anxiety and depression are among the top 10 health concerns that women have. Women are 70 percent more likely then men to experience depression in their lifetime offered Albion s Todd Johnson. Magnesium is an essential mineral and deficiency has been linked to a range of mental health [concerns]. In fact pre-clinical and clinical studies have indicated a relationship between magnesium balance and fear anxiety and depression according to Johnson. In a 2012 study Johnson explained researchers further investigated the previous evidence that magnesium had an effect on mood emotions and reactions to stress. In this study the researchers observed that magnesium deficiency caused an increase in the transcription of the corticotrophin-releasing hormone in the periventricular hypothalamic nucleus and elevated ACTH plasma levels which 40 Nutrition Industry Executive Extra Extra Visit www.niemagazine.com to learn about a delivery system developed by American Science Products Inc. that may remind women of their childhood. Menopause Menopause is another area cited by the Mintel survey and along with it come other health issues including mood. According to Michael Jeffers president of New Mexico-based Helios Corp. which is the exclusive license-holder in North America for EstroG-100 from South Korea s Naturalendo Tech Co. Ltd. ExtroG-100 is a patented ingredient com- FORMOREINFORMATION Albion Minerals (801) 453-2406 American Science Products (805) 377-4792 Helios Corp (505) 982-8836 Lonza (201) 316-9200 Maypro (914) 251-0701 NattoPharma (609) 454-2992 www.niemagazine.com April 2016 Research&Development Formulating With Fats and Oils By Lisa Schofield t hasn t been easy being a fat--or oil. So vulnerable. So volatile. So temperamental and persnickety. But that was then and this is now. And now the health benefits of a wide range of fats and oils can be perfectly captured and delivered to wellnessminded happy consumers. Take soy for example. Richard Galloway oils expert at Missouri-based QUALISOY explained that in response to the ban on dietary trans-fats and the subsequent revocation of the GRAS (generally recognized as safe) status of PHO the U.S. soybean industry has responded by further developing the enzymatic inter-esterification process as a highly functional replacement for most formerly PHObased shortenings. The industry is finding that conventional fully hydrogenated (a process that does not contribute trans-fat) soybean oil inter-esterified with liquid soybean oil or high-oleic soybean oil provides a very broad spectrum of functional shortenings and frying fats he said. Inter-esterified products he emphasized can now be formulated to provide lower saturated fat levels than other non-PHO solutions. Similarly use of high-oleic soybean oil can result in lower saturated fat levels than some other PHO-replacement products. Oil freshness remains a key issue among both formulators and the conApril 2016 www.niemagazine.com I sumer for supplements or functional food and beverages observed Steve Dillingham global director AlaskOmega Ingredients Organic Technologies in Ohio. Oil especially fish oil and omega-3 concentrates can oxidize quickly when exposed to heat and oxygen and once oxidation commences it can t be stopped only slowed. That s why it is critical to have full control over the entire value chain. Dillingham detailed that a test called TOTOX (total oxidation) is a measure of both primary and secondary oil oxidation. This is commonly used by the omega-3 industry as a proxy for oil freshness and GOED (Global Organization for EPA and DHA Omega3s) established a TOTOX limit of 26 for all fish oils and omega-3 concentrates through its voluntary monograph which is the standard for the omega-3 industry. He noted that Organic Technologies recently reduced the TOTOX limit for all its AlaskOmega omega-3 concentrates to 5 more than a five-fold reduction from GOED s limit since actual AlaskOmega TOTOX values typically range between 0-3. The lower TOTOX limit more accurately reflects AlaskOmega s market-leading position for oil freshness he commented. Trace environmental contaminant limits were also significantly reduced to levels virtually undetectable. Organic Technologies is able to manufacture its omega-3 concentrates to such levels of freshness and purity standards through its proprietary process and supply chain Dillingham pointed out. Raw oil is extracted from the trimmings of MSC (Manne Stewardship Council)-certified wild Alaska Pollock sourced from the Bering Sea within a few hours after catch so the raw material is exceedingly fresh from the organism. The oil is then transported to the company s NSF-certified GMP (good manufacturing procedure) manufacturing facility and processed through a proprietary purification and concentration procedure to extract and purify EPA and DHA concentrates to very high purity levels (80 percent EPA DHA). Products are kept under inert gas and away from oxygen throughout the entire process to ensure that AlaskOmega oils retain the utmost freshness. Meanwhile said Galloway much of the former PHO frying oil has been replaced using highly polyunsaturated conventional oils such as canola oil or soybean oil. This results in some degree of rancidity in the food product (such as French fries) after cooking and prior to eating especially when the food is left to sit before serving. Additionally the oil itself will degrade and must be (Continued on page 51) Nutrition Industry Executive 41 MarketingInnovations By Todd Pauli The Shelton Group uilding a website is nothing like building a house. Sure that s pretty obvious but it s especially important to note when you look at it through a design lens. If you build a great house it stands the test of time. Stately colonials tried and true Midwest four squares and even the mid-century steel and glass structures I personally love endure both aesthetically and functionally through the decades. None of this is true when it comes to websites. Websites operate more like that trendy design accent you re proud of one year and then throw to the curb the next as the trend passes on. In that sense sites are close cousins to mauve carpeting and gold bathroom fixtures. Websites once you take a look at the building blocks that comprise them are really nothing more than code. Lines of code based on technology that is always changing and those changes drive the way websites B operate and present themselves. Today s sites are full of big images that stretch across the page and sometimes even videos that play in the background while you navigate the site. This style of site wouldn t have been in the recent past as bandwidth and the code that built these sites just wasn t capable of making them look like they do today. As technology changes and websites improve it becomes necessary to update your site every few years to keep up. Why is it important to keep up It has more to do with meeting your customers expectations and retaining business than it does with simply keeping up with the Joneses. Your customers are web savvy and they expect a certain level of online experience on par with other businesses they interact with online. The old notion that B2B websites don t have to be as robust or that our industry isn t as technical and therefore can afford to be a bit behind in terms of technology is a mistake. No matter how your customers interact with your site they also interact with Google Amazon Apple or any number of best-inclass sites they visit. Having been involved in focus groups to test site concepts through the years I can tell you that these users equate site experience with brand quality. A poor website diminishes the opinion of the brand. This association is evident in both a site s functionality and its design. If customers find it hard to interact with your site on their mobile devices they ll move on. If your site looks incredibly outdated customers will begin drawing conclusions about your products. Everything from site aesthetics navigation and content works together to help customers form opinions about your products just as all marketing tools should. The trick is making sure visitors form the right impression when they visit your site. www.niemagazine.com April 2016 42 Nutrition Industry Executive Now that we know the importance of keeping your website fresh let s look at addressing some site elements specifically. While there are many decisions to be made in terms of refreshing a website here are a few areas that can make the most impact Designing for Mobile-Devices If looking at your site on a mobile phone only shows you part of the picture or takes you to a stripped down mobile only version it s time to optimize. These days sites work across devices by adjusting layouts to fit users screen sizes which is known as responsive design. Responsive sites change the navigation and other layout elements to present the information in an easy-to-navigate manner no matter what device is used. Certain layout elements are best suited for certain screen sizes and responsive sites take full advantage to fit site elements to the user s device. The site s main navigation is a great example of how elements change based on screen dimensions. Large horizontal menus to represent a site s main navigation are standard on laptop and desktop sites these days but they re virtually unreadable if that same menu structure is shrunk to fit on a phone screen. At a certain screen size a responsive website will remove the horizontal menu and replace it with something more readable from a phone screen like the familiar hamburger menu icon consisting of three stacked lines. Users know when this menu is touched on a phone it will expand into links that fill the screen and allow for easy navigation around the site. the way to more visual photo-driven designs. Better ways to code layouts faster connections and optimized image formats have opened up the web and allowed the use of photo and video to more accurately convey a brand s characteristics online. Layouts have also opened up to accommodate wider screens. Graphic Design Elements Not that long ago a photo-rich site would likely choke a visitor s DSL connection leading them to click elsewhere as opposed to waiting for a site to load. The workaround back then was to shy away from photoheavy layouts and use more graphic elements like background colors to provide a site with a little brand personality. Remember the sites that looked like a nicely designed 8.5x11 sheet of white paper with wallpaper that filled out the rest of the screen on either side Changing technology rendering those types of layouts obsolete very quickly and led April 2016 www.niemagazine.com These days we don t think twice about using large hero images across the homepage of a site. Great photos or video to represent your brand is a perfect example of letting the content be the star of the site. Using brand colors across navigation elements buttons and icons contributes to the design of the site but well chosen photos and other visual elements should do the most work in terms of conveying your brand accurately to customers. They create the emotional connection. Since photos have become such an important element in modern site designs let s talk briefly about the photos you choose. Ideally we would all have beautifully staged and professionally shot photos to represent the brand but this option is often too expensive. Working within a more realistic budget as we always do we recommend clients pay for good product shots and a few other key shots to represent the site. These are often wide shots that become a site s hero image. For botanical shots we often get photos from Steven Foster whose decades of industry involvement means he has an enormous library of beautiful images at reasonable fees. Instead of plain bottles and text try getting a more stylized shot worthy of the home page which also contributes directly to your brand s story. For example if you sell an herbal supplement try a shot depicting your product along with examples of the fresh herb arranged on a natural background like slate or weathered wood. The idea is to convey an emotion about the brand and help tell the brand story like fresh and natural in the herbal supplement s case. One more thing about site photos the stock image. Stock photography is often a necessary part of web design because it s much cheaper than sourcing original photography. However it s important to choose photos that depict your brand accurately and uniquely. This is especially true in our industry where brands often have the same overall mission of improving customers health. Try to avoid using the photo of the first happy-looking white-haired couple you run across. Do you know that couple I m sure you d recognize them as they bike together hike together and relentlessly smile at each other while selling everything from joint supplements to fiberinfused snacks. Do the extra work to find stock photos that tell your story uniquely. Site Content Visitors tend to absorb the content of your site in stages. Whether they click through to your site from an ad or they type the URL directly it s important to instantly provide a sense of your brand and a compelling reason to investigate more. This may seem obvious but many sites attempt to put the whole brand story on the homepage creating a cluttered hardto-absorb user experience or put too much emphasis on one single product aspect that is important to the brand owner but doesn t give new visitors an adequate overview or create an emotional connection. Starting with a clean simple and compelling message on the homepage visitors will get an immediate sense of the brand and what it offers. From there they can scroll down and see other aspects of the brand that help them build trust. Don t forget that many times your brand s most popular online presence is not the website but its social media channels. Featuring this type of content Nutrition Industry Executive 43 MarketingInnovations by pulling in popular posts and pieces of content that earned a large audience reaction helps build brand trust by showing how other people are already engaged with the products and sharing the information with others. Brand content should help endear potential customers to the mission and products creating a customer connection that runs deeper than specific product benefits and specs. In fact a brand s website is the home base for all of your content marketing efforts advertising and social media tactics. All of those marketing efforts should be driven by a marketing strategy that gets customers engaged connected and ultimately purchasing. We spend significant amounts of time with clients helping to define their marketing strategies and the customer experiences that will move them from early brand investigation to enthusiastic ambassadors and the types of content and its placement on the website is paramount to making your marketing strategy succeed. Finally site content is also an important consideration when it comes to SEO (search engine optimization). SEO has to do with ensuring your site appears in search rankings when customers search for keywords related to your brand. There are SEO experts people who spend long days in darkly lit basement cubicles studying bounce rates and conversion rates who bring scientific precision to site SEO. I am not one of them. But I can tell you that today more than ever good website content drives good search results. This is really terrific news for those of us just trying to make an honest to goodness site that provides great brand content to our target audiences. The right site content will engage your customers increase visits and dramatically affect search engine rankings. With customers equating a good web experience with brand quality it s more important than ever to keep your website optimized to provide the best customer experience possible. Building a site that genuinely engages visitors requires careful planning and execution to ensure the place where customers often encounter a brand for the first time has the capability to establish trust and inspire long-term brand loyalty. NIE The Shelton Group is a boutique public relations and marketing agency working exclusively in the dietary supplements and natural products industry since 1990. Todd Pauli works with clients to develop comprehensive marketing strategies that integrate social media advertising and content marketing. Prior to joining The Shelton Group Pauli led marketing communications efforts for several well-known businesses including NOW Foods one of the largest supplement manufacturers in the natural channel. Go to www.niemagazine.com mackflavor for info about this advertiser 44 Nutrition Industry Executive www.niemagazine.com April 2016 FunctionalFoods Simple Additions Clean and natural are now the rule for added food colorings and flavorings. By Janet Poveromo I n response to the growing health awareness and food safety concerns consumers are now inclined to seek authenticity in their choices and therefore are seeking products with simple natural non-GMO (genetically modified organism) or recognizable ingredients. This has led to the clean label culture which is gaining momentum and getting more prominent in Europe North America and Asia over the past decade. This clear change in consumer behavior has prompted food manufacturers to switch to natural ingredients to meet market demand. It is inevitable said Bryan See regional product manager with New Jersey-based ExcelVite Inc. Large multi-national food and beverage manufacturers such as Nestle General Mills and Kraft to name a few have started reformulating their products with natural colors and flavors. Additionally major fast food chains such as Pizza Hut and Subway are jumping on the bandwagon by removing synthetic colors or flavors in food preparation in order to meet consumer s growing demand for clean label and to know what s inside the food they consume. April 2016 www.niemagazine.com Ingredients to Watch In 2007 a study published in The Lancet by researchers at the University of Southampton linked increased levels of hyperactivity in young children consuming mixtures of some artificial food colors. The European Food Safety Authority (EFSA) subsequently recommended further safety tests on the six synthetic food dyes-- the so-called Southampton Six. This has led to a E.U.-wide mandatory warning labeling for any food and drink (except drinks with more than 1.2 percent alcohol) that contains any of these six artificial colors. Foods containing tartrazine (E102) quinoline yellow (E104) sunset yellow (E110) carmoisine (E122) ponceau 4R (E124) and allura red (E129) will have to be labeled may have an adverse effect on activity and attention in children. With this new enforcement manufacturers have begun working toward finding natural alternatives to these colors See noted. Most manufacturers and retailers have taken action to remove them and replace them with natural coloring agents. In terms of replacing artificial colors in the range of yellow-orange--particularly Tartrazine (E102) and Sunset Yellow (E110) said See ExcelVite s EVTene natural palm mixed carotenoids extracted and concentrated from sustainable and non-GMO Malaysian palm oil is a natural switch and gaining popularity. Malaysian virgin crude palm oil contains high levels of carotenes in terms of retinol equivalents. It has up to 300 times as many retinol equivalents as carrots leafy green vegetables and tomatoes he added. EVTene contains natural beta-carotene alpha-carotene gamma-carotene lycopene and other minor carotenoids. This unique mixture of carotenoids is commonly found in fruits and vegetables presenting not one single carotene but a wholesome array of carotenoids. Therefore EVTene is a true mixed carotene complex with the highest level of alpha-carotene in the market. What makes EVTene unique is that its carotenoids composition mirrors that of carrots. Certifications At ExcelVite the common request certification from clients are GRAS (generally Nutrition Industry Executive 45 FunctionalFoods recognized as safe) and E-Number See explained. Palm Carotenoids Complex is self-affirmed GRAS with no objection letter from the U.S. Food and Drug Administration (FDA) (GRAS No. 320) and it can be used as a natural ingredient in functional food and beverage products. Furthermore it is a natural extract (carotene) derived from palm fruits that comply with E.U. Commission Regulation No.231 2012 E160a. Being the only GMP (good manufacturing practice)-certified manufacturer of palm phytonutrients tocotrienol complex and carotenoid complex ExcelVite has taken the initiative to submit our EVTene ingredient series for Non-GMO Project Verification and currently our EVTene 10% (H) EVTene 15% and EVTene 20% are Non-GMO Project Verified See said adding that these ingredients are also kosher- and halal-certified. These attributes and certification position EVTene natural mixed carotenoid complex as the natural choice of functional ingredient (pro-vitamin A and antioxidant properties) as well as colorant in various food and drink systems he added. We are definitely seeing a departure of the market from using artificial colors and moving toward coloring foods with food driven by strong consumer demands See noted. EVTene fits right into this trend as it is extracted from a food (i.e. palm oil) and used to color another food drink. States she noted. All other color additives are not permitted. So if you would like to use a certain color the first thing to do is to see if it is listed in the CFR. If it is not listed you cannot use it until it obtains approval via the color additive petition process and is listed in the CFR. If it is listed and does not meet all requirements of the regulation it also cannot be used legally in food until it is approved as a color additive. Regulations for some color additives require specific methods of manufacture limits on impurities and restrictions in use. All color additives must also meet regulations governing adulteration and labeling. Dolan explained that FDA recognizes natural flavors if they meet the definition in 21 CFR 101.22 (a)(3). The hurdles to overcome with natural flavors are similar to colors. But for flavors limitations for method of manufacture specifications and use are not necessarily stated in a CFR regulation she noted. They may be present in a food additive petition GRAS dossier or JECFA evaluation. So users need to consult all potential sources of regulatory information on flavors before deciding to use a particular flavor Dolan added. Some substances present in natural flavors are on the proposition 65 list. Natural substances inherent in food not added by human activity and present at their lowest feasible levels are exempt. It is unclear where natural flavors lie no guidance has been issued. Whether or not they are exempt may be dependent on whether they are inherently part of a particular food or added to a food. Regarding labeling if a food contains a characterizing ingredient and flavor comes from it the word natural can be used before the flavor. The term natural can t be used if the flavor is added to a food that does not contain the flavor. In Vermont the term natural is prohibited if the food contains a genetically modified ingredient unless the ingredient makes up 0.9 percent of the food weight. oped different delivery forms of EVTene natural mixed carotenoids complex. These are oil concentrate water dispersible powder and water soluble emulsion--to cater for applications in a wide range of functional food and beverage formulations. As an example ExcelVite s EVTeneSem cold water soluble natural mixed carotenoids emulsion can be diluted to different concentrations to provide color shades ranging from dark orange to light yellow. From the company s in-house study EVTEneSem does not produce ringing or turn cloudy it is suitable for a clear beverage formula. EVTeneSem Day 1 EVTeneSem Day 30 Regulatory Awareness Laurie C. Dolan PhD a senior toxicologist at Burdock Group a food-safety consulting firm headquartered in Florida pointed out that with many potential uses of new natural colorings manufacturers need to remember that all color additives are considered artificial even if derived from a natural source and require pre-market approval by the color additive petition process. If a substance is deliberately added for its color it is a color additive--even if it is a natural substance like beet juice she said. If an ingredient is used for another purpose (such as a flavor) and it will impart color to food at the anticipated usage rate a color additive petition should be filed otherwise the FDA may consider your ingredient an unapproved color additive. Only color additives that are listed in the Code of Federal Regulations (CFR) and meet all requirements of the regulation may legally be used in food products in the United 46 Nutrition Industry Executive Natural Benefits EVTene is a natural food colorant with nutritional benefits derived from plant. The benefits include natural claim (clean label) extracted from a food GRASapproved non-GMO stable and clear in formulation as well as kosher- and halalcertified. By using EVTene in food and beverage formulations manufacturers can declare using natural colorings from food-- Clean Label. Furthermore the provitamin A and antioxidant properties of alpha-carotene and beta-carotene www.niemagazine.com April 2016 The Trouble With Natural Natural colorings commonly faced color stability issues which translate to short shelf life when developed into a product. In addition natural colorings are more expensive to produce when compared to synthetic colors so ingredient producers have increased their research efforts to address these issues. At ExcelVite said See we devel- provide health benefits in terms of prevention of vitamin A deficiency (improve eye health vis- -vis night blindness) and reduction in risk of some chronic diseases respectively. Recently the prestigious British Medical Journal s Open Diabetes Research and Care (Sugiura M et al. 2015) published a first longitudinal cohort study that demonstrates that long term high consumption of carotenoids especially pro-vitamin A carotenoids (alpha-carotene betacarotene and beta-cryptoxanthin) reduces the risk of type 2 diabetes in middle aged and older Japanese patients. The results show that high concentration of carotenoids especially alpha-carotene beta-cryptoxanthin and total Provitamin A carotenoids (alphacarotene beta-carotene and beta-cryptoxanthin) significantly reduce the risk of type 2 diabetes development. The inverse association between serum carotenoid and risk of type 2 diabetes is not only observed in non-smokers and non-drinkers but also in light drinkers. Interestingly other carotenoids such as lutein lycopene exhibited inverse asso- ciation but the association is not significant. Another new study published in the European Journal of Nutrition (Min KB & Min JY. 2016) shows that increased level of blood carotenoids (i.e. high consumption of carotenoid-rich foods) increases telomere length. Telomere length is a biomarker for age-related diseases. Shorter telomere length is associated with aging cancer and a higher risk of developing age-related disease and vice versa. A new and largest nested case-control study to date (American Journal of Clinical Nutrition (Bakker MF et al. 2016)) demonstrates that high plasma concentration of carotenoids (alphacarotene and beta-carotene) lowers the risk of developing estrogen receptornegative (ER-) breast cancer (i.e. growth of cancer cells that is independent of estrogen hormone). This largest epidemiological study provides an insight into the significant role that alphacarotene and beta-carotene play in the etiology of breast cancer. Among the biomarkers analyzed the breast cancer risk was significantly reduced by 39 to 59 percent when comparing the highest concentration of plasma alpha-carotene and beta-carotene with the lowest concentration among ER-negative breast cancer females. In addition there was a significant inverse association between plasma beta-carotene and ER- PR- (progesterone receptor-negative) patients. However plasma vitamin C zeaxanthin and retinol did not show significant protective effects against breast cancer. NIE References Bakker MF et al. (2016). Plasma carotenoids vitamin C tocopherols and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort. Am J Clin Nutr. doi 10.3945 ajcn.114. 101659. Min KB & Min JY. (2016). Association between leukocyte telomere length and serum carotenoid in U.S. adults. Eur J Nutr. doi 10.1007 s00394-016-1152-x. Sugiura M et al. (2015). High-serum carotenoids associated with lower risk for developing type 2 diabetes among Japanese subjects Mikkabi cohort Study. BMJ Open Diabetes Research & Care e00147 doi 10.1136 bmjdrc-2015-000147. FORMOREINFORMATION Burdock Group (407) 802-1400 ExcelVite Inc. (732) 906 1901 Go to www.niemagazine.com apl for info about this advertiser April 2016 www.niemagazine.com Nutrition Industry Executive 47 ScienceUpdate High Serum Omega-6 Linked to Lower Risk of Type 2 Diabetes new study from the University of Eastern Finland shows that high serum omega-6 polyunsaturated fatty acid concentrations are linked to a significantly reduced risk of type 2 diabetes. The findings were published in the American Journal of Clinical Nutrition. It has been speculated that a high intake of omega-6 polyunsaturated fatty acids may increase the risk of several chronic diseases as these fatty acids have been suggested to promote lowgrade inflammation among other things. However studies conducted on humans have not established a link between even a high intake of omega-6 fatty acids and inflammation. Furthermore omega-6 fatty acids have beneficial effects on for example glucose metabolism. Earlier research has systematically linked especially linoleic acid which is the most common omega-6 fatty acid to a reduced risk of cardiovascular diseases and type 2 diabetes. However scientific evidence relating to the health effects of other omega-6 polyunsaturated fatty acids is not as inconclusive. The serum fatty acid concentrations A of 2 189 men aged between 42 and 60 years and with no baseline type 2 diabetes diagnosis were analyzed at the onset of the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD) in 1984-1989 at the University of Eastern Finland. During a followup of 19 years 417 men were diagnosed with type 2 diabetes. The study found that high serum omega-6 polyunsaturated fatty acid concentrations were associated with a 46 percent lower risk of developing type 2 diabetes during the follow-up. When analyzing the independent associations of different omega-6 polyunsaturated fatty acids a similarly significant association was found between high serum linoleic and arachidonic acid concentrations and a lower risk of type 2 diabetes. However high serum gamma-linolenic and dihomo- -linolenic acid concentrations were linked to a higher risk. The study indicated that high serum linoleic and arachidonic acid concentra- tions are linked to a lower risk of type 2 diabetes. The serum linoleic acid concentration is determined by the person s diet and the main sources of linoleic acid are vegetable oils nuts and seeds. Arachidonic acid is present in meat and eggs however the human body can also make arachidonic acid from linoleic acid. Gamma-linolenic acid and dihomo--linolenic acid are mainly formed in the human body from linoleic acid. Their concentrations in serum are very low in comparison to for example linoleic acid. The association of gamma-linolenic acid and dihomo--linolenic acid with a higher risk of type 2 diabetes has been observed in some earlier studies but the underlying reason remains unknown. All in all however this study suggests that polyunsaturated omega-6 fatty acids have a beneficial impact on the risk of type 2 diabetes. For more information visit www.uef.fi en etusivu. Milk Supplements and Exercise Raise Children s Vitamin D Levels ufficient intake of fortified dairy products is of significant importance for the serum vitamin D level in primary school children shows a new study from the University of Eastern Finland. Children who drink at least three glasses of milk per day had a higher serum vitamin D level than their peers who drink milk in lesser amounts. The use of vitamin D supplements was also associated with a higher serum vitamin D level. Furthermore children who exercise more than two hours per day had a higher serum vitamin D level than children who exercise less than 1.5 hours per day. The article was published online in British Journal of Nutrition. Very few children had severely low serum levels of vitamin D. However 20 percent had a serum vitamin D level lower than 50 nmol l which is often considered as a sufficient level. Children whose blood samples were taken in the autumn had the highest serum vitamin D levels. This may be explained by the S fact that in the summer vitamin D is formed on the skin due to sunlight exposure. In northern latitudes there is not enough sun exposure to maintain sufficient vitamin D levels in the winter season and vitamin D supplementation is often required. A sufficiently high serum vitamin D level is associated with better bone health and there is some evidence that it may also be associated with a lower risk of many chronic diseases. More than 80 percent of the children had a lower intake of vitamin D from food and vitamin supplements than recommended 10 g per day in Finland. Furthermore as many as 40 percent of the children did not use any vitamin D supplements at all. Milk was the most important source of vitamin D amounting to nearly 50 percent of the children s intake. Approximately 30 percent of the vitamin D intake was from dietary fats and approximately 10 percent from fish. The Physical Activity and Nutrition in Children (PANIC) Study is an on-going lifestyle intervention study in the Institute of Biomedicine at the University of Eastern Finland. A total of 512 children aged 6 to 8 years participated in the baseline measurements in 2007-2009 constituting a representative sample of their age group. The PANIC Study produces scientifically valuable information on children s lifestyles health and well-being. The next followup round will begin in early 2016. For more information visit www.uef.fi en etusivu. www.niemagazine.com April 2016 48 Nutrition Industry Executive Ingredient Marketplace 2016 Booth Preview April 27-29 2016 Orlando World Center Marriott Orlando FL The following companies advertising in this issue have submitted information describing their plans for Ingredient Marketplace--product launches show specials and special services are all included below. Booth numbers are provided with each listing to encourage in-person meetings to learn more. Avanti Polar Lipids Inc.--Booth M46 Avanti Polar Lipids (Alabaster AL) Analytical Services Division provides extensive laboratory testing using modern analytical techniques to the research food nutraceutical and pharmaceutical communities for their lipid related projects. Testing under cGLP (current good laboratory practice) and cGMP (current good manufacturing practice) is available with appropriate notification and preparation. Please visit Avanti s new website for more information. For more information call (800) 227-0651 or visit www.avantilipids.com. Natreon Inc.--Booth K43 Join Natreon Inc. (New Brunswick NJ) for the following Lunch Brief presentation Natural Collagen Synthesis Dramatic Breakthrough for Sports Nutrition and Anti-Aging. Sports nutrition and anti-aging are both burgeoning categories and both have a need for natural collagen synthesis. A new clinical study done at Ohio State University showed Natreon s PrimaVie (purified Himalayan shilajit) dramatically upregulated the genes responsible for collagen synthesis. Get the insights about the science from the researchers and how this breakthrough ingredient can support sports nutrition and antiaging formulations. Lunch will be provided. For more information call (732) 296-1080 or visit www.natreoninc.com. Nutraceutix--Booth K39 Nutraceutix (Redmond WA) supplies probiotics and manufactures advanced dietary supplements using its highly regarded patented delivery enhancement BIO-tract. BIO-tract Viablend TraXcaps and patent-pending BIO-tract II improve the performance of probiotics and a wide variety of nutraceuticals for quality conscious brands around the world. Visit booth K39 to learn more about how Nutraceutix can help you and your products stand above the rest. For more information call (425) 883-9518 or visit www.nutraceutix.com. Sabinsa Corporation--Booth I34 Since 1988 Sabinsa Corp. (East Windsor NJ) has pioneered the introduction of numerous standardized and patented botanical extracts for the world markets. The company s NSFGMP-certified contract manufacturing center is based out of Utah providing formulations in capsules and tablets. Sabinsa will be showcasing its latest studies around LactoSpore the GRAS (generally recognized as safe)affirmed shelf-stable probiotic. Visit the booth to discuss the many new possibilities with uC3 Clear the water-soluble curcuminoids. Learn how to build endurance in your sports supplements with Sabeet beet root extract. For more information call (732) 777-1111 or visit www.sabinsa.com. Nutrition Industry Executive 49 Herbally Yours Inc.--Booth J59 Herbally Yours Inc. (Gilbert AZ) provides custom contract manufacturing of dietary supplements and skincare products from formulation to finish. The company formulates performs R&D designs stability studies combines in-house and third-party testing compounding filling packaging testing pelletizing and shipping all within a core focus of QA QC and analytical chemistry. Herbally Yours Inc. s specialties lie in liquid powder capsule (excipient free) serums lotions and creams. The company is NSF certified cGMP NSF GMP for Sport USDA (U.S. Department of Agriculture) Organic and has QAI Organic Certification. For more information call (480) 892-8220 or visit www.herballyyours.net. Jiaherb Inc.--Booth K30 Jiaherb Inc. (Pine Brook NJ & Anaheim CA) was founded on the simple principle of providing the highest quality ingredients backed by superior customer service and competitive pricing. The company is committed to offering its customers peace of mind through stringent quality control perpetual inventory and complete regulatory documentation of all its products. Jiaherb strives to develop new products in partnership with our clients and introduce more companies to the benefits of working with a large-capacity NSF-GMP certified supplier. For more information call (888) JIAHERB or visit www.jiaherbinc.com. April 2016 www.niemagazine.com Equipment&Packaging TruTag Hawaii-based TruTag Technologies Inc. has launched Model 4100 hand-held optical reader which brings satellite-imaging technologies to the service of secure product authentication. Powered by a simple-to-use cloud-connected first-of-its kind solid-state imaging and processing engine the Model 4100 can authenticate in just a few seconds thousands of medicines electronic components industrial parts packaged goods and other items marked with TruTag microtags. TruTag s high-performance Model 4100 reader broadens the scope of objects that can be conveniently scanned for authentication lot number delivery and distribution history and it enhances TruTag s ability to offer its cutting-edge solution to the food electronics consumer goods and life sciences markets making a bigger impact on the prevention of counterfeiting. For more information visit www.TruTags.com. Anritsu Capsule Checkweigher & Antares Vision TCI Tablet & Capsule Inspector New Jersey-based MG America the U.S. subsidiary of MG2 of Bologna Italy and a leading supplier of processing and packaging equipment is launching a variety of premium equipment. Among the lineup will be a new capsule checkweigher from Anritsu as well as the Antares Vision TCI Tablet & Capsule Inspector. The Anritsu Capsule Checkweigher achieves high throughput of up to 230 000 capsules per hour with an accuracy of -0.5mg meeting the industry s most stringent requirements. The machine s exceptional production capabilities deliver exemplary accuracy at high speeds and feature impressive flexibility concerning the various product shapes and sizes it can handle. Its enhanced handling technology eliminates the bouncing of empty capsules and prevents them from potential market entry. The Antares Vision TCI Tablet & Capsule Inspector is a fully automatic standalone machine designed to inspect pharmaceutical capsules and tablets. Versatile smart and efficient the TCI combines high production throughput (up to 300.0000 units hour) with great accuracy in inspection (precision up to 100 m). For more information call (866) 962-3090 or visit www.mgamerica.com. SmartSPEC Label Insight a cloud-based product data engine based in Missouri announced the launch of SmartSPEC a first-to-market solution that helps grocery brands generate and maintain the product data required to participate in SmartLabel a transparency initiative led by the Grocery Manufacturers Association (GMA) and the Food Marketing Institute (FMI). The goal of SmartLabel is to provide consumers with easy instant access to detailed information about the grocery products they buy. Brands participating in SmartLabel are required to create a landing page for each product that features 52 required attributes such as nutrients and allergens and up to 197 voluntary attributes like no GMO (genetically modified organism) and no artificial preservatives. Consumers can access these pages by scanning QR (quick response) codes on product packaging visiting www.smartlabel.org or searching a brand s website. Label Insight s SmartSPEC solution utilizes the company s proprietary technology to analyze food products for each of the required SmartLabel attributes and nearly all of the voluntary attributes as well as provide data hosting and landing page creation services. The fully automated process shortens the time needed to implement SmartLabel taking brands as little as a few days to complete. For more information visit www.labelinsight.com. New Macrowave Bulk Pasteurization Systems Massachusetts-based Radio Frequency Company released the New Macrowave Pasteurization System ideal for batch or conveyorized applications for bagged or bulk product. In a Macrowave heating system an RF generator creates an alternating electric field between two electrodes. The material to be treated is conveyed through an electrode array where this alternating energy causes polar molecules in the material to continuously reorient themselves to face opposite poles much like the way bar magnets behave in an alternating magnetic field. The friction resulting from molecular movement causes the material to heat both rapidly and uniformly throughout its entire mass. Radio Frequency Company has developed a line of energy saving Macrowave Pasteurization Systems that operate at 40 MHz where the depth of penetration and uniformity of heating are optimized thereby ensuring effective microbe kill and avoiding deleterious effects on product quality. Radio Frequency Company offers a full line of systems for the bulk pasteurization and or insect de-infestation of nut meats spices pasta tobacco fishmeal xanthan gum food ingredients and other various products either bagged or in bulk requiring pasteurization. For more information call (508) 376-9555 or visit www.radiofrequency.com. 50 Nutrition Industry Executive www.niemagazine.com April 2016 Research&Development (Continued from page 41) discarded and replaced much sooner than previously partially hydrogenated oils. The very good news is he said high-stability high-oleic soybean oil can replace these oils creating a much better food product with improved appearance mouthfeel and taste while mitigating any net cost increase due to much longer fry life. QUALISOY provides liquid high-oleic soybean oil for deep-fat frying saut ing baked goods creamers crackers chips roasted nuts spray oils pan-release oils and dressings plus inter-estified soybean oil for donut frying cakes cookies and icings. Organic Technologies offers a full range of MSC-certified AlaskOmega omega-3 concentrates and natural fish oils with up to 85 percent omega-3 content in many popular EPA and DHA ratios in both ethyl ester (EE) and triglyceride (TG) form. Fresher oil translates into better product stability longer shelf life and optimal sensory characteristics for finished goods incorporating AlaskOmega omega-3 concentrates Dillingham emphasized. Given proper care and handling during soft gel encapsulation or liquid bottling it should result in fresher better tasting omega-3 finished goods for consumers to enjoy. Enjoyment of better-for-you foods is a primary attribute consumers seek. NIE FORMOREINFORMATION Organic Technologies (740) 622-0755 QUALISOY (312) 861-5236 Advertiser Index Albion Laboratories Inc. Alkemist Labs Avanti Polar Lipids Biova LLC Comar LLC GE Nutrients Inc. Healthco Herbally Yours HSU s Ginseng Enterprises Inc. Jiaherb Inc. KML Laboratories Inc. Mack Flavor Ingredients Inc. Natreon Inc. Nutraceutix Inc. Nutragenesis Icon Group Once Again Nut Butter PLT Health Solutions Inc. Sabinsa Corporation Soma Labs Inc. Texas Best Organics Inc. United States Pharmaceopea Vit-Best Nutrition Inc. C3 13 47 35 28 9 1 20 19 5 10 44 29 12 31 7 3 C2 14 11 C4 15 (801) 773-4631 (714) 754-4372 (800) 227-0651 (877) 682-2673 (856) 507-5402 (949) 502-5760 (800) 477-3949 (480) 892-8220 (800) 388-3818 (888) 542-4372 (208) 267-0818 (951) 683-6245 (732) 296-1080 (425) 883-9518 (802) 257-5345 (888) 800-8075 (973) 984-0900 (732) 7 7 7 - 1 1 1 1 (732) 271-3444 (409) 658-7201 (301) 230-6361 (714) 832-9700 www.niemagazine.com albion www.niemagazine.com alkemistlabs www.niemagazine.com apl www.niemagazine.com biova www.niemagazine.com comar www.niemagazine.com gencor www.niemagazine.com healthco www.niemagazine.com herballyyours www.niemagazine.com hsus www.niemagazine.com jiaherb www.niemagazine.com kml www.niemagazine.com mackflavor www.niemagazine.com natreon www.niemagazine.com nutraceutix www.niemagazine.com nutragenesis www.niemagazine.com onceagain www.niemagazine.com plt www.niemagazine.com sabinsa www.niemagazine.com somalabs www.niemagazine.com texasbestorganics www.niemagazine.com usp www.niemagazine.com vit-best Industry Events April 27-29 Ingredient Marketplace Orlando World Center Marriott Orlando FL www.marketplace.supplysideshow.com May 10-12 VitaFoods 2016 Geneva Palexpo Geneva Switzerland www.vitafoods.eu.com May 26-27 6th Annual European Food Safety & Quality Summit Huis ter Duin The Netherlands www.foodsureeurope.com June 14-16 EastPack & HBA Global Expo Jacob K. Javits Convention Center New York NY www.eastpack.packagingdigest.com or www.hbaglobal.packagingdigest.com July 16-19 IFT 2016 McCormick Place South Chicago IL www.am-fe.ift.org September 21-22 MinnPack Minneapolis Convention Center Minneapolis MN www.minnpack.packagingdigest.com November 15-17 Advanced Manufacturing Expo & Conference Centro Banamex Mexico City Mexico www.manufacturingmx.com April 2016 www.niemagazine.com Nutrition Industry Executive 51 TestingLaboftheMonth Danica Harbaugh Reynaud PhD Global Director of Scientific Innovation NSF International NSF International 789 N. Dixboro Rd. Ann Arbor MI 48105 Phone (734) 769-8010 NSF AuthenTechnologies 2600 Hilltop Dr. Ste. C346 Bldg. B Richmond CA 94806 Phone (510) 914-3290 AuthenTechnologies LLC was founded in 2010 by Danica Harbaugh Reynaud PhD and her husband Dan Reynaud. It was acquired by NSF International in 2015. NSF AuthenTechnologies is the first and and founder NSF only U.S. Food and Drug Administration (FDA) compliant ISO IEC AuthenTechnologies 17025 accredited provider of innovative genetic technologies to improve the authenticity safety and quality of natural products. The company strives to deliver high-quality efficient and effective solutions based on the most cutting-edge science to solve the challenges of its diverse clientele. Prior to joining NSF International Reynaud co-founded AuthenTechnologies LLC which developed an advanced DNAbased identity testing and authentication technology for the nutrition herbals and food industry. Reynaud holds a BA and PhD in integrative biology from the University of California Berkeley and is very active in the botanical sciences. NIE What is the difference between traditional DNA barcoding and AuthenTechnologies Nextgeneration DNA Sequencing Reynaud There are several types of DNA testing useful for identification. DNA barcoding which relies on longer segments of DNA regions and traditional DNA sequencing techniques can only be used on materials consisting of a single species from fresh or living materials. NSF AuthenTechnologies employs a highly specific and sensitive method called Target Specific DNA Sequencing (TSDS) capable of identifying almost any species of plants meats and fungi using shorter segments and validated reference materials--and from a wide range of ingredients and finished products including botanical extracts and mixtures--which traditional DNA barcoding cannot. This includes the detection of unexpected contaminants even those that cannot be distinguished morphologically or chemically. NSF AuthenTechnologies nextgeneration DNA sequencing has successfully identified materials consisting of a single species or a mixture of hundreds of species as well as screened for GMOs (genetically modified organisms) allergens fillers and filth for a range of leading natural and consumer product companies. Its species identification services are compliant with FDA s cGMP (current 52 Nutrition Industry Executive good manufacturing practice) requirements for 100 percent identity testing for virtually any species of plant algae fungus animal or bacteria and can replace other traditionally-used methods such as TLC HPLC HPTLC FTIR and NIR. Therefore you can see that a technology such as NSF AuthenTechnologies is widely useful across all categories of foods and beverages to ensure their purity and safety. NSF International s dietary supplement and food industry clients now have access to the most advanced DNA testing technology available. Combined with NSF International s 70-plus years of auditing testing and certification expertise this technology further helps companies verify the authenticity quality and safety of their finished products and raw ingredients including dietary supplements and botanicals. In fact we have developed a single method for simultaneously testing a food product for all of its ingredients allergens fillers and GMOs. Therefore it can be used as a routine test from seed to shelf--from the living organisms to the finished products. NIE NSF International recently acquired AuthenTechnologies. How did the partnership come about Reynaud Since inception in 2010 AuthenTechnologies has strived to become the thought leader in the industry regarding DNA-based authentication and has built an extensive proprietary database of reference sequences and developed validated and specific procedures for thousands of commercially used species. AuthenTechnologies strategy from the very beginning was to partner with an established and wellrespected organization like NSF International that could help to bring the technology across the globe through its extensive network of laboratories. The acquisition of AuthenTechnologies provides NSF International with next-generation DNA-based species identification services that improve the authenticity safety and quality of natural products including dietary supplements foods and other consumer products. In addition to supporting dietary supplement clients the technology strengthens NSF s supply chain food safety seafood non-GMO and gluten-free certification programs and will be a core component of NSF services designed to help companies avoid issues of food adulteration and fraud. Adding this technology to our global laboratory capabilities aligns with NSF International s objective to remain a technical leader in testing. Extra Extra Visit www.niemagazine.com to read the rest of the interview. www.niemagazine.com April 2016 Go to www.niemagazine.com albion for info about this advertiser Go to www.niemagazine.com usp for info about this advertiser