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Description: In This Issue: Palatable for Pets, Healthy Aging, Science of Ingredients, and Proteins & Amino Acids
VI S SO IT IEm UR OU ag CE R O az ine BO NL .co OK IN A VRM Media Publication E m So AT u ww w. N rc eb oo k www.niemagazine.com May 2016 Go to www.niemagazine.com sabinsa for info about this advertiser Go to www.niemagazine.com healthco for info about this advertiser TableofContents Proud Supporter of VOLUME 21 NO. 4 MAY2016 F E A T U R E S 28 Palatable for Pets Considering their sharp sensory skills development of natural extracts in forms acceptable to pets is the newest trend. 31 All Systems Go The healthy aging market continues to evolve clarify itself and accelerate. 28 A L S O I N S I D E 36 Science of Ingredients 2016 The Science of Ingredients section gives the magazine s advertisers an opportunity to describe the research that substantiates the safety and efficacy of their branded ingredients products and services. C O L U M N S 12 20 26 26 27 54 55 55 Industry News Ingredient News Association News Conventions & Meetings Science Update Equipment & Packaging Advertiser Index Industry Events Supplier of the Month 4 First Word 6 Condition Specific 50 Marketing Innovation 52 Functional Foods 52 56 FREE Subscription (Print Digital or BOTH) & E-newsletter Available www.niemagazine.com Copyright 2016. Nutrition Industry Executive (ISSN 2331-2602) Volume 21 Number 4 May 2016. Nutrition Industry Executive is published monthly (except for bimonthly January February and July August and November December) by VRM Media 431 Cranbury Road Suite C East Brunswick NJ 08816 USA Phone (732) 432-9600 Fax (732) 4329288. All rights reserved including the right to reproduce in whole or in part. Not responsible for unsolicited material. Opinions expressed in by-lined articles or advertisements are not necessarily those of Nutrition Industry Executive or its owners. Publisher is not liable for advertiser product claims or representations. Advertisers assume total responsibility for the contents of their advertisements. Printed in U.S.A. Basic annual subscription rate is 50.00. Periodicals Postage Paid at East Brunswick NJ 08816 and additional mailing offices. POSTMASTER Send address changes to Nutrition Industry Executive P.O. Box 15026 North Hollywood CA 91615-5026. Subscription Customer Service Nutrition Industry Executive P.O. Box 15026 North Hollywood CA 91615-5026 USA Phone (818) 286-3170 Fax (800) 869-0040 niecs magserv.com www.niemagazine.com. Back Issues & Single Copies For order information contact (732) 432-9600 or info niemagazine.com. March issue is 25.00. All other issues are 8.00 each. 2 Nutrition Industry Executive www.niemagazine.com May 2016 Go to www.niemagazine.com plt for info about this advertiser FirstWord A Fresh Take on Aging s a female when you reach a certain age you begin to notice that mainstream media loves telling you what not to do. For example what mature women should never wear Jeans No. Long hair Not after age 40. Tattoos Forget about it The same goes for red lipstick hoop earrings ... the list continues. Perhaps the writers assume women over a certain age are just too old clueless and unattractive to do what they please anymore so they must follow strict guidelines. Well I beg to differ with this assessment and I was happy to read in Lisa Schofield s feature article on Healthy Aging (see page 31) that S bastien Bornet director of global marketing at Horphag Research (exclusive worldwide supplier of Pycnogenol) observed that many people now equate healthy aging to looking and feeling one s best through the advanced years of life e.g. enjoying youthful pliable skin being active and feeling a strong sense of wellness amid aging. For an increasing number of consumers he stated healthy aging also means being able to continue to do the things they have done when younger--to age on one s own terms. Thank you S bastien for the clear-eyed perspective And he wasn t alone. Other participants in the article responded in kind. For Chase Hagerman brand director with Chemi Nutra in Texas there is a significant distinction between aging and healthy A aging in the minds of most consumers. Rather than aging he noted Healthy aging is desirable traits such as remaining active fit sharp and youthful. Along with the active fit and sharp aspects I also think of youthfulness as more than just appearance but also maintaining a sense of humor curiosity and fun. The same applies to men. According to Aparna Kalidindi PharmD BCPS technical sales and marketing manager New Jerseybased Natreon Inc. the term healthy aging is a more positive concept suggesting that aging is a natural process. Well thank goodness for that Conversely Kalidindi added the term anti-aging emphasizes that aging is a race against time. Additionally she said products marketed with that term might cause consumers to have unrealistic expectations about the results. I agree. Rather than anti-aging maybe those products should be marketed as pro-aging. Then maybe by the time the writers of the Top Ten Things Women Over (insert a number over 35) Should Never Do columns find that they are une femme d un certain ge themselves they won t have to worry about being judged a mutton dressed as lamb if they decide to wear red lipstick. Of course we are all aging--if we don t consider the alternative. It s great to have the opportunity to do it as best we can stay as healthy fit and youthful as possible and set a good example for the kids. Publisher Daniel McSweeney Editorial Director DanM VRMmedia.com Associate Russ Fields Publisher RussF VRMmedia.com Advertising Gary Pfaff Sales Manager GaryP VRMmedia.com Editor-in-Chief Janet Poveromo JanetP VRMmedia.com Managing Editor Shari Barbanel ShariB VRMmedia.com Assistant Editor Corinne Anderson CorinneA VRMmedia.com Contributing Writers Lisa Schofield Suzanne Shelton Art Director Robert Certo Production Manager RobertC VRMmedia.com Production Assistant Bryan Zak Graphic Designer BryanZ VRMmedia.com Circulation Manager Rosie Brodsky Rosie StarkServices.com A PUBLICATION OF VRM MEDIA President Daniel McSweeney VRM Media 431 Cranbury Road Ste. C East Brunswick NJ 08816 Phone (732) 432-9600 Fax (732) 432-9288 Email info VRMmedia.com Website www.niemagazine.com VRM Media publishes Nutrition Industry Executive Vitamin Retailer Natural Practitioner and FitnessTrainer magazines. Subscription Customer Service To order a subscription or manage your account please contact us at Nutrition Industry Executive P.O. Box 15026 North Hollywood CA 91615-5026 USA Phone (818) 286-3170 Fax (800) 869-0040 niecs magserv.com www.niemagazine.com Back Issues See the Table of Contents page for price and order information. Connect With Us www.twitter.com www.facebook.com www.linkedin.com www.instagram.com www.pinterest.com vitaminretailer vitaminretailermagazine company vrm-media vitaminretailermagazine vrm_media 4 Nutrition Industry Executive www.niemagazine.com May 2016 Go to www.niemagazine.com jiaherb for info about this advertiser ConditionSpecific For consumers pain relief ingredients that offer clinical substantiation easily managed doses in convenient delivery methods are bio-efficacious and have proven safety continue to prevail. B Y S HARI B ARBANEL E veryone experiences pain from time to time but there are a large number of adults experiencing chronic pain. According to the National Institute of Health s (NIH) National Health Interview Survey (NHIS) approximately 25 million adults (11.2 percent) reported having pain every day in the three months before the survey took place. Further the survey found that adults with more severe pain had worse health used more health care and had more disability than those with less severe pain. Many of those who would have formerly turned to a prescription drug or over-the-counter NSAID (nonsteroidal anti-inflammatory drug) are growing weary. The market for pain relief supplements is growing as consumers are turning away from NSAIDs and other pharmaceuticals due to the risk of adverse effects and drug interac6 Nutrition Industry Executive tions said Aparna Kalidindi PharmD BCPS technical sales and marketing manager for Natreon Inc. in New Jersey. Many older consumers are turning to supplements for natural pain relief. Sonya Cropper vice president of marketing and innovation for Indianabased Verdure Sciences noted that since the pain relief category is so generalized there a number of ingredients that may be a fit because each ingredient offers different health benefits. No one wants to be in pain and the many reasons that could be causing the pain make it difficult to assess individual effectiveness. Many consumers understand that prevention is key and therefore turn to supplements diet and exercise to help maintain a healthy active lifestyle. The case of active lifestyle includes the ability to recover faster from exercise induced inflammation-- there are specific biomarkers associ- ated with this inflammation process that can be targeted and maintained. Pain relief supplements are present in range of condition-specific categories added Greg Ris vice president sales for Indena USA in Washington. For example pain relief supplements are in the joint health category where NBJ estimates retail sales at between 1.5- 2 billion. There are also pain relief products in other categories such as sports nutrition. The opportunity is significant and growing. Pain Relieving Ingredients While inflammation is a natural body response that affects everyone from time to time those who deal with chronic inflammation are often in pain. Ingredients that can help resolve inflammation in a healthy manner can be very beneficial for pain relief noted Nena Dockery www.niemagazine.com May 2016 Go to www.niemagazine.com texasbestorganics for info about this advertiser ConditionSpecific technical services manager for Stratum Nutrition in Missouri. Sometimes when an area becomes inflamed through either injury or normal wear and tear the mechanisms that should turn off the inflammatory processes fail to appropriately function and the inflammation persists. These ingredients are beneficial because they mediate the inflammatory process through their interaction with select inflammatory substances. For example NEM has been shown to decrease levels of key pro-inflammatory cytokines such as TNF- and IL-1. research indicates that MSM may also be effective in mitigating muscle and joint pain associated with physical activity (Withee 2015 Kalman 2012) he continued. The research suggests that the mechanism of action is associated with inflammatory pathways and oxidative stress (Nakoostin-Roohi 2011 Kim 2009 Ahn 2013). Hammond also noted that MSM works well in conjunction with other ingredients. Every person has unique body chemistry and needs and consumers need to have choices so they can find which formulation works for them he explained. MSM has been shown to be effective in combination with many other ingredients including glucosamine chondroitin curcumin arginine boswellic acid and vitamin C. Bergstrom Nutrition s ingredient OptiMSM is the purest and only GRAS (generally recognized as safe)designated MSM available according to the company. It has been included in the majority of the world s best joint-health nutritional supplements and has been a recognized ingredient for treating joint pain discomfort since its inception. Also targeting joint pain is Natreon s AyuFlex a new ingredient that has been launched in the last two years. In one randomized double-blind placebo-controlled trial patients with osteoarthritis for at least six months duration and meeting the ARA functional class I to III with radiological evidence were randomized to receive AyuFlex 250 mg twice daily AyuFlex 500 mg twice daily or placebo. This was a 12-week trial which assessed mWOMAC scores knee swelling index and VAS (visual analog scale) for pain stiffness and disability Kalidindi explained. Patients were allowed to use acetaminophen as a rescue medication. Results from this study showed that patients with osteoarthritis taking AyuFlex had a significant reduction in WOMAC scores knee swelling index and VAS-pain VAS-stiffness and VASdisability. Kalidindi noted that patients taking AyuFlex used significantly less rescue medication (paracetamol) compared to the placebo group. In regard to safety all renal hematologic and hepatic parameters were within normal limits in the treatment group www.niemagazine.com May 2016 ties. Ris noted that since Indena s inception in 1921 ingredients for pain relief have been a part of the company s broad portfolio of botanicals. Indena s most recognized pain relief ingredient is Meriva Bioavailable Curcumin which is supported by 22 clinical trials demonstrating effectiveness for joint health and healthy inflammatory response. More recently the company introduced CASPEROME that combines boswellia with its PHYTOSOME technology. Boswellia has a long history to support a natural inflammatory response he explained. In 2012 Stratum entered into an exclusive joint venture with ESM Technologies the creator of NEM brand eggshell membrane an ingredient supported by multiple research studies demonstrating its benefits to joint structure comfort and function. Stratum Nutrition s premier pain relief ingredient is NEM brand eggshell membrane. NEM has been shown to significantly improve joint comfort in multiple clinical trials Dockery said. NEM helps mediate the immune system inflammatory response by controlling the release of several pro-inflammatory cytokines. NEM does not negatively affect antiinflammatory cytokines so these can continue to function in returning the body to a normal non-inflammatory state. This beneficial action helps explain how NEM can provide relief within days instead of weeks or months. In addition to NEM some of the long-standing ingredients for pain relief include glucosamine chondroitin UC-II SAM-e MSM curcumin boswellia capsaicin and omega-3 fatty acids according to Kalidindi while Indena s Ris added willow bark to the list. Longvida Optimized Curcumin is a longstanding ingredient for Verdure said Cropper who noted that curcumin as a whole has become more widely adopted by the conventional marketplace and is known to offer a variety of tangible health benefits such as systemic inflammation brain health and exercise recovery. In addition Verdure s boswellia ingredient WokVel has been shown effective in supporting joint health through osteoarthritis clinicals. Curcumin & Boswellia Curcumin and boswellia in particular have been getting a lot of attention recently as consumers are learning about their anti-inflammatory proper8 Nutrition Industry Executive MSM MSM (methylsulfonylmethane) has historically been used to maintain proper joint health and as such reduce the side-effects (like pain) associated with unhealthy joints said Tim Hammond vice president of sales and marketing for Washington-based Bergstrom Nutrition. Recently however Go to www.niemagazine.com albion for info about this advertiser ConditionSpecific she explained. In addition to the study in moderately osteoarthritic subjects there are two randomized double-blind placebo-controlled crossover studies that were completed to examine the analgesic activity of AyuFlex in healthy human volunteers. In these studies subjects were given a single 1 000 mg dose of AyuFlex and subjected to a hot air pain model or a mechanical pain model. Both force and time for pain threshold and pain tolerance from both these studies were statistically significant at p 0.001 compared to placebo. both manufacturers and consumers through a strong online presence for our core ingredients. It s always important to critically evaluate the science when deciding among ingredients. Even though an ingredient may claim something a marketer must investigate the supporting data in order to prove and verify the claim he continued. Some ingredients have great support while others either rely on borrowed science. For Meriva Indena has completed the safety pharmacokinetic and clinical studies proving its effectiveness. And while offering research data is important there are other factors that finished product manufacturers need to consider. According to Cropper manufacturers need to be aware of consumer demands. Simply touting a number of clinicals does not refer to the quality or outcome of the clinicals. It is also important to consider any absorption technology or variations which most of the time vastly differ from generic ingredients she explained. In particular ingredients that offer clinical substantiation easily managed doses in convenient delivery methods are bio-efficacious and have proven safety and traceability continue to prevail in the consumer realm. With more consumers educating themselves about the dangers of some OTC and prescription pain relievers it seems that the trend of turning to natural ingredients and dietary supplements will only continue. Many pain relieving drugs have undesirable side effects concluded Rod Benjamin director of R&D and technical services for Bergstrom Nutrition. COX2 inhibitors may cause heart issues. Other pain relievers can be harmful to the kidneys or liver if used incorrectly or for control of chronic pain. Dietary supplements may provide a safer and healthier alternative for managing pain. NIE Supporting Data When it comes to ingredients and finished products consumers want to be able to trust that the product they buy does what it claims to do. This is where suppliers and manufacturers have the opportunity for transparency. At Indena research and development has been one of our core values so we ve always placed an emphasis on validating the effectiveness of our ingredients Ris said. We communicate these benefits to FORMOREINFORMATION Bergstrom Nutrition (360) 693-1883 Indena (206) 340-6140 Natreon Inc. (732) 296-1080 Stratum Nutrition (888) 403-5039 Verdure Sciences (317) 776-3600 THE NUTRITION INDUSTRY S NEWS & INFORMATION RESOURCE NIE s Upcoming Issue Highlights July August September 6 28 16 ad closing 8 11 16 ad closing Company Profiles SupplySide West Show Issue October Nov. Dec. 9 7 16 ad closing 10 25 16 ad closing Washington and the Natural Industry Supply Innovation Our 2016 Media Planner Is Available At NIEmagazine.com 2016-Media-Planner Contact One of Our Ad Specialists Today Russ Fields at 732-432-9600 ext. 102 or e-Mail RussF VRMmedia.com Gary Pfaff at 732-432-9600 ext. 103 or e-Mail GaryP VRMmedia.com 10 Nutrition Industry Executive www.niemagazine.com May 2016 Go to www.niemagazine.com nutragenesis for info about this advertiser IndustryNews NPA Calls for Carrageenan to be Allowed in Organic Infant Formulas he Natural Products Association (NPA) recently submitted written and oral comments to the United States Department of Agriculture (USDA) and National Organic Standards Board (NOSB) regarding the use of carrageenan in organic infant formula. Carrageenan is naturally sourced and has been shown to be safe for use for many years by the FDA (U.S. Food and Drug Administration) and international regulatory authorities stated Dr. Daniel Fabricant CEO and executive director of NPA It is baffling why NOSB in its last go around recommended to the USDA s Agriculture Marketing Service (AMS) its removal from organic infant formula when all the studies out there prove that it is safe for use. Thankfully science prevailed as USDA AMS rejected that recommendation. The exemption and prohibitions granted on the National List are required to be renewed every five years under the Organic Foods T Protection Act by the NOSB. Under the 2013 Sunset review the NOSB reviewed a number of substances including carrageenan. While carrageenan is allowed in organic products it is exempted in organic infant formula. Carrageenan continues to be a vital naturally-sourced food additive in organic foods and infant formula. Carrageenan is commonly used in dairy products to gel thicken suspend or emulsify to enable stabilization binding and dispersion. The FDA continues to maintain the safe use of carrageenan in organic food and infant formula as codified in the federal regulations. NPA supports the FDA to re-evaluate the use of carrageenan if updated toxicity studies become available. Carrageenan is recognized by international regulatory authorities. The World Health Organization (WHO) Joint Expert Committee of Food Additives (JECFA) recently evaluated carrageenan and has again deemed it safe for use as there is absolutely no information to clearly demonstrate a cacogenic effect for food grade carrageenan use in foods or infant formula. NPA urged the NOSB and USDA to conclude that carrageenan is safe at all levels found in food and therefore be permitted for use in both foods and organic infant formula. For more information visit www.ams.usda.gov event nosbspring-2016-meeting-washington-dc or www.npainfo.org. Alkemist Labs Clarifies C of A Policy n April Alkemist Labs (Costa Mesa CA) was told by several industry contacts that they had received an email offering raw herbs for sale that contained lab reports purporting to show identity of several varieties of ginseng and of schisandra. The reports were nearly identical to the format and language Alkemist Labs developed for testing reports but Alkemist Labs neither conducted the tests nor issued the certificates of analysis according to the company. Because Alkemist Labs report format is so distinctive and comprehensive that other labs have apparently begun to mimic the format the company has issued a policy to clear up any confusion All certificates of analysis issued by Alkemist Labs will contain the following Copyright Alkemists Pharmaceuticals 2016. All rights reserved. I Clients may request to use lab reports issued by Alkemist Labs in their marketing materials but must obtain written permission from the company. Changes or redactions are not permitted nor may the Alkemist Lab name be removed or blurred. We have seen two lab reports that copied the formatting layout and wording of our template that I created nearly 20 years ago said Sidney Sudberg LAc DC president and CSO of Alkemist Labs. This report format is unique to Alkemist Labs with my words very carefully and specifically chosen and placed. It is disturbing to see our distinctive report template used anonymously by other companies as it may mislead people to think we did the testing when we did not said Alkemist Labs CEO Elan Sudberg. The Alkemist Labs C of A is valuable because of the reputation we have built for accurate testing and deep knowledge of the products we test. We intend to protect that integrity. For more information visit www.alkemist.com. 12 Nutrition Industry Executive www.niemagazine.com May 2016 Go to www.niemagazine.com alkemistlabs for info about this advertiser IndustryNews FDA Approves Folic Acid to be Added to Masa Flour he U.S. Food and Drug Administration (FDA) has decided to allow manufacturers to fortify their corn masa foods with folic acid. Folic acid is a synthetic form of folate a B vitamin that helps prevent severe defects of the brain and spinal cord when consumed by women before and early [on] in pregnancy an NPR article reported. T Pregnancy women with folate deficiency have a higher risk of giving birth to infants affected with neural tube defects. NPR cited findings from the CDC (Centers for Disease Control) that since 1998 when the FDA required that breads pasta breakfast cereals and other grains made with enriched flour be fortified with folic acid the number of babies born in the U.S. with neural tube defects dropped about 35 percent (about 1 300 babies a year). The CDC urges all women who are capable of becoming pregnant to get at least 400 mcg of folic acid every day. The approval allows manufacturers to voluntarily add up to 0.7 milligrams of folic acid per pound of corn masa flour consistent with the levels of certain other enriched cereal grains the FDA said. The March of Dimes Foundation the American Academy of Pediatrics and others submitted a food additive petition in 2012 to request the extension of voluntary fortification to corn masa flour to increase the folic acid intake for Go to www.niemagazine.com herballyyours for info about this advertiser 14 Nutrition Industry Executive U.S. women of childbearing age who regularly consume products made from corn masa flour as a staple in their diet. Increased consumption of folic acid in enriched flour has been helpful in reducing the incidence of neural tube defects in the general population said Susan Mayne PhD director of the FDA s Center for Food Safety and Applied Nutrition. Our analysis shows that adding folic acid to corn masa flour will help increase the consumption of folic acid by women who consume this flour as a staple in their diet. Hispanic women are about 20 percent more likely than other women to have babies with those conditions [neural tube defects] and they continue to have far lower levels of folic acid intake either through diet or supplements NBC News shared. The FDA could approve the use of a food additive only after conducting a scientific safety review of the information provided in the petition to ensure that the additive is safe for the general population. With regard to folic acid the FDA evaluated the projected human dietary exposure toxicological data and other relevant information including whether folic acid remained stable in corn masa flour. The FDA worked with the petitioners throughout the review process to obtain data needed to address safety questions as expeditiously as possible. Based on that data the FDA concluded that the petitioned addition of folic acid to corn masa flour at a level not to exceed 0.7 milligrams of folic acid per pound of corn masa flour is safe. Exposure estimates from the FDA and the petitioners show that adding folic acid to corn masa flour could increase folic acid consumption in those who regularly consume products made from corn masa flour including many Latina women. The petitioners contend that increased consumption of folic acid will reduce the risk of births with neural tube defects among this group. The FDA s approval is not based on the possibility of this reduced risk but is instead based on a review of the safety of the proposed use of folic acid. Manufacturers may begin voluntary fortification of corn masa flour with folic acid on April 15 2016. For more information visit www.fda.gov. www.niemagazine.com May 2016 Go to www.niemagazine.com xsto for info about this advertiser IndustryNews PLT Health Solutions Launches Global Search for Innovation LT Health Solutions Inc. (Morristown NJ) announced the launch of the PLTNext Global Search for Innovation. The Global Search is designed to connect PLT with ingredient and technology innovators to assist in product development and commercialization. As part of the program PLT is putting its track record of developing and launching successful branded ingredients into supplement food & beverage markets to work for companies who meet the program s criteria and are selected for further collaboration. The Global Search for Innovation allows selected companies and organizations to work with PLT s scientific regulatory intellectual property product development and sales experts to help advance the marketreadiness of their concepts and create commercialization strategies that deliver market penetration and profitability. The Global Search for P Innovation is open to university research programs early-stage or regional companies and other ingredient technology developers. The initial round of PLTNEXT is open from April 11 to July 15 of this year. According to Devin Stagg vice president strategy & business development at PLT Health Solutions PLTNEXT is the company s ongoing business-wide commitment to innovation in the health and wellness space. As part of this commitment the Global Search for Innovation looks to provide innovative organizations the support and resources they need to successfully commercialize their ingredient and technology concepts. For more than six decades PLT Health Solutions has been working with companies all over the world to help successfully commercialize their ingredi- Go to www.niemagazine.com hsus for info about this advertiser 16 Nutrition Industry Executive ents. Toward that end PLT has recently made substantial investments in personnel and systems to accelerate the commercialization of partner innovations--turning superior quality and science into compelling brands. The PLTNEXT Global Search for Innovation is all about putting this infrastructure and expertise to work for the introduction of promising new ingredients and technologies Stagg said. PLT offers ingredient solutions to a broad range of health and wellness sectors including weight management bone and joint health sports nutrition cognitive health heart health immune health and more. The company is encouraging applications based on any ingredient or technology that supports healthier or natural solutions that displace conventional technologies. According to Seth Flowerman the company s executive vice president PLT is engaged in dialogue with a number of major consumer products companies searching for innovative solutions. PLT is often asked by our customers to develop ingredient or technology solutions for pressing industry needs. These range for example from ingredients to support digestive health or improve exercise performance to natural preservative systems. We are looking for partners with innovative approaches to emerging consumer product challenges he said. The application period for the current round of the PLTNext Global Search for Innovation closes on July 15 2016. Pre-commercial concepts as well as ingredients and technology that have previously been launched on a limited or regional basis are eligible for consideration. Criteria for selection will include the novelty of the concept safety testing the quality systems of the organization intellectual property protection and clinical science completed. For more information visit www.pltnext.com. www.niemagazine.com May 2016 NPA Holds 19th Annual Natural Products Day he Natural Products Association (NPA) hosted its members and other industry supporters from across the nation for its 19th Annual Natural Products Day (NPD) in Washington D.C. on April 12 and 13. NPD attendees including retailers suppliers and other industry members met with more than 75 members of Congress and staff to educate them on the industry s issues and natural products role in preventive health and overall wellness. Dr. Daniel Fabricant executive director and CEO of NPA kicked off NPD with advocacy training along with NPA s veteran lobbyists. The training session gave attendees an outline on how to best inform their elected officials on the natural industry and current issues to focus on while talking with legislators and congressional staff. The advocacy training prepared attendees for a successful lobby day and provided the necessary tools to continue building strong relationships with their lawmakers. Congressional Dietary Supplement Caucus member Rep. Reid Ribble (R-WI) addressed the attendees voicing his support of the industry and admiration for the industry supporters taking the time to come to Capitol Hill. He also gave the attendees advice on meeting with legislators and congressional staff. Following the advocacy training the NPA Political Action Committee (NPA PAC) hosted a reception where Sen. Ron T Johnson (R-WI) spoke of his support for the natural products industry. The NPA PAC is currently the largest PAC of any trade association in the natural products industry. On the day of the event attendees met directly with lawmakers and congressional staff from their districts and states to educate them on the natural products industry and current issues. During these meetings attendees shared position papers provided by NPA to make certain offices were fully informed on the current issues in the industry and on the health and economic benefits of natural products. Additionally legislators and staff also learned about a grassroots campaign that NPA is currently running regarding the Health Savings Act of 2016 which would allow reimbursement for dietary supplements through Health Savings Account (HSA) and Flexible Savings Account (FSA). The day on Capitol Hill concluded with a Congressional reception held in the Dirksen Senate Office Building. The more voices we have advocating for the natural industry will make our efforts even more successful and our industry stronger said Fabricant. NPD is a successful day for our industry but it shouldn t stop there we need everyone to maintain communication with their senators and representatives and keep them informed on the current issues. For more information visit www.npainfo.org. AstaReal Announces Corporate Reorganization s of April 1 AstaReal Inc. (Burlington NJ) and AstaReal Technologies Inc. (Moses Lake WA) have formally merged into one fluid singular entity AstaReal Inc. Previously functioning as separate but related companies AstaReal Inc. focused on sales and marketing while AstaReal Technologies established in 2014 concentrated on the U.S. cultivation and production of AstaReal brand astaxanthin (Haematococcus pluvialis). National Sales Manager Joe Kuncewitch expressed the positive outcome of this move. This is an exhilarating time to be part of the AstaReal group of companies he enthused. This merger of respective forces firmly establishes AstaReal as the largest producer of natural astaxanthin in the world and solidifies our position as the absolute global leader of astaxanthin research and development. A Integrating our state-of-the-art manufacturing facility in Moses Lake WA with the sales and marketing arm into one entity helps us to focus on our customer needs in a concerted manner by finetuning their specific requirements with great speed and exceptional attention to detail added Dr. Arun Nair president of AstaReal. This is part of our global strategy to maintain effective leadership of astaxanthin in the United States and rest of the world. AstaReal was the first company to commercially cultivate Haematococcus pluvialis algae for human use as dietary supplements in 1994 and the company has since grown to be the largest producer of natural astaxanthin in the world with two state-of-the-art algae production facilities (Moses Lake WA and Gustavsberg Sweden). For more information visit www.astareal.com. Nutrition Industry Executive 17 May 2016 www.niemagazine.com IndustryNews Cypress Systems Signs Distributor Agreement with AIDP ypress Systems Inc. a privately held California corporation and manufacturer of SelenoExcell Chromium GTF Excell and the NutraFeast line of nutritional yeast products has signed a sales and marketing distribution agreement with functional ingredients distributor AIDP (City of Industry CA). Under this agreement AIDP will market and sell the full line of branded ingredients including SelenoExcell and Chromium GTF Excell to the functional foods and nutraceutical industries. Cypress Systems SelenoExcell High Selenium Yeast is supported by a Clinical Trial Agreement with the Division of Cancer Prevention at the National Cancer Institute and has been the sole intervention agent in a C series of cancer prevention and health related trials. The addition of SelenoExcell and the other food forms of organically bound mineral products will further enhance AIDP s position in providing functional food solutions to food beverage and dietary supplement manufacturers. AIDP is constantly striving to develop partnerships with like-minded ingredient companies who are committed to supplying dietary ingredients backed by the highest standards in science quality and customer service which we can offer to our customers. As the mineral dietary market insists on higher quality standards for organically bound minerals the unique range offered by Cypress will be a great addition to our brand- ed mineral range said Mark Thurston president of AIDP. We re thrilled to partner with Cypress Systems whose long history in the functional ingredients space and goals for the future are well aligned with ours. We are excited to be partnering with an industry leader such as AIDP added Paul A. Willis CEO of Cypress Systems Inc. We believe Cypress Systems rich history with gold standard clinical research coupled with the market leadership of AIDP will make a powerful team in which the industry can place their full confidence. For more information visit www.selenoexcell.com or www.aidp.com. You reHired Utah-based BrandHive a full-servheadquarters in Carol Stream IL. joined Cypress Systems in 2015 as a ice strategic-branding PR and social Staack has more than 25 years of subcontractor to develop and exemedia agency has hired Shilpa experience in the nutrition industry cute social media platforms for the Gauba as its social media and blogand specializes in identifying innovacompany and now oversees marketger outreach strategist. Shilpa has tive and new emerging technologies ing and business development. more than 12 years of corporate as well as launching science-backed AstaReal Inc. (Burlington NJ) has marketing experience along with 10 products to the functional beverage announced two appointments. Dr. years in developing and executing dietary supplement and functional Arun Nair has been named president integrated online and social media foods industry. of AstaReal Inc. He had previously marketing initiatives. Essential Formulas Incorporated served as president for AstaReal AB Nutrition 21 LLC (New York NY) (EFI Irving TX) named Brian Gustavsberg Sweden. He has announced that Sara O Brien has Craig as its director of stratewill now lead both cultivajoined as general counsel of JDS gic affairs. Previously the vice tion production and sales Therapeutics and its wholly owned president of business develand marketing efforts to fulsubsidiary Nutrition 21. O Brien joins opment at Xlear Inc. Craig fill growing demand for Nutrition 21 after working in will help steer astaxanthin-based supplethe intellectual property Essentials Formulas ments and functional foods departments of Willkie Farr & continued growth with and beverages. Gallagher and Ropes & Gray a focus on building In addition nutraceutical Michelle where she most recently spebrand preference iniingredient sales veteran Jenkins cialized in patent litigation. tiating integrated marMichelle Jenkins was named Prinova has announced keting strategies and advisas West Coast manager. Jenkins was the hiring of Richard Staack ing on regulatory matters. most recently West Coast sales manRichard PhD MBA as vice presiCypress Systems Inc. a priager for Blanver. At AstaReal Inc. Staack dent research and commervately held California her territories include the entire cial development. Staack will join Corporation announced that Pacific Coast states west of the Prinova s extensive innovation and Kimbirly Orr has joined the firm to Rockies parts of Texas as well as key product development team and be further develop their growing sales clientele interspersed throughout the based at the company s corporate and marketing strategy. Orr initially region. 18 Nutrition Industry Executive www.niemagazine.com May 2016 Go to www.niemagazine.com comar for info about this advertiser IngredientNews Fruit d Or Supports Cranberry Supplier Testing Program he industry s first-ever cranberry supplier quality program Cranberry Quality Assurance (CQA) based in Canada was introduced by both Stephen Lukawski vice president of RS Specialty Ingredients and leading experts in the nutraceutical industry to ensure ultimate consumer safety in the widening variety of natural whole food cranberry and cranberry juice supplements aimed at urinary tract oral and gut health. According to Lukawski a veteran in the cranberry industry for more than 15 years the CQA is a supplier program that sets new quality standards and assures the cranberry powder being sold has been tested for identity safety purity and efficacy. The objective is to provide cranberry powder that contains the highest standard of quality that protects the industry stakeholders along with the T health and wellness of consumers setting the bar for long-term success of this nutraceutical ingredient Lukawski said. Under this supplier testing program the whole-food cranberry and juice powder submitted will undergo the following tests 1. Fingerprint analysis for identification via MALTI-DOF 2. DNA sequential bar coding for authenticity 3. Analysis for adulteration via MALTIDOF 4. Standardization of biomarkers such as proanthocyanidins (PACs) 5. Anti-adhesion testing to establish efficacy Lukawski noted that the supplier-testing program would include the use of the colorful CQA logo to showcase that the cranberry material used has passed all five steps. When consumers see the CQA logo and the support of manufacturers they will recognize a seal that guarantees that both the supplier and the manufacturer has done their due diligence to provide safety purity and efficacy Lukawski said. He also emphasized the importance of this program in light of cranberry product coming in offshore that has been adulterated with a disparate variety of other ingredients such as grape and peanut skins plum and black bean in order to increase PACs. This program changes the landscape of how cranberry whole food material-- and others--can be sold in the future the company stated. We also hope this program will be a template for other botanicals Lukawski concluded. For more information visit www.crannaturelle.ca. Orgen-C Now GRAS Self-Affirmed AlgaeLife Successful alifornia-based NDI Petition With FDA Orgenetics Inc. is pleased to announce that Orgen-C which is 100 percent USDA certified organic and all natural vitamin C from organic amla fruit extract is now GRAS (generally recognized as safe) self-affirmed. Orgen-C is standardized to 50 percent natural vitamin C with the remaining 50 percent being the same amla fruit extract that contain important co-factors and co-nutrients such as non-citrus bioflavonoids and polyphenols. Introduced in 2007 as the first in the line of Orgen brand ingredients Orgen-C has made ripples in the nutrition industry as the first 100 percent USDA (U.S. Department of Agriculture) certified organic vitamin the company said. It remains to this day the only 100 percent USDA organic vitamin C completely water extracted from organic amla fruit with no synthetic solvents excipients carriers or any filler material. The GRAS self-affirmation status may open Orgen-C to new food and beverage industries the company said. For more information visit www.orgenetics.com or www.orgenfamily.com. C alifornia-based Algae Life Sciences Inc. (AlgaeLife) a subsidiary of BGG announced that it has successfully petitioned the U.S. FDA (Food & Drug Administration) with a new dietary ingredients notification (NDI) for its flagship product AstaZine Natural Astaxanthin. We are happy to have received a letter of acknowledgement without objection from FDA for our flagship product AstaZine Natural Astaxanthin which is derived from microalgae that we carefully cultivate in fully closed glass tube photobioreactors (PBRs) free from contamination said Joe Huff CEO of AlgaeLife s U.S.-based operation. Although we are not the first company to receive an NDI notification for natural astaxanthin this NDI reinforces our commitment to provide the supplement industry with high quality ingredients that you can trust. AlgaeLife produces AstaZine in a variety of forms including organic certified 5 percent powder 5 percent 10 percent and 20 percent oleoresin 2 percent water-soluble powder 2.0 percent and 2.5 percent microencapsulated beadlets. For more information visit www.algaelifesciences.com. C First Product Launch Based on Probi FerroSorb he launch of Probi J rn marks the beginning of products based on the Probi FerroSorb platform. Probi J rn was launched in Sweden by Probi s partner Bringwell a market leader in probiotic supplements. Probi J rn was launched in February in pharmacies in Sweden and is the latest addition to Bringwell s probiotic product range. Bringwell has a 52 percent market share of the probiotic supplement market in Sweden and the existing range includes products based on Probi s platforms Probi Digestis (gastro T health) and Probi Defendum (immune health). The launch of Probi J rn will expand the probiotic offer reach new target groups and strengthen Bringwell s position in the market the company said. Probi J rn is a dietary supplement in the form of vegetable capsules containing a combination of the clinically documented lactic acid bacteria LP299V vitamin C folic acid and a carefully balanced amount of iron. One capsule daily together with the main meal will help meet daily iron requirements while mini- mizing the amount of unabsorbed iron in the intestines the company said. Unabsorbed iron in the intestine is associated with strong digestive discomfort. Probi J rn is targeting women at risk of iron deficiency. According to WHO (World Health Organization) about 20 30 percent of women of childbearing age suffer from iron deficiency with symptoms such as fatigue shortness of breath poor immune function and impaired cognition. For more information visit www.probi.se. www.niemagazine.com May 2016 20 Nutrition Industry Executive PLT Launches Water-soluble Form of 5-LOXIN ew Jersey-based PLT Health Solutions Inc. announced the introduction of a water-soluble version of the company s best-selling 5LOXIN for joint health support. Called AquaLOX the new ingredient is a potent Boswellia serrata extract documented to have a similar pharmacokinetic profile to 5-LOXIN which has been clinically demonstrated to improve joint comfort and protect against cartilage degradation. In addition to being water-soluble AquaLOX represents a major breakthrough with its pleasant taste profile allowing for the first time the use of Boswellia serrata extract for taste-sensitive formulations such as chews gummies stick-packs shots and more the company said. The technology to manufacture this pleasant-tasting water-soluble version of Boswellia serrata has been more than five years in development. According to Seth Flowerman executive vice president at PLT Health N Solutions the development of AquaLOX was driven by a market looking to bring the efficacy clinical support and brand recognition of 5-LOXIN to a broad new range of product types. 5-LOXIN is a market leading jointhealth ingredient available in well over a hundred consumer products on the market today Flowerman said. In a market that demands convenience and novel delivery systems all boswellia extracts were limited because of the challenging taste profile and lack of solubility--and the technology needed to achieve this was tricky. With AquaLOX we are finally able to deliver on our customers wish list and extend the 5LOXIN franchise to a whole new range of products. In a recent human study 5-LOXIN daily provided improvement in joint comfort and mobility within seven days. Daily consumption provided significant benefits in WOMAC VAS and LFI standardized testing methodologies for joint health 5-LOXIN was also shown to significantly inhibit matrix metalloproteinase (MMP-3) enzymes that break down cartilage and connective tissues. 5-LOXIN inhibits an enzyme called 5lipoxygenase. 5-LOX inhibitors follow a distinctly different pathway than COX-2 inhibitors and while both are involved in the breakdown of arachidonic acid 5LOX inhibitors do not exhibit the potentially negative effects that have been associated with COX-2 inhibitors. 5LOXIN is a selective non-redox 5-LOX inhibitor which means that its action is very targeted. Safety for 5-LOXIN is supported by historic usage published human studies and extensive safety and toxicity studies. For more information visit www.plthealth.com aqualox. Probio Stick Earns Health Claims in Canada anada-based Lallemand Health Solutions announced that its probiotic formula Probio Stick (association of Lactobacillus helveticus Rosell52 and Bifidobacterium longum Rosell175 in a stick format) has been recognized by the Canadian Health Authorities for its benefits on stress anxiety and mood balance becoming the first and only probiotic with approved health claims in the gut-brain axis area. C The Natural and Non-prescription Health Products Directorate (NNHPD) the regulatory agency for natural health products in Canada has approved the following new strong claims for Probio Stick (Claim NPN 80021343) Helps to moderate general feelings of anxiety Promotes a healthy mood balance Helps to reduce stress-related gastrointestinal complications such as abdominal pain May 2016 www.niemagazine.com Helps to reduce gastrointestinal complications like abdominal pain and nausea in healthy people experiencing mild to moderate stress Helps to reduce gastrointestinal discomfort (e.g abdominal pain nausea vomiting) in those experiencing mild to moderate stress resulting from life events (e.g academic exams). These specific claims come in addition to previously approved claim Helps to reduce stress-related gastrointestinal complications like nausea and generic probiotic claims ( Probiotic that contributes to a natural healthy gut flora and Probiotic to benefit health and or to confer a health benefit. ) Solange Henoud regulatory affairs manager Americas for Lallemand Health Solutions said This recognition is based on a strong clinical and pre-clinical dossier examining the interactions of our probiotic with the brain-gut axis or second brain an area of growing interest for the scientific community and consumers alike and for which we have been dedicated research efforts for nearly a decade. This lead to the publication of the first clinical study evaluating probiotics benefits on psychological symptoms of stress and anxiety as early as 2010. For more information visit www.lallemand-health-solutions.com. AstaReal Adds More Kosher Products ew Jerseybased AstaReal Inc. announced that its parent company Fuji Chemical Industries Co. Ltd (Japan) is expanding its line of kosher products. On January 7 2016 Fuji received its kosher certificate from the certifying body KLBD (London Beth Din Kashrut Division) which listed AstaReal P2AF (2 percent cold water dispersible powder) as one of the certified products. AstaReal P2AF is ideal for tableting two piece hard capsules and powder pre-mixes for beverage formats. This kosher certification solidifies AstaReal s promise to provide high-quality products the company stated. Joe Kuncewitch national sales manager of AstaReal Inc. said AstaReal is once again showing our commitment to providing the most certified natural astaxanthin available to our customers. We take pride in knowing that what we offer each day is not only the highest quality astaxanthin on the market but also the most highly regarded astaxanthin. For more information visit www.astarealusa.com. N Nutrition Industry Executive 21 IngredientNews Ingredion s Q NATURALE Emulsifier Approved for Use in Canada ngredion Incorporated (Westchester IL) a global provider of ingredient solutions to diversified industries announced that Health Canada has granted approval of its quillaja extract (type 2) as an emulsifying agent for oil-based coloring formulations unstandardized oil-based flavoring preparations and other unstandardized oil-based ingredients that are used in a number of foods and beverages. Effective immediately quillaja extract (type 2) has been added to Health Canada s List of Permitted Emulsifying Gelling Stabilizing or Thickening Agents. Previous to this approval quillaja extract was only permitted as a foaming stabilizing agent in beverages. Known as Ingredion brand QNATURALE derived from the quillaja trees grown in Chile this highly efficient clean label emulsifier can replace alternative emulsifiers such as gum Arabic the company said. This authorization is exciting news because it enables us to extend the unique benefits of Q-NATURALE emulsifier beyond the U.S. and Europe said Dinah Diaz senior marketing manager at Ingredion. We are eager to demonstrate the excellent emulsification capabilities of this clean label emulsifier to our customers in Canada. Q-NATURALE emulsifier can be used in a variety of foods and beverages to improve emulsification capabilities and efficiencies including beverage products flavor concentrates chewing gum gravies and sauces snack foods soups and more. The emulsifier is ideal for use in flavor emulsions and beverage clouds which are formulated in a variety of sparkling and still beverages with actives intense flavors and vibrant colors. Because of its unique functionality the emulsifier also enables a high oil load that produces brilliant clarity in clear beverages and alcoholic drinks. For more information call (866) 961-6285 or visit www.ingredion.us. PreticX Significantly Improves Beneficial Gut Flora alifornia-based AIDP commented on a double-blind randomized placebocontrolled study conducted by researchers at the University of California Los Angeles (UCLA) published in the Frontiers of Physiology which shows that daily doses as low as 1g of PreticX a XOS (xylooligosaccharide) significantly modified gut microbiota helping to grow more species of good gut bacteria and reduce bad bacteria in both healthy people and those who are over weight with unhealthy blood glucose levels. For consumers this emphasizes a critical need for the development of products for healthy digestion focusing on prebiotic fibers to create a new generation of foods and supplements giving optimal digestive support. According to Jennifer Gu PhD AIDP s vice president of research and development people who have abnormal glucose levels showed a different gut microbial population as compared to normal people. PreticX significantly modified gut microbiota in both healthy and over-weight subjects and resulted in dramatic shifts of four bacterial taxa (populations of organisms) associated with people who had abnormal glucose levels. It is important for consumers to understand that having good gut flora is an important part of a healthy digestive ecosystem but one must feed the good gut microbes with prebiotics such as PreticX in order to receive the maximum health benefit Gu said. Advancing scientific research continues to demonstrate that balanced gut microbiota is essential for digestive function and that an unhealthy balance in the gut is a precursor to digestive issues and immune dysfunction. For more information visit www.aidp.com. I C Launch of Viralex Soothe EpiCor Throat Lozenges owa-based Embria Health Sciences a provider of dietary supplement ingredients to the global marketplace and Good Health Products New Zealand jointly announced the launch of Viralex Soothe EpiCor Throat Lozenges into health stores and pharmacies throughout New Zealand (NZ) in April 2016. This is the first lozenge formulated with EpiCor yeast fermentate. EpiCor is widely available throughout the world and is clinically shown to support a strong immune system the company said. We have already been using EpiCor in our Viralex Attack capsule product in our winter immune range from the last winter season 2015 said Julia Van De I Coolwijk of Good Health. We had such a positive response from consumers on the effectiveness of the product and have grown dollar sales by over 65 percent and unit sales by 74 percent in NZ Pharmacy. We wanted to leverage the success of EpiCor by providing this unique ingredient in a different format and to specifically target a different cold and flu symptom--sore throats. We have also developed this product to be complementary to our existing Viralex range. According to Van De Coolwijk EpiCor provides a differentiated product by being natural and fast acting. It was also an effective material for making into a high boil lozenge and with exclusivity in the NZ market it provides the company with an ingredient that enables a strong and unique point of difference from competitors. Jeff Cannon CEO of Embria s parent company Diamond V said These new lozenges open up a new and exciting product form for EpiCor. For more information visit www.epicorimmune.com www.embriahealth.com or www.goodhealth.org. www.niemagazine.com May 2016 22 Nutrition Industry Executive Go to www.niemagazine.com euromed for info about this advertiser IngredientNews BLIS M18 May Increase Chances of Avoiding New Dental Caries ew Zealand-based Blis Technologies and Missouri-based Stratum Nutrition announced a new clinical study on the effects of oral-cavity probiotic BLIS M18 (Streptococcus salivarius) on the development of dental caries in children. The study was published in Clinical Cosmetic and Investigational Dentistry and represents one of the pioneering attempts to analyze the significance of BLIS M18 in dental practice. The results show that BLIS M18 significantly improves the chances of avoiding new dental caries. This new randomized controlled study on BLIS M18 was conducted on 76 children between the ages of 6 and 17 that were classified as high-risk for dental caries on the basis of Cariogram results. Cariogram is a well-recognized clinically proven software program that looks at different caries-related risk factors to aid clinicians in performing consistent dental caries risk assessments. Thirty-eight subjects (half) were supplemented for 90 days with a formulation containing the N oral cavity probiotic BLIS M18 while the other half served as the control group receiving no treatment. The study found that after 90 days of treatment with BLIS M18 there was a statistically significant reduction by more than 30 percent in the global Cariogram outcome including parameters of plaque amount (50 percent reduction) and mutans streptococci (75 percent reduction). These decreases are likely to be a direct consequence of the BLIS M18 bacteriocins interactions with mutans streptococci as well as M18 s ability to colonize in the oral cavity and produce the beneficial enzymes dextranase and urease which are able to counteract plaque formation and saliva acidity. There was no statistical difference observed in the control group. BLIS M18 also demonstrated a very good safety profile with no treatment-related side effects as found in previous clinical trials. Using an objective caries-risk assessment algorithm previously validated in children young adults and seniors the investigators have found that dietary sup- plementation with BLIS M18 significantly increases the chances of avoiding dental caries in the coming year in children diagnosed as high-risk said Dr. Joseph Evans executive manager of research and development for Stratum Nutrition. Although requiring confirmation in a larger controlled trial with development of caries as the primary outcome measure these results suggest that BLIS M18 has the potential to complement a diligent oral hygiene program and nutritionally balanced diet in the ongoing battle against tooth decay. For more information visit www.stratumnutrition.com or www.blis.co.nz. New Publication on Univestin ashington-based Unigen Inc. published a study showing Univestin has no adverse effects on the cardiovascular respiratory and central nervous systems. Univestin has been available in the joint health supplement space through many finished products for more than 10 years and have conducted more than 15 studies ranging from discovery to human clinical trials. Unigen s commercial partners have also conducted their own studies during that time. In this new publication Unigen took a more specific look at Univestin s effect on the cardiovascular respiratory and central nervous systems. In continued support for the third prong of the Univestin triple play Long-Term Safety the study found no adverse effects on these systems at levels much greater than suggested serving size for human consumption. R. Grant Bergstrom vice president of sales & marketing said This is yet one more step in the journey of fulfilling our mission of Bringing the best of nature to humankind. We don t launch an ingredient and then count our work as done. We continue to support these products and our partners through continued research and marketing. The article has been published in Regulatory Toxicology and Pharmacology Issue 77 pages 184-191. For more information visit www.unigen.net. W Chemi Nutra Announces Water Dispersible Phospholipid Compounds exas-based Chemi Nutra announced the introduction of novel water dispersible specialty phosphatidylserine (PS) and phosphatidic acid (PA) phospholipid ingredient compounds for use in applications including beverages RTDs shots and gels while providing documented unique health benefits. SerinAid Disperse 3.0F contains Chemi s patented water dispersible PS notable as PS is considered one of the safest most scientifically studied natural compounds for maintaining and improving cognitive abilities--concentration learning memory recall and focus--as well as benefiting dementia mood stress and behavioral attention deficits. PS has been granted two qualified health claims by the FDA (U.S. Food and Drug Administration) related to cognitive dysfunction and dementia in the elderly. Mediator Disperse 7.5F contains Chemi s patented water dispersible PA scientifically proven to significantly activate the mechanistic target of rapamycin (mTOR) signaling pathway which in turn regulates both muscle protein synthesis and muscle protein breakdown in essence providing increased muscle mass T and strength gains to individuals engaged in muscle stressing type exercise. These specialty water dispersible compounds were developed in collaboration with 3i Solutions based in Ohio a leader in ingredient nanodispersion technology. About 20 years ago we began working with 3i Solutions to perfect a stable highly bioavailable water dispersible liposomal PS said Scott Hagerman president of Chemi Nutra. With 3i Solutions demonstrated capabilities and our combined application knowledge in functional drinks we are very excited that SerinAid Disperse PS and Mediator Disperse PA can now be easily and effectively added to functional beverages a rapidly evolving segment in the functional foods and sports nutrition arenas. Charles Brain president of 3i Solutions said We are excited that 3i Solutions can offer our long history of expertise in nanodispersion technology in the functional beverage and RTD arenas. For more information visit www.cheminutra.com. 24 Nutrition Industry Executive www.niemagazine.com May 2016 Go to www.niemagazine.com igy for info about this advertiser AssociationNews AHPA Appoints Robert Wildman to Chair Sports Nutrition Committee he American Herbal Products Association (AHPA) appointed Dr. Robert Wildman chief science officer at Post Active Nutrition Brands as the new chair of the Sports Nutrition Committee during a meeting at Natural Products Expo West in Anaheim CA. Wildman succeeds Ray Jaglowski vice president of technical and regulatory at Twinlab Corp. who chaired the committee for the past two years. AHPA s members have greatly appreciated Ray s leadership and contributions to the sports nutrition industry and to AHPA over the past years said AHPA President Michael McGuffin. We are looking forward to working with Rob and thank him for his willingness to assume leadership of the committee. We expect AHPA and the sports nutrition industry to benefit from his extensive experience. Wildman is the author of four books T including Sports & Fitness member of the Academy of Nutrition & Dietetics (AND) Nutrition and The and the National Strength & Nutritionist Food Nutrition Conditioning Association & Optimal Health. He has (NSCA). He is a registered also written more than 75 and licensed dietitian and referred journal articles has worked with hundreds of chapters and abstracts on athletes at every level and nutrition performance and serves as adjunct research health aspects. He is the crefaculty in the Department of ator of TheNutritionDr.com. Robert Wildman Human Nutrition at Kansas The regulated sports supState University. plement industry is rapidly growing and AHPA s Sports Nutrition Committee is evolving creating exciting new opporcomprised of more than 30 companies tunities and challenges Wildman said. and was chartered in 2010 to promote I look forward to working with AHPA the responsible commerce of products and its sports nutrition members to help marketed for sports nutrition. Under ensure the responsible commerce of Jaglowski s leadership the committee sports supplement products and meet consumer demand for high-quality prod- developed a guidance policy adopted by AHPA in 2014 for the labeling of proucts. tein in food and dietary supplements. Wildman is also an advisory board For more information visit member and fellow of the International www.ahpa.org. Society of Sports Nutrition (ISSN) and a Conventions&Meetings 16th Annual ISCB & 5th Interim ASP Meeting T Go to www.niemagazine.com somalabs 26 Nutrition Industry Executive he 16th Annual ICSB (International Conference on the Science of Botanicals) & 5th Interim ASP (American Society of Pharmacognosy) Meeting was held on April 11-14 2016 in Oxford MS. This was a full joint meeting of the ASP and the ICSB. With the help of the Oxford Conference Center the conference consisted of both social and entertainment activities that ran alongside the rich and informative scientific agenda. This year s meeting explored the topic of synergy between natural products and human health. To this end the conference will review discuss and explore the confluence of current research topics related to natural products research and development as well as topics related to safety quality and regulatory aspects. Attendees were able to hear from a line-up of worldrenowned speakers including keynote speaker Larry Walker director of the National Center for Natural Products Research (NCNPR) University of Mississippi Steven Musser deputy director for scientific operations CFSAN Nakissa Sadrieh director cosmetic division U.S. Food & Drug Administration (FDA) among others. Attendees also had the opportunity to gain a perspective on developments in natural products and botanicals with a focus on current trends including regulatory aspects find out the latest research and interact with researchers during a large poster session and establish collaborations between universities and research institutes and industry. For more information visit www.oxfordicsb.org. www.niemagazine.com May 2016 ScienceUpdate Adherence to Nutrition Recommendations Use of Supplements Essential for Vegans egans adhere to nutrition recommendations in varying degrees according to a new Finnish study. Some vegans who participated in the study followed a balanced diet while others had dietary deficiencies. Typical deficiencies were an unbalanced use of protein sources a low intake of berries fruits and nuts as well as failure to use nutrient fortified food products. The majority however used vitamin B12 and D supplements and calciumfortified drinks as recommended. The findings were published in PLOS ONE. The serum vitamin D concentrations were below the reference values in 24 percent of the vegan group. They also had lower concentrations of beta-carotene selenium iodine and essential fatty acids than the control group following a non-vegetarian diet. According to the researchers the findings highlight the need of vegans to get nutrition guidance and to use the recommended nutrient supplements. Moreover closer attention should be paid to the intake of vitamin D and iodine among vegans. Vegetarian and vegan diets are V increasingly common in Western societies. However in order to ensure the intake of all the necessary nutrients vegetarian and vegan diets need to be composed in a well-rounded manner. Research into the nutritional status of vegans nevertheless remains scarce. The study analyzed the nutritional status of young adults who had been following a vegan diet for an average period of eight years. The study involved six male vegans and 16 female vegans and the matched control group comprised eight men and 11 women who followed a non-vegetarian diet. The researchers were especially interested in the intake and concentrations of nutrients that are limited or lacking in vegetarian foods for example vitamin B12 vitamin D selenium iodine and essential fatty acids. The food intake of the study participants was analyzed from three-day food records and their nutritional status was measured from blood and urine samples. The diet of the vegan group was exclusively limited to plant-based foods and their intake of legumes tofu and soy flour was higher than the control group s but no other significant differences were observed. Nutrient supple- ments were used by 91 percent of the vegan group and 78 percent of the control group. Vitamin B12 supplementation was used by 91 percent of the vegan group vitamin D supplementation by 77 percent and the majority also used calcium-fortified drinks. The vitamin B12 concentrations of the vegan group were within the reference values as were the values of the control group. The serum vitamin D concentrations were below the reference values in 24 percent of the vegan group and in 6 percent of the control group. Vegans also had lower concentrations of betacarotene selenium iodine and the essential EPA and DHA fatty acids. All in all however vegans had higher polyunsaturated fatty acid concentrations and lower saturated fatty acid concentrations than the control group. In addition the concentrations of soy polyphenols were high in vegans. The median concentration of iodine in urine was below the recommended levels in both groups. Earlier research shows that the intake of iodine has decreased in Finland over the past years. Iodine is present in milk and iodine-fortified salt the use of which have declined. For more information visit www.uef.fi en etusivu. Vitamin D Level Body Fat in Newborn Linked to Health Status in Pregnancy oes a newborn s vitamin D level relate to the mother s weight during pregnancy Results from a study published in PLOS ONE provides ample evidence that yes higher body mass index (BMI) in mothers is associated with lower vitamin D levels in their babies. This is a concern since low vitamin D at birth may be associated with reduced bone mineral density in the long term as well as increased risk of allergic disease and obesity. Our study suggests that overweight or obesity in pregnancy is linked to lower vitamin D levels in both the mother and the newborn said Jami Josefson MD endocrinologist at Ann & Robert H. Lurie Children s Hospital of Chicago and assistant professor at Northwestern University Feinberg D School of Medicine. More research is needed however before we can make broad recommendations about the need for greater supplementation of vitamin D for overweight pregnant women. Obesity in pregnancy has become increasingly common. In addition to lower vitamin D levels it has been associated with heavier infants who then are at higher risk for childhood obesity and type 2 diabetes. Currently Josefson and Wendy Brickman MD also an endocrinologist at Lurie Children s are involved in a follow-up to the large international study that discovered the importance of increased maternal glucose level even when it is not full blown diabetes. It was still associated with higher birth weight and body fat in the newborn. The follow-up study at Lurie Children s and nine other centers around the world sets out to see how those kids and mothers fare eight to 12 years later. These observational studies will help us develop and test targeted interventions so we can provide mothers and children the best opportunities for longterm health said Josefson. For more information visit www.luriechildrens.org. Nutrition Industry Executive 27 May 2016 www.niemagazine.com Considering their sharp sensory skills development of natural extracts in forms acceptable to pets is the newest trend. By Janet Poveromo T he emphasis on pet health has always been high with more consumers taking that extra step to maintain the good health of their companion animals and protect them from environmental stress. And the pet has a say on which healthy foods treats and supplements they are willing to consume. Shaheen Majeed marketing director with Sabinsa Corp. in Utah (with offices in New Jersey) noted that while the pet health industry is growing the use of supplements has recently become more widely accepted. According to Pet Supplements in the U.S. Edition 5 market research a compound annual growth rate of 3.7 percent has been observed between 2010 and 2014 thus increasing the supplement market to 541 million USD in 2014. There is a 28 Nutrition Industry Executive demand for natural ingredients with potential benefits that are safe to consume in different dosage forms Majeed said. It makes a lot of sense that powders pastes gels and liquids would be more popular dosage forms as anyone who has tried to get their dog or cat to swallow pills would attest. Bill Bookout president of the National Animal Supplement Council a non-profit trade association said the council s focus is animal supplements similar to dietary supplements for people. These products help improve the quality of life for dogs cats and horses. Animal supplements oftentimes mimic trends in human supplements and can provide support as a component to a complete nutritional diet or a specific health issue. The industry is growing between 4 to 7 percent each year from various market research groups who publish data on the topic and there is an increasing consumer focus on natural organic and non-GMO (genetically modified organism) products he noted. Steve Peirce president of RIBUS Inc. in Missouri agreed that the pet market is growing nicely and on how it is happening. The human influence is strong in the pet treat industry particularly in key areas such as clean labels which addresses which ingredients to avoid texture feel in the hands etc. while the pet has input in the area of consumption he said. In the area of nutrition Peirce noted many contract manufacturers of human dietary supplements are also producing pet supplements because www.niemagazine.com May 2016 they are made with human-grade ingredients. There is a strong convergence in the nutrition sector. According to Peirce RIBUS s sales increased more than 50 percent in the pet nutrition (pet supplements with Nu-RICE and NuFLOW) sector during 2015 but it is difficult to separate the human sales vs. the pet sales he said. Evolving Market There has been a dramatic increase in interest in organic pet snacks supplements and food over the last several years similar to the growth of the organic human food industry according to Peirce. Majeed added that animal health aside from what they are genetically predisposed by breed is largely dictated by the food and nutrients they ingest the amount of exercise they get and the toxins to which they are exposed. It is logical that the higher the nutritional quality of food the healthier the animal. Recently people have started spending more money on their pets than in the past he said. He continued Functional supplements are targeted to many of the conditions humans themselves address such as allergies digestive disorders joint health inflammation stress and heart health. As consumers become more used to using supplements for their own health the natural progression is for them to extend that to their families including the furry ones. Bookout confirmed that products that help maintain joint health probiotics omegas and immune support and GI (gastrointestinal) health all remain strong and added that on the dog and cat side equally as important as the product category is the delivery system and palatability. You can have the greatest product in the world and if you cannot get the animal to accept the product readily then the consumer won t continue to buy it. Soft chews and other innovative delivery systems with optimum palatability are increasing he added. approach hits two key areas the consumer is looking for. Peirce noted that bone joint dental tooth coat and skin health are strong categories that are medically related. Products for pet weight management and aging are supporting categories. Not only is natural important for pet owners but phytonutrients with adaptogenic benefits probiotics and micronutrients used to supplement dietary sources are being sought to help improve resistance to oxidative stress and enhance pets quality of life during aging. Natural supplements are preferred by consumers and holistic veterinarians Majeed said and explained Supplements may complement medications by helping reduce the dosage of primary medication and by giving a synergistic effect. Sabinsa offers the following ingredients to improve pet health and Majeed said the company is seeing a lot of interest in all of them LactoSpore VG Shelf stable probiotic of Bacillus coagulans that produces L( ) lactic acid. It plays an important role in balancing the gastrointestinal microflora and offers immunomodulatory effect. Boswellin VG Extracted from the gum resin of Boswellia serrata. It significantly reduces severity of joint inflammation. Curcuminoids VG Standardized extract from the rhizomes of Curcuma longa Curcuminoids VG is a unique composition of three curcuminoids mainly curcumin bis-demethoxy curcumin demethoxycurcumin. Curcuminoids are well recognized to have antioxidant anti-inflammatory immunomodulatory and wound-healing potential. VetZyme Sabinsa s proprietary combination of enzymes that help in proper digestion and better absorption of food. The enzymes include -amylase neutral protease lipase cellulose and lactase. VetPerine Enriched from fruits of Piper nigrum and standardized to contain 95 percent piperine VetPerine is used as a potential bioavailability enhancer. Ongoing research in the field of pet Organic Pet Food Standards I Leading the Category On the pet side noted Bookout the delivery system is especially important for dogs and cats because owner compliance is highly driven by acceptance from the animal. Companies such as Kemin Nutrisurance have concentrated on palatant products that meet the acceptance levels of the pets while still complying with natural guidelines. This May 2016 www.niemagazine.com n 2008 the National Organic Standards Board (NOSB) approved a recommendation for organic standards specific to pet food. The recommendation aimed to align pet food composition and labeling with the USDA (U.S. Department of Agriculture) organic regulations U.S. Food and Drug Administration requirements and state pet food regulations. The NOSB recommendation was enabled by the work of the Pet Food Task Force which included individuals from pet food manufacturing organic consulting and federal agencies. The pet food industry and other organic stakeholders eagerly await standards providing clear and consistent composition and labeling requirements for organic pet food. The National Organic Program (NOP) has prioritized the completion of this rulemaking which includes completion of an economic impact statement. NOP is scheduled to release a proposed rule and open comment period in the foreseeable future. The Organic Trade Association (OTA) will continue to monitor the process and engage members in the comment process as soon as the proposed rule is released. (See more at www.ota.com what-ota- does public-policy organic-standards emerging-standards pet-food sthash.nrnzfgtv.dpuf). Currently organic pet food producers are using the human food standards for organic. This works for the most part said Gwendolyn Wyard OTA s senior director of regulatory and technical affairs but the problem is the allowance for vitamins and minerals. It s specific for human fortification and these [NOSB recommended] pet food standards will be specific to the needs of pets versus people. Rules for Origin of Livestock Animal Welfare Standards and Pet Food all of which are being decided--together will provide greater clarity for organic livestock product and organic pet food. With actual standards for pet food the organic livestock sector may see growth in organic pet food and enhanced market opportunities for producers Wyard said. Nutrition Industry Executive 29 nutrition Majeed said will offer new products in the future that will find applications for reducing stress from which companion animals suffer as much if not more than their human family members and offer antimicrobial benefits. Continued research also supports the functional benefits of various ingredients noted Bookout. People are very familiar with ingredients like glucosamine and chondroitin however new ingredients like hyper-immunized egg marketed as Immuflex from Trouw Nutrition would be one example of new ingredient innovation backed by science he added. In the area of palatability and preservation there are developments that are natural mold inhibitors which is part of new research Kemin Nutrisurance is testing. RIBUS s focus is on rice hulls and bran which are being used in place of chemicals such as magnesium stearate monoglycerides and silicon dioxide. of certain ingredients (such as magnesium stearate monoglycerides and silicon dioxide). I am seeing more grainfree products which is a big change from the past focus on rice and lamb products. People want to move away from grain as a filler. This is where RIBUS provides grain extracts as functional alternatives to chemistry lab sounding ingredients. Peirce also pointed out that organics are growing rapidly in the pet arena. This is driven by the human involvement and desire for clean labels non-GMO traceability and desire for fewer chemicals in their pet s food. You could have a great product and great ingredients but if the pet does not like the taste the consumer will not continue buying. -- Bill Bookout President National Animal Supplement Council cows horses and so on by regulatory bodies he continued. Even studies on experimental animals like rats rabbits mice and guinea pigs are banned. Hence fixing the dosage in the absence of such studies is a challenging task. Sabinsa s products for pets are based on ayurvedic medicine having 5 000 years of historical usage including use on animals. They have been thus been found safe to use in pets. He noted that dosage forms that are in the form of treats that animals find tasty is far better for compliance than pill forms that may be difficult to administer. Peirce addressed the dosing of medical-related products. We are focused on nutrition treats and some pet foods. But for administering pills one creative dosing aid is the soft pill pocket--a small-formed soft treat that you can drop a pill into and the pet consumes it with no difficulty. RIBUS Nu-RICE (rice extract) is a perfect product to aid in the forming of the pocket and to help keep it soft over time until it is used. Food Safety and Pet Food The biggest news affecting pet food according to Bookout is the implementation of the Food Safety Modernization Act (FSMA) and larger companies are in the process of meeting the FSMA requirements. FSMA really goes further than the requirements for human dietary supplement products focusing more on complete and total supply chain management which is a good thing he said. NASC has specifically made it a priority to stay ahead of the regulatory curve and our Preferred Supplier Program was implemented to address qualifying and differentiating quality suppliers while at the same time addressing the cost of quality. The real question is how much quality is the consumer willing to pay for. NIE Trends to Bark About Animal supplement trends typically follow trends of humans however Bookout said they are somewhat lagging. I think overall consumers are becoming increasingly informed and educated about product quality and what products contain. You can also see similar trends driving the market toward more premium and super premium diets as well. Having said this and while education is certainly a key effectively reaching the consumer with accurate and correct information is sometimes challenging. He added that people should not believe everything they read on the internet. Offering nutritional benefits to pets in dosage forms readily acceptable by them is a challenge in the industry Majeed said. Plant extracts come with gritty colors and odors. With very sensitive and sharp sensory skills pets do not accept natural extracts very easily. Development of natural extracts in forms acceptable to pets and fortification of pet foods is the newest trend. Clean label is huge even for pet foods. Peirce explained This involves transparency traceability and avoidance 30 Nutrition Industry Executive Dosing and Delivery The delivery system for pets is extremely important said Bookout And at least as important of the function and benefits of the actual product. You could have a great product and great ingredients but if the pet does not like the taste the consumer will not continue buying. Soft chews in the supplement area is increasing in this category and will continue to increase along with other innovative delivery systems on the companion animal side. Offering natural extracts with odors and colors that are acceptable by pets is a challenge Majeed agreed but noted that with more than 25 years of experience in the field of nutraceuticals across the globe ingredients from Sabinsa have been successfully incorporated in a number of formulations. A serious limitation on innovating pet care products is the ban of studies trials on pets like cats dogs Extra Extra Visit www.niemagazine.com to read about Ribus s expansion into the pet category and beyond. FORMOREINFORMATION Kemin Nutrisurance (515) 559-5365 National Animal Supplement Council (760) 751-3360 Ribus Inc. (314) 727-4287 Sabinsa (732) 777-1111 www.niemagazine.com May 2016 ALL SYSTEMS GO The healthy aging market continues to evolve clarify itself and accelerate. By Lisa Schofield A s industries evolve especially those that continue unabated growth in R&D science and consumer demand so too does terminology and the products that represent that terminology. Take healthy aging. Although this term appears nebulous that very characteristic allows for product development flexibility that can reflect research elucidating how the human body responds to the mere act of living. Discussion of how the term is perceived and defined is warranted and recommended before heading into R&D. For the most part the idea of healthy aging means keeping what I have now --whether this is in physical ability mental ability or appearance mused Barbara Davis PhD RD vice president medical & scientific affairs for New Jersey-based PLT Health Solutions Inc. For different individuals the idea of achieving and or maintaining peak performance begins at different ages and is focused on different conditions. S bastien Bornet director of global marketing at New Jersey-based Horphag Research (exclusive worldMay 2016 www.niemagazine.com wide supplier of Pycnogenol) observed that many people now equate healthy aging to looking and feeling one s best through the advanced years of life e.g. enjoying youthful pliable skin being active and feeling a strong sense of wellness amid aging. For an increasing number of consumers healthy aging also means being able to continue to do the things they have done when younger--to age on one s own terms. When it comes to healthy aging he said heart skin joint and cognitive health are all important drivers for consumers that seek natural wellness support. Consumers who want to age well often note the health conditions that can arise later in life and that motivates them to be proactive in preparing for advanced years. For Chase Hagerman brand director Chemi Nutra Texas there is a significant distinction between aging and healthy aging in the minds of most consumers. He believes that if you were to ask people what words come to mind when they visualize the word aging likely the depictions would be slow moving (and driving) hunched over forgetful and wrinkled skin. These characteristics are the antithesis of healthy aging he asserted. Healthy aging is desirable traits such as remaining active fit sharp and youthful. Healthy aging summarized Aparna Kalidindi PharmD BCPS technical sales and marketing manager New Jersey-based Natreon Inc. is the maintenance of optimal physical mental and social functioning in older adults. Eric Anderson senior vice president of global sales and marketing NattoPharma USA Inc. New Jersey agreed noting that the term healthy aging means preserving systemic functioning and preventing acceleration of age-related degradation as proven through long-term research. Harking to the idea of category evolution--a term that is being abandoned by forward-thinking and responsible industry entities is anti-aging. This is also a crucial point moving forward. According to Kalidindi the term healthy aging is a more positive concept suggesting that aging is a natural process. Conversely the term antiaging emphasizes that aging is a race against time. Additionally he said products marketed with that term may Nutrition Industry Executive 31 ALL SYSTEMS GO cause consumers to have unrealistic expectations about the results. Davis agreed The term healthy aging offers more realistic expectations for what consumers can expect in terms of support and endpoints. What this support means varies from person to person and is best thought as peak performance under any set of age health conditions. In the words of John Lennon (who would be 75 now) Well you know ... we re all doing what we can. Hagerman pointed to the prefix anti- ( acting to prevent something ) as unrealistic because aging is inevitable. The more powerful antiaging term might catch the attention of consumers more but the term healthy aging is far more realistic and achievable. Much in the way that many consumers don t trust overhyped products anti-aging has a tendency to over promise and under deliver. ture and lipid metabolism. Combined in Xanthigen they support weight loss as demonstrated by clinical research said Davis. She reported that a clinical trial performed in 151 overweight and obese non-diabetic females that underwent a hypocaloric diet for 16 weeks showed that Xanthigen caused a significant reduction in weight and body fat percentage as compared with placebo. Further analysis revealed statistically significant improvements in blood lipid profiles inflammatory markers blood pressure and waist circumference. The more powerful anti-aging term might catch the attention of consumers more but the term healthy aging is far more realistic and achievable. -- Chase Hagerman Brand Director Chemi Nutra PLT s Satiereal is a patented clinically studied satiety ingredient derived from saffron. Satiereal is thought to work by improving levels of the neurotransmitter serotonin which plays a role in increasing the satiety state while decreasing appetite. Satiereal has been tested in two randomized double-blind placebo controlled clinical trials. One study was conducted with 60 healthy only slightly overweight women (BMI 25-30). Satiereal intake over the eight weeks resulted in a significantly greater body weight reduction than the placebo group. Satiereal decreased snacking by 55 percent compared to a 28 percent reduction in the placebo group. New Jersey-based Pharmachem Laboratories Phase 2 Carb Controller through its mechanism of action of temporarily disabling amylase activity during digestion of meals addresses the healthy support of weight management and blood sugar response. Clinical studies demonstrate that a proprietary white bean extract (Phase 2) has the ability to reduce the post-prandial spike in blood glucose levels. Specialty Ingredients Below are some of the promising ingredients with compelling research that address specific concerns during the aging process. (Note that editorial space prevents the presentation of all relevant ingredients for more suppliers of innovative healthy aging ingredients please refer to Nutritional Industry Executive s Annual Sourcebook.) Experiments conducted incorporating the extract into food and beverage products have found that it can be integrated into various consumables without losing activity or altering the appearance texture or taste of the food. In totality research demonstrates that Phase 2 has the potential to induce weight loss and support healthy blood sugar caused by carbohydrates through its alpha-amylase inhibiting activity. Weight issues compound blood sugar insufficiency as well as cardiovascular status metabolic syndrome often presents in middle age. Annie Eng CEO of HP Ingredients (HPI) in Florida explained a tie-in with metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). NAFLD is a condition that exacerbates unhealthy cholesterol levels blood sugar insufficiency and weight fat accumulation. Evidence shows that NAFLD is often associated with metabolic syndrome (MS) NAFLD has been identified as the hepatic manifestation of MS. In a placebo-controlled trial of 107 patients exhibiting MS and NAFLD those that took 650 mg twice daily of HPI s Bergamonte bergamont polyphenolic fraction (BPF) for 120 days had a significant reduction of serum total cholesterol LDL-C and triglycerides. This effect was accompanied by significant reduction of serum glucose transaminases gamma-glutamyl-transferase steato test and inflammatory biomarkers such as TNF-a and CRP. Weight Metabolic Syndrome It is a known fact that adults begin to slowly pack on pounds starting in their 30s due to biological changes and lifestyles that tend to be more sedentary. Overweight condition can and often does lead to cardiovascular complications and blood sugar insufficiency. PLT Health Solutions Xanthigen supports healthy body weight through the synergistic effects of the natural compounds found in brown seaweed (Undaria pinnatifida) a source of fucoxanthin and pomegranate seed oil rich in punicic acid. Separately the bioactive compounds in these two ingredients target pathways involved in body weight regulation including adipocyte differentiation resting energy expendi32 Nutrition Industry Executive Cardiovascular Health Cardiovascular issues and concerns affecting middle-aged consumers goes beyond blood lipid profiles and several ingredients have been shown to be effective in a potential multi-factorial cardiovascular support formula. For example according to Bornet A study found that a Pycnogenol and coenzyme Q10 (CoQ10) combination (PycnoQ10) naturally strengthens the heart increasing the blood volume ejected with each beat. In addition Pycnogenol has also been found to improve endothelial function (2015) and reduce metabolic syndrome risk factors. Misguided calcium is another potential problem that has come to the forefront of cardiovascular research--calcification in arteries is considered a huge risk factor for dramatic cardiovascular events. NattoPharma s MenaQ7 Vitamin K2 www.niemagazine.com May 2016 Go to www.niemagazine.com natreon for info about this advertiser ALL SYSTEMS GO as MK-7 (MenaQ7 Crystals and MenaQ7 PURE) is the only patented K2 on the market that has been clinically validated to simultaneously deliver cardiovascular benefits. Vitamin K2 as MK-7 activates K-dependent proteins in the body that help the body properly utilize calcium. In the case of cardiovascular health Matrix Gla Protein (MGP) inhibits calcium from depositing in arteries and blood vessels keeping them healthy and flexible. According to Anderson a breakthrough published study monitored 244 healthy post-menopausal women (aged 55 to 65) who took 180 mcg MenaQ7 or placebo for three years using pulse wave velocity and ultrasound techniques. Results confirmed that citamin K2 as MK-7 not only inhibited agerelated stiffening of the artery walls but also made a statistically significant improvement of vascular elasticity. NattoPharma has several other published studies showing arterial protective benefits of MenaQ7 consumption. therapeutic benefits for the MenaQ7 group as compared to the placebo group. Preserving bone density is of course highly desirable. However if joint health is ignored mobility will be impaired--and today s active adults won t sit down for that. cartilage damage reducing inflammatory C-reactive protein and reducing AP-1 & STAT3 in synovial tissue Eng explained. Several studies on Pycnogenol noted Bornet demonstrated its ability to promote joint mobility and naturally relieve discomfort. It was also shown that after supplementing with Pycnogenol joints were more flexible and less medication was required. In addition Pycnogenol has been found to lower several key inflammatory markers of joint soreness such as COX-2 enzymes C-reactive protein reactive oxygen species and NFkappaB. Bone and Joint Health In addition to benefiting cardiovascular wellness MenaQ7 also promotes bone health by activating osteocalcin which binds calcium to the bone mineral matrix producing stronger healthier and denser bones. A three-year study of MenaQ7 and 244 healthy women published showed the first clinically statistically significant protection of the vertebrae and the hip (femoral neck) against bone loss Anderson reported. This was achieved with a nutritional dose of 180 mcg daily of MenaQ7. The MenaQ7 supplementation group significantly increased the circulating active osteocalcin (cOC) a well-established biomarker for bone and vitamin K status. The inactive osteocalcin (ucOC) in the MenaQ7 group decreased with 51 percent 21 percent as compared to the placebo group ( 4 percent - 49 percent). After three years of supplementation maintenance in both bone mineral content and bone mineral density were statistically significant in the MenaQ7 group. Moreover bone strength was statistically improved demonstrating 34 Nutrition Industry Executive Similar to cardiovascular health joint health is more than just about preserving cartilage it s also about managing the inflammatory cascade. Formulas or packs that suitably and effectively address both will get the nod of approval--and purchase--by consumers. HPI s Paractin is a patented extract of Andrographis paniculata standardized to Andrographolide 14-deoxyandrographolide and Neoandrographolide. According to Eng studies have shown ParActin to promote healthy inflammatory response by naturally invigorating the PPAR gamma response inhibiting NFkappaB the key regulator of the human inflammatory response system thereby naturally reducing pro-inflammatory cytokines and proteins associated with pain and redness from everyday activities. Various studies have shown that ParActin works by inhibiting NF- B from binding to DNA inhibiting IKK inhibiting COX-2 and reducing PGE2 decreasing rheumatoid factor (TNF-a) reducing IgA and IgM which results in Cognition The ability to be as mentally flexible and active is also a key desire of aging Americans. The fear of issues that cause severe memory lapses and other brain dysfunctions remains common especially if a recent ancestor has had such complications. SerinAid PhosphatidylSerine (PS) from Chemi Nutra is a brain health ingredient whose evidence is so compelling said Hagerman that the FDA (U.S. Food and Drug Administration) granted two health claims for it indicating that it may reduce the risk of cognitive dysfunction and dementia in the elderly. This is especially notable since it is the only ingredient to have a qualified health claim for cognitive health Hagerman asserted. A 2015 study concluded Phosphatidylserine is required for healthy nerve cell membranes and myelin. Aging of the human brain is associated with biochemical alterations and structural deterioration that impair neurotransmission. Exogenous PS (300 800 mg d) is absorbed efficiently in humans crosses the blood brain barrier and safely slows halts or reverses biochemical alterations and structural deterioration in nerve cells. It supports human cognitive functions including the formation of short-term memory the consolidation of long-term memory the ability to create new memories the ability to retrieve memories the ability to learn and recall information the ability to focus attention and concentrate the ability to reason and solve problems language skills and the ability to communicate. It also supports locomotor functions especially rapid reactions and reflexes. According to Bornet several studies www.niemagazine.com May 2016 have found Pycnogenol to offer a wide range of cognitive health benefits among a broad audience including women experiencing peri-menopause and menopause seniors and most recently Baby Boomers 55 and over. Energy Energy is the key that powers healthy aging in many ways. It drives physical and mental fitness. The very idea of napping on a porch in the mid-afternoon once considered a luxury of retirement is as of 2016 s retirees rather abhorrent. Kalidindi described Natreon s PrimaVie as a clinically proven purified shilajit containing dibenzo--pyrones (DBPs) DBP-Chromoproteins (DCP) fulvic acid and more than 40 different minerals. Fulvic acid independently stimulates mitochondrial energy metabolism protects mitochondrial membranes from oxidative damage and helps channel electron rich DBPs into the mitochondria to support the electron transfer chain. Several clinical studies have shown that PrimaVie can boost mitochondrial energy improve exercise performance and increase testosterone levels. It has shown to increase ATP synthesis and protects coenzyme Q10 from degradation by oxidative free radicals in the mitochondria. It is an ideal anti-aging product due to its ability to boost mitochondrial energy and up-regulate the genes responsible for collagen synthesis by several hundred fold. PrimaVie has shown beneficial effects in male reproductive health in two clinical studies. LJ100 is HPI s Eurycoma longifolia extract standardized to 40 percent glyco saponins 28 percent eurypeptides 30 percent polysacharides and eurycomanone. Eng noted that Eurypeptides is clinically proven at Massachusetts Institute of Technology (MIT) for its androgenic properties. Created by the original researchers at MIT and University Malaya this product has been shown in human clinical trials an ability to increase energy enhance sports performance promote a favorable anabolic state and increase fat free mass. According to one study it has been shown to be useful by both middle-aged senior men and women to increase muscle force through a natural increase in total and free testosterone production. Another study noted that it may help improve the Aging Male Symptom score and testosterone concentration of aging men. These are a few stellar examples of how far suppliers have come via investment in research to support ingredients that provide a wide range of appealing efficacy to help millions of aging Americans live their fullest and most vibrant lives possible. NIE Extra Extra Visit www.niemagazine.com to read more about what healthy aging issues are garnering the attention of article participants. FORMOREINFORMATION Chemi Nutra (866) 907-0400 Horphag Research (201) 459-0300 HP Ingredients www.hpingredients.com Natreon (732) 296-1080 NattoPharma USA (609) 454-2992 Pharmachem Laboratories Inc. www.pharmachem.com PLT Health Solutions (973) 984-0900 May 2016 www.niemagazine.com Nutrition Industry Executive 35 ScienceofIngredients 2016 section has been offered to help manufacturers gain a better understanding of the ingredients and services available that can make their products stand out. It gives the magazine s advertisers an opportunity to describe the research that substantiates the safety and efficacy of their branded ingredients products and services. These companies have responded to this opportunity with information about the health concerns their products are intended to address histories of nutrients behind their ingredients and details of research that has been carried out. In order to bridge the gap between interested parties and those participating in this section we ve also provided company addresses phone numbers email and website addresses to make obtaining additional information as easy as possible. 36 Nutrition Industry Executive S ince 2002 Nutrition Industry Executive s Science of Ingredients Following is an index of companies participating in this year s Nutrition Industry Executive Science of Ingredients section Albion Minerals ............................................37 BioCell Technology LLC ..............................38 Biova LLC ......................................................39 Comar ............................................................40 Euromed USA Inc. ........................................41 HealthCo ........................................................42 IgY Nutrition LLC ..........................................43 Natreon Inc. ..................................................44 Nutragenesis ................................................45 PLT Health Solutions ....................................46 Sabinsa Corp. ................................................47 U.S. Pharmacopeial Convention (USP) ..........48 Xsto Solutions LLC ........................................49 www.niemagazine.com May 2016 ScienceofIngredients 2016 Albion Minerals 101 N. Main St. Clearfield UT 84015 Phone (801) 773-4631 (800) 453-2406 (U.S. & Canada) Fax (801) 773-4633 Email info albionminerals.com Website www.albionminerals.com Magnesium--An Essential Mineral and Why Form Matters F or brand manufacturers and product formulators minerals may sometimes take a back seat as other new and innovative ingredients take a spotlight in supplement food and beverage markets. However the human body cannot function properly without minerals. amplifies protein synthesis.2 Magnesium Deficiency and Its Impact The daily recommended intake of magnesium for adults is 310 to 420 mg. It has been estimated that approximately 60 percent of individuals in the U.S. may not have adequate dietary intake.3 Although magnesium is ubiquitous in the diet there is no major food that provides extremely high amounts and only about 30-40 percent of dietary magnesium is actually absorbed (depending on intake).1 It has been suggested that the inadequate dietary intake of magnesium may be a risk factor or correlated to several chronic diseases including sudden cardiac death 4 Alzheimer s disease 1 diabetes metabolic syndrome 1 obesity3 and strokes 1 to name a few. For these reasons dietary supplementation of magnesium may be beneficial. The Critical Role of Magnesium While all minerals are important evidence continues to unfold regarding the critical role magnesium plays. Magnesium is a cofactor in more than 300 enzyme systems and regulates approximately 80 percent of biochemical reactions.1 Magnesium is the fourth most abundant mineral in the human body involved in many critical functions including Normal bone growth Maintenance of heart rhythm and blood pressure Formation and contraction of muscle Energy production and formation of ATP Nerve conduction Maintenance of mood and cognitive function A system of major importance that relies heavily on magnesium is that of cell proliferation. In this system magnesium has been shown to have direct influence on cell cycling protein synthesis and growth factor response. Protein synthesis is highly dependent on intracellular magnesium concentrations. Increasing the magnesium content Which Form is Best It is important to look at the research and evidence regarding the bioavailability of magnesium. There are many different forms of the mineral. Inorganic magnesium forms include Oxides Sulfates Carbonates Chlorides While organic forms include Organic acid salts (citrates malates) Complexes Chelates So which form is best Organic mineral amino acid chelates (Figure 1) have been scientifically proven to be more easily absorbed into the human body. At the 2016 Experimental Biology meetings research was presented that demonstrated that Albion Magnesium Bisglycinate was highly absorbed in vitro using a Caco-2 human intestinal cell Figure 1 Mineral Acid Chelates are complex model.5 In this study it was structures where the mineral is bound by amino found that Albion Magnesium acids to form a heterocyclic ring. Bisglyinate had greater absorption than magnesium oxide and magnesium citrate. Additional research suggests that Albion Magnesium Bisglycinate combined with magnesium oxide may have some benefits6 without compromising bioavailability.5 Magnesium has a reputation for causing gastrointestinal distress and laxation when take in high doses. Thus it is important that a highly bioavailable source or magnesium be well tolerated. In research presented at 2016 Society of Toxicology meetings it was shown that in healthy adults Albion Magnesium Bisglycinate at dosages of 300 450 and 600 mg of elemental magnesium there were no significant differences in tolerability and gastrointestinal distress as compared to a maltodextrin placebo.7 These findings corroborate earlier research in subjects with ileal resections.8 Albion Magnesium Bisglycinate Chelate has the dual advantage of being both highly bioavailable and highly tolerated. It provides an ideal solution to provide dietary supplementation to support adequate magnesium status. Mineral Innovations Albion Minerals has proven that its amino acid chelates are effective in more than 200 studies and 70 human trials. Albion has also been granted more than 100 patents in the field of mineral nutrition worldwide. References 1 Volpe SL. Adv. Nutr. 4 378S 383S 2013. 2 Proc Natl Acad Sci USA 76 3917-3921 1979. 3 Nielson FH. Nutr Rev 68 333-340 2010. 4 Chiuve SE et al. Am J Clin Nutr 93(2) 253-260 2011. 5 Hartle J et al. FASEB J 30(No. 1 Supplement) 128.6 2016 in press. 6 www.albionminerals.com human-nutrition magnesium-white-paper Accessed April 8 2016 7 Ashmead S et al. The Toxicologist Supplement to Toxicological Sciences 150(1) Abstract 2457 2016. 8 Schuette SA. J Perenteral Enteral Nutr. 18 430435 1994. Nutrition Industry Executive 37 May 2016 www.niemagazine.com ScienceofIngredients 2016 BioCell Technology LLC 4695 MacArthur Ct. 11th Fl. Newport Beach CA 92660 Phone (714) 632-1231 Fax (714) 632-5866 Websites www.biocelltechnology.com www.biocellcollagen.com BioCell Collagen Feed Your Skin and Joints ith the aging Baby Boomer demographic the number of adults in ages ranging above 50 years is increasing. Not surprisingly dietary supplement products claiming to slow aging or improve joint mobility and skin appearance for this demographic are heavily prevalent on the market. However the science behind both aging related declines and mechanism of action of nutraceuticals needs to be understood in order for informed decisions to be made by consumers. BioCell Collagen is a patented and clinically tested joint and skin health supplement that stands apart based on its providing hydrolyzed forms of three essential connective tissue components (collagen type II chondroitin sulfate and hyaluronic acid) in a naturally derived and extremely bioavailable matrix. Six published studies support the safety and efficacy of BioCell Collagen. BioCell Collagen is selfaffirmed GRAS (generally regarded as safe) and is protected by multiple U.S. and international patents. Furthermore BioCell Collagen has the following health claim approved by NHPD Health Canada Helps to relieve joint pain associated with osteoarthritis of the hip and knee and helps to maintain healthy skin. W tents. Collagen fibrils are universally found in all connective tissues. Therein they provide a structural network that is both rigid enough to maintain the form of these abused tissues but pliable enough to provide the cushioning or elasticity required for joint and skin health maintenance. Collagen comes in many flavors depending upon its location in the body. More than 20 different types of collagen have been identified but generally speaking you ll find two types of hydrolyzed collagen in the supplement aisle TYPE I III which is abundant and found primarily in the hides bones and skin of animals. TYPE II which is rarer and purer because it is only found in cartilage where it naturally coexists with hyaluronic acid and chondroitin sulfate in a blood-free environment. Scientifically Proven in Multiple Human Clinical Trials Dietary supplementation of collagen and its more bioavailable hydrolyzed forms have become obvious choices for combating age-related joint and skin issues as they provide necessary building blocks for the degenerating tissue(s). BioCell Collagen has proven to be a safe and effective means to help maintain connective tissue health in both joints and skin. Only one collagen-containing supplement BioCell Collagen has a natural matrix of hydrolyzed bioavailable forms of all three connective tissue components (col- The Science of Aging and Connective Tissue Health Aging gradually weakens connective tissue via the depletion of collagen and glycosaminoglycan (GAG) con- lagen as well sulfated and non-sulfated GAGs). BioCell Collagen a unique and patented nutraceutical that supports both collagen and GAGs with low molecular weight forms of each component is clinically tested to improve joint comfort in 89 percent of test subjects. Clinical studies also indicate that BioCell Collagen promotes improved maintenance of normal musculoskeletal tissue and recovery during sports activity. Remarkably still more clinical studies demonstrate increases in skin hydration and skin elasticity indicating BioCell Collagen bolsters connective tissue health in the skin. A quick trip around the floor of Expo West and it was easy to see the exploding popularity of dietary supplements for healthy aging. In fact as the science behind BioCell Collagen improves and additional structure function claims are tested via clinical trials this ingredient class is sure to only grow in popularity and use. References 1 Schauss AG et al. Acute and subchronic oral toxicity studies in rats of a hydrolyzed chicken sternal cartilage preparation. Food Chem Toxicol. 2007 45(2) 315-21. 2 Schauss AG et al. Effect of the novel low molecular weight hydrolyzed chicken sternal cartilage extract BioCell Collagen on improving osteoarthritisrelated symptoms a randomized double-blind placebo-controlled trial. J Agric Food Chem. 2012. 60(16) 4096-101. 3 Lopez HL et al. Evaluation of the Effects of BioCell Collagen a Novel Cartilage Extract on Connective Tissue Support and Functional Recovery From Exercise. Integr Med. 2015. 14(3) 30-8. 4 Schwartz SR et al. A randomized double blind clinical pilot trial evaluating the safety and efficacy of hydrolyzed collagen type II in adults with osteoarthritis 2004 FASEB J.P94. 5 Schwartz SR et al. Ingestion of BioCell Collagen a novel hydrolyzed chicken sternal cartilage extract enhanced blood microcirculation and reduced facial aging signs. Clin lnterv Aging. 2012. 7 267-73. www.niemagazine.com May 2016 38 Nutrition Industry Executive ScienceofIngredients 2016 Biova LLC Kansas Bioscience Authority Venture Accelerator Park 10900 S. Clay Blair Blvd. Ste. 1000 Olathe KS 66061 Phone (877) OVACORE (877) 682-2673 Fas (913) 815-4048 Email clear biova.com Website www.biova.com High-protein Uniform Ingredient Profile Helps BiovaFlex Deliver Fast Five-day Joint Health Results With a Variety of Delivery Options. percent protein standard. hen it comes to specifying And for the most important ingredients for natural prodclinical research shows that ucts it s not uncommon for BiovaFlex does make a consistent formulators to want both consistency difference when it comes to joint and variety. health. Of course consumer product According to a recent randomdevelopers want rock solid science ized double-blind placebo-conand uniform ingredient specs said trolled crossover research study a Kathy Hockla channel manager for daily 450 mg dose of BiovaFlex Biova. That said they re often inquiring about our water soluble egg was associated with improved joint range of motion (ROM) in the membrane (WSEM) ingredients neck back hips shoulders knees because they re new different. And and other joint areas often afflictthey re always very interested in the ed with soreness as the body multiple delivery formats our WSEM ages. Study participants also ingredient portfolio offers. reported increased activity levels Biova s WSEM ingredients are marand energy. And subgroup analyketed globally and include BiovaFlex sis showed reduction of back pain-- for joint health BiovaDerm for skinas one might experience from exercare and BiovaPlex for animal health cise and or daily activity--after just applications. five days.1 Our patented processes ensure The article Support of Joint uniform ingredient profiles guaranFunction Range of teeing manufacturers are Motion and Physical getting high-protein Activity Levels by WSEM--every time said Consumption of a Matt Stegenga president Water-Soluble Egg of Biova. We have a 88 Membrane percent protein standard Hydrolyzate is based in our human joint health on the study conducted ingredient BiovaFlex and by NIS Labs Klamath consistently get around Falls OR and pub90 percent protein. lished in the September Similarly both BiovaDerm 2015 Journal of and BiovaPlex are similarMedicinal Food. ly standardized at 85 Matt Stegenga BiovaFlex offers the percent protein--with Biova President solid science manufacmore than a decade turers and consumers invested in developing are looking for said egg membrane products Stegenga. Today s I believe beneficial results consumers can easily come from high protein access the research of levels. their favorite products Biova s patented ingredients. They want OvaPure and Hydro5 something convenient processes maintain the in a form they can take natural complement of and fast results. proteins including glyManufacturers are carecosaminoglycans collafully considering scigen elastin desmosine Kathy Hockla and isodesmosine that ence behind the ingreBiova Channel Manager make up BiovaFlex s 88 dients they want in May 2016 www.niemagazine.com W their products. With BiovaFlex relief doesn t have to come in a pill which 40 to 70 percent of adults report issues with swallowing.2 Forward-thinking manufacturers are embracing the variety of products they can create with BiovaFlex added Hockla. Our WSEM ingredients expanded delivery options encourage formulators and marketers to target consumer products far beyond traditional tablets. With our ingredients manufacturers can consider what s new and know their product will still produce results. Biova s patented water soluble process creates expanded delivery options for consumer products including functional foods beverages lotions and more. A focus on sustainable production anchored by vertical integration with some of the largest U.S.-domestic egg producing and processing partners assures Biova unmatched raw material supply--the right combination of access and capability to drive opportunity and growth worldwide. References 1 Biova.com research or at the Journal of Medicinal Food http online.liebertpub.com doi pdfplus 10.1089 jmf.2015.0041. 2 www.swallowingtablets.com. Nutrition Industry Executive 39 ScienceofIngredients 2016 Comar One Comar Pl. Buena NJ 08310 Phone (856) 507-5400 Website www.comar.com Package Material for Nutraceutical Products Custom Plastic Packaging PET Versus HDPE PET or HDPE is the most basic question for a nutraceutical manufacturer and packaging company. As with other types of foods nutraceuticals and pharmaceutical products very careful considerations must be made in designing packaging. Does the bottle need to be more resistant to light oxygen or moisture permeation Is re-sealability or child resistancy a requirement When it comes to plastic bottles and other kinds of plastic containers highdensity polyethylene (HDPE recycling symbol two) and polyethylene terephthalate (PET recycling symbol one) are the two most common plastic resins used in containers. But how do you decide between the two HDPE resins are known for their high strength-to-density ratio making it durable and stronger than other types of plastic. HDPE is opaque a good moisture barrier and has good impact strength. HDPE bottles also are able to withstand freezing temperatures well and higher temperatures moderately well. It s because of these properties for example that HDPE plastic is most commonly used in milk jugs and other dairy containers which must help keep out light that could quickly spoil milk products. Additionally HDPE is chemically inert and can be molded in sizes shapes and colors to fit specific needs. PET is more widely used for beverages like soft drinks and bottled water. That is because PET resins are a highly effective oxygen barrier and an effective moisture barrier. PET bottles typically clear and glossy in appearance. Oriented PET offers excellent impact resistance in lightweight packages. PET can also be molded in sizes shapes and colors to fix specific needs. PET is more temperature sensitive than HDPE. With the right designs either type of resin can make an ideal packaging material for nutraceutical products. It is typical to see vitamins and supplement products in PET packers and probiotics and in HDPE. Sports nutrition powders can be found in both HDPE and PET. Other Major Concerns in Health and Wellness Packaging In addition to choosing the most appropriate type of plastic resin for custom product packaging there are still other important factors to consider. Consumers are also interested in responsible recycling. Fortunately not only are HDPE and PET 100 percent recyclable but as much as 100 percent of a particular package can be made from recycled materials as well. And with 9 400 curbside collection operations and 10 000 drop-off sites currently accepting HDPE and PET these are two of the easiest materials to recycle in the world. Also many consumers interested in supplements and health products are concerned about the presence of BPA or bisphenol A. This industrial chemical has been used in food and beverage packaging and even though the U.S. Food and Drug Administration has deemed it safe in low levels many consumers are nervous about its presence in food products. For that reason it s crucial to emphasize that both PET and HDPE are BPA free. Finally although supplements are not regulated in the same way that pharmaceuticals are many companies are choosing to proactively invest in childsafe custom packaging for vitamins and nutritional supplements especially gummy forms. 40 Nutrition Industry Executive www.niemagazine.com May 2016 ScienceofIngredients 2016 Euromed USA Inc. 9103 Club House Rd. Presto PA 15142 Phone (412) 279-8808 (877) 696-3960 Fax (412) 279-8809 Email besure euromedusa.com Website www.euromed.es Selecting the Best Saw Palmetto Extract How to be Sure By Linda Roxanne Bryer T he recent events in the news regarding inconsistencies in the quality of herbal supplements-- based on the attorney general of New York s random testing of botanical extracts--have created a buyer beware mentality. This issue has raised lots of eyebrows--and a lot of questions--from consumers the media and other industry manufacturers alike. It also has raised awareness of the absolute necessity for reputable companies to reassure their customers that their botanicals--take saw palmetto as one example--are not only regulatory compliant but safe as well as efficacious. Today so many saw palmetto extracts are available on the American marketplace it leaves everyone with the question How can consumers be sure This is where Euromed USA comes in. This company has been creating outstanding botanical extracts for more than 40 years and has always been consistently compliant. The company s high quality extracts have not only been tested for safety efficacy and purity but has also won the seals of approval now needed more than ever before. In 2012 Euromed USA was awarded the NSF GMP (good manufacturing practice) Certification in record time followed by receiving the prestigious ISO 14001 Certification. In 2012 Euromed USA was awarded the NSF GMP (good manufacturing practice) Certification in record time followed by receiving the prestigious ISO 14001 Certification. Now more than ever before it is critical for consumers and manufacturers alike to use only extracts that have been scientifically proven to work via studies. When consumers or manufacturers use saw palmetto extracts that do not have any clinical proof behind them they are taking an unnecessary risk with their health. prescription is necessary to obtain a proven effective treatment it spares the expense of the medical practitioner s fees it spares the high costs of prescription drugs and most importantly for health it eliminates exposure to drugrelated side effects. For additional information about Euromed s extracts call (877) 696-3960 or email BeSure EuromedUSA.com Reassurance in its Highest Form Science Euromed s branded CO2 supercritical saw palmetto extract sold under the registered name of Prosterol has been the subject of important recent studies. The most recent study published just last month is a mechanism of action study of Prosterol versus the original prescription drug standard for treating enlarged prostate in men a drug called finasteride. In this study Euromed s extract Prosterol was found to work in the same way as and just as well as finasteride 1 and just as well as another well-known saw palmetto extract that is made with the harsh solvent hexane.2-5 Another significant study is a human clinical trial done with a popular European prostate product that uses Euromed s Prosterol exclusively. In this study Euromed s extract was found to be just as effective as the current largest selling prescription drug for enlarged prostate (a product called tamsulosin or Flomax).6 This offers many benefits No doctor s References 1 Pais P Villar A Rull S. Determination of the potency of a novel Saw palmetto supercritical (CO2) extract (SPSE) for 5-reductase isoform II inhibition using a cell-free in vitro test system. Research and Reports in Urology. 2016 8 1-9. 2 Scaglione F Lucini V Pannacci M Caronno A Leone C. Comparison of the potency of different brands of Serenoa repens extract on 5 -reductase types I and II in prostatic co-cultured epithelial and fibroblast cells. Pharmacology. 2008 82 270 275. 3 Habib FK Ross M Ho CK Lyons V Chapman K. Serenoa repens (Permixon) inhibits the 5-reductase activity of human prostate cancer cell lines without interfering with PSA expression. Int J Cancer. 2005 114 190 194. 4 Giulianelli R Pecoraro S Sepe G et al. Multicentre study on the efficacy and tolerability of an extract of Serenoa repens in patients with chronic benign prostate conditions associated with inflammation. Arch Ital Urol Androl. 2012 84 94 98. 5 Perry R Milligan G Anderson P Gillon A White M. Real-world use of Permixon in benign prostatic hyperplasia determining appropriate monotherapy and combination treatment. Adv Ther. 2012 29 538 550. 6 Argirovic A Argirovic Dj. Does the addition of Serenoa repens to tamsulosin improve its therapeutical efficacy in benign prostatic hyperplasia Vojnosanit Pregl 2013 70(12) 1091-1096. Nutrition Industry Executive 41 High Standards Visible Proof Euromed USA has set the bar high. Euromed s saw palmetto extracts--as with all of the company s botanical extracts--are manufactured according to the highest standards in the industry using good agricultural practices optimal extraction technology and performing 20 laboratory tests for identity purity and potency. The company s proprietary PhytoProof process represents the ultimate in quality control. Joe Veilleux general manager of Euromed USA stated Our PhytoProof emblem is the new golden seal of approval that offers recognizable proof positive that Euromed s strict quality control standards stand behind each and every botanical extract we produce signifying our company s ability to consistently deliver a proven effective product. It is our goal for everyone to know that they can Be Sure with Euromed. May 2016 www.niemagazine.com ScienceofIngredients 2016 HealthCo 244 Knollwood Dr. Bloomingdale IL 60108 Phone (800) 477-3949 Fax (630) 545-9080 Email sales healthco-intl.com Website www.healthco-intl.com Stevia FSE A Unique And Markedly Different Stevia Sweetener D espite stevia s relatively recent arrival to the food and beverage marketplace this exceptionally sweet herb has a very rich history. The earliest known use of stevia according to documents stored at Paraguay s National Archives can be traced back to the mid1800s when it was used by the indigenous Guarani natives. Known as kaa-he-e (sweet herb) it was initially used in medicinal preparations in addition to a tea-like drink known as bitter mate. In 1931 French chemists Bridel and Lavielle were the first to successfully isolate Stevioside and Rebaudioside A from the leaves of the dtevia plant. Approximately 40 years later during the 1970s Japanese researchers successfully isolated individual dteviosides from stevia leaves each one sharing the same dteviol molecule nine have been discovered to date. From there the popularity of Stevia evolved rapidly. Within 20 years it was universally accepted as Japan s No. 1 sweetener. In the 1980s stevia became available in the Natural Products marketplace but could only be sold as a dietary supplement not a sweetener.1 It wasn t until 2008 that the U.S. Food and Drug Administration (FDA) permitted stevia to be used as a food additive and that was largely due to efforts by Coca Cola and Cargill to gain approval.2 The initial stevia offerings were highly processed extractions wit ha somewhat bitter aftertaste. Stevia FSE is a unique and markedly different stevia sweetener. While most stevia ingredients on the market have a bitter aftertaste enzyme treated Stevia FSE provides a better-rounded sweetening profile that is ideal for numerous food applications. Stevia FSE utilizes the whole stevia leaf and is not an isolated fraction like Reb A which is said to require additional added substances to mask the bitter aftertaste. No flavorings or masking agents are used in stevia FSE because none are needed. The natural enzyme treatment enhances its organoleptic (sensory) properties. Stevia FSE is 60-100 times sweeter than sugar (sucrose). Stevia FSE is also NOP Certified Organic and kosher. Since spring 2010 STEVIA FSE has generally recognized as safe (GRAS) status after a comprehensive review of safe42 Nutrition Industry Executive While most stevia ingredients on the market have a bitter aftertaste enzyme treated Stevia FSE provides a better-rounded sweetening profile that is ideal for numerous food applications. ty and toxicology data by an independent panel of scientists.3 Utilizing the platform of general purpose non-nutritive sweetener for foods and beverages self-affirmed GRAS status allows manufacturers additional freedom to add Stevia FSE in a variety of foods and beverages ranging from baked goods to milk products breakfast cereals cheese egg products processed vegetables soft candy soups snack foods non-alcoholic beverages imitation dairy products hard candy chewing gum granulated sugar and even seasonings and flavors. The benefits of this natural herb extract are many. Stevia contains no calories and is therefore ideal for individuals conscious of their caloric intake. Additionally stevia ranks extremely low on the glycemic index scale a chart used to measure a food s impact on insulin release following the consumption of food. As a result stevia is appropriate for diabetics and those with compromised insulin activity. Stevia is approximately 60 to 100 times sweeter than white crystalline table sugar. Perhaps most appealing Stevia is highly versatile and can be used in practically any application that calls for conventional sugar or high fructose corn syrup (HFCS). This provides both economic and health benefits when used in bulk beverage and other food production settings. No natural or artificial low calorie sweeteners or added flavors of any kind are used during the manufacturing process nor are they added to the finished product. Erythritol is a corn-based sweetener commonly used in many Reb A stevia products but not used in Life Balance Stevia Sweetener. Stevia FSE is 100 percent vegetarian and vegan suitable and free of common food allergens including yeast dairy egg gluten wheat soy sugar starch salt artificial colors flavors or fragrances. In order to ensure the highest levels of purity it is tested for heavy metals pesticides bacteria and other potentially harmful contaminants. Life Balance Stevia Sweetener is both pH and temperature stable making it ideal for use in many functional foods and beverages. References 1 McCaleb Rob (1997). Controversial Products in the Natural Foods Market. Herb Research Foundation. 2 Stevia sweetener gets US FDA go-ahead . Decision News Media SAS. 18 December 2008. 3 HealthCo Receives GRAS Status for STEVIA FSE New Hope 360 May 19 2010 http newhope360.com supply-news-ampanalysis healthco-receives-gras-status-stevia-fse. www.niemagazine.com May 2016 ScienceofIngredients 2016 IgY Nutrition LLC 6520 N. Western Ave. Oklahoma City OK 73116 Phone (405) 242 5387 Email info igynutrition.com Websites www.igynutrition.com www.hyperimmunegg.org www.igymax.com IgY Max Specifically Immunized Egg for optimal GI Health By Susan J Hewlings PhD RD R ecent research suggests that that the typical Western diet consisting of a high fat high sugar low fiber intake has altered the diversity of the human gut microbiome leading to dysbiosis.1 Dysbiosis is defined as a shift in the microbiota composition resulting in an decrease in the number of beneficial microbes accompanied by an increase of harmful microbes in the intestinal tract.2 Diet induced dysbiosis is thought to contribute to many diseases including metabolic syndrome diabetes cancer inflammatory conditions neurological pathologies and psychiatric disorders.1 3 These changes not only occur over the long term intake of such a diet but can occur in a single day.1 Because of the increased awareness of dysbiosis and its negative effects there has been increased consumer demand for pro- and prebiotics in the dietary supplement nutraceutical and dietary ingredient markets. It has been suggested that probiotics may play a role in correcting the dysbiosis. However they are strain specific and since dysbiosis can present differently in each person they may not always address the imbalance.2 Prebiotics may offer an alternative or symbiotic benefit to probiotics as they have been used to stimulate beneficial bacteria to help to restore balance. In contrast to the probiotic action which provides living microorganisms prebiotics stimulate the activity of healthful bacteria. A prebiotic is defined as a selectively fermented dietary ingredient that results in specific changes in the composition and or activity of the gastrointestinal microbiota thus conferring benefit(s) upon host health. 2 IgY Max is much like a prebiotic in that it changes the composition and activity of the microbiome. Countless intestinal microorganisms comprise our intestinal microbiome where they serve to aid in digestion supply important nutrients and vitamins and provide immune function. When unwelcome bacteria are present the space for good bacteria is limited. Think of a garden overrun with weeds. Just like the weeds pathogens leave no room for beneficial flora to grow taking up vital nutrients needed to survive. IgY antibodies contained in IgY Max help the body eliminate only the harmful bacteria May 2016 www.niemagazine.com and leave the good microbes intact. IgY antibodies are antibodies from chicken eggs. They work by significantly reducing harmful bacterial adhesion and growth in the GI (gastrointestinal) tract thereby helping to minimize inflammation by decreasing cytokines and HSCRP. IgY antibodies offer several advantages over mammalian IgG antibodies they have a three to five times higher immunogenicity they do not increase inflammatory cytokines and they have a 20 times higher immunoglobulin concentration per unit. Moreover IgY antibodies have a highly specific rapid and local onset of action are non-toxic 10 and they do not stimulate the human complement system thus preventing non-specific inflammation. Antigen-specific IgY products have been shown to be effective in promoting gut function and immunity in humans 11 as well as in reducing the side effects of dysbiosis.12 IgY Max is a polyvalent antigen specific IgY product targeting 26 of the most common human-relevant pathogens. Other IgY products only target one pathogen and therefore are monovalent. IgY Max is a unique digestive and immune function ingredient that promotes GI health by increasing gut wall integrity 13 improving bowel function 12 and reducing non-beneficial bacteria adherence and in doing so functions much like a prebiotic. However it is slightly different than a prebiotic in that it in addition to favorably altering the composition of the microbiome it supports the digestive tract lining promotes proper microbial adhesion supports immune system health supports the body s natural defenses and promotes proper cytokine balance. Moreover IgY Max is able to exert its activity within the entire length of the GI tract.10 Due to its mechanism of action IgY Max is an effective tool to address issues caused by dysbiosis. IgY Max is a safe and viable option for anyone who wants to maintain and improve total GI function. Made from whole eggs that have been spray dried but otherwise unaltered IgY Max is GRAS (self affirmed generally recognized as safe) and holds a Master Food Additive file number. IgY Max as a standalone product is NSF Certified for Sport. Available exclusively from IgY Nutrition IgY Max is a unique dietary supplement that provides optimal digestive function through the power of IgY and passive immune technology. By reducing competition in the gut IgY Max provides enough room for probiotics to grow. Don t let bad bacteria condemn your health use IgY Max to support your microbiome. References 1 David LA et.al. Diet rapidly and reproducibly alters the human gut microbiome. Nature 2014 505 559-578. 2 Ducatelle R et.al. A review on prebiotics and probiotics for the control of dysbiosis present status and future perspectives. Animal. 2015 9(1) 43 48. 3 Distrutti E Monaldi L Ricci P Fiorucci S. Gut microbiota role in irritable bowel syndrome New therapeutic strategies. World J Gastroenterol. 2016 22(7) 2219-41. 4 Di Bartolomeo F. Startek J.B. and Van den Ende W. Prebiotics to Fight Diseases Reality or Fiction . Phytother. Res.2013 27 1457 1473. 5 Cummings J Antoine J Azpiroz F et al. PASSCLAIM1-Gut health and immunity. European Journal of Nutrition. 2004 43(S2) II 118 II 173. 6 Kamada N Chen G Inohara N N ez G. Control of pathogens and pathobionts by the gut microbiota. Nature Immunology. 2013 14(7) 685-690. 7 Chalghoumi R Th wis A Beckers Y Marcq C Portetelle D Schneider YJ. Foodborne Pathog Dis. 2009 6(5) 593-604. 8 Rahman S et.al. Oral passive IgY based immunotherapeutics. Human Vaccines and immunotherapeutics. 2013 9(5) 1039-1048. 9 Miles Laura. Effects of Hyperimmune Eggs on HSCRP Levels Results of a private clinical trial. Unpublished study. 10 Munhoz LS et.al. Avian IgY antibodies characteristics and applications in immunodiagnostics. Cienca Rurall. 2014 49(1) 153-160. 11 Kovacs-Nolan J Mine Y. Egg yolk antibodies for passive immunity. Annu Rev Food Sci Technol. 2012 3 163-187. 12 Jacoby H. Moore G. Wnorowski G. Inhibition of diarrhea by immune egg a castor oil mouse model. Journal of Nutraceuticals Functional & Medical Foods 2001 3(2) 47-53. 13 Ambekar R. Effect of a nutritious drink fortified with immune egg in improving the weight and enhancing the well-being of subjects. Unpublished study.1998. Nutrition Industry Executive 43 ScienceofIngredients 2016 Natreon Inc. 2-D Janine Pl. New Brunswick NJ 08901 Phone (732) 296-1080 Fax (732) 296-1075 Email info natreoninc.com Website www.natreoninc.com AyuFlex A Vegetarian and Organic Product for Joint Health O steoarthritis (OA) is one of the most common forms of arthritis and is the leading cause of disability in American adults. Commonly affected joints include the finger knee hip spine and metatarsophalangeal joints of the foot. The goals of treatment in osteoarthritis include resolution of symptoms prevention or reduction in disease progression and improvement of functional ability. These goals can be accomplished with non-pharmacologic and pharmacologic therapies.1 There are several different pharmacologic therapies including acetaminophen and oral NSAIDs which are most commonly used. Acetaminophen is commonly used due to its relative safety profile however reports of acetaminopheninduced hepatotoxicity have increased in recent years. Oral NSAIDs such as ibuprofen and naproxen are recommended as initial therapy in more moderate to severe cases of OA.1 Patient-related factors should be considered prior to initiating oral NSAIDs due to the adverse risks associated with these medications including gastrointestinal toxicity kidney impairment and cardiovascular risks.1 Natreon s AyuFlex is a clinically proven water-soluble vegetarian organic nonGMO (genetically modified organism) product for joint health. It is derived from edible fruits of Terminalia chebula an ancient ayurvedic plant and standardized to high levels of bioactives.2 The main mechanism of action appears to be via inhibition of COX-1 COX-2 and 5-LOX enzymes.3 It has been used in India for thousands of years for its anti-inflammatory and analgesic effects without the adverse effects that are associated with acetaminophen and NSAIDs.2 In one randomized double-blind placebo-controlled trial patients with osteoarthritis for at least six months duration and meeting the ARA functional class I to III with radiological evidence were randomized to receive AyuFlex 250 mg twice daily AyuFlex 500 mg twice daily or placebo.2 This was a 12-week trial which assessed WOMAC scores knee swelling index and VAS (visual analog scale) for pain stiffness and disability. Patients were allowed to use acetaminophen as a rescue medication. Results from this study showed that patients with osteoarthritis taking AyuFlex had a significant reduction 44 Nutrition Industry Executive AyuFlex is standardized to pharmaceutical quality and recent studies have shown significant reductions in mWOMAC scores knee swelling index and VAS-pain stiffness and disability scales. in WOMAC scores knee swelling index and VAS-pain VAS-stiffness and VAS-disability. Of note patients taking AyuFlex used significantly less rescue medication (paracetamol) compared to the placebo group. In regards to safety all renal hematologic and hepatic parameters were within normal limits in the treatment group. GI (gastrointestinal) adverse effects such as dyspepsia and diarrhea were the most commonly reported in the treatment group (n 3). AyuFlex was well tolerated and no serious adverse events were observed during this study.2 In addition to the study in moderately osteoarthritic patients there are two randomized double-blind placebo controlled crossover studies that were completed to examine the analgesic activity of AyuFlex in healthy human volunteers. In these studies subjects were given a single 1000 mg dose of AyuFlex and subjected to a hot air pain model or a mechanical pain model. Both force and time for pain threshold and pain tolerance from both these studies were statistically significant at p 0.001 compared to placebo.4-5 OA is one of the leading causes of disability in the United States. Due to adverse effects associated with traditional treatments of OA such as oral NSAIDs and acetaminophen patients are turning to dietary herbal supplements. AyuFlex which is derived from the ancient ayurvedic plant Terminalia chebula is an optimal choice for joint health. AyuFlex is standardized to pharmaceutical quality and recent studies have shown significant reductions in mWOMAC scores knee swelling index and VAS-pain stiffness and disability scales. In addition only three patients experienced mild adverse effects (diarrhea and dyspepsia) during treatment with AyuFlex and no subjects discontinued the study due to adverse events. Thus AyuFlex a vegetarian organic non-GMO and water-soluble product is a safe and effective supplement for joint health support. References 1 Arthritis Foundation. Osteoarthritis Fact Sheet. 2013. 2 Pingali UR et al. A Randomized Double Blind Placebo Controlled Parallel-Group Study to evaluate the analgesic effect of Terminalia chebula Crominex and their combination in subjects with Osteoarthritis (Pending publication). 3 Reddy et al. Chebulagic acid a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz. induces apoptosis in COLO-205 Cell Line. Journal of Ethnopharmacology 124 (2009) 506-512. 4 Pokuri VK et al. A Randomized Double Blind Placebo Controlled Cross Over Study to evaluate analgesic activity of Terminalia chebula in healthy human participants using mechanical pain model. (Pending publication). 5 Kumar UC et al. Evaluation of Analgesic Activity of Terminalia Chebula in Healthy Human Participants Using Hot Air Pain Model A Randomized Double Blind Placebo Controlled Cross Over Study. The Journal of Clinical and Diagnostic Research. 2015. 9(5) FC01-FC04. www.niemagazine.com May 2016 ScienceofIngredients 2016 Nutragenesis 167 Main St. Ste. 208 Brattleboro VT 05301 Phone (802) 257-5345 Fax (802) 251-6981 Email info nutragenesis.com Website www.nutragenesis.com Human Clinical Trial Demonstrates Bergavit 40 s Significant Cardiovascular Health Benefits T he need for natural efficacious cardiovascular support is growing as the population ages. bergamot citrus (Citrus bergamia) has been used traditionally in the Mediterranean region to support cardiovascular health and metabolic wellness as a result of beneficial flavonoid bioactives contained in the fruit. According to legend Christopher Columbus brought the fruit back to Italy from Berga Spain in the 15th Century and now the majority of the world s bergamot production occurs in the Calabria region of Italy with its ideal growing conditions. A recently published human clinical trial has now demonstrated that a highly concentrated proprietary extract of bergamot sold under the trade name Bergavit 40 helps support healthy cardiovascular function at a low 400 mg daily dose. LDL which are not associated with cardiovascular health. Proposed Mechanisms of Action Multiple mechanisms of action have been proposed for bergamot s cardiovascular health properties including reducing LDL oxidation 5 increasing LDL receptor gene expression6 and excretion of cholesterol from the body 7 and activating a master physiological regulatory switch in the body that affects metabolism.8 Bergavit 40 was developed by Bionap SRL (Belpasso Italy) a vertically integrated provider of a select portfolio of Mediterranean-sourced nutraceuticals and is exclusively marketed by NutraGenesis LLC in North America. Bergavit 40 Proprietary Extract Supports Healthy Cardiovascular Function Bergavit 40 is a proprietary extract of Bergamot citrus that is standardized to the highest levels of flavonoid bioactives in the industry ( 39-42 percent flavonoids including neoeriocitrin naringin and neohesperidin). This ingredient represents an entirely new breakthrough in the bergamot cardiovascular health category because a recent six month long human clinical trial has demonstrated that Bergavit 40 supports healthy cardiovascular function at a dose of only 400 mg once daily.4 In this trial involving 80 subjects daily consumption of the amount of flavonoid bioactives found in 400 mg of Bergavit 40 led to significant improvements in blood lipids. Total cholesterol LDL and triglycerides decreased significantly by up to 12 20 and 17 percent respectively while HDL increased up to 8 percent by the end of the study. The researchers also found that while at the beginning of the study the subjects LDL was divided between small medium and large size fractions consumption of the bergamot flavonoids resulted in a shift in the LDL profile to larger healthier LDL by the end of the study with only traces of small and medium size LDL remaining. In addition this study was the first to show that intake of bergamot extract led to a significant reduction in carotid intima-media thickness (by up to 25 percent in the treatment group). This technique which uses ultrasound technology is highly recommended by clinicians because of its relationship with heart health (lower levels are healthier). Bergamot Juice Extract has Been Evaluated in Multiple Human Clinical Studies Previously several human clinical trials had investigated extracts of bergamot juice and showed that cardiovascular benefits were achieved only at higher doses. For example a 2011 study showed that subjects who took 500 mg of bergamot juice extract once or twice daily over a 30 day period had improved total cholesterol LDL and HDL cholesterol and triglyceride levels by the end of the study.1 Another research group found that daily consumption of either 1 000 mg of bergamot juice extract or 10 mg of rosuvastatin for 30 days resulted in about the same significant improvements in total cholesterol LDL and HDL cholesterol and triglycerides.2 In a follow-up study researchers instructed subjects to take 650 mg of bergamot juice extract twice daily for 120 days which resulted in significant improvements in both LDL and HDL cholesterol compared to placebo.3 The researchers also recorded a beneficial shift in the LDL profile of subjects in the treatment group during the study. These subjects had significantly greater amounts of healthier large size LDL particles and significantly less smaller size May 2016 www.niemagazine.com References 1 Mollace V et al. 2011. Hypolipemic and hypoglycaemic activity of Bergamot polyphenols From animal models to human studies. Fitoterapia 82 309-316. 2 Gliozzi M et al. 2013. Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDLcholesterol LOX-1 expression and protein kinase B phosphorylation in patients with hyperlipidemia. Int J Cardiol 170(2) 140-145. 3 Gliozzi M et al. 2014. The effect of Bergamotderived polyphenolic fraction on LDL small dense particles and non-alcoholic fatty liver disease in patients with metabolic syndrome. Adv Biolog Chem 4 129137. 4 Toth PP et al. 2016. Bergamot reduces plasma lipids atherogenic small dense LDL and subclinical atherosclerosis in subjects with moderate hypercholesterolemia A 6 month prospective study. Frontiers Pharmacol 6 299. 5 Trovato A et al. 2010. Citrus bergamia Risso & Poiteau juice protects against renal injury of dietinduced hypercholesterolemia in rats. Phytother Res 24 514-519. 6 Kumar A et al. 1997. Phorbol ester-induced low density lipoprotein receptor gene expression in HepG2 cells involves protein kinase C-mediated p42 44 MAP kinase activation. J Lipid Res 38 2240-2248. 7 Miceli N et al. 2007. Hypolipidemic effects of Citrus bergamia Risso et Poiteau juice in rats fed a hypercholesterolemic diet. J Agric Food Chem 55 10671-10677. 8 Bruckbauer A and Zemel MB. 2014. Synergistic effects of polyphenols and methylxanthines with leucine on AMPK sirtuin-mediated metabolism in muscle cells and adipocytes. PLoS One 9 e89166. Nutrition Industry Executive 45 Go to www.niemagazine.com plt for info about this advertiser ScienceofIngredients 2016 Sabinsa Corporation 20 Lake Dr. East Windsor NJ 08520 Phone (732) 777-1111 Fax (732) 777-1443 Email info sabinsa.com Website www.sabinsa.com LactoSpore S abinsa s LactoSpore is a shelf stable microbial preparation from Lactobacillus sporogenes (Bacillus coagulans MTCC 5856). The normal human digestive tract contains about 400 different bacteria that help reduce the growth of harmful bacteria. Among them the largest group of bacteria in the intestine is the lactic acid producing bacteria. LactoSpore produces L( ) lactic acid and grows in the temperature range of 35 C to 50 C and an optimum pH range of 5.5-6.5. Current lifestyle conditions are stressful effecting human health in multiple ways. Stress may be caused by sudden changes in food-consumption patterns exposure to environmental pollutants life events or extensive travel. Under such adverse circumstances an imbalance is created in the system that may cause harmful bacteria to become predominant. This often impairs normal gut function and leads to various problems ranging from inefficient digestion diarrhea constipation and flatulence to severe gastrointestinal disorders. A logical and effective approach to restoring the balance of intestinal flora is the use of probiotics. A well recognized superior and potential probiotic is a species among Lactobacillus - L. sporogenes. This species remains in its natural sporulated form which on activation in the acidic environment of the stomach can germinate and proliferate in the intestine to produce the favored L ( ) form of lactic acid and effectively prevent the growth of other pathogens. Sabinsa supplies LactoSpore of following strengths 6 billion spores g 15 billion spores g showing stability during processing and storage. (Majeed M et al. 2016. International Journal of Food Science and Technology. doi 10.1111 ijfs.13044) Gastrointestinal Health Benefits Irritable bowel syndrome (IBS) is a common disorder that affects the colon causing symptoms such as cramping abdominal pain bloating gas diarrhea and constipation. The effect of LactoSpore in offering relief to patients suffering from IBS has been clinically evaluated in a randomized double blind placebo controlled study. The study showed a significant decrease in symptoms like bloating vomiting diarrhea abdominal pain and stool frequency in the group receiving LactoSpore. A decrease in severity and improvement in quality of life was also observed. (Majeed M et al. 2016. Nutrition Journal. DOI 10.1186 s12937016-0140-6) Advantages Preparations of LactoSpore in various dosage forms such as tablets capsules granules or powder have the following benefits over many other probiotics 1. The natural sporulated form enables them to be more thermo-stable and retain viability through processes such as spray drying during preparation and during storage before consumption. 2. This also enables them to survive in gastric secretions and bile of the upper digestive tract to reach the intestine safely. 3. Once established in the digestive tract they produce lactic acid and other antagonistic substances to inhibit the growth of pathogenic bacteria and improve digestive health. Safety The safety of LactoSpore in healthy volunteers has been established through a human clinical trial. A dosage of two billion spores of LactoSpore once daily was given to 40 healthy human volunteers for 30 days and analyzed for laboratory parameters (blood hematology and clinical chemistry parameters) anthropometric measures (weight BMI blood pressure and heart rate) adverse events Bristol Stool Score tolerability questionnaire and bowel habit diary. LactoSpore was established to be safe and tolerable in healthy participants on evaluation of all the above parameters (Majeed M et al. 2016. J Clin Toxicol. doi 10.4172 21610495.1000283). Stability in Functional Foods Probiotics are widely accepted when incorporated in functional foods. With stability a common concern LactoSpore s shelf stable spore form has allowed successful incorporation in various functional foods. Its stability in baked muffins and waffles hot beverages such as coffee frozen fudge frostings and toppings and beverages such as apple juice and glucose syrup has been evaluated with LactoSpore May 2016 www.niemagazine.com Topical benefits Probiotics play an essential role in skin care as well which has been clinically established through recent studies. LactoSpore has been incorporated successfully for supporting healthy skin topically in products such as soaps. While it imparts a positive effect on skin by modulating mechanisms related to the immune system it also provides benefits for atopic conditions by restoring residential and beneficial skin microflora. (Majeed M et al. 2015. EuroCosmetics 10-11). Nutrition Industry Executive 47 ScienceofIngredients 2016 U.S. Pharmacopeial Convention (USP) 12601 Twinbrook Pkwy. Rockville MD 20852-1790 Phone (301) 881-0666 (800) 227-8772 Email mediarelations usp.org Website www.usp.org USP Verified Mark R ecent reports challenging the quality of dietary supplements have prompted industry leaders and health professionals to find ways to distinguish quality products from subpar products as they strive to protect their brands and consumers. A prominent solution that manufacturers health professionals and consumers have relied upon is to look for the USP Verified Mark. Pharmacists Know and Trust USP Verified Pharmacists are strong proponents of the USP Verified Mark primarily because they are familiar with USP s role in establishing quality standards for medicines. Since 1906 Congress has required that medicines sold in the U.S. meet public standards and recognized the US Pharmacopeia and the National Formulary or USP and NF as official compendia of those standards. Pharmacists are accustomed to seeing the letters USP on the medicines they dispense. So when the quality of dietary supplements are challenged it is not surprising that they would look to USP for an assurance of quality. How can we protect patients in this milieu asked Cydney McQueen PharmD in a Guest Editorial published in the March 2016 issue of the journal Hospital Pharmacy. Her answer Provide education on the problem of quality and practical guidance on how to navigate store shelves. Her top recommendation for both pharmacists and consumers is to look for thirdparty verification of quality specifically the USP Verified Mark. Sarah Erush PharmD clinical manager of the Pharmacy at the Children s Hospital of Philadelphia took this approach one step further and required her hospital pharmacy to try to only stock dietary supplements that have been independently tested for product quality. She also prefers the USP Verified Mark. law was that it created a disincentive for what had been an accepted practice adding the letters USP after the product or ingredient name to indicate it was made to USP standards. But many manufacturers still wanted a way to indicate their products were made using USP s rigorous science-based standards. So at the request of industry USP created USP Verified a voluntary independent third-party verification program based on USP standards to help address their concerns. The USP Verification process includes facility audits full document review of quality control procedures and testing products against USP s public standards. Products that meet USP s rigorous procedures are awarded the USP Verified Mark. The USP Verified Mark offers assurance that what s on the label is in the bottle in the right amount it has been tested for harmful levels of contaminants and will break down so it can be absorbed by the body. Early participants in the program were NatureMade and Costco s Kirkland Signature brand. The USP Verified Mark makes a participant s commitment to quality visible and helps differentiate their products in a competitive marketplace. and test methods for all of the botanical extract products and ingredients targeted by the NYAG. None of these standards currently include DNA test methodology. None of the brands cited in the NYAG s letters were USP Verified. If they were USP would have conducted an investigation to ensure they complied with standards found in the USPNF and USP would stand by the quality of those products. Media Reports Advise Readers to Look For the Mark Increased scrutiny of the dietary supplement industry did not end with the investigation by the NYAG. Federal enforcement actions against a few manufacturers of products primarily in the sports sexual enhancement and weight loss segments included product recalls and other events making dietary supplement quality a steady focus of news reports over the past year. Many stories have pointed to USP Verified and other third-party seals as a way to help consumers choose quality products. Demand for Verification Seals is Growing The supplement industry is under unprecedented scrutiny. Reports of poor quality among products in a few segments have called into question the quality of almost all products. And independent verification seals are popular and a useful tool to help distinguish quality products. Pharmacists national brands major retailers and the media rely on these seals to help patients consumers and readers determine quality products. Consumers are learning to look for the USP Verified Mark to ensure what s on the label is what s in the bottle. As a result interest in the USP Verified program is growing. More information about the USP Dietary Supplement Verification Program can be found at www.uspverified.org. www.niemagazine.com May 2016 Retailers Can Look to USP Verified to Manage Risk In February 2013 the New York attorney general (NYAG) sent cease and desist letters to several major retailers demanding they remove some of their herbal dietary supplement products from store shelves because tests using DNA methodology showed they did not contain the ingredients listed on the label. Although the test methods used by the AG s office were challenged the move garnered negative press for those retailers and the industry. Among the 500-plus quality standards for dietary supplements and dietary ingredients in the USP-NF are standards Industry Appeals to USP to Help Make Quality Visible When Congress created a separate regulatory category for dietary supplements in 1994 it continued to recognize USP standards as official but made them voluntary. An unintended consequence of this 48 Nutrition Industry Executive ScienceofIngredients 2016 Xsto Solutions LLC 45 S. Park Pl. Ste. 148 Morristown NJ 07960 Phone (973) 975-4224 Fax (973) 545-0221 Email info xstosolutions.com Website www.xstosolutions.com Cuvitus New for Muscle and Joint Support M uscle and joint pain can range from minor and annoying to significant and debilitating. To most people the cause is really less important than finding relief during the period of discomfort. Generally there is temporary pain and discomfort from short term over exercise or exertion and there is chronic or long-term pain from disease conditions such as arthritis. Dietary supplement claims are limited to marketing only to the pain and discomfort associated with the temporary activities versus ongoing conditions. Short term over exercise includes activities such as running a mini marathon or working in the yard all weekend which can lead to muscle and joint pain. By doing something (or overdoing something) that we don t routinely do on a daily basis we meet the temporary criteria. Using muscles we don t normally use often causes soreness and pain the next few days. Metabolically we are increasing specific pro-inflammatory cytokines such as TNF-alpha and certain interleukins which have been scientifically linked to the process of pathological pain.1 Using these cytokines as biomarkers for pain we can begin to track whether a compound will beneficially reduce pain and soreness from temporary over exercise or exertion. Cuvitus is a soothing tonic for muscle and joint pain from temporary over exertion and exercise. tion of TNF- and certain interleukin cytokines thought to be a result of cellular nuclear translocation of NF-k.2 Additional studies on animal and human cells (ex-vivo) confirmed the in vitro research. In the first human study athletes form the Italian Army Carabinieri Olympic Track and Field team participated in a yearlong study observing a reduction in pain level from training as the benefit of Cuvitus on muscle pain. In this open label study 65 percent of the athletes reported positive effect versus 10 percent or less reporting supplementation had little or no effect.3 In a second human observational study over a nonstatistically relevant population of adult people (more than 21 years of age) the participants were followed by 10 physicians for a treatment period of 10 to 30 days. The 50 subjects enrolled in the study suffered from various type of acute or chronic pain. Almost 40 percent of the participants reported strongly positive benefit and 80 percent of participants reported results as positive and strongly positive. 4 In each human study the participants were given between one and four doses at 150 mg each. It was later determined that two doses (300 mg) where probably adequate for the response. Safety of Cuvitus While cucumbers have been consumed safely by humans for centuries one has to ask if an extract of the same fruit with its potential concentrations are equally as safe To confirm the safety profile Cuvitus gherkin extract has been tested for safety using acute toxicity formats as well as mutagenic and cytotoxicity platforms. No toxic properties were observed and no abnormal findings were recorded in any of the three toxicoloty study formats. The cuvitus compound is a free flowing tan colored powder which can be easily formulated in tablets and capsules. The researched dose is 150 mg with a recommendation of one or two doses per day. The loading time is two to three days and there have been no reported side effects and no adverse events. Cuvitus is a soothing tonic for muscle and joint pain from temporary over exertion and exercise. Contact Xsto Solutions at info xstosolutions.com or visit the company s website at www.xstosolutions.com. Cuvitus Efficacy for Pain With this in mind recent scientific research out of Europe has focused on a newly isolated compound extracted from the Cucumis sativus fruit commonly referred to as cucumbers. Cucumbers have long been appreciated for their cooling and soothing effect for sunburn skin and puffy eyes. They have also been a staple of many diets for their refreshing and low calorie properties. With a unique extraction process the active beneficial compounds of the Gherkin cucumber have been commercialized as Cuvitus an exciting new ingredient for use in nutrition and dietary supplementation. The initial scientific research looked at in vitro studies where cells were stressed using LPS (lipopolysaccharide) a popular model for initiating cellular stress and observing the normal response of cell proliferation. Cells exposed to the Cuvitus extract showed lower proliferaMay 2016 www.niemagazine.com References 1 Intl Anethesial Clin. 2007 Spring 45(2) 27-37. 2 Inflamm. Res. (2013) 62 461-469. 3 Unpublished data from Crown Health Gherkin Lugano Switzerland 2013. 4 Unpublished Data from Crown Health Gherkin Lugano Switzerland 2014. Nutrition Industry Executive 49 MarketingInnovations By Suzanne Shelton The Shelton Group he term crisis communications sounds big and scary. It makes you think of a recall of a dangerous product FTC (Federal Trade Commission) problems or an attack by an attorney general. It requires preparation and thoughtful informed handling and should not be taken lightly. I ve seen a shift in the impact of communication however and recommend that in today s world all communications programs should be taken as seriously as crisis communication necessitates. There s an old saw in the military In a crisis you rely on your training. And training implies planning. Thinking about how to respond in a crisis must be done beforehand and the steps to take and who should take them should be part of a predetermined plan. You don t after all decide how T to evacuate the building after the fire starts. In the old days you may have had to deal with a reporter or two badgering you at the door. Or figure out how to respond to a firm letter from an attorney. The world of social media has turned this on its head. Communicating with all of a company s constituents has been revolutionized. This requires that companies reevaluate their approach ranging from when big problems come up right down through when the occasional unhappy customer posts on your Facebook page or Tweets at you. You always want to get ahead of bad news but it s even more important not to create it for yourself. If you have not thought through how to handle these situations here are some specific situations to think about. An Actual Crisis Forward-thinking companies anticipate potential future negative situations and prepare to minimize or negate their impact. Just as you should have a plan in place for the day the FDA (U.S. Food and Drug Administration) inspector knocks everyone should know what to do when bad news comes calling. If you have laid the groundwork with your customers by creating trust it can reinforce consumer confidence. Your crisis communications team should already be in place before you need one. This involves identifying the areas of expertise and responsibility that will make up the team and establishing a protocol to follow. Areas of responsibility are likely to include Regulatory compliance Legal www.niemagazine.com May 2016 50 Nutrition Industry Executive Manufacturing QA Marketing Public relations Brand manager Decide in advance how you will communicate and establish timeframes for your staff s responses. Sometimes it s best not to make a statement and the group will need to come to consensus on that. But if you do respond do it quickly--within a day or two at most. If you still have not issued a statement within a week it may be best not to--you do not want to appear that you are fumbling for a response. Choose an authority to make final decisions if some team members are not available. Since a timely response is important it is a good idea to have some draft language developed and agreed upon in advance for various situations that may arise. It s far better to have it and not need it than the reverse. Think beyond external communications--internal is just as important. The switchboard person should be given instructions right away as to how to route any calls. Everyone likely to be asked questions should have specific responses along with instructions not to elaborate. And everyone in house likely to hear about the situation should know what s going on and what you are doing about it. A crisis FAQ is a useful main document from which all other communications are pulled. It can include Acknowledgement of the crisis Details about the incident How the company found out Who was alerted when and how Specific actions taken in response Real or potential effects Steps taken to prevent future occurrence Staff contact information Crisis communication isn t just about challenges visible in the outside world. Internal affairs call for forethought as well. For example if an important change happens at the company such as a key staff member leaving abruptly don t let the rumor mill get started. Make a clear yet reassuring statement right away because gossip loves a vacuum. It s always better to be gracious and wish the departing staff member the best in future endeavors. And make sure the social media account passwords are changed when staff members leave make sure you control the dialogue and not a possiMay 2016 www.niemagazine.com bly disgruntled ex-employee. The retailer H&M once fired 60 staff members some of whom tweeted gems such as We re tweeting live from HR where we re all being fired Exciting and Just overheard our marketing director (he s staying folks) ask How do I shut down Twitter These are not complete checklists just examples of the types of things to think about as you evaluate and update your communications programs. And one overarching rule of thumb Keep it brief. Verbosity can look like dissembling and inadvertently reveal more than you intended. Social Media Concerns Social media has not just revolutionized the speed of the spread of communication it has changed its nature. Today more than ever what starts as a relatively minor complaint can become a crisis if not handled well and promptly. Social media can amplify ill-considered statements out of all proportion. What in the past might have been a snide aside muttered to a like-minded colleague can now take on ogre-like proportions if broadcasted with the social media bullhorn. Social media feels intimate but it s not it s best not to Tweet something you wouldn t feel comfortable with seeing on a billboard. Earlier in the history of this new medium a company s social media responsibilities were often delegated to someone such as an unpaid intern. Today that s asking for trouble. Think about the communication style of the social media users you do choose. You don t want to give the company s Twitter credentials to that staff member with the sometimes inappropriate sense of humor or you could end up with your own version of the DiGiorno Pizza WhyIStayed disaster (chiming in on a conversation about domestic violence with WhyIStayed You had pizza. Major social media fail ). Pay attention to the voice of your social media. It says who not what your company is so make it a conscious choice. I always suggest people check out the Riot Fest Twitter Guy as a distinct example of just the right personality for that particular company. RiotFest is somewhat of a celebrity for his running jokes and playful tone all the while doing an excellent job conveying information followers want and need. Find the voice that is right for your company. Consumers are making more customer complaints via social media today than ever before because it usually works. With all the hoop jumping required to be connected to an actual person on the telephone at companies today most people don t even want to try so they tweet or post on Facebook. Here are five rules on how a company can respond 1. Address it publically--acknowledge immediately or yes we realize (something) happened. 2. Accept responsibility--Apologize. People are able to forgive much more easily when there is a prompt mea culpa. Cover-ups and blaming others fan the flames. 3. Offer direct contact to resolve negative situations--Say what needs to be said to answer questions and allay concerns of observers then take the conversation with the main party offline for direct resolution. 4. Demonstrate that you authentically care--I read an article recently about an author who responds to every one star review on Amazon.com and offers to refund their money. Apparently he has sent three people a check but won many more fans and customers because he has demonstrated that he cares. 5. Never underestimate the power of self-deprecating humor--The most effective responses are timely they are personal and they use humor. While this isn t a complete guide to not creating a crisis via social media or handling communications in a crisis this should start you thinking about your communication programs and what you may need to review and revise them. If your team doesn t include someone who already knows all of this that s the first thing you should correct. NIE The Shelton Group is a boutique public relations and marketing agency working exclusively in the dietary supplements and natural products industry since 1990. For more information visit www.sheltongrouppr.com Suzanne Shelton has provided public relations services to both international and domestic dietary supplement and natural products manufacturers suppliers and associations. Nutrition Industry Executive 51 FunctionalFoods Demands Innovation drives protein s appeal to a wider audience. Protein By Corinne Anderson C onsumers are becoming increasingly aware of the value of adding protein to their diet whether it is related to satiety effects weight management or a more balanced diet said Brent Petersen associate director of research at California-based Glanbia Nutritionals. Diversification isn t the only approach we can see in the market. Protein is emerging as a premier macronutrient across multiple categories. However it is also a challenging ingredient to work with and food and drink manufacturers are looking into new ways to optimize the functionality of every application Petersen added. The world s population is growing and the peoples appetite for dietary protein is also increasing noted Alan Rillorta director of branded ingredient and protein ingredients at Californiabased AIDP Inc. Animal proteins can only go so far and so opens the door for new sources of protein we might not have ever thought of before. Plant Protein As a marketer of soy protein DuPont Nutrition & Health believes that soy 52 Nutrition Industry Executive protein is well positioned to capitalize on the growing interest in protein particularly as that interest moves more mainstream said Jean Heggie strategic marketing lead at the Missouribased company. Soy protein is a high-quality plantbased protein with proven health benefits and great functional performance in a wide range of flavor sensitive application. This distinguishes it among other popular plant protein choices which tend to be lower in protein quality and not as versatile or functional in food and beverage applications Heggie said. In addition Heggie explained that compared to dairy proteins soy protein is more economic equivalent in protein quality and environmentally friendly. For any company wishing to make its mark in the plant-protein market soy protein s supply reliability and documented low carbon footprint advantages also make it a preferred choice. Plant-based proteins have been an emerging trend in the past few years. New sources being utilized as proteins include pea rice sacha inchi hydrolyzed wheat hemp coconut sunflower pumpkin cranberry quinoa chickpea potato and algae Rillorta explained. And it doesn t stop there. There is constant development of new plant protein ingredients and insect proteins too like cricket Rillorta added. Blends Another trend that has taken the protein industry by storm is the blending of various protein sources to achieve a collective balance of each of their distinct benefits in nutrition Rillorta said. I think in the near future we will also see more plant and animal protein blends. Pea and whey protein can have terrific symbiosis. Pea can help balance the higher cost of whey protein and whey can help augment methionine and cysteine amino acids where pea protein is lacking. Blending the ingredients has its merits as it can also take on different applications from powders to bars and gummies. We ve developed unique ingredient lines to deliver immediate protein levels in nutritional bar applications Petersen shared. Some protein solutions are 100 percent dairy while others blend whey and soy proteins. Several vegan protein combinations (pea chia soy and flaxseed) have also been recently introduced under the barGAIN and www.niemagazine.com May 2016 HarvestPro product lines to deliver softer texture a longer shelf life and clean flavor and nutritional profiles. Milk & Whey While some trends are falling into the vegan category a secondary trend for those seeking milk and whey proteins has also emerged. The demand for certified organic grass fed and hormone free is taking off said Benoit Turpin MSc CNHO vice president of international sales-human nutrition for Minnesota-based Milk Specialties Global. Milk Specialties has been adding manufacturing capacity at just about every single manufacturing facility encompassing both raw material manufacturing (such as whey protein concentrates whey protein isolates milk protein concentrates milk protein isolates and micellar casein) as well as contract manufacturing (blending and packaging). Being that milk and whey proteins offer some of the best naturally occurring amino acids profiles (both essential amino acids (EAA) and branched chained amino acids (BCAA)) both categories are in very high demand Turpin explained. In addition to the focus on organic food manufacturers prefer a U.S. origin protein source versus an off-shore supply said Tyler Lorenzen president Proteins and Ingredients World Food Processing in Minneapolis. There are many reasons for this but we feel the sustainability proximity to the source and manufacturers proves to be a valuable supply chain strategy. active health conscious consumers. Protein s popularity shows no signs of abating and this demand will drive innovative methods of formulation using new protein sources according to Petersen. While dairy proteins continue to be a popular ingredient specific trends like vegan and GMO-verified are driving demand for products that deliver more protein per serving while consumer preference for label transparency will see longevity in plant-based proteins such as pea flax and hemp. Proteins deliver different tastes and textures so formulation challenges and successes will vary depending on the end product. -- Brent Petersen associate director of research Glanbia Nutritionals World Food Processing has seen an accelerated growth in pea protein over other plant protein sources such as soy Lorenzen shared. Our PURISPea Protein hits every major food trend such as clean label non-GMO allergen friendly gluten free and dairy free while not compromising on great taste and mouth feel. New Demands What is behind these increasing trends in organic grass-fed and plant-based Consumers are looking for simple sustainable organic options including non-GMO (genetically modified organisms) gluten free and vegan. Heggie agreed. That is why DuPont Nutrition & Health has invested significantly in understanding the sensory functional and nutritional synergies in blending proteins both dairy and soy and soy and other plant proteins. Consumer interest in protein is expanding and coming from many different segments said Heggie. Demand is strong in the traditional sports nutrition and weight-management markets who have always been interested in protein and new opportunities are emerging targeting child nutrition healthy aging and among mainstream May 2016 www.niemagazine.com Innovations There is a growing number of exciting and innovative protein delivery formats Rillorta said. Aside from the traditional powder protein delivery system some of these protein ingredients are finding their way into places we never really thought of before ice cream cereals cookies and even meat substitutes. Pea protein is extruded to the consistency and texture of chicken and beef. Proteins deliver different tastes and textures so formulation challenges and successes will vary depending on the end product Petersen added. The key aspect is having the ability to process and develop ingredients and concepts in a way that is appealing to consumers. Customers are looking for novel sensory experiences. With this in mind Turpin said Milk Specialties has developed a wide range of lightly fermented high protein Milk Protein Concentrates (for smoothie-type applications) as well as specific recipes of savory snacks. Extended shelf life is also a challenge that formulators encounter that innovations have addressed. Milk Specialties offers proteins with functional properties so that in addition to the extraordinary amino acid profiles its proteins allow formulators to design products with less stabilizers and extended shelf lives. Furthermore Milk Specialties has the ability to selectively enrich certain protein hydrolysates with specific amino acids Turpin said. Protein fortification continues to be a hot topic in the industry Petersen said. Protein-fortified gummy snacks are becoming a popular alternative to healthy snacking. This new type of product application fulfills the need for convenient protein supplementation and opens the way to a new category in the industry. Glanbia Nutritionals developed BevWise I-300W series a range of whey proteins designed for use in gummy applications. Usually when adding protein to gummy applications changes in texture can cause clogs in the equipment. BevWise s functional properties allows manufacturers to overcome the traditional formulation challenges Petersen shared. Protein s appeal is more universal today thus flavor is becoming more important in executing high-protein foods and beverages Heggie said. As more mainstream consumers explore the protein beverage category taste and ease of dispersibility become important criteria for building brand preference in the dry blended beverage market. DuPont Nutrition & Health recently introduced SUPRO XT 221D Isolated Soy Protein a new protein for dry blended beverages that offers best-inclass dispersibility along with excellent flavor and functional performance Heggie added. Protein Research DuPont s Beverage Drivers of Liking Study is a sensory-based study that looks at the universe of commercial ready-to-drink high-protein beverages to understand what drives consumer liking in this category. This knowledge enables us to help (Continued on page 55) Nutrition Industry Executive 53 Equipment&Packaging Munson Ribbon Blender New York-based Munson released a new Munson Ribbon Blender that meets pharmaceutical standards and blends up to 65 cubic feet (1.84 m3) of powders pastes or slurries. The unit model HD-3.5-7-S316 is constructed of 316 stainless steel with continuous welds having 0.25 in. (6 mm) radii a 4 interior finish and external removable seals. The blender s 2 1 length-todiameter ratio is said to distribute ingredients uniformly during loading blending and discharge. It forces a split double-helical agitator through stationary material producing homogeneous blends in five to six minutes typical. Tight tolerances of 1 16 to 1 32 in. (1.6 to 0.8 mm) between ribbon blades and the vessel wall minimize residual product in the trough following discharge reducing material waste and cleaning time. It is equipped with a hinged and gasketed cover with safety interlocks. Options include a dust hood inlet with removable grating for ease of loading spray lines for liquid additions CIP manifolds and 6 or electropolished interior surface finishes. Available sizes range in capacity from 1 to 1 000 cubic feet (.03 to 28 m3). For more information call (800) 944-6644 or visit www.munsonmachiner.com. Automatic Film Splicer Minnesota-based Douglas Machine Inc. recently released the Douglas Contour Series M-60 Multiwrapper with Automatic Film Splicer which allows operators to stage clear of printed film while machine is running. Splicing is automatic without an operator present resulting in precise print registration and reduced machine downtime. The multiwrapper runs single dual or triple stream bundles of PET bottled water at various cycle speeds up to 60 per minute to meet the filler rate. For more information call (320) 763-6587 or visit www.douglas-machine.com. Serialization-ready Printed Packaging Components Texas-based Platinum Press Inc. a provider of health care packaging soultions for the pharmaceutical medical device and animal care sectors that specializes in labels folding cartons (including secondary blister packaging) inserts outserts and medication guides -- offers a variety of serialization-ready printed materials amounting to ideal platforms on which to apply final track and trace data onto packaged pharmaceutical products. In supplying a variety of substrates and printing options conducive to track and trace compliance the printing company is a serialization specialist. With offerings including DataLase and Laser Ablation Platinum Press has the equipment and technological capabilities required to produce materials fully prepared for final serialization and has invested in coding and marking equipment ideally suited to the parent-child aggregation of pharmaceutical products. Platinum Press offers multi-factor authentication using both overt and covert anti-counterfeiting measures and has extensive experience addressing needs for track and trace marking at both the unit and aggregate levels. For more information call (469) 733-1506 or visit www.platinumpress.com. Cognex MX-1000 Mobile Terminals Cognex Corporation a Massachusetts-based supplier of machine vision systems and industrial barcode readers used in factory automation and logistics announced the availability of a new product line ruggedized mobile terminals. Cognex s MX-1000 series of mobile terminals offers manufacturers logistics companies and many other organizations that currently rely on expensive inflexible and purpose-built mobile terminals a revolutionary new method for performing tasks such as inventory management logistics and field service. The MX-1000 combines the ease-of-use low-cost and flexibility of off-the-shelf smartphones together with a rugged hand-held assembly that holds both the phone and a specially designed Cognex barcode reader that outperforms competitors laser-based and camera-based systems the company said. Cognex designed the MX-1000 after detailed discussions with leading companies that use mobile terminals and who were also customers of Cognex s machine vision products and barcode readers. Those customers were dissatisfied with their current mobile terminals which they described as proprietary expensive closed systems which are both difficult to build applications on and costly to maintain. They urged Cognex to design a flexible mobile terminal that includes Cognex s field-proven barcode reading technology. For more information call (855) 426-4639 or visit www.cognex.com. 54 Nutrition Industry Executive www.niemagazine.com May 2016 FunctionalFoods (Continued from page 53) our customers define and implement formulation strategies that can improve the sensory performance of their brands Heggie noted. Our study also reinforced that beverages based on blends of dairy and soy proteins tend to result in higher liking scores than either all-dairy or all-plant-based beverages. Studies in the areas of sports nutrition are also important in regard to proteins and amino acids. Extremely popular in the sports nutrition market for its muscle building potential whey proteins are now at the center of research projects investigating weight loss recovery and bone health Petersen pointed out. Thanks to their unique amino acid content and rapid digestibility whey proteins are thought to reduce osteoarthritis-related bone loss and support healthy bones. One study that supported this was an in-vivo study at the University of Korea Whey Protein Concentrate Hydrolysate Prevents Bone Loss in Ovariectomized Rats which confirmed once again whey protein concentrate hydrolysate s capacity to improve bone loss induced by ovariectomy in rats. In addition to the hundreds of studies done on soy protein one in particular that DuPont supported looked at the value of soy and dairy blends for building muscle mass demonstrating that these blends have the capability to extend the window of time post-exercise when muscle building can occur. This research has implications for products that are designed to help maximize muscle gains Heggie shared. Clinical trials of pea and rice protein show the same efficacy as whey protein in building and retaining muscle mass according to Rillorta. This shows promise that plant proteins can be just as good as animal proteins and is just what we need to battle the long established stigma that plant proteins are inferior to animal proteins. Rillorta noted. We are really excited to show some of our innovative proteins that may alter some of the current opinions on amino acid absorption of pea protein Lorenzen added. To the Future Innovations continue to happen from new concepts to delivery systems Lorenzen said. We find some of our customers making the consumption of protein more tailored to the on-the-go consumer not stopping at only bars and shakes but stretching the potential to applications covering every meal that can be taken during a fast-paced schedule. Petersen agreed adding More and more options are being offered in the grocery aisles in a variety of applications including dairy beverages and bakery to meet the needs of the most discerning customers. NIE FORMOREINFORMATION AIDP Inc. (866) 262-6699 DuPont Nutrition & Health (314) 659-3000 Glanbia Nutritionals (800) 735-8137 Milk Specialties Global (952) 942-7310 World Food Processing (641) 672-9651 Advertiser Index Albion Laboratories Inc. BioCell Technology LLC Biova LLC Comar LLC Euromed USA Inc. Healthco Herbally Yours HSU s Ginseng Enterprises Inc. IgY Nutrition LLC Jiaherb Inc. Natreon Inc. Nutragenesis Icon Group PLT Health Solutions Inc. Sabinsa Corporation Soma Labs Inc. Texas Best Organics Inc. 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Javits Convention Center New York NY www.eastpack.packagingdigest.com or www.hbaglobal.packagingdigest.com July 16-19 IFT 2016 McCormick Place South Chicago IL www.am-fe.ift.org May 2016 www.niemagazine.com Nutrition Industry Executive 55 SupplieroftheMonth Kevin Salerno President HORN Human Established in 1961 HORN is North America s premier distributor of specialty ingredients and raw materials. Its specialized team of technically expert and trained professionals serve dedicated market segments that encompass six distinct distribution business units including Nutraceuticals FoodTech Animal Wellness and Care Elements. HORN an employee-owned ESOP company and for more than 50 years takes an entrepreneurial approach in serving its valued partners. President of HORN Human Nutrition Kevin Salerno leads the operations of this progressive division. There are two strategic business units in the division--HORN Nutraceuticals and HORN FoodTech--as well as Nutri Granulations a manufacturing plant that provides engineered granulation solutions for various market applications and grades. Since assuming the title of president in 2003 Salerno has been instrumental in advancing the company s industry presence and influence in the world of ingredients distribution. Nutri Granulations has also since become a leading FDA (U.S. Food and Drug Administration)-licensed granulation facility. HORN 16050 Canary Ave. La Mirada CA 90638 Phone (800) 442-4676 Website www.ethorn.com Nutrition NIE HORN recently unveiled its human nutrition division. What was the company s motivation to create the new division Salerno Since HORN s inception in the early 1960s our company has tackled challenges and taken on opportunities with an entrepreneurial approach. It is part of HORN s DNA. Our business ventures attest to our dedication of serving our partners and our industries. Nutri Granulations HORN s manufacturing arm is a perfect example of HORN s out-of-the-box problem-solving style. HORN took on this manufacturing plant that primarily processes calcium carbonate to become the economic and environmental solution to better serve West Coast customers when Proposition 65 changed the game for many industries including ingredients distribution. It is with that same entrepreneurial spirit that HORN reorganized our distribution business model. We recognized the natural crossovers within the markets of functional foods nutraceuticals pharmaceuticals and other human nutrition markets and seized to fortify our efforts to strengthen our industry offering and presence. The HORN FoodTech business unit was under what was formally called our Ingredients Division. Bringing HORN FoodTech and HORN Nutraceuticals business units under one division solidifies our efforts broadens our 56 Nutrition Industry Executive capabilities and provides a platform for HORN to further improve the way we serve our industries all while maximizing the business opportunities with existing partnerships. Additionally the launch of HORN Human Nutrition also creates better synergies with the principal suppliers we proudly represent. It s a win-win. And the response from our partners have been very positive. NIE What are the benefits that the industry is already experiencing from this reorganization Salerno One of our most valued resources at HORN is our people--a team of technically expert and experienced professionals working and training closely with our world-class principal suppliers. The launch of HORN Human Nutrition division offers the industry a bigger team working in unison to carry out the strategies for serving our valued customers. This also means a larger product portfolio of best-in-class standard ingredients and innovative ingredients that target topics most relevant to today s consumers. This includes functional ingredients and science-based innovations that address weight and blood sugar management blood pressure and heart health immunity sports nutrition bone health and women s health among others. Under the HORN Human Nutrition division both business units (FoodTech and Nutraceuticals) and their respective customers have access to our expert resources. I mentioned earlier that people are our most valued resources. An integral part of that team is Sandy Chien PhD HORN s vice president of innovative products who provides clinical expertise in identifying science-driven innovations and is also available for formulation support. NIE What other innovative ventures does HORN have in the pipeline Salerno HORN offers many valueadded benefits to the industry including innovations that parallel with our partners needs. Expect to hear more about HORN s innovative technologies for alternative delivery systems and the release of Celera Nutrient Enhanced Gum which will be mass produced in our manufacturing plant in La Mirada CA from the newly formed manufacturing and distribution partnership with NuCorp LLC. We also have more innovative ingredients in the pipeline including a new distribution partnership with SloIron. Extra Extra Visit www.niemagazine.com to read the rest of the interview. www.niemagazine.com May 2016 Go to www.niemagazine.com biova for info about this advertiser Go to www.niemagazine.com usp for info about this advertiser