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Description: In This Issue: Improving the Supplements Narrative in Washington DC, Sports Nutrition, Sleep Support, and Marine Ingredients

A VRM Media Publication www.niemagazine.com October 2017 Don t miss a single issue of NIE in 2017...go online to renew your free subscription today NIEmagazine.com October17 Go to www.niemagazine.com sabinsa for info about this advertiser Go to www.niemagazine.com healthco for info about this advertiser TableofContents Proud Supporter of VOLUME 22 NO. 8 OCTOBER2017 F E A T U R E S 20 A Stress-free Dose of Zs Having life cause its share of stress can be difficult enough to deal with especially when it affects sleep. Natural ingredients and products are teaming up to help consumers get the sleep they yearn for. 24 Improving the Supplements Narrative in Washington DC 28 Sports Nutrition Industry Update Sports nutrition supplements are in energetic demand by a wide range of consumers who want physical improvement more quickly than with diet and exercise alone. C O L U M N S 20 A L S O I N S I D E 6 12 17 18 19 38 46 47 47 Industry News Ingredient News AHPA Update Association News Science Update Research & Development Equipment & Packaging Advertiser Index Industry Events Supplier of the Month 4 First Word 35 Nutraceuticals 40 Building Better Brands 43 Ingredient Technology 40 48 FREE Subscription (Print Digital or BOTH) & E-newsletter Available www.niemagazine.com Copyright 2017. Nutrition Industry Executive (ISSN 2331-2602) Volume 22 Number 8 October 2017. Nutrition Industry Executive is published monthly (except for bimonthly January February and July August and November December) by VRM Media 431 Cranbury Road Suite C East Brunswick NJ 08816 USA Phone (732) 432-9600 Fax (732) 4329288. All rights reserved including the right to reproduce in whole or in part. Not responsible for unsolicited material. Opinions expressed in by-lined articles or advertisements are not necessarily those of Nutrition Industry Executive or its owners. Publisher is not liable for advertiser product claims or representations. Advertisers assume total responsibility for the contents of their advertisements. Printed in U.S.A. Basic annual subscription rate is 50.00. Periodicals Postage Paid at East Brunswick NJ 08816 and additional mailing offices. POSTMASTER Send address changes to Nutrition Industry Executive P.O. Box 15026 North Hollywood CA 91615-5026. Subscription Customer Service Nutrition Industry Executive P.O. Box 15026 North Hollywood CA 91615-5026 USA Phone (818) 286-3170 Fax (800) 869-0040 niecs magserv.com www.niemagazine.com. Back Issues & Single Copies For order information contact (732) 432-9600 or info niemagazine.com. March issue is 25.00. All other issues are 8.00 each. 2 Nutrition Industry Executive www.niemagazine.com October 2017 Go to www.niemagazine.com plt for info about this advertiser FirstWord The Right Price his summer when Amazon announced its plan to acquire Whole Foods I interviewed several industry experts to get their input for a special report published in Nutrition Industry Executive s sister publication Vitamin Retailer. It s no surprise one of the top concerns that came up was the question of pricing. Would Whole Food s Whole Paycheck formula overtake Amazon s bargain pricing model or vice versa This is one of the first major combination of two completely different sales channels for natural products direct to consumer internet sales and a large brick and mortar retail chain said Jim Emme CEO of Illinois-based NOW. The Amazon model is fast service at a low price while the Whole Foods model had been a culture of trust with the consumer with products at a premium price. How the dichotomy of these pricing models will sync up is going to be interesting to observe. Retailer Mo George-Payette CEO of Mother s Market & Kitchen in California offered her perspective. It leads to wondering how it will have an impact on the overall industry and which retailers will be further impacted from the growing demand for organics and nonGMO (genetically modified organism) products to farmers growers incorporating other resources to support supply to pricing structure competition to of course fulfillment methods she said. We are seeing many regional brokers join forces with others to stay afloat more independent brands signing on with larger companies across all categories and frankly it is a sign of our fast-paced changing times. In Darrin Duber-Smith s Building Better Brands article he also addresses the impact the Amazon Whole Foods T merger may have on pricing (see page 40). He wrote In an industry that has seen Whole Foods Markets rapidly and unceremoniously be acquired by Amazon it should be clear that the path to success is becoming increasingly perilous. The key is to justify your price point by considering a number of different but related factors. Shortly after the merger Amazon announced that Whole Foods customers would see changes immediately. There were price slashes on certain products--specifically named--such as whole trade bananas organic avocados and organic large brown eggs. We re determined to make healthy and organic food affordable for everyone. Everybody should be able to eat Whole Foods Market quality -- we will lower prices without compromising Whole Foods Market s long-held commitment to the highest standards said Jeff Wilke chief executive of Amazon Worldwide Consumer in a news release. According to the Washington Post (which by the way is owned by Jeff Bezo) the price cuts are just the first step Amazon will integrate Amazon Prime as a customer rewards program for Whole Foods shoppers and Prime members will get extra discounts and offers. Whole Foods private-label brands will be available for purchase online through Amazon Fresh and Prime Pantry. Duber-Smith stressed that this is something for brand marketers to keep in mind These days this industry has precious little room for high-end players that offer questionable added value while commanding high price points. Marketers of branded products will have to take pricing somewhat more seriously in this new paradigm. Publisher Daniel McSweeney Editorial Director DanM VRMmedia.com Associate Russ Fields Publisher RussF VRMmedia.com Advertising Gary Pfaff Sales Associate GaryP VRMmedia.com Editor-in-Chief Janet Poveromo JanetP VRMmedia.com Managing Editor Shari Barbanel ShariB VRMmedia.com Associate Editor Nicholas Saraceno NicoS VRMmedia.com Contributing Writers Darrin C. Duber-Smith James J. Gormley Lisa Schofield Art Director Robert Certo Production Manager RobertC VRMmedia.com Production Assistant Bryan Zak Graphic Designer BryanZ VRMmedia.com Circulation Manager Rosie Brodsky Rosie StarkServices.com A PUBLICATION OF VRM MEDIA President Daniel McSweeney VRM Media 431 Cranbury Road Ste. C East Brunswick NJ 08816 Phone (732) 432-9600 Fax (732) 432-9288 Email info VRMmedia.com Website www.niemagazine.com VRM Media publishes Nutrition Industry Executive Vitamin Retailer Natural Practitioner and FitnessTrainer magazines. Subscription Customer Service To order a subscription or manage your account please contact us at Nutrition Industry Executive P.O. Box 15026 North Hollywood CA 91615-5026 USA Phone (818) 286-3170 Fax (800) 869-0040 niecs magserv.com www.niemagazine.com Back Issues See the Table of Contents page for price and order information. Connect With Us www.twitter.com www.facebook.com www.linkedin.com www.instagram.com www.pinterest.com vitaminretailer vitaminretailermagazine company vrm-media vitaminretailermagazine vrm_media 4 Nutrition Industry Executive www.niemagazine.com October 2017 Go to www.niemagazine.com jiaherb for info about this advertiser IndustryNews U.S. Sales of Herbal Supplements Increase in 2016 .S. consumers spent an estimated 7.7 percent more on herbal dietary supplements in 2016 than in the previous year according to the recently published HerbalGram Herb Market Report for 2016. The report which appears in issue 115 of the American Botanical Council s (ABC) quarterly peer-reviewed journal HerbalGram shows strong continued growth for these products with total U.S. retail sales surpassing 7 billion for the first time reaching a total of 7.452 billion in 2016. ABC s annual market report for herbal supplement sales is based on U.S. retail sales data from market research firms SPINS and IRI as well as Nutrition Business Journal (NBJ). The report covers only retail sales of herbal dietary supplements and does not reflect the sales of most herbal teas botanical ingredients used in cosmetics or government-approved herbal drug ingredients in over-thecounter medicines. Herbal supplement sales in mainstream U.S. retail outlets in 2016 totaled approximately 943.9 million according to SPINS and IRI. NBJ which includes different sources in its dataset determined a higher total of 1.336 billion in mainstream sales for 2016. Horehound (Marrubium vulgare) an herb commonly found in U natural cough drops and lozenges ranked first in total mainstream U.S. retail sales for the fourth consecutive year. Wheatgrass (Triticum aestivum) and barley (Hordeum vulgare) in combination experienced the strongest mainstream sales growth in 2016 with a 131.9 percent increase in sales from the previous year. This report documents the consistent growth of consumer demand for natural remedies as evidenced by the increased sales of herbal dietary supplements said Mark Blumenthal founder and executive director of ABC. This is indicative of a welldemonstrated long-term trend toward natural medicine and consumers interest in taking responsibility for their own health via the responsible use of herbal medicine as an integral part of self-care. HerbalGram s market report also details the top-selling and fastest- growing herbal ingredients in U.S. natural and health food outlets in 2016. Natural product trends that may help explain some of the largest percentage sales increases for particular herbs are also discussed. The report explores the increasing consumer familiarity with ayurvedic ingredients the rise of adaptogenic herbs shifting preferences toward supplements that support overall health and wellness and the growth of herbal products with bitter properties and digestive health benefits. The report includes a detailed table of the 40 top-selling herbs (as primary ingredients in herbal dietary supplements) in the mainstream channel and a table of the 40 top-selling botanicals in the natural channel. It also includes a graph and table with total estimated sales of herbal supplements in all channels since 2000 (as determined by NBJ) a table with retail channel definitions and tables with sales broken down by product type (single-herb vs. combinationherb supplements) and total sales for NBJ s individual market channels. For more information visit http cms.herbalgram.org herbalgram issue115 hg115-herbmarketrpt.html ts 1504886451&signature 58fc70214fb006d9add2f4309d1 dd843. American River Nutrition Launches New Brand Identity Website and DeltaGold Tocotrienol Ingredient merican River Nutrition (Hadley MA) has unveiled new branding ranging from logos to a new website for the company and its DeltaGold tocotrienol vitamin E ingredient. Having spent many years focusing on the science of annatto-derived tocotrienols we felt it was time for American River Nutrition to move to the next level in marketing our DeltaGold said Anne Trias MS American River Nutrition product director. With our new look and website in place and an exciting new clinical study on DeltaGold that adds significantly to the existing body of science publishing shortly we re enthusiastic about future growth. Todd Pauli of The Shelton Group a A boutique marketing and PR firm working in the dietary supplement industry since 1990 led the rebranding effort. It was an honor to work with the people who not only introduced tocotrienols but also maintain such dedicated focus on the science that supports DeltaGold said Pauli Shelton Group partner. Inspired by the particular shape and color of the annatto plant from which DeltaGold is derived we sought to tell American River s unique story of being both leading scientists and U.S.-based ingredient manufacturers. Founded by Dr. Barrie Tan notable expert in the field of vitamin E tocopherols and tocotrienols American River Nutrition has exclusive focus on tocotrienols from the annatto plant as the purest source of delta- and gamma-tocotrienols which emerging research has proven to contain some exceptional benefits that are not shared by their tocopherol counterparts. For more information visit www.americanrivernutrition.com. www.niemagazine.com October 2017 6 Nutrition Industry Executive Go to www.niemagazine.com gcinutrients for info about this advertiser IndustryNews Associations Respond to Study Findings on Cancer Risk and Smokers Taking Vitamin B Supplements he Natural Products Association (NPA) has rejected a study by researchers blaming vitamin B use by male smokers for an increased risk of cancer. Dan Fabricant PhD president and CEO of NPA pointed to environmental factors and tobacco use as the more likely cause for increased cancer risk. Fabricant is a former head of the Dietary Supplement Division at the U.S. Food and Drug Administration (FDA). Epidemiologists from the Ohio State University Comprehensive Cancer Center--Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC--James) Fred Hutchinson Cancer Research Center and National Taiwan University reported their findings in the August 22 2017 issue of the Journal of Clinical Oncology. In the study Theodore Brasky PhD of the OSUCCC--James and colleagues analyzed data from more than 77 000 patients participants in the VITamins And Lifestyle (VITAL) cohort study a longterm prospective observational study designed to evaluate vitamin and other mineral supplements in relation to cancer risk. All participants were aged between 50 and 76 were recruited in the state of Washington between the years 2000 and 2002. Upon enrolling in the study participants reported information to researchers about B-vitamin usage over the past 10 years. This included dosage information--a critical but often missing detail needed for strong risk assessment and association research. For this new analysis researchers used statistical techniques to adjust for numerous factors including personal smoking history age race education T body size alcohol consumption personal history of cancer or chronic lung disease family history of lung cancer and use of anti-inflammatory drugs. This sets all of these other influencing factors as equal so we are left with a less confounded effect of long-term B6 and B12 super-supplementation said Brasky. Our data shows that taking high doses of B6 and B12 over a very long period of time could contribute to lung cancer incidence rates in male smokers. This is certainly a concern worthy of further evaluation. People who want to avoid cancer should avoid using tobacco because smoking causes lung cancer not vitamin B said Fabricant. This study is flawed and ignores the potential for a host of other environmental factors and causes. Millions of healthy individuals use vitamins and supplements including vitamin B to support their lifestyles. Duffy MacKay ND senior vice president scientific and regulatory affairs for the Council of Responsible Nutrition (CRN) also released the following statement We urge consumers to resist the temptation to allow sensational headlines from this new study to alter their use of B vitamins especially without further understanding of the nature of this study and a conversation with their health care practitioners. The numerous benefits of B vitamins from food and dietary supplements including supporting cognition heart health and energy levels are well established and this study in the Journal of Clinical Oncology doesn t change those facts. Additionally this observational study doesn t prove causality between B vitamins and lung cancer risk and in actuality has some significant limitations to consider. Those limitations include the dependence on the ability of the study population ages 50 76 years old to remember and accurately report what they consumed over a 10-year period prior to the start of the study. Further the results of this study conflict with the results of previous studies including a randomized control trial as well as two studies that measured vitamin B6 serum levels and demonstrated reduction in lung cancer risk. Due to the limitations and its misalignment with the greater body of scientific evidence the study should be interpreted with caution. For consumers the key takeaway from this study is that smokers have a higher risk of lung cancer than nonsmokers. If you have concerns about lung cancer or B vitamins we recommend talking with your doctor or other health care practitioner. We remind consumers that dietary supplements are intended to supplement not replace a healthy diet. They cannot--and will not--reverse the potential harm from unhealthy behavior such as smoking. For more information visit www.npainfo.org www.crnusa.org or www.cancer.osu.edu. AIC and Matrix Fine Sciences Announce Partnership assachusetts-based AIC Inc. has announced its latest partnership with Matrix Fine Sciences Pvt. Ltd. India (MFS) which is a leading producer of nutraceuticals specializing in the manufacturing of non-GMO (genetically modified organism) natural tocopherols plant sterols and their derivatives. As an NACD & ISO-registered sales and marketing company AIC said it is looking forward to expanding Matrix s presence in the North American market. MFS and AIC have partnered to pro- M vide quality specialty ingredients in the North American market. In partnering with Matrix Fine Sciences Pvt. Ltd we recognize them as a well-respected and responsible manufacturer of natural ingredients which have excellent synergy with AIC s existing product portfolio said Mark Robertson executive vice president of marketing at AIC. MFS provides the quality and technical expertise our customers and the market demand. A collaborative partnership with AIC will help us facilitate assets and profes- sional skills for optimizing customer requirements added Kunal Sikchi managing director of MFS. This alliance supports the idea of capitalizing on products (vitamin E and its derivatives) manufactured by MFS and AIC s access to the market. At the same time this strategic partnership with AIC will help us enhance our goal of providing the MFS range of products to our customers at their doorstep. For more information visit www.aicma.com or www.matrixfinesciences.com. www.niemagazine.com October 2017 8 Nutrition Industry Executive Go to www.niemagazine.com olcott for info about this advertiser IndustryNews Lycored Shares Success of Japan Umbrella Honesty Project n an effort to give back to the community while launching its Good in Bloom program in Japan Lycored (Be er Sheva Israel) installed shareable umbrella stands to help give the people of Tokyo Kyoto and Hiroshima a break from the sun. Lycored s umbrella stands operated on a leave a penny take a penny principle Use it when you need it and then leave it for someone else when I you re done. A test in both honesty and courtesy these stands acted as a little social experiment--results were measured by how many umbrellas were returned. Overall 84 percent or more people returned the umbrellas they borrowed with 98 percent of people in the city of Kyoto demonstrating the characteristics Lycored set out to test. Participants in all three cities met the project with excitement and gratitude as they enjoyed the chance to strengthen the bonds within their neighborhoods. They were happy to help Lycored rethinkbeautiful by shielding their skin from the sun and were even happier to pass along the experience. To view a video about the program visit https vimeo.com 232549474 for more information visit www.lycored.com. Lallemand Receives USP s GMP Certificate for Canadian Production Facilities allemand Health Solutions announced that both of its Canadian probiotic production plants in Montreal and Mirabel successfully passed the United States Pharmacopeia (USP) Quality Systems Good Manufacturing Practice (GMP) audit. The company thus has become the first probiotic production facilities to receive this quality certificate. Such achievement illustrates our long-standing commitment to quality and demonstrates the level of our quality systems said Francine Mondou president of Lallemand Health Solutions. For our customers this helps provide them with assurance in the quality of our probiotic production operation. It also represents a stepping stone for those willing to get their finished product compliant with the USP verified program. USP is the most authoritative source for dietary supplement GMP audits. USP s GMP audit program serves dietary supplement and dietary ingredient manufacturers. It provides assurance that dietary supplement manufacturers not only meet FDA (U.S. Food and Drug Administration) cGMPs but exceed them as it is the only program that requires manufacturers to comply with both FDA and USP GMPs. USP GMPs include requirements of particular interest to retailers such as recall procedures expiration dating supported by stability data for instance explained John Atwater senior director of verification services for USP. This is the first time a probiotic production facility s GMP quality systems have been verified by USP and this can facilitate the task for the companies wanting to participate in USP verified program for their finished products as more and more dietary supplement companies are interested in doing so. Solange Henoud regulatory affairs director at Lallemand Health Solutions further commented In practice this means that USP s audit found that Lallemand s quality system provided sufficient assurance that its two Canadian manufacturing sites met applicable FDA and USP GMP audit requirements. With the reputation of USP we are confident that this will facilitate recognition by regulatory authorities beyond borders. For more information visit www.lallemand-health-solutions.com. Mazza Innovation Funds Expansion and Grows Senior Management Team azza Innovation Ltd. (Canada) has announced that it has raised 2.8 million (Cdn) from existing and new shareholders to fund an expansion of operations at its Delta BC PhytoClean extraction facility. Details of the financing have not yet been released. The company also announced the appointment of three senior executives to manage expanding customer demand for its solvent-free ingredients and PhytoClean extraction process. Chris Tower joins the Mazza Innovation executive team as vice president of sales Jim Pratt has been named president of the company and Andy Tjahyana has been hired as the vice president of business development. Mazza s financing round was comprised of several institutional and individual investors including Natural Products Canada (NPC) a not-for-profit corporation that streamlines commercialization of natural products. NPC is very proud to partner with Mazza and the other investors in this opportunity said Shelley King chief executive officer of Natural Products Canada. Mazza has a proven technology highgrowth potential in an expanding market and a service that can benefit the whole natural products industry. Demand for Mazza s botanical ingredients has been growing at a rapid pace since our opening last year and experienced senior executives are now required to help us manage that growth added Mazza Innovation CEO Benjamin Lightburn. Enabled by 2.8 million in new financing from investment partners such as NPC we re pleased to welcome Chris Tower Andry Tjahyana and Jim Pratt to our management team. This financing will also fund a number of accompanying expansion programs in service sales and marketing and extraction capability. These changes will enable us to meet rising customer demand from around the world. For more information visit https mazzainnovation.com. L M 10 Nutrition Industry Executive www.niemagazine.com October 2017 Naturex Sponsors NHP Research Alliance and Partners with TRU-ID y sponsoring the Natural Health Products (NHP) Research Alliance as a silver sponsor Naturex (Avignon France) in a collaborative approach with other industry stakeholders is helping to take botanical identification to the next level. DNA barcoding offers a lot of potential for botanical testing but only if it s performed on the right raw material according to the company. One of the NHP Research Alliance s main goals is to develop and curate a Standard Biological Reference Material (SBRM) DNA library for botanical species used in the industry. This library will be founded on herbarium vouchers genome scans and ancillary data that will facilitate the development of new standards for DNA testing in the NHP industry. Naturex in partnership with TRU-ID will support this initiative by funding and supplying fully traceable botani- B cal samples that will be used as botanical standards. Transparency and safety are consumer concerns that cannot be ignored said Dr. Antoine Bily global director of R&D at Naturex and we want to ensure that Naturex stays at the forefront of the research in this field. As novel molecular diagnostic tools and standards are developed leading NHP companies will be recognized as early adopters of DNAbased biotechnology and will be able to promote good practices within the industry as members of the NHP Research Alliance Advisory Board. Literally thousands of samples in the supply chain are currently being tested using DNA methods at TRU-ID and Naturex is leading the industry with supplying funding and samples from the supply chain from farm to manufacturing facilities. The NHP Alliance provides standard operating protocols and molecular diagnostic tools that will allow Naturex to test at their facilities with third party oversight and certification from TRU-ID added Dr. Steven Newmaster director of the NHP Research Alliance. Many other industry sponsors are contributing resources at varying levels as a wave of industry support mounts to address the research and development of DNA-based tools for ingredient authentication. For more information visit www.naturex.com. You reHired Charkit Chemical Company LLC (Norwalk CT) has announced that Robert Christopher Chris Gallagher has been named as a Charkit account executive. As a member of the sales team Gallagher will not only be supporting the company s growth with current customers--he will also be taking us into untapped markets. Illinois-based FutureCeuticals Inc. has appointed Dr. Nagendra Rangavajla as the chief science officer (CSO). In this role Nagendra will use his knowledge of the industry and technical expertise to lead the research and development (R&D) team in envisioning evaluating and setting scientific priorities organizing the scientific team and capabilities coordinating communication and providing the administrative structure that supports the scientific team. Q Laboratories (Cincinnati OH) recently hired Cathleen Owen as director of quality. In her Chris Gallagher new role she will oversee Q Laboratories Quality Assurance Unit (QAU) maintaining accreditations and certifications including ISO 17025 and cGMPs (current good manufacturing practices) as well as supervising internal audits and facilitating external audits. EAS Consulting Group LLC (Alexandria VA) has hired Timothy Stewart PhD as the new independent advisor for dietary supplements. Stewart has been an independent consultant for EAS since 2013. Capstone Nutrition (Ogden UT) has announced the appointment of Adam Adelmann as vice president of sales. Adelmann brings to Capstone more than 20 years of sales experience with a significant background in the nutraceutical industry including nearly 10 years at Capsugel where he most recently served as national sales manager in its Consumer Health and Nutrition division. Cathleen Owen To better serve its growing customer base in North America New Jersey-based BENEO Inc. has announced a significant expansion of its NAFTA sales and support team. Members of BENEO s expanded sales team include Mike Dail regional sales manager Midwest U.S. Rick Jackson regional sales manager Great Lakes U.S. and Carolina Saenz who was named sales assistant for the NAFTA team. Ernesto Duarte sales manager will support BENEO s sales activities in Mexico focusing mainly on the northern area of the country working from his office in Monterrey while Steven Gumeny will become NAFTA regional product manager for rice ingredients and functional proteins. October 2017 www.niemagazine.com Nutrition Industry Executive 11 IngredientNews AstaPure Astaxanthin Approved by Anvisa Brazil srael-based Algatech (Algatechnologies) Ltd. received the Brazilian Health Regulatory Agency (Anvisa) approval for its all-natural astaxanthin AstaPure to be used as a food ingredient. Approval was granted thanks to the high quality and purity of this powerful product. This approval makes Algatech the first astaxanthin supplier to start marketing its clean-label astaxanthin under the AstaPure brand in Brazil. AstaPure is sourced from the Haematococcus pluvialis microalgae cultivated in a proprietary fully controlled closed system of glass photo-bioreactors energized by the abundant natural sunlight of the Arava desert. Brazil has the largest nutritional and supplements market in South America. According to Euromonitor vitamins and dietary supplements recorded a sales total of 1.3 billion (U.S.) in 2015 in Brazil an 11 percent increase over the previous year. The market shows no I Aquamin Preserves Bone Structure Composition and Strength Study Finds recent study published in Calcified Tissue International shows that Aquamin (Ireland) is more successful in impeding the deterioration of bone like that brought on by osteoporosis than calcium carbonate. In the study titled A Natural Calcium-Rich Marine Multi-mineral Complex Preserves Bone Structure Composition and Strength in an Ovariectomised Rat Model of Osteoporosis the calcium-rich marine multi-mineral complex s efficacy in preventing the onset of bone loss was compared to the effects of calcium carbonate in ovariectomised rats suffering from osteoporosis. A signs of slowing down due to a growing and increasingly health conscious middle class. Brazil holds the leading supplement market in South America and we strongly believe this approval will create further possibilities in the region said Gary Brenner project development manager for Algatech. Collaborating with our distributor Ayalla Sao Paulo we aim to increase our sales and promote our products in cooperation with the leading brand customers in the food cosmetics and dietary supplements segments. For more information visit www.algatech.com. New Patents Granted to Sabinsa s Cosmetics Division In U.S. and E.U. abinsa Cosmetics (New Jersey) a division of the Sami Labs--Sabinsa Group has been granted two new patents on novel cosmetic compositions both developed from research on combinations of the company s branded ingredients. These most recent patents are likely to fuel the company s growth in the cosmetic industry given the high demand for sunscreen lotions and hair growth formulations. United States patent US 9498423 describes a synergistic composition comprising of glucogallin (1-O-galloyl--D-glucose) or glucogallin and total gallates from Amla (Saberry) concentrate of liquid endosperm of Cocos nucifera (Cococin) and the selenopeptides (-L-glutamyl-Se-methyl-L-selenocysteine and -L-glutamyl- L-selenomethionine) for maintaining the morphology and numbers of the dermal papilla cells when exposed to stress signals. The composition protects the dermal S papilla cells from stress signals (UVB radiation) and the numbers of live dermal papilla cells are maintained at a level of 95 percent or more when the dermal papilla cells are exposed to UVB radiation levels ranging from 0.8 J cm2 to 1.0 J cm2. This composition has also been patented in Europe (EP2695603) Japan (JP6064274) New Zealand (NZ600307) and Russia (RU2606752). Sabinsa s cosmetic division has also received a patent in Europe (EP2461786) for a composition comprising glucogallin (1-O-galloyl--D-glucose) Amla (Saberry) and concentrate of liquid endosperm of Cocos nucifera (Cococin) for promoting hair growth. This composition also protects dermal papilla cells from UV rays. The invention has previously been granted a patent in in Australia (AU2010326651). For more information visit www.sabinsa.com or www.sabinsacosmetics.com. At the completion of the 20-week study the trabecular architecture in participating specimens was measured to assess bone structure composition and mechanical properties. The results of the study showed less deterioration of the trabecular bone on specimens ingesting Aquamin compared to those ingesting calcium carbonate. In addition the trabecular architecture of the rats ingesting Aquamin also proved to be significantly preserved when compared to that of rats ingesting calcium carbonate. This new research highlighting the beneficial effects Aquamin has on bone health is very compelling and indicative of ways to address bone deterioration said David O Leary commercial manager of Marigot Ltd. the creators of Aquamin. Studies such as these continue to support Aquamin s proven efficacy as a mineral ingredient for dietary supplements not only to help maintain bone health but digestive and joint health as well. For more information visit www.aquamin.com. www.niemagazine.com October 2017 12 Nutrition Industry Executive Graminex Receives Health Canada Approval for PollenAid and Prostanex raminex LLC (Michigan) producer of Graminex Flower Pollen Extracts received Health Canada Approval under the Natural and Nonprescription Health Products Directorate (NNHPD) for its PollenAid and Prostanex Flower Pollen Extract formulations. Health Canada s certification guarantees that Graminex products meet the highest quality standards according to the guidelines of Health Canada s Health Products and Food G Branch s Mandate. The mandated guidelines take an integrated approach to managing the risks and benefits in regards to supplements and health food to safe guard the consumer against inferior products. Graminex now has products that are pre-approved by Health Canada s NNHPD. We are excited to offer Canadian customers new health care products backed by the current certification. Our customers are once again assured that Graminex continues to meet the highest standards in the market today stated Justin E. Ritter regulatory affairs. For more information visit www.graminex.com. MenaQ7 Vitamin K2 Again Shown to Inhibit Hardening of Arteries new study of renal transplant recipients a group shown to express subclinical vitamin K deficiency examined whether K2 supplementation would correct this deficiency and thus improve arterial stiffness. The study has published in the Journal of the American Society of Hypertension and the vitamin K2 used in the study was MenaQ7 Vitamin K2 as MK-7 from NattoPharma (Norway and New Jersey). This Lebanese study evaluated in the KING trial (a singlearm pilot study) to see if there is an association between vitamin K2 supplementation and the change in both subclinical vitamin K status and indices of arterial stiffness among 60 renal transplant recipients with stable graft function. The results showed that eight weeks of MK-7 supplementation (360 mcg day as MenaQ7) was associated with significant improvement in arterial stiffness and 24-hour peripheral and central pressures. The mean reduction in cfPWV was 1.4 m s which was well beyond the reduction of 1 m s recommended for a clinically relevant vascular effect. For more information visit www.nattopharma.com or www.menaq7.com. Steviva Ingredients Introduces Plug-in Ice Cream Mix he low-sugar high-protein ice cream category is blowing up. With the exponential success of better-for-you ice cream brands such as Halo Top which has seen a 2 500 percent increase in sales in 2016 the sub-category has come to life. Manufacturers we ve spoken with say their biggest challenge is coming up with a recipe that yields the desired nutritionals yet still tastes excellent and also has the right mouth feel and creamy texture of traditional ice cream said Thom King president and CEO of Steviva Ingredients in Oregon. So we created a low-sugar high-protein dry mix that gives dairy producers a plug-in solution to take the guesswork out of creating a superior product with fewer than 80 calories per serving. A proprietary blend of PuRefine MonkSweet monk fruit extract ErySweet 100 stevia and erythritol blend milk protein concentrates and natural gums and stabilizers HiPro Ice Cream Dry Mix enables manufacturers to create a homestyle ice cream with a short ingredient list that yields an impressive five grams of protein and just 8.3 grams of carbs per serving. As with all Steviva Ingredients sweetening system solutions HiPro Ice Cream Dry Mix is GMO (genetically modified organism)- and allergen-free and kosher-certified. For more information visit www.stevivaingredients.com. A T Fibregum is Certified FODMAP Friendly exira (France) s Fibregum has been successfully certified FODMAP Friendly by the Australian FODMAP Friendly certification program. The FODMAP Friendly program is the only registered certification trademark worldwide. The laboratory tests the FODMAP levels in food and gives the certification to the ones low in FODMAP. N As a reminder FODMAP is an acronym that stands for fermentable oligosaccharide disaccharide monosaccharide and polyols. These fermentable sugars are poorly absorbed in the gastrointestinal tract and so easily and quickly fermented by gut bacteria causing IBS (irritable bowel syndrome) manifestations (i.e. gas bloating and discomforts) for predisposed people. Thanks to its highly branched struc- ture Fibregum a FODMAP-friendly non-digestible carbohydrate is gradually fermented from transverse colon to descending colon without generating discomforts. Moreover with its guaranteed minimum content of 90 percent fiber Fibregum is a way to contribute to the dietary fiber intake. For more information visit www.nexira.com or www.fodmapfriendly.com. Nutrition Industry Executive 13 October 2017 www.niemagazine.com IngredientNews Ganeden Continues Canadian Expansion with New Health Canada Approvals s a result of recent regulatory work Ganeden (Mayfield Height OH) has made advancements for the usage of its patented and shelf-stable probiotic strain GanedenBC30 (Bacillus coagulans GBI-30 6086) in Canada. The company received a no objection letter from Health Canada which provides further support for approved probiotic wording and allows Canadian companies fortifying with GanedenBC30 to make additional health claims. The no objection letter from Health Canada confirms that products fortified A with GanedenBC30 can make any of the general health claims that are allowed in the country s probiotic monograph and also provides opportunities for new gut flora language on packaging. This new approval makes it easier for companies to educate consumers on the benefits of GanedenBC30 on their food and beverage product packaging. Canada has become a strong market for probiotic fortification in foods and beverages and we are dedicated to advancing regulatory approvals and probiotic language both there and internationally said Dr. David Keller vice president of scientific operations for Ganeden. Our goal as a leader in the space is to make it as easy as possible for food and beverage manufacturers to fortify with a high-quality probiotic ingredient and to also provide direction on probiotic-related health claims and educational content. For more information visit www.ganedenprobiotics.com. Taiyo Presents a New Raw Coffee Bean Ingredient unctional WGCP (whole green coffee powder) derived from raw coffee beans using a patented technology improves both mental focus and concentration for up to six to eight hours helps to reduce and stabilize blood glucose levels and can act as an appetite suppressant. Compared with coffee extracts WGCP powder contains caffeine and a wide variety of other valuable coffee bean components such as chlorogenic acids antioxidants minerals and dietary fibers. This natural raw coffee bean ingredient delivers sustained caffeine release whereas caffeinated beverages such as coffee or energy drinks often provide a short-term peak of heightened alert- F ness Taiyo (Germany) s WGCP offers a continuous supply of caffeine for a period of six to eight hours--without the associated side-effects of jitters a rapid heartbeat and the well-known boom and bust phenomenon. Conventional energy drinks have often been criticized for their immediate caffeine boost and subsequent period of fatigue. Because of its sustained caffeine release WGCP is suitable for natural and gentle energy products. And as well as concentration or endurance and performance positionings it can also be marketed as a weight management ingredient owing to its appetite-suppressing effect. Benefiting from excellent technolog- ical properties manufacturers can incorporate WGCP in a variety of food formulations such as breakfast cereals oatmeal granola bars and drinks as well as dietary supplements such as protein powders shots or capsules. Developed in collaboration with physicians WGCP s efficacy has been demonstrated in clinical studies and as the ingredient is vegan free from gluten and non-GMO (genetically modified organism) it meets current consumer demands. For more information visit www.taiyogmbh.com en . Improved Dental Hygiene for Vulnerable Seniors ack of proper oral care in nursing home patients is leading to increased risk of serious illnesses including heart disease stroke diabetes COPD and dementia. Top health researchers are discovering that taking simple steps such as using products made with Fruit d Or s premium wholefruit cranberry powder and water-soluble organic cranberry juice powder may be a smart way to gain control over this alarming situation. There are great opportunities for the natural products industry to step in because traditional methods are too harsh ineffective or difficult to use confirmed Stephen Lukawski director of L global sales and product development Fruit d Or Nutraceuticals (Canada). He noted that Fruit d Or whole-fruit cranberry and organic cranberry water-soluble juice powders are ready to be produced in chewing gums lozenges mints sachets stick packs and efferves- cents. In his white paper How Cranberry Benefits Oral Health Philip Domenico PhD confirmed that biofilm--the slimy substance formed by bacteria--is linked to oral infections which may lead to heart disease diabetes and other disorders. The red pigments in cranberries have been shown to inhibit biofilm formation he noted. These proanthocyanidins (PACs) are the most abundant phytochemicals extracted from cranberry fruit ... like Teflon they prevent the attachment of pathogens to host tissues. For more information visit www.bestcranberry.com. www.niemagazine.com October 2017 14 Nutrition Industry Executive Salacia Extract Helps Curb Appetite and Manage Blood Sugar n the recent CARBS (carbohydrate appetite reduction blood sugar and satiety) study researchers at Rutgers University observed that a proprietary salacia extract demonstrated appetite reduction satiety and blood sugar management benefits. Native to the Indian subcontinent salacia is a genus of woody climbers well known for its traditional use in ayurveda as a medicinal food supplement for various health conditions. The recent paper Appetite and gut hormones response to a putative -glucosidase inhibitor Salacia chinensis in overweight obese adults a double blind randomized controlled trial published in the journal Nutrients discussed the findings of the CARBS Study. CARBS was a randomized double blind placebo-controlled three-way crossover study and the first to examine the effects of a proprietary extract of I Salacia chinensis (from OmniActive s [Morristown] OmniLean) on glycemic indices and gut hormones after a meal. OmniLean taken with a meal resulted in an improved glycemic response and changes in gut hormones in healthy overweight obese individuals thereby reducing blood sugar spikes and impacting appetite and satiety. The herb Salacia chinensis was shown to reduce glycemic indices and affect gut peptides after a meal. What does this mean It means Salacia chinensis from OmniLean may be an appetite modulator and because it lowers glycemic indices would be beneficial to persons at risk for diabetes including overweight obese person said Sue A. Shapses PhD RD one of the lead researchers on the CARBS study. For more information visit www.omniactives.com. Weider Launches Three Workout Products With Sustamine eider (Germany) a sport and specialty nutrition company launched three new workout products in Europe that should meet the demands of fitness and exercise lovers according to the company. Each is anchored by Sustamine (a registered trademark of Germany-based Kyowa Hakko Bio Co. Ltd.) LAlanyl-L-Glutamine. Two of the products are ready-to-drink supplements. Weider BCAA RTD contains a blend of vitamins niacin B6 and Sustamine that boosts energy reduces fatigue and supports a healthy immune system. Each lemon-lime flavored 250 ml can [use AlgaeHealth contains 3 g of here] branch chained amino acids-- leucine isoleucine and valine--that impact muscle growth. For better hydration and endurance Weider Rush RTD packs 10 active ingredients including 200 mg of Sustamine that combine to increase muscle development improve focus and boost liquid absorption during and after physical activity. The 250-ml orange-flavored drink is designed for all types of athletes--from daily exercisers to amateurs and professionals. The newly redesigned Total Rush 2.0 gives a final nudge to complete a workout and avoid energy slumps common after training. Like its ready-to-drink siblings Total Rush 2.0 contains 200 mg of Sustamine to increase muscular glutamine levels and improve hydration. It [use DDW here] comes in four flavors raspberry orange cola and lime-lemon. For more information visit www.kyowa.eu www.kyowa-usa.com or www.weiderworld.com. W Latest Research Unveiled Novel Pathway For T3 in Hair Follicle Regeneration esearchers at Ohio State University Wexner Medical Center uncovered a novel pathway for hair follicular regeneration. Palm tocotrienol complex (EVNol SupraBio) is shown to induce hair follicle growth via protein expression of epidermal E-cadherin dependent beta-catenin the key signaling molecule for inducing pluripotent stem cells in the adult skin. In this study male mice with mutated leptin receptor were applied with either 5 mg cm2 palm tocotrienol rich fraction (TRF) (ie. EVNol SupraBio bioenhanced palm tocotrienol complex supplied by ExcelVite) or placebo on shaved dorsal skin thrice per week for 21 days and the evaluation of hair growth was recorded by the color of dorsal skin. The mechanism of palm TRF-induced hair growth the dependency on the loss of E-cadherin and the activation of beta-catenin for hair follicle formation were examined by quantification of gene expressions immunoprecipitation and immunoblots. When compared to placebo palm TRF treated group showed significant- R ly increased number of anagen (ie. cycle of growth) hair follicles increased fetal characteristics of hair follicular development in the adult skin increased epidermal keratinocyte proliferation significant decreased Ecadherin expression that was associated with high translocation of betacatenin-Tf3 leading to upregulation of gene expressions of Oct4 Sox9 Klf4 c-Myc and Nanog skin-specific pluripotent factors that support hair follicular regeneration. These factors are also known as the Yamanaka Transcription Factors --discovered by Dr. Shinya Yamanaka joint-recipient of the 2012 Nobel Prize in Physiology or Medicine. Yamanaka discovered that mature cells can be reprogrammed to become pluripotent. The researchers concluded that palm TRF suppression of epidermal Ecadherin induced beta-catenin and nuclear translocation is the novel pathway that leads to expressions of pluripotent factors and subsequently promotes anagen hair cycling in adult skin. For more information visit www.excelvite.com. These statements have not been evaluated by the Food and Drug Administration or the European Commission. This product is not intended to diagnose treat cure or prevent any disease. Nutrition Industry Executive 15 October 2017 www.niemagazine.com IngredientNews Salt of the Earth Appoints Exclusive Distributor for West Europe srael-based Salt of the Earth Ltd. appointed Kreglinger Specialties (Belgium) as its exclusive distributor for Mediterranean Umami an all-natural sodium reduction ingredient. Kreglinger will be responsible for the U.K. Ireland Belgium The Netherlands Luxemburg and France. Mediterranean Umami a winner of IFT17 Food Expo Innovation Award is a I sodium-reduction solution for the food industry. It boasts a great umami flavor profile perfect for creating healthier foods. Mediterranean Umami consists of simple consumer-friendly ingredients-- vegetable extracts and sea-salt--making it an all-natural clean-label ingredient. For more information visit www.saltoftheearthltd.com or www.kreglinger.com. Sensus Obtains Non-GMO Project Verified Certification For Chicory Root Fiber ensus (The Netherlands) announced that its Frutafit and Frutalose products have been Non-GMO Project Verified in the United States. Consumer demand for non-GMO (genetically modified organism) foods is on the rise and creating products that are in line with this trend is increasingly key to success for today s producers. By enabling our customers to use a trusted and recognizable seal on pack we can help them to provide consumers with greater transparency on ingredient sourcing and ultimately facilitate more nonGMO choices said Carl Volz president--America Sensus. S In total 10 Frutafit and Frutalose products have been approved as non-GMO in the United States. Frutafit inulin and Frutalose oligofructose are prebiotic soluble dietary fibers that offer several nutritional and functional properties including highly researched benefits for digestive wellness and weight management. Unlike alternative fiber sources such as corn chicory root is a clean label solution offering extra appeal for manufacturers looking to expand their portfolio using ingredients from a natural source. For more information visit www.inspiredbyinulin.com. 16 Nutrition Industry Executive www.niemagazine.com October 2017 AHPAUpdate Leading Industry Association Speaks Directly to Nutrition Industry Executive Readers A New Domestic Sustainable Supply of Forest Cultivated Medicinal Herbs A broad coalition of non-governmental organizations (including AHPA) governmental agencies universities and private industry formed two years ago to improve production and market opportunities for forest farming of medicinal herbal grown in Appalachia. Funded by the National Institute of Food and Agriculture (NIFA) under the Beginning Farmer and Rancher Development Program (BFRDP) the Appalachian Beginning Forest Farmer Coalition (ABFFC) promotes and expands cultivation and conservation of native forest medicinal products. It prepares forest farmers to supply raw material that is both forest-grown verified and certified organic to herbal product industries. In turn this allows herbal products manufacturers to reduce their impact on the environment and market and sell sustainable clean products to consumers. The ABFFC has trained hundreds of new and aspiring forest farmers in Appalachia and beyond and connected stakeholders across the industry. Their work is focused on a new domestic and sustainable supply of forest cultivated medicinal herbs backed up by profitable and predictable production that meet the needs of the growing sector of herbal products consumers who are concerned about where their herbs come from and how they are grown. In addition to training and technical assistance the coalition has played a leading role in coordinating harvests of forest farmed raw material sold by coalition farmers for premium prices to herbal products manufacturers who are leading the way in connecting consumers with these sustainable forestgrown products from Appalachia. Some manufacturers are already looking to capitalize on the growing demand for high-quality sustainably and domestically produced medicinal herbs by introducing product lines featuring forest farmed materials. quences of long-term wild harvests of slow growing forest medicinal plants such as black cohosh goldenseal and American ginseng are increasingly in question and threats to native populations could lead to shortages in supply that affect the availability of these sought after herbal products. Additionally attempts to source raw materials from elsewhere and internationally can create expensive quality control challenges adding to increasing consumer concern and scrutiny. tion of herbs within their native environment and surrounded by companion species and associated flora and fungi for development of optimal chemical activity. Finally forest farming also provides a new income opportunity for many in Appalachia a region of historic economic distress which has recently been further strapped in the face of a dwindling coal mining industry. NIE Learn More ABFFC website www.appalachianforestfarmers.org ABFFC YouTube channel with nearly 200 videos on forest farming ranging from growing harvesting processing marketing and how to make value added products to stories featuring beginning and long-time farmers www.youtube.com channel UCAZP07pEpCzWuGGeI1veWQ Farmer feature videos Harding s Farm www.youtube.com watch v JVaI60N -vB0 Equinox Botanicals www.youtube.com watch v lPz6gQf Qheo Eliana s Garden www.youtube.com watch v g1eZ7W FMTNE&t 1s Different forest farming methods www.youtube.com watch v jcLVIldm W34 www.youtube.com watch v JnrgLZzv ewk. The ABFFC has trained hundreds of new and aspiring forest farmers in Appalachia and beyond and connected stakeholders across the industry. Many in the Appalachian forest region are interested in native medicinal herbs but cultivation of these plants in their native forested settings for sale has been constrained by historically low prices paid for raw materials that are typically gathered from the wild. However the situation is changing due to concerns about plant population sustainability and product quality combined with growing demand for products that are Made in America. Forest farming of native woodland medicinal plants allows for increased quality control and traceability across the supply chain while keeping forest ecosystems intact and conserving wild plant populations attending to main points of concern among the growing herbal products consumer base. Additionally a new and growing body of research supports the cultiva- Background Native Appalachian forest plants have long been in high demand in the herbal products market. The vast majority of raw materials from this region come from wild harvests. However the environmental conseOctober 2017 www.niemagazine.com Michael McGuffin President and Board of Trustees American Herbal Products Association (AHPA) Nutrition Industry Executive 17 AssociationNews CRN Announces Key Speakers for The Conference he Council for Responsible Nutrition (CRN) has announced several keynote speakers for its upcoming event The Conference taking place October 18 to 21 at The Ritz-Carlton Dove Mountain in Marana AZ outside of Tucson. The Conference CRN s Annual Symposium for the Dietary Supplement and Functional Food Industry takes place in tandem with The Workshop CRN s Day of Science a daylong symposium focused on relevant scientific discussions of dietary supplements and nutrition topics taking place October 18. Kicking off the first full day of sessions at The Conference on Thursday October 19 is Stephen Ostroff MD the U.S. Food and Drug Administration s (FDA) deputy commissioner for Foods and Veterinary Medicine who will discuss the agency s regulatory priorities for dietary supplements and food. On Thursday afternoon Bryce Hoffman author of Red Teaming How Your Business Can Conquer the Competition by Challenging Everything will share insights on how companies can stress-test their strategies identify missed opportunities and expose hidden threats in order to help them suc- T ceed in today s rapidly changing global economy. Friday begins with a keynote address from Bob Woodward two-time Pulitzer Prize-winning journalist and associate editor at the Washington Post. A journalistic icon that gained international attention when he and Carl Bernstein broke the deeply disturbing news of the Watergate scandal in 1972 Woodward will share insights on the current political climate. Friday afternoon Stephen Wunker consultant entrepreneur and author of Jobs to be Done A Roadmap for Customer-Centered Innovation and articles for major outlets including Forbes Harvard Business Review and The Financial Times will discuss ways of connecting with the dietary supplement consumer based on his innovative methods followed by a panel discussion with industry experts. Saturday morning the popular Breakfast With ... session will feature Mark Halperin senior political analyst NBC News and MSNBC. Halperin coauthor of New York Times bestsellers Double Down Game Change 2012 and Game Change Obama and the Clintons McCain and Palin and the Race of a Lifetime among other books is at work on the third Game Change installment scheduled for publication in early 2018 and acquired by HBO for a planned mini series following the success of the 2012 Game Change adaptation by HBO Films. The final keynote session following Breakfast With... on Saturday morning will feature Brian Solis digital analyst business strategist futurist and author of the best-selling books X The Experience When Business Meets Design The End of Business as Usual and What s the Future of Business In addition to these keynote talks The Conference will include sessions on nutritional gaps and ways to fill them highlights from the CRN 2017 Consumer Survey on Dietary Supplements pathways to dietary supplement consumers understanding poison control center data for dietary supplements and more. For more information visit www.crnusa.org 2017events. THE NUTRITION INDUSTRY S NEWS & INFORMATION RESOURCE NIE s Upcoming Issue Highlights Nov. Dec. Jan. Feb. 10 25 17 ad closing Supply Innovation Healthy Blood Sugar Heart Health Engredea at Expo West Show Issue 12 14 17 ad closing Our 2018 Media Planner Is Available At NIEmagazine.com 2018-Media-Planner Contact One of Our Ad Specialists Today Russ Fields at (732) 432-9600 ext. 102 or e-Mail RussF VRMmedia.com Gary Pfaff at (732) 432-9600 ext. 103 or e-Mail GaryP VRMmedia.com 18 Nutrition Industry Executive www.niemagazine.com October 2017 ScienceUpdate Global Warming May Cause Spike in Asthma Allergy Symptoms new study finds that exposure to a widespread outdoor fungus can increase cell damage (oxidative stress) in the airways. This spike weakens the airways barrier defense system that when functioning normally removes infection- and allergy-causing organisms (mucociliary clearance). The study was published in the American Journal of Physiology Cell Physiology. Alternaria alternata is a fungus that produces spores in the dry warm weather of late summer and early fall. Previous studies have found that alternaria produces up to three times more spores when atmospheric carbon dioxide (CO2) levels are high. Airway exposure to the fungal spores may induce allergy symptoms and asthma in some people. A research team from the University of Minnesota and the Mayo Clinic took A cells from the lining (epithelium) of human airways and exposed them to alternaria. The researchers analyzed the exposed cells to determine the effects of fungal exposure on permeability properties and barrier function of the epithelium. When permeability is compromised proteins and nutrients can leak out of the lining and into the airways. In addition reduced barrier function can let bacteria and other allergens enter the airways increasing the risk of inflammation and infection. The research team also measured oxidative stress or cell damage in the treated cells. Exposure to alternaria produced more cell damage in the cells of the airway s lining. Fungus-treated cells had higher concentrations of calcium which prompted the epithelial cells to secrete more salt and fluid than usual. Salt and fluid secretion is normally associated with improved mucociliary clearance--keeping the airways free of allergens. However prolonged exposure [to alternaria] leads to disruption of epithelial barrier function that would ultimately reduce mucociliary clearance the researchers wrote. Reduced mucociliary clearance typically makes allergy symptoms worse. Current climate-warming trends may intensify the problem the research team noted. These results suggest that continuing increases in atmospheric CO2 associated with global climate change will increase both the level of alternaria exposure and antigenicity [the ability to produce an immune response] of spores that come in contact with the airways. For more information visit www.the-aps.org. Telomere Length May Be Associated With the Cognitive Response to a Lifestyle Intervention new study from the FINGER trial team shows that participants with shorter leukocyte telomere length (LTL) had more pronounced benefits on cognition following the multidomain lifestyle intervention. These findings are very promising as individuals with shorter telomeres may represent an at-risk group said Dr. Shireen Sindi lead author of the study based at Karolinska Institute (Sweden) and Imperial College London (U.K.). Telomeres are found at the end of chromosomes (which hold our DNA) protecting them from deteriorating or getting tangled up with neighboring chromosomes. Telomeres play an important role in the process of cell division. The current study is the first to assess whether baseline LTL can modify the effects of a multidomain lifestyle intervention on cognition among older adults who are at risk for cognitive decline. The results showed that the beneficial intervention effects on cognition were more pronounced among individuals with shorter baseline LTL particularly for executive functioning. Consistent with previous studies unhealthy lifestyle was associated with shorter baseline LTL among FINGER participants. A This suggests to us that participants with shorter LTL had more room for lifestyle improvements when they entered the study said Sindi. Adjusting for lifestyle however did not attenuate the observed findings. Considering that shorter LTL has been associated with poor cognitive performance and dementia it is very encouraging that the multidomain lifestyle intervention was especially beneficial among individuals with higher risk commented the authors. In the absence of disease-modifying drugs for dementia and Alzheimer s disease preventive initiatives have recently gained much attention as a promising intervention approach. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is a comprehensive multidomain prevention trial including nutritional guidance exercise training computer-based cognitive training and intensive management of vascular and metabolic risk factors. In this trial 1 260 older adults (aged 60-77) were randomly allocated to the intervention or control groups (the latter receiving standard health advice). After two years cognition scores (measured by the Neuropsychological Test Battery) were higher in the intervention group for total cognition as well as various cognitive domains. This study was the first and largest of its kind using a multidomain approach with long follow-up duration and leading to a paradigm shift in the field of dementia prevention. More recently researchers in the FINGER team have been investigating the underlying biological mechanisms associated with the positive intervention effects. Sindi and colleagues have been examining the role of LTL in the trial. When telomere length is shortened their capacities to protect DNA are compromised. LTL is considered a biomarker of aging and aging-related diseases representing cells biological age rather than chronological age. The team is currently investigating the impact of the multidomain lifestyle intervention on LTL among FINGER participants as this will provide insight on potential methods to enhance LTL. For more information visit www.iospress.nl. Nutrition Industry Executive 19 October 2017 www.niemagazine.com A Stress-free Dose of Zs Ingredients & Concerns When it comes to sleep and stress management ashwagandha is a major contributor--ingredients such as Sensoril a brand of ashwagandha root and leaf extract have made it a bit simpler for formulators to use. Finished goods companies are recognizing that consumer demand is for products that give recognizable benefits and help them feel less stressed and sleep better noted Bruce Abedon PhD vice president of scientific and regulatory affairs at Vermont-based NutraGenesis LLC. That is why these companies are choosing clinically tested ingredients like Sensoril standardized ashwagandha root and leaf extract which was shown to significantly reduce stress and sleeplessness in a randomized double-blind placebo-controlled clinical trial. Sensoril s experiential benefits in these areas have made it the topselling patented root and leaf extract of ashwagandha in the industry. Sensoril also is a go-to ingredient for formulators because it is self-affirmed GRAS [generall recognized as safe] is easy to work with and water-soluble so can also be used in liquid delivery systems is non-GMO [genetically modified organism] and gluten free and comes in both conventional and certified organic versions. Another dual-action ingredient is Lactium an Ingredia Nutritional product (based in France that also developed CranMax Benexia and Celadrin) which not only helps with sleep but decreases anxiety-related symptoms as well according to the manufacturer s website. Lactium is a one-of-a-kind hydrolysate of milk proteins that contain www.niemagazine.com October 2017 Having life cause its share of stress can be difficult enough to deal with especially when it affects sleep. Natural ingredients and products are teaming up to help consumers get the sleep they yearn for. By Nicholas Saraceno I t s safe to say experiencing some sort of stress in life is inevitable. The reasons behind it can vary as people face different situations at school the workplace or social relationships. In fact according to 2014 stress statistics gathered by both the American Psychological Association and the American Institute of Stress 73 percent of people in the U.S. regularly experience psychological symptoms caused by stress while 77 percent of people regularly experience physical symptoms caused by stress. More so it can take a toll on a person when sleep is compromised. Aware of the situation natural ingredient suppliers have developed and continue to develop ingredients for products that not only calm one s stress but can also help one get a good night s sleep. 20 Nutrition Industry Executive a bioactive peptide with relaxing properties which regulate stress naturally said Mitch Skop senior director of new product development at Pharmachem Laboratories Inc. in New Jersey. In addition Lactium is capable of facilitating and promoting sleep with no or minimal sedative properties. As a result Skop added that when producing these natural ingredients manufacturers should make sure that they do not result in the hang-over type of side effects that is associated with traditional medication. Abedon agreed. For sleep the main concern is that the ingredient helps people fall asleep and stay asleep without having sedative properties. In this way when people wake up they feel refreshed he said. For stress the main concern is that the ingredient is experiential which is why Sensoril is such a successful ingredient in this area. Sensoril provides these kinds of healthy sleep-related benefits. protection of existing neurons and growth of new neurons as well as through nerve transmission. In addition Nutragenesis ashwagandha product provides innovation through practicality and efficacy. Not only are both the roots and leaves are utilized but its beneficial content is believed to be greater. Most ashwagandha ingredients are derived from roots only Abedon noted. Sensoril is an innovative nutraceutical ingredient because its unique manufacturing process utilizes both roots and leaves of ashwagandha for the extraction process. Ashwagandha leaves are naturally richer in glycowithanolide bioactive content than roots. This results in Sensoril having the highest levels of ashwagandha glycowithanolide bioactives of any ashwagandha extract sold (Sensoril is standardized to a minimum of 10 percent glycowithanolides). The premium bioactive content allows Sensoril to be highly effective at a low daily dose. Finding Ways to Innovate When appealing to customers it is helpful for creativity to be involved in the process. Iowa-based Kemin Industries Inc. for instance via its Human Nutrition and Health division has made its innovative mark by trendsetting. Kemin developed Neumentix from patent-pending non-GMO spearmint plant lines. These plants are grown on family farms in the U.S. in accordance with good agricultural and sustainable farming practices said Kim Colletti global cognition product manager with the company. In fact Kemin s spearmint plants are the first spearmint to be certified sustainably grown in the U.S. These special plants serve as the source for this innovative dietary ingredient Colletti explained. The native polyphenolic profile of the leaves is harnessed through a patent-pending drying technology followed by a gentle water-extraction method that preserves and maintains the natural phenolic constituents which are greater than 50 in number. The resulting extract is dried and undergoes rigorous quality testing prior to release. This exciting cognitive ingredient is targeted to not only support cognitive performance specifically focus and working memory but also support the ability to get to sleep quicker. Additionally looking closer at how key molecules in Neumentix may work there are four potential mechanisms of action--antioxidant defenses October 2017 www.niemagazine.com Ease of use is also a consideration for stress and sleep products. Customers often prefer finished products that can be consumed quickly and with more convenience and Skop pointed out that Lactium succeeds on both levels. Lactium he said can be offered in a number of ways including ready-todrink beverages powdered ready-tomix drinks soft chews gummies and in a tasty hard candy form. This is especially sweet at night as it could be considered a little treat while winding down before bedtime. Market Status Experts in the natural ingredient industry concur--as long as people continue with their ways of life stress will be an ongoing part of the day. Consequently this can result in a lack of sleep for some. Falling short in the sleep department does not go unnoticed as a large portion of the population is aware that sleep is a prime component of living a balanced healthy life. Brian Zapp director of marketing with Applied Food Sciences Inc. in Texas found this to be anything but a shock. It is no surprise that people value their sleep he observed. Eighty-eight percent of the U.S. general population said getting adequate sleep is extremely important in how they maintain a healthy lifestyle (NMI April 2017). This was the largest segment of concern ahead of mental attitude and stress management. But some interesting data suggests that consumers also feel they are falling short in their health goals in achieving that sleep Zapp added. He pointed out that 42 percent of the U.S. population indicated that over the last 10 years their ability to get a good night s sleep has gotten worse (NMI April 2017). What s also telling is that 55 percent of those polled also feel that their energy level has worsened over the last 10 years as well (NMI April 2017). Americans tend to be overworked and under-rested. To supplement our lack of energy Zapp said many Americans fill their days with caffeine so it is no wonder then that the U.S. population is left hardwired and their quality of sleep is suffering. Zapp added that Around 70 million Americans have sleep problems (The National Center on Sleep Disorders Research) Relaxation beverages are a 218 million industry worldwide (IBISWorld 2016) More natural solutions are needed to compete with the largely dominant OTC (over-the-counter) and pharmaceutical sleep solutions. With various issues surrounding people s difficulty sleeping a common response would be to seek a solution to the problem. With prescription medications presenting unwanted consequences some individuals are seeking alternatives. Consumers are becoming more interested in natural sleep remedies due to concerns with side effects dependency and safety of prescription medications 1 noted Colletti. Neumentix Phenolic Complex K110-42 an extract produced from Kemin s patented spearmint varieties meets the need for Nutrition Industry Executive 21 A Stress-free Dose of Zs a safe and natural sleep aid. Neumentix is not only for working memory improvements but also is shown to support sleep. People who took Neumentix for benefits in working memory found they fell to sleep faster and easier at night. When taken in the morning participants taking 900 mg of Neumentix reported that they got to sleep easier and faster at night compared to subjects who took placebo. 2 ents that are not clearly identified. 4. Kava can have several extraction methods. By optimizing the beneficial lactones and reducing or eliminating the negative ones are your suppliers providing you with the safest extract that formulation experts can confidently use in products 5. How are your suppliers scientifically validating the measurement of those actives An ingredient should be clinically efficacious regulatorily compliant competitively priced well tolerated possess a low efficacious dose be easy to work with have methods that exist to test it analytically for bioactive content and ID it qualitatively to meet GMP requirements and have no supply issues. -- Bruce Abedon NutraGenesis LLC Skop stressed the validation of ingredient claims. For example Lactium promotes sleep while producing no or minimal sedative properties. In fact a study supporting this was published in the peer-reviewed scientific journal Behavioural Brain Research. Pharmachem is concerned with proving the effectiveness of this hydrolysate Skop noted. The study authors found that Lactium induces sleep promotion as shown by an augmented pentobarbital-induced sleep in mice and an increased slow (delta) EEG wave in rats. This sleep-promoting effect is probably mediated through the GABAergic neurotransmitter system Skop explained. The probable sedative effect of Lactium was evaluated through the open-field and rota-rod test and compared with the results of mice treated with the benzodiazepine drug diazepam. Consistent with previous studies diazepam decreased (after single treatment) the locomotor activity of mice in the open-field test. A decreased locomotor activity in this test is considered to reflect the sedative effects of a substance. Lactium did not significantly Formulation & Research When it comes to providing ingredients suppliers must be able to cover all bases to ensure top-notch quality. An ingredient should be clinically efficacious regulatorily compliant competitively priced well tolerated possess a low efficacious dose be easy to work with have methods that exist to test it analytically for bioactive content and ID it qualitatively to meet GMP [good manufacturing practice] requirements and have no supply issues said Abedon. Sensoril ashwagandha extract meets these requirements. After being asked about tips for successful formulation Zapp referenced Kava-kava (piper methysticum) a plant grown in many of the South Pacific islands. He noted the active compounds in kava called kavalactones have been studied in more than a dozen different human clinical papers over the last 20 years for their benefits in anti-anxiety stress and sleep support (Pittler 2000). Although these specific ones apply to the mentioned botanical Zapp suggested questions that ingredient manufacturers keep in mind when formulating. These can be altered to a specific ingredient. 1. Are your suppliers using only noble cultivars that have grown to maturity (about three years) 2. Due to microbial issues are your suppliers overseeing harvesting utilizing standardized practices that eliminate environmental contaminants 3. Are your suppliers manufacturing only the correct parts of the plant namely the root and rhizome The actives in kava are present throughout the plant so avoid micronized ingredi22 Nutrition Industry Executive alter the locomotor activity of mice. This result indicates that this substance has no strong sedative effects. Similar results were observed in the rota-rod test. In the study Lactium was orally administered in 75 150 300 or 500 mg kg of body weight. Then acute or repeated behavioral changes consequential to Lactium consumption were observed in various experimental procedures that would characterize the sedative (open-field and rota-rod test) and sleep-promoting (pentobarbital-induced sleeping test and EEG monitoring) activities of a substance. The most commonly used and prescribed benzodiazepine diazepam was used as a reference drug in these experiments. Being that proof of validity is a necessity the current stress and sleep market has shown that values within the industry are continuing to increase. The current market requires higher standards for stress and sleep ingredients compared to a decade ago observed Abedon. In greatest demand are ingredients that are supported by one or more double-blind placebo-controlled human clinical trials which demonstrate an ingredient s superior efficacy in healthy subjects. NIE References 1 Passport. Is the perfect sleep a dream Trends in calming and sleeping products June 2014. Euromonitor. 2 RDBPC 12-week study (Fonseca et al. [Abstract] American Academy of Neurology Conference Washington D.C. 2015.) evaluated healthy men and women between the ages of 50 and 70 with age-associated memory impairment. The study showed significant differences between active and placebo groups on improvements in working memory and ease of falling asleep. Working memory is a type of short-term memory system that allows temporary storage and manipulation of sound speech visual and spatial information. Working memory is critical to a wide range of cognitive tasks including attention multi-tasking and complex thought is highly correlated with measures of mental aptitude and has been found to be affected by the aging process and other factors such as stress or lack of sleep. Please contact Kemin for details on clinical findings. Extra Extra Visit www.niemagazine.com to read about a study explaining why poor sleep does not always have to be associated with depression. FORMOREINFORMATION Applied Food Sciences Inc. (800) 345-9666 Kemin Industries Inc. (515) 559-5100 NutraGenesis LLC (802) 257-5345 Pharmachem Laboratories Inc. (800) 526-0609 www.niemagazine.com October 2017 Go to www.niemagazine.com balchem for info about this advertiser By James J. Gormley The Participants Are Mike Greene Senior Vice President Government Relations Council for Responsible Nutrition (CRN) Washington D.C. Mark A. LeDoux Chairman and CEO Natural Alternatives International Carlsbad CA Scott C. Tips JD President National Health Federation (NHF) Monrovia CA ou want a friend in Washington Get a dog. This is a quote that while wrongly attributed to Harry S. Truman may still well resonate with many industry members who have interacted with legislators and regulators in Washington D.C. This panel of experts--which represents perspectives from the natural products industry in addition to trade and consumer advocacy organizations-- attempts to shed light on current challenges to (and questions about) the industry and its products coming from many quadrants from critics to bad actors to regulatory rollouts to even a new White House administration s posture on regulatory burdens. Y James S. Turner JD Chairman Citizens for Health Washington D.C. Michael McGuffin President American Herbal Products Association (AHPA) Washington D.C. 24 Nutrition Industry Executive NIE There is a current executive order that effectively creates both a partial regulatory freeze and a requirement that any new regulation be offset by the www.niemagazine.com October 2017 elimination of existing ones. Explain why this is good bad or a non-factor for the natural products industry. LeDoux Our industry has sought responsible and relevant regulations for the last 25 years. With the passage of DSHEA (Dietary Supplement Health and Education Act) in 1994 we expected the FDA (U.S. Food and Drug Administration) to create and publish good manufacturing practices (GMPs) for our industry but that effort took a long time. [In fact] it took a decade to implement something which should have been promulgated and adopted far sooner. Regulatory agencies exist through public laws and public funding. and the industry which supplies the tax revenues expects appropriate oversight. Recently there has been much discussion between the agency and the industry groups about proposed rules and guidance associated with new dietary ingredient filings and protocol but after repeated attempts to engage in meaningful dialogue this process seems to have stalled as well. The new administration has promulgated some principles regarding regulatory reform which can presumably remove some bureaucratic obstacles to innovation and should actually foster business growth. However with the concerns for food safety and the continued emphasis on transparency by consumers and local attorneys general it is not clear whether the administration order will have much impact either positively or negatively. Turner It s hard to predict right now if this would be good or bad for the natural products industry or the consumers it serves. What is clear is that the partial regulatory freeze and the one in two out requirement do create a level of uncertainty in regard to the status of the NDI (new dietary ingredient) guidance for example any movement on the definition of natural and more. Some observers have said that a slowdown in policy and rulemaking is not necessarily the same thing as a downturn in inspections or enforcement. Some have noted that this may be a chance for the right kind of economic analysis of the NDI guidance and an opportunity for the FDA and industry to take a good hard economic look at the putative consumer benefits real or imagined of the ramifications of guidance documents such as this. While less overt oversight might October 2017 www.niemagazine.com equate to more freedom to innovate the question becomes one of consumer confidence--or lack of confidence--in the supply of natural ingredients dietary supplements and functional foods. Time will tell the proof is in this case almost literally in the pudding. Tips Regulations are not cost free. Regulations impose financial and nonfinancial burdens upon any industry that increase costs to the consumer reduce competition and exclude innovative products from the marketplace. Almost all if not all of the regulations imposed by the Federal government on the dietary supplement industry are completely unnecessary. The free market with freedom of speech would allow the industry to self-regulate. -- Scott C. Tips Almost all if not all of the regulations imposed by the Federal government on the dietary supplement industry are completely unnecessary. The free market with freedom of speech would allow the industry to self-regulate. The most highly regulated sectors of business financial and insurance are the rifest with fraud and bad actors. Think about that. Regulations do not automatically bring with them better business conduct rather they actually foster more criminal activity and corruption as the least ethical businesses engage in bribery and cronyism with the regulators. So any reduction in regulation--so long as it is coupled with ethical players unfettered right to protect themselves through a non-corrupt court system and consumer choice--is a good thing for the dietary-supplement industry. because those regulations affect critical health safety financial or national security matters or for some other reason. Does this critical health or food safety exception apply to the natural products industry and to the final rollout of the FSMA (Food Safety Modernization Act) and the NDI Guidance LeDoux The argument that these two areas of regulatory oversight may be exempt from the White House directive is plausible but industry is unclear as to the sentiments of the agency because there has been a lack of transparency on where the agency is headed. Recently several industry participants have informed the agency of a variety of companies selling their products [via] e-commerce that are directly violative of current laws and regulations. The agency has not addressed these even after acknowledging that these problems clearly exist. This has to change particularly when you have a situation where health risks [have been] identified with ingesting products that are illegal per se. Turner We don t know yet whether the otherwise required by law or public-safety proviso will allow the FDA to avoid the two for one requirement in regard to dietary supplements and ingredients. It is hard to know what to root for existing guidance for which the ramifications are unclear or a stay on this guidance regarding which we are also unclear. It s not even a case of the devil you know is better than the devil you don t because we don t even know the devil either. McGuffin FDA s implementation of FSMA or finalizing of NDI Guidance do not appear to be impeded by the new administration or this specific executive order. NIE In a memorandum to agency heads the White House noted Notify the OMB Director promptly of any regulations that in your view should be excluded from the directives [...] NIE Representative Mia Love (R-UT) has taken on a new role as co-chair of the Congressional Dietary Supplement Caucus (DSC) replacing Rep. Jason Chaffetz. In a press release dated August 5 Congresswoman Love said I m excited to begin work on behalf of the 68 percent of Americans who take dietary supplements every year. She added Not only do dietary supplement companies provide jobs and opportunities here they give consumers the opportunity to make educated choices to fill critical nutrient gaps and Nutrition Industry Executive 25 achieve better health. Do Rep. Love s remarks potentially represent one sign of a new era in the recognized mainstreaming and greater legitimizing of dietary supplements in America If so how If not why Greene CRN is thrilled to be working with Rep. Mia Love of Utah in her new role of Republican co-chair following the departure of former member of Congress Jason Chaffetz. Her interest in nutrition and dietary supplements will be an asset to the Dietary Supplement Caucus (DSC) as it moves into its 12th year. I believe her leadership will also be helpful as she works with the other co-chairs Rep. Jared Polis (D-CO) and Sens. Orrin Hatch (R-UT) and Martin Heinrich (D-NM). We find that when CRN meets with elected officials in the House of Representatives or in the Senate many acknowledge their own use of dietary supplements. Health and wellness and good nutrition are mainstream and the DSC is a reflection of that. The caucus is bipartisan and bicameral and the 35 members of Congress who are current members of the DSC are representative of all facets of Americans who use and believe in dietary supplements. The DSC remains the best way to share information about dietary supplement regulation products and nutrition with legislators and staff. McGuffin Rep. Love s statement and engagement in the caucus are another indication that dietary supplements have been accepted by mainstream America. As more consumers use supplements to improve their quality of life more representatives in Congress are recognizing the importance of these products. In addition AHPA and other supplement industry trade groups are working hard to inform lawmakers about the significant positive impact this industry has on the U.S. economy. More and more lawmakers understand the positive impact the industry has on consumer wellbeing and the economy thanks to concerted advocacy efforts by groups representing the industry on Capitol Hill. 26 Nutrition Industry Executive LeDoux Representative Love is from a district that is well populated with companies engaged in manufacturing and distributing dietary supplements so this is a welcome endorsement of our efforts. However more has to be done with oversight of the various agencies and departments that may not share her sentiments. The caucus is bipartisan and bicameral and the 35 members of Congress who are current members of the DSC are representative of all facets of Americans who use and believe in dietary supplements. The DSC remains the best way to share information about dietary supplement regulation products and nutrition with legislators and staff. -- Mike Greene For example after attending the recent Codex Alimentarius Commission meetings in Geneva Switzerland an opportunity arose to push back on what U.S. industry and academia believe are artificially low NRVs (nutrient reference values) for two essential nutrients vitamins D and E and the U.S. delegation did not object to this adoption even though these numbers are far below equivalents in the U.S. and other developed nations. When industry members approached U.S. government personnel they were told that this was not a big issue for the U.S. government. Really Addressing deficiencies that can lead to serious health risks and attendant costs to the medical care system [are] not of interest to the U.S. government Miss Love and her colleagues in Congress would be well advised to ask members of the Codex offices of the U.S. Department of Agriculture and the Food and Drug Administration why they have adopted this illogical position. Turner While congressional member organizations (CMOs) such as the Dietary Supplement Caucus appear to be taking heat of late by critics and plaintiff attorneys who represent the not-so-huddled masses of those who believe that only the lobby around synthetic chemicals and prescription drugs should have its supporters on Capitol Hill dietary supplementation is part of a consumer self-care movement that features a strong belief in the value of a clean healthy food supply and diet and healthy skepticism regarding drugs and chemicals. Rep. Love supports this consumer mandate and for that she deserves our support. Tips Rep. Love s remarks are very welcome but until we eliminate the stranglehold that the [...] pharmaceutical industry and Big Ag have over our health and nutrition there is still a long row to hoe. NIE More than 170 million Americans take dietary supplements and the industry contributes 122 billion and over 750 000 jobs to the economy. Supplements definitely have a seat at our dinner table. Is this message getting through in Washington to U.S. legislators and to state legislators such as in New York state What evidence do we have one way or the other that supplements also now have a seat at the table in D.C. and in Albany McGuffin These numbers demonstrate that the industry is mainstream among consumers but some lawmakers and regulators still seem behind on this. Several myths and misconceptions about supplement safety efficacy and regulation persist and industry critics frequently exploit these myths making the supplement industry a target for regulators and negative media coverage. The supplement industry continues to work diligently to debunk misconceptions by building relationships with lawmakers and regulators to ensure they have accurate information about this well-regulated class of goods. Greene The message is getting through but more work needs to be done. Whether we are sharing information about the 170 million Americans who take dietary supplements annually the 750 000 good paying U.S. jobs that are created by the dietary supplement industry or the most recent NBJ dietary supplement sales figures at roughly 41 billion many on Capitol Hill are aware of the size and rapid growth of the dietary supplement industry. www.niemagazine.com October 2017 There are still issues that need to be addressed at the federal level like ensuring low-income Americans have access to a multivitamin mineral dietary supplement through government programs like SNAP (Supplemental Nutrition Assistance Program) or WIC (Women Infants and Children) or allowing a family to use their tax-free medical savings accounts like a health savings or flexible spending account (HSAs FSAs) to purchase dietary supplements. In addition key states like New York and Massachusetts continue to introduce dietary supplement legislation because they believe the federal oversight system put in place by DSHEA is not appropriate and therefore we should expect continued activity in activist state capitals like Albany Trenton Boston and Sacramento. State and local concerns will continue to grow so we in government relations must be vigilant. And having a state presence and sharing important facts will be [vital] as we meet with state and local decision makers. Turner Hard to see where the federal government has all of its sights set at the moment especially in light of the very muddy waters now due to the regulatory freeze. However at the state level New York has its fair share of state lawmakers who want all sorts of warnings on supplement labels and who would be more than happy based on past task forces and efforts to move the state in the direction of pre-approval of supplements ingredients and claims while needlessly alarming consumers about those same beneficial products. And where goeth New York and California so eventually goeth other states too. On balance supplements might be a little better respected by legislators attorneys general and regulators than they were in the early 1990s but the forces arrayed against American consumers in this health battle are no less potent than ever before. Tips While true that supplements have a seat at our dinner table that does not mean that anyone is actually talking to us while seated there We are mostly eating alone. Certain trade organizations especially the Council for Responsible Nutrition have been responsible [in] convincing certain politicians and regulators that dietary supplements are legitimate. However the political and regulatory October 2017 www.niemagazine.com players change often and then the task of convincing new faces must take place. It s a never-ending game albeit one that I think we will ultimately win. After all dietary supplements do have value and do work. Supplements might be a little better respected by legislators attorneys general and regulators than they were in the early 1990s but the forces arrayed against American consumers in this health battle are no less potent than ever before. -- James S. Turner NIE In June 2017 the GAO issued a report that drew attention to big problems of some wild claims and irresponsible marketing regarding dietary supplements geared for memory and cognition. Recognizing that we have a rapidly growing pool of aging Baby Boomers who are living longer what are these extreme cases an example of Fly-by-night outfits masquerading as legitimate dietary supplement companies selling questionable nostrums or is this a case where we need to take a good hard look at ourselves as an industry Turner The natural products industry is at a crossroads. There is a powerful body of evidence supporting responsible use of supplements that support cognitive health. The population of older Americans who could benefit from these food supplements has never been greater. As our needs grow so do the interests of brain-boosting supplement makers and marketers. The vast majority of these products and manufacturers are beneficial and legitimate respectively. However there will always be a small number of irresponsible purveyors who will prey on vulnerable consumers who are fearful of aging and who are desperate for solutions and support. We strongly support efforts to mar- ginalize and aggressively pursue enforcement actions against despicable outfits such as these. McGuffin This is more of an enforcement issue and the regulated industry vocally supports strong enforcement of current laws and regulations that prohibit the marketing of these products with false or misleading claims. Better enforcement would likely go a long way to clamping down on unscrupulous companies. At the same time it is worth investigating claims that are allowed for supplements. Many claims that are not misleading and supported by evidence are still prohibited for this class of goods. Tips Undoubtedly there are bad actors in that market segment just as there are in every other business. The best and most moral way to counter such bad actors is through unfettered free-market mechanisms that allow for the free flow of consumer information and through legal actions brought in non-corrupt courts that will greatly discourage and minimize bad actors. Remember no system is perfect and there will always be bad actors in any industry. The goal is not to eliminate them entirely but rather to minimize their presence and ill effects. That is best accomplished through free-market mechanisms not through perhaps well-intentioned but heavyhanded and misguided over-regulation. LeDoux This is an area where the FTC (Federal Trade Commission) needs to step up oversight. I would hazard a guess that most of these products are not from responsible members of our industry but rather from opportunists who see a way to make a lot of money in a short time by taking advantage of people in need. Advertising standards need to be tightened and frankly companies selling products with unsubstantiated claims need to be heavily fined and their owners subjected to personal liability. NIE What are the biggest supplement industry problems we need to aggressively address right now and how will this help us in Washington LeDoux If one looks at the big picture the real issues that are in front of the industry are a. Protection of intellectual property and enhancing research and protection of patented ingredients. (Continued on page 42) Nutrition Industry Executive 27 Sports nutrition supplements are in energetic demand by a wide range of consumers who want physical improvement more quickly than with diet and exercise alone. Here s how to get in the game and win. By Lisa Schofield P erhaps more than any other category sports nutrition is flexing its muscles and enduring a marathon of research and development. And excitement truly abounds here-- because it s all about getting into one s best shape feeling stronger more lithe and more competitive on all fronts. If your team is thinking about launching or expanding a sports nutrition product or line there are ample opportunities as it s not just for the devotees of the Arnold Classic (also known as the Arnold Sports Festival) anymore. According to a Euromonitor 2016 report Global Sports Nutrition Retail Value the sports nutrition category has undergone dramatic growth--from 6.7 billion in 2010 to 10.8 billion in 2015. This growth stems from the increase in consumer recognition of the value of sports nutrition supplementation for 28 Nutrition Industry Executive achieving fitness goals observed Peter Schouw Andersen head of science and sales development for Denmark-based Arla Foods Ingredients. The category was typically very niche-oriented but has expanded with consumers focusing on weight-management and fitness so sports nutrition has become increasingly attractive to mainstream or casual users. Furthermore he stated another important group has now emerged most notably in developed markets and in the urban centers of developing markets. It is comprised of people who are dedicated sports and exercise enthusiasts but are not athletes. Rather they are highly motivated people who see fitness as the gateway to a high-performance lifestyle. In the context of sports nutrition products we call these people fitness lifestyle users. In agreement is Rick Antonoff CEO of Novel Ingredient Services in New Jersey who said that just during the past five years alone the lines between the sports nutrition weight management and energy categories have blurred melded and are more relevant for different groups. For example he pointed out bodybuilders and professional athletes who were core users of sports supplements now realize they need to generate energy to power through vigorous workouts and burn fat to stay lean and toned not just build muscle. Endurance athletes the traditional consumers of energy supplements now want to build lean muscle. And those seeking to lose weight are now consumers of sports nutrition to get the most out of their exercise regimens. Antonoff added that sports nutrition supplementation has become mainstream with benefits for people of all www.niemagazine.com October 2017 ages and walks of life-- active lifestyle enthusiasts as well as a more general active and health-conscious consumer group. These include Gen-Xers and Millennials as well as seniors soccer moms and dads on the go he commented. These individuals not only want to stay physically active and maintain lean toned physiques--they are leading busy high-energy lives and need nutritional support to help them through the day. Shaheen Majeed president-worldwide Sabinsa New Jersey emphasized that the sports nutrition segment has seen much evolution in the past several years--the category continues to see a flux of newer products that emphasize other attributes beyond weight management and muscle-building protein powders. Majeed pointed to three factors playing significant roles in the category expansion consumers awareness about the actual meaning of being healthy both physically and mentally significance of maintaining optimal strength and stamina and the role of natural supplements in achieving all these in a natural way. Nutritional needs are now being recognized as somewhat different between male and female athletes. Noted Tim Hammond vice president of sales and marketing for the Washington-based Bergstrom Nutrition Recognizing how nutritional needs can differ significantly between genders is an evolution that presents exciting opportunities. Sports nutrition research has historically focused on male athletes overlooking the nutritional needs of females. We see nutritional support for women as an under-developed market with huge potential and are moving forward with female-focused OptiMSM research. Providing supplements that support proper nutrition and maintain hormonal balance may help minimize the effects of the female athlete triad. This expansion in sports nutrition said Alison Raban certified food scientist BI California was primarily propelled by the ubiquitous protein trend we have seen across the supplement and food and beverage industries on the whole. Health-minded consumers she noted are demanding not only more protein but variety of protein sources especially plant-based proteins and grass-fed whey and in new and better-tasting delivery formats. Even though whey protein powders still dominate rice and soy proteins are gaining October 2017 www.niemagazine.com traction in the plant-protein space. An increasing number of new brands are differentiating themselves by switching to plant-based proteins. Novel sources like nuts and pulses have been gaining traction with vegan consumers as well as a growing group known as flexitarians who limit the amount of animalbased products they consume in their overall diet she reported. According to Andrew Wheeler direc- Gyms or fitness centers have evolved to more than a place of merely working out. These have instead become wellness centers that emphasize lifestyle habits dietary needs physical therapy etc. -- Sendhil Pani President Bayir Inc. tor of marketing for Illinois-based FutureCeuticals Inc. today we live online versus go online and it is evident in the imagery and content online as it is focused on not just muscle but shifting to providing information centered around healthy lifestyles and the whole food movement (i.e. natural ingredients plant proteins plant-based ingredients and clean label transparency). Consumers read the ingredient deck look for organics and non-synthetic options ... which mirrors clean label consumers in the food and supplement sector. Today there is no typical sports nutrition consumer asserted Missy Lowery MSc senior manager marketing for Capsugel in New Jersey. In fact she observed sports nutrition is quickly evolving into an active nutrition market driven by several demographic groups--seniors who want to maintain mobility and independence young affluent consumers who have an alwayson-the-go lifestyle who demand cleanlabel supplements (organic natural sustainable vegan non-GMO [genetically modified organism]). This emerging consumer group wants supplements that will generally help them gain more energy and endurance lose more weight build and maintain muscle relieve muscle soreness and feel perform and recover better. But most active nutrition consumers are familiar with protein but not many of the other sports nutrition ingredients that have been developed by the core users she said. With fitness goals programmed into apps they are following the social media influencers more than the guy on the next machine at the gym much less body builders and extreme athletes. Overall observed Sendhil Pani president Bayir Inc. New Jersey the current dietary guidelines from the Office of Disease Prevention & Health Promotion provided a framework for physical activity that has truly been the impetus for change in the sports nutrition category. Sports nutrition has moved beyond competition to a desire and drive for sustainable good health. Gyms or fitness centers have evolved to more than a place of merely working out. These have instead become wellness centers that emphasize lifestyle habits dietary needs physical therapy etc. The important item to note is that there is more crossover between the sectors of medical care and fitness with a more holistic outlook on overall health. Fitness Trends Who remembers Jazzercise It was all the rage in the 70s and early 80s. Taebo had its run in the 90s. Pilates Zumba yoga and now Tough Mudder and Cross-Fit are enjoying moments. Americans love trends and are quickly willing to try them out and follow them. Keeping up with how people are enjoying their fitness is important when it comes to developing supplements as many ingredients can help achieve goals more quickly and safely. Currently the two most popular exercise fitness trends are body weight training and high-intensity interval training (HIIT) according to the American College of Sports Medicine (ACSM) which surveyed approximately 2 000 fitness professionals exercise physiologists and researchers. The former features no equipment and is flexible to fit any level of ability. HIIT alternates quick bursts of highintensity exercise with short rest periods and appeals more to serious athletes and younger demographic groups like Millennials who work out harder and more frequently than any generaNutrition Industry Executive 29 more sustained energy. Novel Ingredient Services recently launched Kinetiq Advantra Z plus standardized levels of narigin and hesperidin two citrus bioflavonoids that occur naturally in the bitter orange fruit. This thermogenic ingredient has been shown to further boost resting metaboltion before them Antonoff explained. ic rate and increase resistance exercise HIIT fitness movements like CrossFit performance. Its new patented fenuBootcamp spinning and Tabata training greek extract Physicor breaks down fat help build muscle and torch calories. and inhibits fat storage and also ampliThey are great for the mental and physi- fies insulin-like growth factor that signals cal components of health but place a the body to produce lean muscle and lot of wear and tear on the body. strengthen bones. He added that sports nutrition supAndersen observed that participation plements with performance ingredients in endurance events is growing like Advantra Z and Kinetiq that safely between 2009 and 2014 according to increase energy and intensify exercise www.runrepeat.com the number of tolerance are ideal for these conpeople participating in marathons sumers. worldwide rose by 13.25 percent. According to Antonoff Advantra Z Another exercise form gaining traction patented bitter orange extract has been is CrossFit which he noted is now feashown to intensify exercise tolerance as tured in more than 10 000 affiliated much as 83 percent. It safely increases gyms worldwide half of which are in the metabolism to jumpstart weight-loss U.S. These activities put great pressure efforts and help increase lean muscle. on the muscles so fast recovery Its main active compound natural pbecomes a priority. Participants can synephrine--a stable synephrine isobenefit from switching from standard mer--has a long half-life to provide whey proteins to whey protein hydrolysates which are superior-quality proteins that have essentially been finely chopped--or pre-digested --so they can be absorbed more rapidly by the body Andersen explained. In fact whey protein hydrolysates like our Lacprodan HYDRO.365 can cut recovery times from days to hours. Hammond agreed noting that the typical weekend warrior has become more intense with the advent of HIIT CrossFit and obstacle racing (Tough Mudder and Spartan) which necessitate higher levels of focus skill and physical performance. These open up new marketing and formulation opportunites Go to www.niemagazine.com americanlaboratories for info about this advertiser way beyond just 30 Nutrition Industry Executive fueling he maintained. Published research on endurance and resistance athletes show that MSM may reduce muscle pain damage and soreness helping to protect muscles and joints from exercise-induced damage and speeding recovery he added. People who participate in CrossFit triathlons cycling mountain biking and high-intensity team sports such as basketball or hockey said Wheeler can benefit from FutureCeuticals FruiteX-B elevATP VitaCherry Sport and Coffeeberry which can help boost nitric oxide for energy boosting. Body building remains popular and elevATP Spectra Neurofactor and ModCarb are ingredients for sports supplements to support enhanced power performance and recovery. Raban attributes the countless fitness and exercise trends such as P90X to SoulCycle to Zumba to the increase in consumer awareness of overall health and the benefits of following a healthy lifestyle. The increased participation in high-intensity exercises such as CrossFit is especially noteworthy because of its meaningful impact on the supplement and food and beverage industries she commented. The paleo diet she said was first popular with CrossFit enthusiasts and has impacted trends in supplements foods and beverages. High-protein supplements sports nutrition products following the paleo diet are gaining traction she described and this is leading to the increase in animal-based protein that is parallel with the growth of plant-based protein products. Popular proteins include grass-fed whey protein and collagen from egg and chicken and bone broth. www.niemagazine.com October 2017 Go to www.niemagazine.com natreon info about this advertiser Exercise said Majeed is now being seen in a different perspective there s more to it. For example yoga is being designed intelligently to help different sport categories like gyrotonic or areal yoga etc. he said adding that several of Sabinsa s ingredients are suitable for the sports nutrition category. Sabeet is Sabinsa s standardized red beetroot extract high in nitrates clinically demonstrated to improve athletic performance via endurance boosting. It also helps maintain optimal energy level. DigeZyme is a proprietary multienzyme complex which Majeed said has recently been proven to help reduce pain associated with delayed onset muscle soreness induced by exercise. Research has been shown that protease one of the enzymes in DigeZyme can reduce bruising swelling and athletic injuries. And Sabinsa s ashwagandha extract helps to increase stamina endurance and improve overall health. Ashwagandha may be a great addition to one s workout regimen as it can help suppress the oxidative stress induced by longer workout sessions Majeed said. Bayir Inc. s ashwaganda said Pani is and adaptogen increasingly used for energy and muscle recovery chondroitin coleus garcinia glucosamine and fenugreek extracts are also excellent for muscle recovery while curcumin fits into fitness to help manage exerciseinduced inflammation. Sports Nutrition Ingredient News As this sector is growing energetically and the meaning of exercise is evolving covering new ground so too are suppliers keeping up with research and new ingredients to maintain relevance and fulfill the new demands--and expectations--as described here. BI s newest plant-based protein is Lentil Protein a concentrate that is standardized to 55 percent protein. According to Raban it has a clean flavor profile that lacks the bitter astringency found in some other plant-based proteins. BI s Lentil Protein can be used in shakes both ready to drink and ready to make and other functional foods like bars and proteinenhanced snacks. Several existing ingredients have new studies demonstrating efficacy. A new double blind placebo-controlled study (2017 Journal of International Society of Sports Nutrition) showed study participants who used OptiMSM and ran a half marathon experienced clinically significant reductions in both muscle and joint pain according to Hammond. Sabinsa s DigeZyme has recently been clinically evaluated for its ability to manage delayed onset muscle soreness induced by standardized eccentric exercise. In Go to www.niemagazine.com somalabs for info about this advertiser this double-blind placebo-controlled clinical trial of 20 healthy male participants those who took DigeZyme (50 mg) three times a day for three days experienced significantly decreased pain and tenderness induced by exercise according to Majeed. Additionally he noted the level of pro-inflammatory biomarkers like creatine kinase and lactate dehydrogenase also declined. According to Antonoff a new placebo-controlled double-blind study looked at the effects of Advantra Z (2017 Nutrition and Dietary Supplements ) on energy and appetite control in 40 overweight adults. The participants who consumed a chocolateflavored chew containing 100 mg Advantra Z 15 to 30 minutes before their two largest meals of the day for 30 days reported significantly higher positive scores for eating appetite control and energy enhancement as compared to placebo. Also he reported Novel Ingredient Services Physicor has received selfaffirmed GRAS (generally recognized as safe) status for use not only in nutritional supplements but also functional foods and beverages which are key to the sports nutrition category. Sports nutrition supplements containing curcumin that address exerciseinduced inflammation may benefit from Bayir Inc. s nano-curcumin for which the company recently received approval of a process patent according to Pani who noted that research on curcumin nano-particles shows it can provide a broader range of applications particularly with beverage applications. The nano-curcumin is water dispersible which makes it more user-friendly he said. Delivery From Capsugel are two formulation technologies--micronization and selfemulsification--designed to improve bioavailability and threshold dosage of solid and semi-solid actives for delivery in capsules. Both of these formulation techniques may also eliminate the need to fill a capsule with extra amounts of ingredients to compensate for inefficient absorption according to Stan Glab manager of formulation and product development. Micronization Glab explained works on the principle that the smaller the particles the more easily a nutrient can be taken in by capillaries it reduces ingredient particle size to improve absorption. For example in liquid form www.niemagazine.com October 2017 32 Nutrition Industry Executive Go to www.niemagazine.com deerland for info about this advertiser L-arginine can be micronized--as well as solubilized--in a free-flowing liquid with a high concentration of active ingredients. Encapsulating this liquid formulation in a Licaps hard shell capsule in a nitrogen-flushed environment has been shown to maintain stability compared to other forms of L-arginine he said. Some actives might not be able to be micronized enough to be readily absorbed so self-emulsification which Glab said takes micronization a step further is warranted. These are best if they are solubilized into a liquid base. Those that can t dissolve in water must be dissolved in oil instead. Solubility is achieved only when a specific dissolving agent is compatible with a molecule s chemical structure. Liquid formulators can select from a range of emulsifiers. With the right match the nutrient is solubilized and supplement bioavail- ability improves Glab detailed. For example with self-emulsification a single-dose liquid form of L-carnitine can become fully solubilized into a pure L-carnitine with all L-form and no Dform the D-form is known to deplete Lcarnitine concentrations in skeletal and cardiac muscles. In this case Glab explained solubility can be achieved by eliminating tartrate salts in the original form via a self-emulsifier--a specific dissolving agent that is compatible with the L-carnitine molecule s chemical structure. A base form of L-carnitine can also be solubilized within minutes a higher potency can be seen with this higher form. To maintain stability the pure liquid is then encapsulated in a Licaps hard shell capsule flushed with nitrogen to eliminate oxygen and then hermetically sealed. Whether it s plant proteins mixed with other sports nutrition ingredients in capsules bars powders or beverages the sports nutrition sector will continue to innovate and sometimes reinvent itself and in some cases no doubt will lead fitness trends. Today there are so many ways to get into better physical shape and more consumers are making their own programs and cutting-edge science-backed sports supplements foods and beverages are a key part of their winning regimen. NIE According to www.femaleathletetriad.org The Female Athlete Triad is a syndrome of three interrelated conditions that exist on a continuum of severity including energy deficiency with or without disordered eating menstrual disturbances amenorrhea and bone loss osteoporosis. Extra Extra Visit www.niemagazine.com to read an interview with Brian Jordan technical manager NSF Certified for Sport NSF International. FORMOREINFORMATION Arla Foods Ingredients 45 8938 100 Bayir Inc. (609) 524-9505 Bergstrom Nutrition (360) 693-1883 BI (310) 669-2100 Capsugel www.capsugel.com FutureCeuticals (888) 452-6853 Novel Ingredient Services (973) 808-9000 Sabinsa (732) 777-1111 Don t miss a single issue of NIE in 2017 ... go online to renew your free subscription today NIEmagazine.com October17 34 Nutrition Industry Executive www.niemagazine.com October 2017 Nutraceuticals Nutrients Under the Sea 3 index faster than other omega-3s. Aker BioMarine s newest products include Superba2 which features enhanced encapsulation properties as well as improved smell taste and visual appearance and Superba Boost a new krill oil concentrate which contains higher amounts of phospholipids choline and omega-3s. These products (among others) are all made possible using Flexitech a patented technology exclusive to Aker BioMarine in the omega-3 market. Beyond fish and krill marine plants offer a number of health benefits. [There is] growing awareness of additional minerals and their importance [other] than single minerals such as calcium explained David O Leary commercial manager of Ireland-based Marigot Ltd. creator of Aquamin. Aquamin meets this requirement being a natural plant-derived marine multi-mineral. Nutrition Industry Executive 35 By Shari Barbanel t is said that the ocean is vastly still a mystery and although it covers more than 70 percent of the planet s surface 95 percent of it still remains unexplored according to the National Oceanic and Atmospheric Administration. However the marine life we are aware of and have studied offers a plethora of ingredients that have a number of health benefits for those of us on land. While omega-3 essential fatty acids or EFAs from sources like fish and krill may be the most recognizable in the category in recent years the omega-3 segment of the market has had its ups and downs. After reports of negative studies omega-3 sales took a dip but are regaining strength. During the past couple of years the omega-3 market saw periods of decline and struggle but most recently it s rebounding and heading into new and exciting areas said Becky Wright marketing and communications director-- Superba Aker BioMarine Antarctic US in New Jersey. In fact according to the Global Organization for EPA & DHA Omega-3s (GOED) the omega-3 I supplement market in the U.S. has leveled off. It is still contracting slightly but nothing like the 10 to 15 percent per year we were seeing a couple of years ago. Today companies are starting to see sales growth and innovation which is positive for the overall market. According to a May 2017 Grand View Research report the global omega-3 supplement market is expected to reach 57.07 billion by 2025. Further in 2016 the fish oil segment of the omega-3 market was valued at 27.9 billion. And while fish oil has been a mainstay marine ingredient for many years now krill oil is becoming increasingly popular among consumers for its many health benefits. Krill oil s omega-3s in particular are mostly bound to phospholipids which has a profound effect on how EPA and DHA are delivered in the body. Several studies have demonstrated that phospholipid-bound omega-3s get into the blood quicker and more efficiently Wright explained. When this is measured using the omega-3 index test krill oil has been shown to raise the omega- October 2017 www.niemagazine.com Nutraceuticals the use of independent third-party certifying bodies. We provide a logo and trademark along with a well documented website and easy-to-understand video to help marketers communicate the benefits of the ingredients he added. Sustainability is something that Aker BioMarine takes very seriously as it has been at the core of the company s mission since inception Wright noted. Committed to supplying health ingredients that benefit people while operating in a manner that does not compromise the health of our planet and its oceans Aker BioMarine practices sustainability on many levels from technology to third party certification she explained. Additionally for two years in a row Aker BioMarine received an A rating for sustainability from the Sustainable Fisheries Partnership (SFP). when attracting not only consumers but manufacturers as well O Leary noted. Proven science is key. Detailing unique efficacy around mineral bioactivity and related absorption and additional functionality around anti-inflammatory properties for joint health are also important to understand the mechanisms of absorption how the minerals are actively being absorbed. Effectiveness of products is often a challenge in an industry that aims at preventing diseases and maintaining the well-being of the consumers but Aquamin has strong and published science to help demonstrate its effects added Berthomieu. Aquamin is a marine multi-mineral complex providing bioactive calcium magnesium and 72 other trace marine minerals for the fortification of food beverage and supplement products. According to the company Aquamin is derived from 100 percent seaweed which absorbs trace minerals from the surrounding seawater. This form of absorption coupled with Aquamin s structure results in a mineral rich product that is neutral tasting free of chalky texture and easily absorbed by the human body. Delivery In regard to delivery some marine ingredients such as fish oils may be difficult for some consumers to stomach--due to pungent smells and fish burps. According to Stan Glab manager of product development and formulation for South Carolina-based Capsugel many marine oils are delivered in soft gels--either gelatin or vegetarian but there can be a downside to them. They contain plasticizers that create micro-channels in gelatin that allows oxygen to enter pungent odors to seep out odd tastes to jolt the palate and the potential for ingredient migration into the shell he explained. Oxidation can compromise the integrity of the ingredient. Antioxidants can be added but not everyone wants to take added ingredients or can tolerate flavorings or perfumes to manage the smells in the bottle. Other standard delivery forms are hard gelatin capsules Glab continued. They can more successfully block smells and mitigate oxidation because they don t contain plasticizers that create microchannels. Hard capsules come in fish bovine and porcine gelatin. The newest addition to hard capsule delivery are vegetarian capsules that either have superior oxygen barrier properties or can delay the release of the liquid ingredient. Capsugel has chosen to go the hard capsule route. In fact scientists at Capsugel s Liquids Formulations Centers in Greenwood and Colmar France created unique hard capsule technologies that deal with a number of the delivery issues that omegas may have including combination of incompatible ingredients odor viscosity and compromised ingredient integrity due www.niemagazine.com October 2017 Sustainability Transparency & Research Marine ingredients--both plant and fish--are not new to the industry however how they are sourced has become a hot topic over recent years--as suppliers manufacturers and consumers want to ensure that the ecosystem stays intact and that the ingredients and products they produce are up to par. Sustainability and traceability will always be important topics for consumers when it comes to marine ingredients said Wright. According to 2016 data from the Natural Marketing Institute (NMI) supplement users are looking more closely at where ingredients are sourced from showing strong preference for natural organic and sustainable sources. O Leary agreed noting Sustainability is key and needs to be at the forefront so that customers and consumers can have confidence that the material being supplied is being harvested in an environmentally responsible manner. Other factors include clean tasting ingredients that are easy to include stable under processing allergen free and clean label suitable for inclusion in functional food and health supplement applications. Greg Berthomieu vice president of strategic partnerships for Californiabased Stauber the North American distributor of Aquamin explained that the sustainability issue linked to marine ingredients could also be handled via 36 Nutrition Industry Executive Today s consumers are savvy--they know what they want and they aren t afraid to demand the information they require to make an informed decision. Informed consumers are making choices to eat healthy and this has created demand for all natural clean label plant derived safe and proven ingredients-- all of these facets and requirements are met with by Aquamin broad offering said O Leary. Wright agreed that transparency is important to consumers. Aker BioMarine owns and controls its entire supply chain assuring brand holders (and consumers) a secure supply volume product quality and seamless service she said. The company also utilizes a GPS tracking system that can pinpoint the exact location of each krill batch processed and some of its clients actually use those coordinates on their bottle labels. Access to research is also beneficial to sensitivity to moisture oxidation acidic environment as well as wide working temperature ranges. The result is dosage form solutions that address specific delivery challenges managing burp back and bad taste while protecting integrity of ingredients from moisture and acidic environment. Capsugel s DRcaps for Liquids is a hydroxypropyl methylcellulose (HPMC) capsule that resists the acidic environment of the stomach without the use of enteric coatings. According to the company this vegetarian capsule has inherent acid-resistant polymer properties so the capsule won t disintegrate in the stomach but opens immediately once the pH rises above 6.8--out of the acidic environment of the stomach at or near the entry into the intestines. Because the capsule is made of lowmoisture HPMC it also can help shield ingredients from destabilizing moisture in the package before ingestion and protect from acid after ingestion. It is also especially appealing to the healthy lifestyle consumer because of its certifications for vegetarian vegan halal and kosher. To deal with the issue of pungent smells Capsugel offers Licaps hard capsule which are hermetically sealed using LEMS technology. In addition the Licaps capsule is filled with nitrogen during encapsulation to keep oxygen out throughout the manufacturing process. The company s fish gelatin version Licaps Ocean Caps capsule provides manufacturers with the ability to offer an all-marine product when used for marine and krill oils while Capsugel s vegetarian version Licaps Vcaps Plus capsule provides additional protection for hygroscopic or moisture sensitive ingredients because the HPMC polymer is very low in moisture. It has great appeal to the healthy lifestyle market because of its certifications for vegetarian vegan non-GMO (genetically modified organism) halal and kosher providing an all vegetarian offer when paired with plant-based oils Glab said. NIE FORMOREINFORMATION Aker BioMarine Antarctic US (732) 860-0137 Capsugel (888) 783-6361 Marigot Ltd. 353-21-4378727 Stauber (888) 441-4233 FAMILY OF PRINT AND DIGITAL MEDIA Branch Out With VRM s .com gazine NIEma VitaminRe tailer.com Fitness om rMag.c Traine NaturalPra ctitionerM ag.com Contact One of Our Ad Specialists Today Russ Fields at (732) 432-9600 ext. 102 or e-Mail RussF VRMmedia.com Gary Pfaff at (732) 432-9600 ext. 103 or e-Mail GaryP VRMmedia.com October 2017 www.niemagazine.com Nutrition Industry Executive 37 Research&Development he word efficacy is commonly associated with dietary supplements--but what does it really mean and when consumers demand proof will you confidently have it Dr. Arturo Liz n-Nordstr m CEO Monteloeder USA Florida has observed that brand marketers are becoming increasingly aware that consumers are losing faith in general and non-personalized supplementation as one size fits all is being more and more discredited. Any given diet or supplement may work for some people but not for others. Liz n-Nordstr m said he believes that it is now more important for brand manufacturers to provide personalized health solutions to consumers. Many of Monteloeder s customers are including digitization in their portfolios in what the supplier calls its Health 3.0 Revolution. The use of technology (mobile apps wearable devices etc.) provides the consumer and industry with information regarding health habits and the real effects of the health ingredients in each and particular individual that is consuming them (e.g. diet physical activity monitoring of biological parameters). With this information the companies can provide a personalized service to its cus- T tomer base. When customers use more personalized supplements they may experience the benefit more quickly and powerfully and ergo will realize the efficacy. Stephen Lukawski director of sales partner and business development for Fruit d Or Nutraceuticals of Quebec Canada opined The term efficacy can be very misleading to consumers. One positive study does not mean efficacy. Encouraging yes but if you cannot repeat this study to obtain the same results then this creates false hope. Research studies need to have better design of protocols. Efficacy Challenges Not all efficacy is the same--not only does it vary between ingredient types (e.g. CoQ10 and ashwaghanda) but within each type and this can pose a problem in communications. With cranberry for example said Lukawski if you do not identify what is inside the cranberry or what the starting material contains then you cannot identify the active biomarkers within. Once the biomarkers such as PACs in cranberry are identified the biomarkers then need to be standardized from lot to lot in order to provide consistency from batch to batch. Then you need to link the biomarkers to the research along with test methods and reference standards. What good is science and research if you cannot repeat the study and obtain the same results This is the problem with the term efficacy. Probiotics and enzymes are another example of potential challenges in translating efficacy clearly. Most consumers are accustomed to associating milligram weight as a function of potency but in enzymes and probiotics the units used to define efficacy are significantly different pointed out John Deaton vice president of science and technology for Georgiabased Deerland Enzymes & Probiotics. While the brand marketers understand it s a bigger challenge to communicate this in a way for consumers to understand. Unlike traditional supplements that are measured by weight enzymes are measured by their activity and often in varying units. It s important for the consumer to know that for enzyme-based supplements more milligrams don t necessarily equal increased potency. Even though probiotics also are not measured by weight he added communicating efficacy is a bit more straightforward. Probiotics are commonly measured in colony-forming units (CFU) and for the www.niemagazine.com October 2017 38 Nutrition Industry Executive most part brands are all communicating this. And although most consumers may not understand the definition of CFU they do recognize it as a function of strength and understand that the higher the number the more potent--and therefore more effective. A challenge with probiotics Deaton said is that there is a point where the benefits of increased CFU max out depending on the strain. The Nature of the Ingredient and the Consumer In order to truly demonstrate efficacy of an ingredient emphasized Liz nNordstr m it is necessary to have deep knowledge of its nature its active constituents what has been published in the scientific literature as well as what similar products are in the market and how they compare with the new ingredient. But you cannot overlook studying the consumer marketplace what habits are developing in your audience what they want and how they want to use the resulting product he added. We directly interact with the potential consumers to obtain initial feedback about their requirements desirable results and possible worries. This feedback continues with the pilot clinical studies where the volunteers communicate the perceived results and indicate their level of satisfaction with the ingredient. We also include in our clinical studies the use of digital devices (mobile apps wearable technology etc.) as well as surveys to assess compliance adherence to treatment level of satisfaction and quality of life then incorporate these results in our digital portfolio. In this manner we are capable of correlating product consumption experience with lifestyle habits using the digital devices are tools to measure efficacy which can be perceived by the consumer he explained. Showing Your Work--Efficacy Proof Examples Asking your supplier to show its proof of efficacy from the beginning through final shipment for manufacturing should be a requirement. According to Deaton Deerland s first step is to determine the structure of the ingredient. For enzymes this is analysis of the amino acid structure. Probiotics uses genome sequencing a laboratory process that determines the DNA sequence of an organism. This sequence reveals what the various genes that make up the genome do how different genes interact and how the various parts of the October 2017 www.niemagazine.com genome are coordinated. This is an essential first step in determining safety of the ingredient. For example Deerland s DE111 strain of Bacillus subtilis was genetically sequenced in partnership with Cornell University and was found to contain no plasmids deleterious genes or antibiotic resistant genes he said. Sequencing also reveals genes that may offer certain benefits. For example the sequencing of DE111 showed that the strain contains genes that increase IgG and IgA (antibodies) which support immune health. Next Deerland s research and development team performs in-vitro testing to determine how an enzyme or probiotic will function under physiological conditions. Depending on the enzyme or probiotic strain this will include a variety of testing methods. For example Deerland s enzyme product ProHydrolase was tested using gel electrophoresis to determine how quickly and efficiently the product could break down whey protein for better absorption of amino acids. The same method was used with Glutalytic to determine that product s effect on gluten digestion. If in-vitro testing is successful the next step is human clinicals which in Deerland s case are submitted to and approved by an Institutional Review Board (IRB) prior to commencing enrollment. The company has human clinical studies on ProHydrolase DE111 Glutalytic and PreforPro. When the study is complete and the data has been analyzed the study abstracts are submitted to applicable peer-reviewed journals for publication Deaton explained. Published studies allow the public to access the clinical results and efficacy of a product. Cran-Max a whole cranberry concentrate from Pharmachem Laboratories has always shown strong clinical results expressed Mitch Skop senior director of new product development. Published human clinical studies show supplementing with Cran-Max supports urinary tract health. A newer test method for cranberry ingredients has revealed hidden proanthocyanidins (PAC) in Cran-Max a proprietary cranberry concentrate. These PACs were previously undetectable by the standard industry testing method as they were bound to the fiber of the patented Bio-Shield delivery system according to Proprietary Nutritionals Inc. (PNI) supplier of the ingredient. We applied new analytic methods to discov- er PACs bound to fiber and other cell wall components of cranberry Skop said. These insoluble PACs which are bioactive in the body were previously undetectable by the DMAC test. It is an important finding for whole cranberry products and should give manufacturers more confidence in using them. Fruit d Or explained Lukawski begins testing its Cran Naturelle ingredient with DNA barcoding to prove that the starting material is indeed cranberry. Processes such as drying milling etc. may cause a breakdown of DNA structure making it more difficult to detect DNA in the finished product. The company also uses MALDI-TOF mass spectrometry to authenticate A-type PAC. Collectively these sophisticated analytics will support efficacy standardization and authentication from the beginning to the end of the process he said. Liz n-Nordstr m stated he believes that any ingredient must go through a series of studies to prove its efficacy using a similar approach as that performed by the pharmaceutical industry known as the bench to bedside approach. Using Monteloeder s MetabolAid for example he described the ingredient is first tested and compared with similar products using in-vitro (human and or mouse cell lines for example immortalized human adipose cells to study a fat-reducing ingredient) and in-vivo models (i.e. a genetically obese mouse model). The studies include biochemical parameters changes in gene expression metabolomics etc. Once its efficacy has been proven in the lab the ingredient is extrapolated to the clinic performing at least two pilot studies with volunteers. In this case the analysis performed is generally non- or minimally invasive (blood sampling questionnaires anthropometric parameters etc.) When formulating and considering ingredients research how testing shows identity and its active constituents then obtain and critically review the animal and human studies. Work with the supplier to ensure you can easily translate this information to the consumer in order to build brand trust and loyalty. NIE FORMOREINFORMATION Deerland Enzymes & Probiotics (800) 697-8179 Fruit D Or (888) 472-2275 Monteloeder USA monteloederusa.com Pharmachem Laboratories (800) 526-0609 Nutrition Industry Executive 39 BuildingBetterBrands By Darrin C. Duber-Smith ver the past 50 years marketers of natural and organic products up and down the supply chain have enjoyed a distinct luxury that most marketers only dream of--a constantly expanding market consisting of consumers who are willing to pay a premium for specialty products that they consider to be superior to mainstream alternatives. And it is certainly true that natural and organic ingredients do tend to be more expensive than their more standardized synthetic counterparts. It is also true that a relative lack of volume has historically kept prices higher than they would otherwise be if these products were consumed at a higher rate. Indeed there have been pressures that have forced marketers to maintain high price points. But to be fair it is also true that ingredient suppliers finished goods manu- O facturers distributors and retailers alike have long enjoyed some rather comfortable profit margins relative to their mainstream counterparts. This sort of pricing power tends to disappear as an industry matures but the natural products sector has been in high growth for as long as most of us can remember and still seems to have more gas in the industry tank. Of course the overall lack of agreement as to what natural really means and possible regulation in the future as the FDA (U.S. Food and Drug Administration) currently reviews its options (not to mention any new scrutiny of DSHEA [Dietary and Supplement Health and Education Act of 1994]) looms as threats in this historically lucrative marketplace. Yet overall things still look pretty rosy for natural products marketers--unless of course like me you too are concerned about what new entrants such as Amazon might do to the industry s long-established pricing model and consequently to some of the industry s recognized players. Premium Prices For years most marketers in the industry have successfully employed a premium pricing strategy and have positioned their brands (and all of the products within the brands) as premium offerings replete with higher quality ingredients more sustainable packaging and more socially responsible business practices. These things cost money after all and as long as the products deliver on the promises marketers make about them things tend to work out rather well. And as long as the market continues to grow rapidly an industry can theoretically maintain a large number of fairly homogeneous competitors www.niemagazine.com October 2017 40 Nutrition Industry Executive who all charge elevated prices. But at this time it might not be a slowing market or high ingredient costs or too much competition that pose the greatest threat to the natural products industry s status quo. Rather an even more pressing threat looms from expanding channels of distribution characterized by larger players who enjoy vast economies of both scale and scope and who are often the captains of their respective channels. Amazon and Wal-Mart come to mind as two retailers able to offer obscenely low prices due in large part to this leadership. The big natural and organic brands that these huge retailers carry also enjoy large economies of scale and scope even if they don t have the most influence within their channels and some are beginning to explore distribution options that fall well outside of the traditional manufacturer-to-grocery channel retail model. Great care must be made to avoid channel conflict which is often created when manufacturers undercut retail partners on price by offering products at lower prices in other channels and it is clear that the distribution options for all branded products continue to increase. have a very succinct model to help us become more adept at pricing our products. And in an industry that has seen Whole Foods Markets rapidly and unceremoniously be acquired by Amazon it should be clear that the path to success is becoming increasingly perilous. The key is to justify your price point by considering a number of different but related factors. A New Paradigm While much of this is certainly excellent news for consumers it is not good news for marketers who are unable to compete effectively on price in this new era for nutritional supplements and other natural products. And in the 25 years that I have been working with companies in this sector I have noticed that pricing strategy is an often under-developed piece of the marketing mix. This is fine as long as the party keeps going but the rise of natural discounters such as Sprouts the ongoing mainstream retailers (Wal-Mart Kroeger et al.) as well as the growing importance of ecommerce players such as the online behemoth Amazon in selling natural products should make every marketer in the industry pause and assess pricing strategy. One of the best ways to do this is to look at pricing first with respect to your brand strategy. Brand identity and image have quite a bit to do with how much money consumers will exchange for any good or service and it is no different for marketers of nutritional supplements functional foods or other natural-based products. But there are other important factors in play and luckily we October 2017 www.niemagazine.com The Five Cs of Pricing The fact that they all begin with the letter C makes them easier to remember as a framework for pricing strategy but although easy to remember the Five Cs are nonetheless challenging to apply. The point of the model isn t to choose one or more of the Cs but rather to first consider all five simultaneously. Indeed one of the Cs might eventually be favored over the others as a strategic focus but all should be considered nonetheless. Whether I am consulting or teaching business students I like to use a white board with cost on the far left channel and company in the middle and competition and consumer at the far right of the board. This way it is easy to see how each element contributes to the final manufacturer s suggested retail price point (we all know that retailers can ultimately charge whatever they want). The Five Cs of Pricing are Cost (COGS G A SM) Channel (Dist. retailers) Company (Profit margin) Competition (Current prices) Consumer (What will they pay ) Cost This category includes all of the elements involved in making a single unit (cost of goods sold) as well as per unit contributions from general and administrative expenses (non-unit producing activities like overhead) and sales and marketing. One must first estimate the quantity to be produced so that the proper per unit contributions for each of the three areas can be established. Together these three elements comprise the per unit cost of whatever it is the marketer is trying to sell. Cost is a good place to start in pricing because this is one of a marketer s major constraints but the nature of ingredients and packaging as well as the quantity produced are all variables a marketer might be able to manipulate in order to achieve a desired COGS number. Channel In the majority of cases the manufacturer doesn t sell directly to the consumer and so the distributor and retailer each take a major cut of the total retail price for their services. Sometimes this commission can run upwards of 60 percent of the total retail price which is why so many branded product marketers are looking for ways to bypass the intermediaries and sell directly to the consumer with lower prices and vastly higher profit margins. Of course this also has the potential to create channel conflict and can result in the intermediaries dumping your product in favor of more cooperative brands. This is becoming a very thin line to walk as the channels of distribution for supplements and other natural products continue to expand and the lines between natural and mainstream become increasingly blurred. The bottom line with this particular C is that the marketer has just about zero control over what it has to pay its downstream supply chain partners for their services. For those who prefer an indirect channel to the consumer this is just a cost of doing business and luckily the increased volume that these intermediaries offer can help make up for the shortfall that smaller profit margins create. In other words if you sell more stuff your margins don t have to be terribly high. Wal-Mart provides an instructive example. Company Profits are what makes the world of commerce go round and company objectives always revolve around turning a profit so that earnings can be reinvested in the company or returned to shareholders. As such any contribution model must consider a per unit Nutrition Industry Executive 41 BuildingBetterBrands profit margin which is really just the difference between cost and channel considerations and the final retail price point. Unless a marketer is employing ROI pricing which favors company over all of the other Cs profit might be simply what s leftover. Competition Unless you are creating an entirely new product category which is exceedingly rare in marketing there are probably already a number of competitors that offer the same category of product and meet the same set of consumer needs. This means that a competitive analysis must be conducted to determine how to price the product in relation to competing products in similar stores. Pricing a product at slightly above or slightly below the competition is a strategy often used in a hypercompetitive environment when competition must be favored over all of the other Cs. Consumer Obviously focus groups surveys and simple observation can tell us much about which segments of consumers are likely to pay what prices for what goods and so no pricing strategy should be initiated until it is somehow validated by marketing research. Marketers don t necessarily need to conduct their own studies in most cases because unless you are creating an entirely new category there is probably already a ton of secondary data out there. You just need to find it. But if you do have the time to do some primary research you might learn some interesting things about your brand in addition to pricing considerations. The often-employed premium pricing strategy mentioned earlier in this article has largely resulted from research (both formal and anecdotal) that shows that most people will pay somewhat more for a natural product. Indeed marketers do have a great deal of control over the suggested retail price. tudes behaviors on an ongoing basis is a must. The Cs should harbor no surprises. Finally always have an eye on lowering prices and increasing volumes. These days this industry has precious little room for high-end players that offer questionable added value while commanding high price points. Marketers of branded products will have to take pricing somewhat more seriously in this new paradigm. In the words of baseball hall of famer and philosopher Yogi Berra The future ain t what it used to be NIE Darrin C. DuberSmith MS MBA is a senior lecturer at the Metropolitan State University of Denver s College of Business (since 2003) and has more than 30 years of specialized expertise in the marketing and management profession including decades of work with natural organic and green sustainable goods and services. He has published more than 90 marketing-related articles and book chapters in various publications and has presented at more than 50 executive-level events. A frequent media contributor as well as recipient of The Wall Street Journal s (WSJ) InEducation Distinguished Professor Award in 2009 and WSJ s Top 125 Professor Award in 2014 Duber-Smith is author of Cengage Learning s KnowNow Marketing blog at http community.cengage.com gecresource2 info b marketing. He can be reached at ddubersm msudenver.edu. Pathway to Progress In short the lazy days of pricing in the natural products industry are probably on the wane. Just as marketers had to step up their collective game in the 1990s to make products more palatable to a market that was rapidly expanding beyond the traditional hippie base marketers must now face a new reality with regard to pricing. And this shift promises to be far more painful than the last one. Many brands will not survive the coming consolidation when the market finally does begin to slow. Here is some advice. Use your brand strategy as a starting point for pricing. Price follows Product and use the Five Cs of Pricing as a guide for determining your suggested retail price point considering all Five Cs in your decision but perhaps with a focus on one over the others for purposes of product and brand positioning. Isolating each C and looking at it as part of the whole pricing picture can help you better justify the final price point you decide upon. Do aim for consistency across related SKUs in your product mix. Products within product lines for example should be priced consistently. It is also important to understand which elements of pricing you can control and which ones you cannot. For example most marketers have more control over costs and the suggested retail price point than they do channel. Assessing supplier costs projected product velocity channel relationships options competitive pressures and consumer atti- (Continued from page 27) b. Assessing the real cost-benefit analysis associated with dietary supplementation and reduction of disease 42 Nutrition Industry Executive states. c. Assuring adequate and timely enforcement of DSHEA by the FDA Office of Dietary Supplements and the FDA legal staff. d. Improving fair and free trade through enforcing WTO (World Trade Organization) standards of transparency of regulations. In essence USTR (U.S. Trade Representative) needs to force open markets that are happy to sell U.S. industry their raw materials but which make sales of finished products to their markets unduly burdensome. e. Adoption of a list of pre-DSHEA grandfathered nutrients. f. Improving seizure enforcement and prosecution of criminals falsely hiding behind our industry with knowingly adulterated goods. NIE Extra Extra Visit www.niemagazine.com to read the continuation of the article. www.niemagazine.com October 2017 IngredientTechnology Innovating Ingredients Palatability utilizing byproducts and clean labels are among the considerations when suppliers work on their latest most innovative ingredient offerings. By Janet Poveromo ften the best sources in the search for novel natural functional ingredients are the ones that are the most innovative. Interesting results come from combinations of new processing methods blends addressing trends etc. and suppliers are working on their ability to respond to consumer demands. O Dry Lipids Denis Neville CEO of CoreFX Ingredients based in Chicago IL said CoreFX Ingredients has invested significant resources in its specialty dry lipid technologies. Our focus has been the creation of dry stable oils which satisfy consumers need for vegan GMO (genetically modified organism)-free ketogenic and paleo he said. In some instances we can satisfy all of these requirements in one solution. We combine unique spray drying techniques with optimized emulsifying agents to deliver dry stable ingredients. Once dried our emulsion stabilizing techniques ensure complete encapsulation of the oils to maximize shelf life. With this stability also comes free flowing powders which can be used in many applications for natural product markets i.e. nutritional beverages bars tableting and gummy bears. At Kerry Satya Jonnalagadda director of nutrition - ProDiem with Kerry (based in Ireland) said the growth of both plant protein and healthy fats have inspired two new product launches this year. Intended for use in bars beverage and baked goods ProDiem is a blend of pea rice and oat protein optimized for nutrition. ProDiem is formulated using a proprietary process to improve texture and utilizes our flavor masking technology to reduce the off-notes traditionally associated with plant protein Jonnalagadda said. The company also offers dry lipids. NutriVie is a range of nutritional lipids intended for use in powdered beverage applications. NutriVie has been specially formulated to offer a guaranteed and specific fatty acid profile. Additionally we leveraged our technical expertise to reduce if not remove unwanted ingredients to provide a cleaner label product while maintaining stability over shelf life she added. Although plant protein continues to grow manufacturers now face challenges in taste texture and nutrition Jonnalagadda noted. ProDiem however meets the demand for plant protein while delivering on taste nutrition and functionality. ProDiem has been developed to address both taste and nutrition and offers a smoother texture more neutral taste and a high protein quality. Whey protein and other animal based sources are considered the gold standard with a PDCAAS--protein digestibility corrected amino acid score--of 1.0. The NutriVie range plays into the fat is back trend Jonnalagadda said offering products that deliver on nutrition and overcome technical challenges associated with nutritional lipids. NutriVie provides a precise fatty acid profile for more targeted health Nutrition Industry Executive 43 Pulse Ingredients At Ingredion headquartered in Westchester IL Patrick Luchsinger marketing manager Nutrition and Pet Food noted the company and Canadabased AGT Foods were recently honored at IFT this year with an innovation award for its Clean Taste Pulse ingredients. Co-developed by Ingredion and AGT Foods a physical process reduces the beany grassy and other undesirable flavors in pulse flours and pulse proteins without affecting protein content and quality overall nutritional quality and functionality. This flavor improvement enables food manufacturers to use the ingredients at increased levels in current applications such as pasta snacks bakery and crisps and in new applications such as alternative dairy beverage confectionery and savory products he said. The new clean taste technology innovation is useful for the natural products industry because it allows proteins from vegetable sources to be included in applications where they were limited in use before because of affecting the taste of the end product. This opens up new applications and higher protein and fiber content by pulses he noted. The challenge of getting as much protein included in the application without affecting the taste of the endproduct and using the lowest amount possible is one of the reasons why Ingredion focused on the clean taste technology with pulses Luchsinger explained. Manufacturers are looking for ways to add value to their products in ways that make sense without incurring exorbitant costs. So it is a technical challenge to fortify an application with a high protein content using less and less of an amount and one that we decided to address he added. October 2017 www.niemagazine.com In addition to satisfying accreditations we are also very conscious of delivering functional dry oils that work well in many applications and taste good. In additional to specialty oils we also are dairy experts and use our dairy heritage to create authentic dry grass fed butter and creams which can be organic and GMO-free. These all-natural ingredients are true to their dairy origins. We are creating dry stable oils with minimal encapsulation materials and with gentle drying techniques to ensure oil stability Neville continued. The oils we are stabilizing are sensitive to oxidation so we are careful in how we treat the oils to ensure maximum stability on drying. These oils include MCT CLA borage evening primrose and fish. IngredientTechnology benefits a cleaner label to meet consumer demand yet still performs well technically over shelf life despite these enhancements. In addition Kerry is addressing the low sugar trend. Teresa Polli senior manager marketing communications said Kerry s TasteSense Sweet offering is the company s platform for delivering nutritionally optimized products while still providing consumer inspired signature tastes and adding back the overall taste experience that is lost when sugar is removed. Our range of taste solutions optimizes the taste experience and addresses reduced calorie product challenges that occur when sugar is removed from formulations including flavor rebalancing sweetness optimization mouthfeel improvement and masking challenges she said. Our solutions have been successfully sensory validated to rebalance taste in products that have up to 30 percent less added sugar. It delivers a consumer friendly natural flavor labeling opportunity and is available in multiple delivery formats to support a variety of formulation requirements. When we address added sugar reduction adding the taste experience back is quite complex as several things happen--sweetness is reduced sourness increases bitter or off tastes increase mouthfeel and or viscosity decreases Polli added. Alternative sweeteners may build back sweet but other attributes must be adjusted for including balancing the temporal profile onset middle finish adjusting the sourness and re-balancing of the acidity masking the bitterness and off-taste from components in the food beverage matrix and finally masking of bitterness as well as the off-taste from the alternative sweetener itself. King noted that chewable vitamins and gummies are a bursting category. Our sweetening systems can deliver 100 percent clean-label sugar reduction. Additionally our sweetening systems are the leading plug-in replacement for sugar in many functional beverages both powdered and RTDs as well as mealreplacement bars. Problems tackled include covering offnotes from high-intensity sweeteners-- the company s key competency according to King. We are on the leading edge of sweetness modulation as well as clean-label sugar reduction. Our R&D labs are here to help our clients with reformulation saving them hours and hours of bench work and thousands in fees. (chewy) texture for at least 12 months or more in ambient storage conditions. Furthermore the ingredient is all natural and derived from cows milk helping to keep the recipe simple and ensure consumer demand for clean and clear labels is met. Deterioration in the texture of protein bars over time is a big problem for snack bar suppliers--and retailers too Povlsen continued. Reducing the shelf life of a protein bar can increase levels of waste. Just as bad if shoppers buy and consume protein bars that have become unpleasantly hard consumer loyalty and repeat purchase rates could be adversely affected. It s no secret that protein can sometimes present formulation challenges and that s why we invest significantly in the development of protein solutions that address common problems with texture and taste. This opens the door to new product development opportunities that will tap into the growing popularity of high protein products. Bill Smith global director sweet-beverage R&D and innovation at Sensient Flavors based in Hoffman Estates IL said Protein Solutions--part of the company s Taste Modulation portfolio--provides customized solutions to mask the off-notes and the poor textures that protein delivers. Whether the protein is grainy beany sour bitter or astringent our team can create a tailored solution that allows customer product s signature tastes to come through in the best possible way. He noted that protein can also undergo taste changes over time and from processing techniques. Our technologies can help mitigate off notes that develop from age as well from some of the more extreme processing techniques. Collaboration with our in-house sensory experts enable us to validate the enhanced stability initially and over time with American Society of Testing and Materials International standards (Sub Committee E18) and ISO TC34 SC12 certified testing. With a focus on natural ingredients Sensient s proprietary extraction techniques offer product quality with opportunities for provenance declaration and more true-to-taste authentic profiles that consumers seek in natural products Smith noted. Our proprietary maskers are designed to offer customers consumer-friendly labeling as our solutions can be natural non-GMO kosher allergen-free or can be customized to other www.niemagazine.com October 2017 Due to textural deterioration during shelf life--a common issue with high-protein snack bars--it s likely that many of the bars had lost their soft and chewy texture by the time they were eaten. -- Inge Lisa Povlsen Arla Foods Ingredients More News on Protein Citrus Sweetener Also focusing primarily on clean-label sugar reduction and natural high-intensity sweeteners is Icon Foods (formerly Steviva Ingredients) based in Oregon. Not yet formerly announced Thom King president and CEO described the company s most recent endeavor. Our latest innovation in sweeteners is a sweetness modulation system called CitruSweet. It utilizes an extract of citrus peel that when synthesized produces a compound that is 2 000 times sweeter than sugar. When added to a natural carrier CitruSweet can completely remove off notes that stevia or monk fruit may impart. 44 Nutrition Industry Executive Inge Lisa Povlsen senior category manager for bakery and beverages at New Jersey-based Arla Foods Ingredients pointed out that nearly half of all U.S. consumers--45 percent--purchased a high protein snack bar in the past month according to research by Packaged Facts. However she said due to textural deterioration during shelf life--a common issue with highprotein snack bars--it s likely that many of the bars had lost their soft and chewy texture by the time they were eaten. Our formulation experts have developed a solution to this problem. Nutrilac PB8420 is a whey protein that ensures protein bars retain an indulgent cohesive specific labeling needs. Smith pointed out that with the increasing interest in clean labels in the industry it is important to help consumers source options that best fulfill their business needs. Sensient helps in designing specific systems to address needs and the matrix within which they are being used. We offer guidance and insights through the help of sensory and analytical expertise relative to shelf-life of products which is a key driver for taste concerns that customers have. Probiotics Connie Sindelar probiotics application development group leader with DuPont in Madison WI said We are seeing companies want to include many new functional ingredients into nutraceuticals foods and beverages. They also want to combine multiple functional ingredients into one format. At DuPont we are very focused on ensuring these ingredients work well together to give the product good texture color and of course taste. Dupont has a sensory lab where it tests its customers formulas to ensure they will be well accepted by the consumer. We have had a lot of interest lately from supplement food and beverage companies on using probiotics in their products Sindelar added. We have a strong technology team that supports our customers with specific application support and new technologies we re using. When adding probiotics to food for best success it is helpful to have microbiologists and food scientists working together to understand what may be impacting probiotic survival and how to best sustain it. In terms of technology processes we are using genomics and molecular tools to develop new identification and enumeration procedures to advance the industry. What s great about probiotics Sindelar said is they are a natural product and can often get Non-GMO Project Verified and organic label status. At DuPont we work with our customers to help them understand the probiotics portion of these requirements so they can sell into the natural products industry. Using genomic tools and microbiology experience we can get a better understanding of what the probiotic cell needs to survive and we can put them in an environment they like. This way we can offer probiotics that are natural kosher halal and contain no added allergens. October 2017 www.niemagazine.com There are two main probiotics challenges Dupont sees and works on every day--stability and efficacy Sindelar added. From a stability perspective we are seeing companies wanting to use probiotics in many different types of supplement food and beverage formats which can be challenging from a stability perspective. We have many ongoing technical development projects to ensure we can help customers meet shelf life in any of the new formats they re looking for. Demonstrating probiotic efficacy is also a challenge because of the time and expense. But we feel it is very important and have invested a substantial amount of money in clinical trials to prove the health benefits of our probiotics and we will continue to do this. The mechanism of probiotic action is still being elucidated and we are investing research and development dollars on that as well. The Next Developments When it comes to new developments suppliers put their faith in their scientific expertise. Sindelar said she s seeing packaging innovation to help prolong probiotic stability. In addition to what s available on the market we re also working with our material experts internally to see where their new developments could also benefit the probiotics industry. DuPont has experts from a wide range of scientific expertise who are all working together to make our customers successful. Innovation is collaborative effort Jonnalagadda added. We continue to develop innovative ingredients and complete solutions for our customers led by consumer insights emerging key trends with taste and nutrition as our focus. As we move forward on our clean label journey we continue to leverage our technical R&D and nutritional expertise to optimize solutions that address the balance between consumer demand functionality and science taste and nutrition. Additionally as a company we are committed to a sustainable future in food by meeting the needs of the present without compromising the ability of future generations to meet their own needs. Not to be overlooked Luchsinger stressed the importance of thinking green. To keep on trend with consumers with sustainability and environmentally friendly ingredients manufacturers are looking at technology from waste streams and side streams of manufacturing processes--whether it is leftover whey from strained Greek yogurt or spent grains from beer food ingredient companies are investigating on finding innovative new ways to give byproducts and byproducts high in nutrition new life in food applications. NIE FORMOREINFORMATION Arla Foods Ingredients (908) 604-8551 Core FX Ingredients (773) 271-2663 DuPont (800) 255-6837 Icon Foods (310) 455-9876 Ingredion (800) 713-0208 Kerry (North America) (608) 363-1200 Sensient Flavors (800) 445-0073 Nutrition Industry Executive 45 Equipment&Packaging Heat Shrink Tunnel Features Auto-lift to Protect Conveyors Bottles From Overheating The Pharmafill HT6B Heat Tunnel by New Jersey-based packaging machinery manufacturer Deitz Co. features an optional Emergency Auto-Lift (EAL) that automatically raises the heat tunnel high above the conveyor in the event of a power failure and or when the operator stops the conveyor by E-stop button. Quickly stopping the conveyor while pneumatically raising the heat tunnel the Emergency Auto-Lift system allows the heat to dissipate safely to prevent damage to the stopped conveyor to the packaged products in process and to their tamper-evident bands. Line downtime for conveyor repair or replacement and associated costs are eliminated along with potential safety hazards and risk of product loss. The heat tunnel with the Emergency Auto-Lift system accepts bottles cans jars vials tins and other glass metal and plastic containers up to 10 inches high. Heating the tamper-evident neck bands with two 3 000-watt tubular heating elements the heat tunnel quickly generates the high heat needed to shrink the plastic bands onto the bottles and retains the heat inside for continuous energy-efficient operation at speeds up to 100 bottles per minute. The Pharmafill heat shrink tunnel with Emergency Auto-Lift rolls up to any conveyor and comes mounted on an adjustable-height lift stand that raises and lowers the tunnel height to match the containers being processed. The heat tunnel machine is manufactured from stainless steel and anodized aluminum for sanitary operation and does not come into contact with the bottles or other containers. For more information visit www.deitzco.com. Primera Introduces LX500 Color Label Printer LX500 is Minnesota-based Primera s newest and most affordable desktop color label and tag printer according to the company. Its high-yield tri-color ink cartridge keeps cost per label low. Fast print speeds and an optional built-in guillotine-style cutter allow users to quickly and easily print and cut their short-run labels. In addition LX500 has a lower MSRP price than the printer it replaced which was called LX400 and is up to 270 percent faster on labels printed with comparable print quality. LX500 s MSRP price is 1 295 while the LX400 was priced 200 higher at 1 495. The LX500c (with cutter) is priced at 1 395 (MSRP) in the U.S. and Canada. Typical applications include product labels for coffee wine bakery confectionary meat cheese and hundreds of other specialty and gourmet foods. LX500 also accepts tag stock that can be cut with the optional built-in cutter making it ideal for producing visitor convention and meeting badges. LX500 can also be used for private labeling test marketing pre-press proofing and retail shelf labeling. Printer drivers are included for Windows 7 8 10 along with Bartender Ultralite Software (for Windows) to format label designs add barcodes QR codes etc. Most other popular graphic design programs for Windows can be used to design and print labels. A Mac driver is currently under development and will be available soon. Qualified substrates include many different inkjet label materials including Primera s exclusive Tuffcoat Extreme white and clear polyester and white BOPP. Paper labels are also available in high-gloss and matte finishes. For more information visit www.primeralabel.com. 46 Nutrition Industry Executive www.niemagazine.com October 2017 Advertiser Index American Laboratories Inc. Balchem Albion Deerland Enzymes GCI Nutrients Healthco Jiaherb Inc. Natreon Inc. Nutragenesis Olcott Plastics PLT Health Solutions Sabinsa Corporation Soma Labs Inc. United States Pharmaceopea 30 23 33 7 1 5 31 C3 9 3 C2 32 C4 (402) 240-3332 (801) 773-4631 (800) 233-4483 (650) 697-4700 (800) 477-3949 (888) 542-4372 (732) 296-1080 (802) 257-5345 (630) 584-0555 (973) 984-0900 (732) 7 7 7 - 1 1 1 1 (732) 271-3444 (301) 230-6361 www.niemagazine.com americanlaboratories www.niemagazine.com balchem www.niemagazine.com deerland www.niemagazine.com gcinutrients www.niemagazine.com healthco www.niemagazine.com jiaherb www.niemagazine.com natreon www.niemagazine.com nutragenesis www.niemagazine.com olcott www.niemagazine.com plt www.niemagazine.com sabinsa www.niemagazine.com somalabs www.niemagazine.com usp Industry Events November 6-7 Global Functional Food and Dietary Supplement Summit 2017 Fleming s Deluxe Hotel Frankfurt-City Frankfurt Germany www.hfsseu.com November 28-30 Food Ingredients Europe Messe Frankfurt Frankfurt Germany www.figlobal.com fieurope November 30-December 3 SOHO Expo Gaylord Palms Hotel and Convention Center Kissimmee FL www.southeastnpa.org October 2017 www.niemagazine.com Nutrition Industry Executive 47 SupplieroftheMonth Lonza Consumer Health & Nutrition Beth Tormey Consumer Health 5451 Industrial Way Benicia CA 94510 Phone (800) 783-4636 Lonza Consumer Health & Nutrition combines expertise in high-quality science-backed ingredients with formulation know-how and indus& Nutrition try-leading capsule and encapsulation technologies to create innovative solutions for consumer health and nutrition companies. The comLonza pany s deep clinical knowledge supports specialty ingredients with proven performance enabling customers to address consumer health concerns via new differentiated health products. Lonza Consumer Health & Nutrition applies consumer market insights and its extensive experience in pharmaceutical delivery science to help its customers improve bioavailability targeted delivery swallowability taste and odor masking of their nutritionals. The company s technology enables unique combination products and provides visually appealing dosage forms that meet the expectations of today s health-conscious consumers. Lonza also brings exceptional service capabilities global regulatory expertise and expert technical service to support its customers in quickly delivering differentiated nutritional products to market. A veteran in the specialty ingredients consumer health and personal care industries Beth Tormey now heads Lonza s Consumer Health & Nutrition business after seven years as global head of sales. NIE Lonza recently acquired Capsugel and Micro-Macinazione. What was the company s motivation behind these acquisitions Tormey The acquisitions are in line with Lonza s stated strategy to accelerate growth and deliver value along the health care continuum by complementing our existing offerings and by opening up new market opportunities in the pharma and consumer health care and nutrition industries. With the acquisition of Capsugel Lonza adds a trusted brand with a large breadth of technologies that it believes will expand the market reach of both companies contract development and manufacturing organization (CDMO) and products businesses. It also supports Lonza s strategic ambition of getting closer to the patient and end consumer. Additionally Micro-Macinazione is one of Europe s leading contract manufacturers providing micronization of active ingredients for the pharmaceutical and fine chemical industries. This acquisition positions Lonza as the global leader in the field of micronization services by building on Lonza Capsugel s existing micronization clinical and commercial manufacturing capabilities that are based in Quakertown PA. cell application center expands Lonza s support for our researchers. This new online suite provides scientists with educational materials and product information to assist with vital endothelial cell research. As endothelial cells regulate many homeostatic processes within the body their dysfunction has important implications for diseases such as diabetes cardiovascular disease and cancer. Increasing our understanding of endothelial cells could help researchers to develop more effective drugs to treat these diseases. NIE In July Lonza launched Ibex Solutions. Can you explain the concept and what it offers customers Tormey Ibex Solutions provides a clear demonstration of Lonza s commitment to constant innovation and adding value to its customers and partners. Ibex Solutions is an innovative new biological development and manufacturing concept coupling flexibility in facility build-out with fully tailored business models and leveraging Lonza s expertise and service network in Visp (CH). Construction began in June 2017 with a formal groundbreaking ceremony expected in the second half of the year. Several hundred new positions are expected to be created. NIE The company also expanded its support for researchers with an endothelial cell application center. What is the purpose of it Tormey The newly launched endothelial 48 Nutrition Industry Executive NIE Is there anything else you would like to add Tormey I recently relocated from Lonza s Basel Switzerland headquarters to Benicia CA to lead a newly repositioned global consumer health and nutrition business that has undergone a noteworthy transformation thanks in part to two significant investments. In September 2016 the company purchased InterHealth Nutraceuticals and most recently it successfully completed its acquisition of Capsugel in July 2017. The strategic acquisitions of Capsugel and InterHealth Nutraceuticals in combination with Lonza s nutrition ingredient portfolio create a business with significant global reach supported by regional sales and marketing teams. Located in Benicia the CH&N business is situated in Northern California s Bay Area a global hub for pharmaceutical biotech and health innovation. Consequently as the CH&N business continues to grow it will have immediate access to the region s top talent and technology. Chief among the priorities for Lonza s CH&N business is to support the continued global market share growth of its UC-II Undenatured Type II Collagen ingredient for joint health. Specifically the UC-II ingredient has seen multiyear double-digit growth despite a slowdown in growth within the global joint health market. The company has also immediately begun exploring new methods to enhance synergies between its ingredients and its new capsule and encapsulation expertise obtained through the Capsugel acquisition. These initiatives combined with Lonza s ongoing focus to advance its ingredients through research and development are expected to drive the business in line with Lonza s corporate strategy. www.niemagazine.com October 2017 Go to www.niemagazine.com nutragenesis for info about this advertiser Go to www.niemagazine.com usp for info about this advertiser