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Description: In This Issue: Healthy and Amazing Aging, Drinks and Bars, Vision Health, and Using Video Effectively.

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NI Ne A VRM Media Publication V w isi W tO Em eb u ag si r az te in e. co m May 2015 Go to sabinsa for info about this advertiser Go to healthco for info about this advertiser TableofContents Proud Supporter of VOLUME 20 NO. 4 MAY2015 F E A T U R E S 28 Healthy and Amazing Aging Wellness science and technology are merging and becoming a mainstream way to deliver dramatic improvements for healthy aging and longevity. 34 Beyond What Meets the Eye New ingredients and today s trends help expand the variety of options to support eye health. 37 Science of Ingredients A L S O I N S I D E 8 16 22 23 24 26 54 54 54 56 Industry News Ingredient News Association News AHPA Update Science Update Conventions & Meetings Equipment & Packaging Advertiser Index Industry Events Supplier of the Month Nutrition Industry Executive s Science of Ingredients section is designed to help manufacturers gain a better understanding of the ingredients and services available that can make their products stand out. C O L U M N S 4 6 First Word Condition Specific 47 Production Line 50 Marketing Innovation 52 Functional Foods FREE Subscription (Print Digital or BOTH) & E-newsletter Available Copyright 2015. Nutrition Industry Executive (ISSN 2331-2602) Volume 20 Number 4 May 2015. Nutrition Industry Executive is published monthly (except for bimonthly January February and July August and November December) by Vitamin Retailer Magazine Inc. 431 Cranbury Road Suite C East Brunswick NJ 08816 USA Phone (732) 432-9600 Fax (732) 432-9288. All rights reserved including the right to reproduce in whole or in part. Not responsible for unsolicited material. Opinions expressed in by-lined articles or advertisements are not necessarily those of Nutrition Industry Executive or its owners. Publisher is not liable for advertiser product claims or representations. Advertisers assume total responsibility for the contents of their advertisements. Printed in U.S.A. Basic annual subscription rate is 50.00. Application to Mail at Periodicals Postage Prices is Pending at East Brunswick NJ 08816 and additional mailing offices. POSTMASTER Send address changes to Nutrition Industry Executive P.O. Box 15026 North Hollywood CA 91615-5026. Subscription Customer Service Nutrition Industry Executive P.O. Box 15026 North Hollywood CA 91615-5026 USA Phone (818) 286-3170 Fax (800) 869-0040 niecs Back Issues & Single Copies For order information contact (732) 432-9600 or info March issue is 25.00. All other issues are 8.00 each. 2 Nutrition Industry Executive Celebrating 20 Years of Excellence 1995-2015 May 2015 Go to plt for info about this advertiser FirstWord Transparency Great and Small ince the investigation of herbal products led by New York Attorney General Eric Schneiderman the supplement industry has been placing more emphasis on transparency. In fact the industry trade organization Organic & Natural Health Association (Organic & Natural) met with the New York attorney general s office on April 15 in what they said was an effort to bridge communication gaps between the millions of consumers who want quality dietary supplement and herbal products and the companies that make them. Organic & Natural was recently formed by industry leaders and experts who were frustrated with the lack of true transparency between business and consumer groups when it comes to quality organic and natural products according to the organization. Todd Harrison Organic & Natural s president and a partner in Washington with the law firm Venable LLP added that Ensuring supply chain integrity must start at the earliest possible point which means manufacturers of raw ingredients need a strong working relationship with farmers and that appropriate cGMPs (current good manufacturing practices) be instituted at the point where raw materials are manufactured. It would make sense to apply the FDA s (U.S. Food and Drug Administration) cGMPs (code 21 CFR Part 111) to raw material manufacturers. While the issue of integrity and transparency is certainly of great importance I wonder if adding another cGMP layer to raw material suppliers would be appropriate since GMPs have been set up for the makers of the finished product to assure quality. Would that extra step be cost prohibitive for small farmers small companies and everyone else involved Would it guarantee the trustworthiness of the supplier Legally the supplier is obligated to provide safe products that are what they say they are already. And isn t the Food Safety and Modernization Act forecasted to address this issue further I discussed how small businesses could provide transparency with Beth Lambert CEO of New Jersey-based Herbalist and S Alchemist (H&A) a company with just under 20 employees. From the start H&A was set up to ensure botanical purity she said. The company addresses transparency by using botany to identify ingredients she said. Long ago we developed a relationship with Rutgers University to do third party identity testing for ingredients in a powdered form and for anything else we have questions on. We have added a commercial lab that has a good reputation for doing knowledgeable work. Recently H&A increased product prices 4 to 5 percent to cover the cost of testing and regulatory requirements including full microbial testing on all finished products. We have long done heavy metal testing and we ve added that level. Part of the price increase is to cover that issue Lambert said. Lambert added that company is listing more information about company procedures on their website. As far as our price increase we sent a letter out to all of our customers and got wonderful responses back from people who want to support quality. The feedback included a sympathetic response It must be difficult to deal with these issues wrote one customer. H&A still has the best tinctures on the market as far as I m concerned. Even the price increase elicited a positive response. I will happily pay a little extra for your products. I can be assured of what I am getting. There s no price too high for that another customer wrote. Lambert said she believes small companies can still enter the supplement industry and provide transparency but she warned there s a lot of work. As for suppliers Lambert said H&A encourages small farmers to expand their businesses into the herbal market. And she also questioned the benefit of additional regulatory layers. We want safe consumables and good guidelines but you don t want to overburden people at the same time. You put regulation on when there s a necessity. What is the real balance Publisher Daniel McSweeney Editorial Director DanM Associate Russ Fields Publisher RussF Advertising Roy Kieffer Sales Manager RoyK Advertising Gary Pfaff Sales Associate GaryP Editor-in-Chief Janet Poveromo JanetP Managing Editor Shari Barbanel ShariB Assistant Editor Cristina Goodwin CristinaG Contributing Writers Todd Pauli Lisa Schofield Art Director Robert Certo Production Manager RobertC Production Assistant Bryan Zak Graphic Designer BryanZ Circulation Manager Rosie Brodsky Rosie A PUBLICATION OF VRM MEDIA President Daniel McSweeney VRM Media 431 Cranbury Road Ste. C East Brunswick NJ 08816 Phone (732) 432-9600 Fax (732) 432-9288 Email info Website VRM Media publishes Nutrition Industry Executive Vitamin Retailer Gluten Free Retailer Natural Practitioner and FitnessTrainer magazines. Subscription Customer Service To order a subscription or manage your account please contact us at Nutrition Industry Executive P.O. Box 15026 North Hollywood CA 91615-5026 USA Phone (818) 286-3170 Fax (800) 869-0040 niecs Back Issues See the Table of Contents page for price and order information. Connect With Us vitaminretailer vitaminretailermagazine company vrm-media vitaminretailermagazine vrm_media 4 Nutrition Industry Executive Celebrating 20 Years of Excellence 1995-2015 May 2015 Go to jiaherb for info about this advertiser ConditionSpecific Pain O ne of the most common types of daily pain is joint pain mostly due to arthritis which affects more than 52 million (one in five) in the United States. In fact arthritis is also the nation s most common cause of disability as it leads to joint inflammation pain and stiffness that can limit one s ability to take part in regular daily activities said Catherine David product manager Neptune Technologies & Bioressources Inc. in Laval QC Canada. The most common treatment for joint pain associated with arthritis is non-steroidal anti-inflammatory drugs (NSAIDs) David noted. However these have many side-effects associated with long-term use. Those who suffer from arthritis and or joint pain and who need daily relief can benefit from a natural alternative that is fast-acting effective and does not cause side-effects with prolonged use. Consumers are looking for natural and effective solutions for the relief of their daily pain and ingredients that do more than just mask or cover symptoms of pain but rather address the underlying problems that are causing the pain David added. Although glucosamine and chondroitin formulations currently dominate the joint health category sales are on a gradual decline given mixed results from more recent clinical trials and the emergence of effective alternatives. A good alternative is Neptune Krill Oil (NKO) which has anti-inflammatory properties--a daily dose of 300 mg of NKO significantly inhibits inflammation and reduces arthritic symptoms within a 6 Nutrition Industry Executive Addressing From joint pain to migraines suppliers are finding fast effective relief for what hurts. B Y J ANET P OVEROMO short treatment period of seven to 14 days. In fact a clinical study showed that after seven days of treatment NKO reduced both pain and stiffness. Another choice is BioCell Collagen. There is no doubt that we are well positioned to capture a significant portion of this market with our best-in-class BioCell Collagen ingredient said Suhail Ishaq president of Californiabased BioCell Technology LLC. Each year approximately 128 billion is spent on products for joint comfortrelated issues by U.S. consumers according to the Arthritis Foundation. Although joint supplements are used by older people more there is a recent trend of their usages by the young population to keep healthy and mobile Ishaq pointed out. 20 different types of collagen have been identified we know that the type of collagen and the molecular weight play a role in the bioavailability and mechanism of action said Ishaq. Type 1 collagen and type 2 collagen are the most common types of collagen found in supplements he explained. Type 1 collagen is derived from hides bones and skin of animals whereas type 2 collagen is only found in cartilage where it naturally coexists with hyaluronic acid and chondroitin sulfate in a blood-free environment. Of these types collagen is either unhydrolyzed (also known as undenatured) or hydrolyzed. In its original unhydrolyzed state collagen molecules are very large and therefore not effectively absorbed by the intestines. Hydrolyzation breaks down the collagen into small molecular weight fragments to enhance absorption without affecting its beneficial components. Trends and Mechanisms of Action Glucosamine and chondroitin supplements by far have the largest market share given their long history of use and mass market penetration. However newer and more advanced ingredients are leading the next generation of supplements in the category. The big question on the mind of health care practitioners today is what is next in joint health said Ishaq. BioCell Collagen offers significant advantages with its advanced patented composition which mirrors human articular cartilage and provides bioavailable collagen type II chondroitin sulfate and hyaluronic acid for the comprehensive maintenance of healthy joint function. Biocell Collagen is fully backed up by published scientific research. As over Celebrating 20 Years of Excellence 1995-2015 Safety Efficacy Sustainability BioCell Collagen contains a patented composition of hydrolyzed collagen type 2 chondroitin sulfate and hyaluronic acid in a highly absorbable matrix form that has been the subject of numerous human clinical trials including safety efficacy and bioavailability. This natural matrix of three constituents is key to the effectiveness of the ingredient. This composition and synergy is unique to BioCell Collagen and cannot be found in any other collagen ingredients or blends according to the company. (Continued on page 27) May 2015 Go to biova for info about this advertiser IndustryNews AHPA Testimony Outlines Adequacy of Homeopathic Drug Regulation he Food and Drug Administration s (FDA) current regulation of homeopathic drugs provides sufficient substantial oversight of these products according to testimony presented by the American Herbal Product Association (AHPA) at a public hearing held by FDA on April 20-21. The hearing Homeopathic Product Regulation Evaluating FDA s Regulatory Framework After a QuarterCentury was held to gather input on appropriate regulatory policy for homeopathic medicines. AHPA s testimony presented by Will Woodlee partner at Kleinfeld Kaplan and Becker LLP highlighted several points that demonstrate the adequacy of FDA s current regulatory framework for homeopathic medicines in protecting public health and ensuring consumer access to safe products. T Woodlee stressed that under the existing framework companies are required to register their facilities and to list their drug products with FDA which along with other investigative and surveillance tools provides the agency with the means to identify manufacturers marketers and products as candidates for education administrative action or enforcement action as necessary or appropriate. The current regulatory framework also provides FDA with sufficient information on adverse events associated with over-the-counter (OTC) homeopathic drug products to allow the agency to protect the public health according to AHPA s testimony. Manufacturers are required to maintain records of all adverse events reported to them and must maintain records and reports regarding complaints. When required firms must investigate those complaints and upon request make their files available during FDA inspections. Woodlee also noted that FDA s existing regulatory framework for homeopathic drug products appropriately reflects the small safety risk inherent to these highly diluted products. In addition AHPA is not aware of any data indicating that consumers perceive appropriately marketed OTC homeopathic drug products as substitutes for prescription drugs and AHPA believes FDA currently has adequate enforcement authority to address any OTC homeopathic drug products that are inappropriately marketed for non-OTC indications or without adequate directions for use. For more information visit or GNC Reaches Agreement with NYAG n March 30 GNC (Pittsburgh PA) announced that it reached an agreement with the New York Attorney General (NYAG) that affirmed the company s Herbal Plus products were in full compliance with the federal Food and Drug Administration (FDA) current good manufacturing practice (cGMP) requirements and acknowledges GNC s full cooperation with the AG s inquiries. In its response to the NYAG s inquiry GNC provided the results of rigorous tests conducted both internally and by independent third parties. These tests provided conclusive evidence that GNC s products are safe pure properly labeled and in full compliance with all regulatory requirements. The testing also demonstrated that the company s products contain all herbal extracts listed on their respective labels. In addition a former senior FDA cGMP expert performed a comprehensive review of GNC s manufacturing processes for the products at issue and found them to be in compliance with all applicable requirements. Accordingly GNC has restored its full assortment of Herbal Plus products to all GNC stores in O New York State. GNC also announced that it will expand its testing processes deeper into its supply chain by leading ongoing industry efforts to integrate source material traceability standards including DNA barcoding where appropriate (prior to extraction processes) and enhance certain other aspects of its operations to provide consumers even greater confidence in its products. GNC said that it believes these measures which would not have impacted availability of the products subject to this review will result in the adoption of stricter minimum standards across the broader industry. As our testing demonstrated and this agreement affirms beyond any doubt our products are not only safe and pure but are in full compliance with all regulatory requirements said Michael G. Archbold CEO GNC. A robust testing regimen careful sourcing regimen and Celebrating 20 Years of Excellence 1995-2015 detailed manufacturing specifications have always been core elements to ensuring that we provide our customers with high quality products. Our customers trust and value our products and we are steadfastly committed to maintaining that trust and confidence. As an industry leader we have always gone above and beyond the minimum requirements in pursuing quality for our consumers and we will continue to lead the efforts for higher standards. This is good for consumers good for the industry and good for GNC. GNC has preserved the specific product lots of the five products that were the subject of the NYAG inquiry for use in defending the Company against the lawsuits that have been filed subsequent to the NYAG s February 2 letter despite the fact that there is no prohibition against the sale of such products. GNC believes these lawsuits are completely without merit and will defend itself aggressively. Identical products to those that have been preserved remain available for sale to consumers at GNC stores in New York State. For more information visit May 2015 8 Nutrition Industry Executive Prominent Indian Minister of State Visits Sabinsa Sami Labs abinsa Corporation s (East Windsor NJ) sister company Sami Labs Limited (Bangalore India) was honored with a visit by Honorable Minister Shripad Yasso Naik a prominent member of Parliament. Minister Naik was appointed last November by India s Prime Minister Narendra Modi as Minister for Ayush established to promote yoga and ayurveda India s traditional health and wellness modalities. Sabinsa Sami Founder Dr. Muhammed Majeed while briefing the Honorable Minister on the history of Sabinsa Sami group s innovative ingredients and formulations offered by the company in both nutraceuticals and cosmeceutical segment expressed his concern for the ayurvedic medicinal S plants which are in danger of extinction from overharvesting in various parts of the country as popularity of Indian herbs has grown worldwide. Majeed emphasized that the only way to control further loss of medicinal plant species and ensure survival Honorable Minister Shripad Yasso Naik (left) greeted by Dr. Muhammed Majeed of these essential compoThe Honorable Minister expressed nents of India s centuries old practices his appreciation for the achievements of healing would be to encourage both of Sabinsa Sami group and applauds sustainable harvesting of plants from the efforts by Majeed in actively utilizthe wild and cultivation especially by small farmers and communities. Sabinsa ing the age-old tradition of the country to further human health. has had a robust cultivation program For more information visit for many years which serves as a model of sustainability. USPTO Confirms Validity of Certain Neptune Patent Claims N eptune Technologies & Bioressources Inc. (Laval QC Canada) received confirmation on the validity of certain claims on its 351 Patent (U.S. Patent No. 8 278 351). The positive decision by the Patent Trial and Appeal Board (PTAB) of the U.S. Patent and Trademark Office (USPTO) triggers the payment of ongoing royalties to Neptune by Aker Biomarine and Enzymotec. As part of settlement and license agreements established in December 2013 and April 2014 with Aker and Enzymotec respectively royalty levels in the U.S. depended on the outcome of the USPTO s reexamination of certain claims in Neptune s 351 patent. This is yet another example of the strength of Neptune s patent estate. In light of the PTAB s decision Aker and Enzymotec will be obligated to make royalty payments to Neptune based on their sales of licensed krill oil products in the U.S. said Jim Hamilton president and CEO of Neptune. The decision clearly supports the validity and enforceability of our 351 composition of matter patent. Now that the positive decision has been rendered we can collectively turn our attention to building the industry and growing the krill oil market. Hamilton added Neptune remains resolute in building and defending its intellectual property (IP). We pioneered the omega-3 phospholipid krill oil market and we continue to receive patents May 2015 worldwide with an emphasis on North and South America Asia and Australia and we remain committed to protecting this valuable asset. For more information visit Go to herballyyours for info about this advertiser Celebrating 20 Years of Excellence 1995-2015 Nutrition Industry Executive 9 IndustryNews DuPont Nutrition & Health Launches New Positioning uPont Nutrition & Health (Copenhagen Denmark) has launched a new platform to reinforce the strength of the company s offering to customers and the food industry. Titled It s What s Inside the positioning cites all of the key attributes that make DuPont a global leader in specialty food ingredients and food protection with a foundation in the strength of its people-- nutrition and food scientists consumer and market insight experts global marketers and sustainability leaders in addition to its broad product portfolio. We are more than 7 000 people in over 40 countries all working to help our customers make what we eat and drink safer more nutritious and more affordable said Ruth Farrell global D business communications leader DuPont Nutrition & Health. This new positioning allows us to promote our full offering--it is not just the physical ingredients that make the difference it is a combination of all the intangible ones working together. Every day there are 150 000 more people in the world. Our objective is to help our customers provide the foods beverages and supplements that consumers are seeking to give them the nutrition taste and energy they need. The primary goal of the new positioning is to increase awareness of DuPont Nutrition & Health as a leader in the food ingredients industry so key stakeholders readily understand its role in the food space and how its collective capabilities deliver unmatched value for customers. The positioning will be used to promote DuPont Nutrition & Health across all communications platforms including advertising public relations collateral materials at trade shows and in traditional and online media. For more information visit IFANCA Names DSM Company of the Year T he Islamic Food and Nutrition Council of America (IFANCA) has selected DSM (Parsippany NJ) as the Company of the Year. The award recognizes DSM s outstanding halal compliance implementation and program of label control for halal logo and markings. Stephan Heck DSM s senior director quality management accepted the award at a banquet dinner on behalf of the company at IFANCA s 17th International Halal Food Conference in Illinois. The number of halal consumers is increasing and has now reached 1.6 billion making halal food beverage and dietary supplement products one of the fastest growing consumer segments in the world. DSM has liaised with halal certification Go to uckele Celebrating 20 Years of Excellence 1995-2015 bodies to develop and implement a halal policy and management system to ensure its nutritional ingredients meet the stringent halal requirements. We are honored to be receiving this prestigious award which reflects our commitment to supporting the growing requirements of the international food industry with global halal programs and ingredients that are suitable for halal products said Heck. We are dedicated to delivering products that meet the halal requirements. Our goal is to be the preferred provider of nutritional solutions to halal consumers worldwide. We are delighted to recognize DSM as the Company of the Year stated Muhammad Munir Chaudry president of IFANCA. Its dedication to global halal programs and supporting the increasing number of halal consumers with high quality nutritional ingredient solutions is outstanding. For more information visit or May 2015 10 Nutrition Industry Executive Go to kyowa for info about this advertiser IndustryNews Bayir Inc. Receives NSF GMP Certification ayir Inc. (Wilmington DE) the newly launched North American division of Bayir Group of India has announced that its key facility in Bangalore India just received NSF GMP (good manufacturing practice) certification (certification number C0217775-01). Bayir s sophisticated manufacturing plant is multi-functional and is also ISO 22000 2005 certified as well as certified by ANVISA Brazil Hamburg Germany and Drug Controller of India. All the company s facilities are audited and approved by several key international clients and organizations. This plant manufactures glucosamine and Bayir is currently the world s No. 1 manufacturer of glucosamine for the B regulated market. Its material is pharmaceutical grade and is considered to be the highest quality glucosamine that is available in the market today. Bayir s glucosamine is supported by multiple DMFs (drug master files) in Europe North America (Mexico) South America and the Middle East. Bayir s facility underwent a recent expansion in capacity leading to production optimization benefits. It has increased capacity from 600 tons to 900 tons annually. According to Sendhil Pani head of international marketing this was possible due to a strategic investment from Rabo Bank in the parent company. Anchoring and fueling all of Bayir s manufacturing and processing capabilities is a true world-class R&D team said Pani. From finished dosage forms to ingredients in the nutraceutical arena our R&D has focused on and achieved breakthrough research that ensures tangible value for longevity in business and relevance in the everchanging global market for nutritional and botanical health supplements and related products. For more information call (302) 268-6363 or visit Tea Expert and Entrepreneur Steven Smith Passes Away at 65 S teven Smith who co-founded household tea brands including Tazo Stash and Steven Smith Teamaker died March 23 in Portland OR from complications due to liver cancer. A philanthropist as well as a tea visionary Smith worked tirelessly to create new and different tea blends for his company while giving back to the communities in India where many of the ingredients were sourced. Smith created some of Tazo s most recognizable blends including the Awake breakfast tea and Zen green tea he and his partners eventually sold the company to Starbucks in 1998 for a reported 9.1 million dollars. Today the company is worth more than 1 billion. Smith continued in the highend tea business opening Steven Go to nutritional Celebrating 20 Years of Excellence 1995-2015 Smith Teamaker with his same philosophy of quality and compassion. Steve was truly one of the most remarkable passionate compassionate and genuine people I ve ever met in the herb community said Mark Blumenthal founder and executive director of the American Botanical Council (ABC). He was a good friend and great supporter of ABC s nonprofit educational mission. All of us in the herb community have lost a true friend and brilliant champion for tea and many other herbs. Smith is survived by his wife Kim daughter Carrie and son Jack. The family suggests contributions in Smith s memory be made to Mercy Corps School Education Retention Program in which Smith was personally involved to aid the people and communities that grew his tea. For more information and to donate on the Mercy Corps School Education Retention Program visit May 2015 12 Nutrition Industry Executive Go to saybrook for info about this advertiser IndustryNews Schultz Named President of Stauber California You reHired BI Nutraceuticals (Long Beach CA) has announced that Michael Wagner has joined the company as a food science engineer. In this role Wagner will assist in providing solutions for complex functional food formulation challenges faced by BI s customer base and will help support the company s continued expansion in the food and beverage industry. Joel Melilo joins Horphag Research USA (Hoboken NJ) as vice president of sales and marketing. His responsibilities include managing and cultivating the sales performance of the region contributing to optimizing the branded ingredient marketing efficiency in multiple channels and collaborating closely with key customers. Wixon (St. Francis WI) has named Jean Hansen as logistics manager. Hansen will be responsible for oversight of the logistics staff that handles inbound receipts and outbound shipping from the company s headquarters and off-site distribution center. She will manage all transportation functions devise strategic plans and develop process improvements that maximize efficiency and customer satisfaction. Amin Talati & Upadhye (Chicago IL) has announced that Joseph E. Cwik has joined the firm as a new member and will focus on areas of business and intellectual property litigation. Deerland Enzymes (Kennesaw GA) has announced the hiring of several new positions in the company. Gina Labellarte has been named the company s research and development manager and Carol Maeder has been hired to the position of human resources manager. The company has also announced the addition of two inside sales representatives Nick Walton and Sarah Garcia. Garcia will focus on internationSeth al accounts while Walton will serve Flowerman mainly domestic customers. PLT Health Solutions Inc. (Morristown NJ) appointed Seth Flowerman executive vice president and Devin Stagg vice president strategy and business development for the company. In his new role Flowerman Devin Stagg will run PLT s corporate leadership team oversee corporate strategic initiatives and manage strategic alliances while Stagg will be responsible for developing and implementing corporate strategy across a broad range of initiatives. Unigen Inc. (Seattle WA) announced that Regan Miles has been selected to lead the company as president and CEO. Miles most recently served as president of Next Pharmaceuticals Inc. where he led the firm in launching multiple new products and growing sales exponentially. Matthew Lemp has been hired as chemistry laboratory group leader at Q Laboratories Inc. (Cincinnati OH). Lemp will be responsible for sample flow through in the chemistry lab and will also have a role in analyst training and scheduling new client development and expanding lab capabilities. May 2015 S tauber (Fullerton CA) has announced that Jim Schultz has been named president of Stauber California effective April 13 2015. Jim will be based out of Stauber s Fullerton California headquarters said Dan Stauber CEO. Initially he will have the primary responsibilities of leading our companywide sales efforts as well as helping to direct our sourcing and materials departments. Schultz has been in the distribution business for more than 30 years holding various management and executive positions with Univar Brenntag and most recently as founder CEO of Green Wave International (formerly DNP). Schultz has been responsible for executive oversight on supply chain operations corporate growth strategies and development of product branding. He has strong insight and history with China (having travelled extensively in China while establishing and managing operational companies within mainland China). I have known of Stauber since I first started in the industry many years ago. Stauber has an impeccable reputation and a tradition of unquestionable integrity and core values Schultz said. I am honored to be part of their team. For more information call (888) 441-4233 or visit Go to somalabs 14 Nutrition Industry Executive Celebrating 20 Years of Excellence 1995-2015 Go to natreon for info about this advertiser IngredientNews AIDP Announces Magtein GRAS Designation A IDP (City of Industry CA) has announced that Magtein magnesium L-threonate a patented compound for cognitive health and Alzheimers disease has received a letter of no objection from the Food and Drug Administration (FDA) confirming its GRAS (generally recognized as safe) designation. This milestone means that using Magtein in selected food categories at a level of up to 0.12 percent. Magtein was extensively studied in cell culture in animal studies for its mechanisms of action its effects on brain function as well as its safety published in neurological journals including Neuron and supported by top neurological scientists in the world including Nobel Prize winners. One reason Magtein restores the neural cells to their healthy youthful conditions are by blocking background signal activation while many other brain ingredients drugs continue stimulating cells. Recently a human clinical study using Magtein was performed and preliminary results indicate a significant improvement in memory and cognition. Receiving a GRAS designation from the FDA is a huge step for Magtein said Kathy Lund vice president of mar- keting and business development at AIDP. It allows us to move beyond our current market in dietary supplements into the massive food and drink manufacturing industry. Consumers will now potentially be able to get a wide variety of foods from baked goods to beverages to processed juices and soups containing Magtein and reap the many health benefits of this form of magnesium. For more information call (866) 262-6699 or visit Glanbia Announces Strategic Agreement With Brassica Protection Products alifornia-based Glanbia Nutritionals has made a strategic agreement with Brassica Protection Products LLC (Balimore MD) for the distribution of its patented ingredient truebroc glucoraphanin a high quality and powerful antioxidant derived from broccoli seeds. Truebroc contains 13 percent glucoraphanin which is the highest concentration of glucoraphanin currently available on the market and is extracted from seeds grown in the U.S. using a proprietary patent protected water extraction method which is self-affirmed generally recognized as safe (GRAS) and is kosher and halal. Once consumed truebroc is converted to sulforaphane which remains activated up to three days unlike common ingested antioxidants that last only a few hours. The addition of truebroc glucoraphanin to the Glanbia Nutritionals portfolio of premier ingredients provides customers with a premium long-lasting antioxidant further expanding on the innovative ingredient choices Glanbia offers for inclusion in foods and supplements said Ram Nimmagudda PhD director of business development for Glanbia Nutritionals. For more information visit or Beyond Meat Uses NutriFusion s GrandFusion utriFusion (Hilton Head SC) a provider of natural nutrition and phytonutrient products for food manufacturers formed an agreement with Californiabased Beyond Meat a leading developer of plant-based products that replicate the texture and taste of meat. Beyond Meat is incorporating NutriFusion s whole organic non-GMO (genetically modified organism) concentrated nutrient-rich food ingredient GrandFusion vegetable blend into its Beast Burgers and Beastly Sliders. Both are 100 percent plant-based and incorporate all the protein and iron of beef packed with antioxidants ALA omegas calcium vitamins B-6 and B-12 and potassium. In addition the Beast line is 100 percent gluten- and soyfree and is made without GMO ingredients. NutriFusion chose it for its ability to help Beyond Meat achieve its nutritional goals with ingredients coming only from natural sources. We are building The Future of Protein and the Beast Burger and Beastly Sliders are significant steps in that direction said Ethan Brown co-founder and CEO of Beyond Meat. NutriFusion made it possible to meet our nutritional goals without using synthetic ingredients which is a benefit that consumers value. For more information visit or C N Superba Krill Oil Now Non-GMO Project Verified W ashington-based Aker BioMarine Antarctic US has announced that its flagship ingredient Superba Krill oil is now Non-GMO Project Verified. This certification adds another layer of transparency to the company s supply chain and shows that all components used to make Superba Krill oil contains no genetically modified 16 Nutrition Industry Executive organisms (GMOs). Superba Krill has already been certified by the Marine Stewardship Council (MSC) as being sustainable and 100 percent traceable. It took us more than a year to secure this certification but it was well worth it. With full traceability now on several levels we can assure industry that our ingredients are carefully and constantly monitored said Becky Celebrating 20 Years of Excellence 1995-2015 Wright the company s marketing director. Our customers--and their customers--have a right to know what is in their products--and what is not. For more information call (206) 855-6736 or visit May 2015 Go to jgpizzey for info about this advertiser IngredientNews OmniActive Presents Two CurcuWIN Posters ijaya Juturu PhD FACN manager of global scientific and clinical affairs with OmniActive Health Technologies (Morristown NJ) presented two posters on emerging science surrounding highly soluble curcumin (CurcuWIN) during this year s Experimental Biology (EB) meeting which ran from March 28 through April 1 at the Boston Convention and Exhibit Center Boston MA. The curcumin posters were based on in vitro and in vivo model studies conducted by OmniActive in collaboration with researchers from Firat University in Turkey. OmniActive is engaged in studies like these as we continue to contribute to the growing science of innovative forms of curcuminoids such as CurcuWIN noted Jayant Deshpande PhD CTO OmniActive. These studies further broaden the usage of curcuminoids into a variety of novel formulations. V The first study Curcumin (CurcuWIN) Improves Antioxidant Capacity and Reduces Inflammation Following Downhill Running-Induced Muscle Damage investigated the effects of curcumin supplementation on changes in serum parameters and antioxidant status of muscle in rats after exhaustive exercise on a motor-driven rodent treadmill. A significant decrease in LDLcholesterol and triglycerides was also observed in CurcuWIN treated groups. These results suggest CurcuWIN is a potential ingredient for preventing muscle damage as well as improving exercise performance and increase in time of exhaustion. In the other study--antioxidant properties and safety evaluation of curcumin (CurcuWIN)--the antioxidant effects and safety of curcumin supplementation in rats was monitored for a period of six weeks. CurcuWIN s antioxidant effects were shown by significant decrease in muscle oxidative stress markers and the significant improvements in antioxidant enzymes in curcumin treated groups. Demonstrating the safety of CurcuWIN no treatment related changes in liver and kidney functions and no histopathological changes were observed. Study results indicate that CurcuWIN is safe has antioxidant properties and reduces oxidative stress markers. In October 2014 OmniActive won an award at the American College of Nutrition s (ACN) 55th Annual Conference in San Antonio TX for the poster Soluble Curcumin (CurcuWIN) in the Prevention of Diabetic Retinopathy via Modulation of Antioxidant Activity and Genetic Pathways in vivo Model. For more information visit (866) 588-3629 or visit Mariani Packing Partners with Ganeden Biotech alifornia-based Mariani Packing Company has partnered with Ohio-based Ganeden Biotech. This partnership allows Mariani to build upon the company s legacy of innovation through the development of a new portfolio of dried fruit snacks and ingredient products utilizing GanedenBC30 Probiotic Cultures. According to Miranda Ackerman director of innovation and business development for Mariani Packing We are very excited for our upcoming launch of consumer products initially focused on digestive health and overall wellness as well as the portfolio of fruit ingredients in development that we will be able to provide for our global customers. Combining the natural health benefits of dried fruit with a highly stable probiotic culture will allow consumers to add probiotics to their everyday snacking and eating occasions in a more versatile and convenient way. As the market and education on probiotics increases consumer awareness continues to grow--currently about 80 percent of consumers know what probiotics are and associate them with a health benefit. This dried fruit innovation combines prebiotics and probiotics into a truly functional health product that is complemented by antioxidants said Dr. Holly Petty director of technical services and innovation for Mariani Packing. For more information visit or fukiKale May Help Support Healthy Blood Pressure new study gives kale in organic powdered form all the more reason to be hailed the superfood king of leafy greens. The organic kale powder called fujiKale has been shown to be effective in lowering blood pressure blood glucose and cholesterol according to clinical study results presented at the 37th Annual Scientific Meeting of the Japanese Society of Hypertension. As part of releasing the study results Q SAI USA Inc. (Torrance CA) officially introduces fujiKale a USDA (U.S. Department of Agriculture)-certified organic kale in ultra-fine powder that features a patented production process (Japan Patent No. 5214089) to the U.S. market. Titled An exploratory study of the efficacy of Q SAI kale powder (fujiKale) on lifestyle diseases the study used 80 male and female participants aged 30 to 74 who met the study parameters ingested 14 grams of fujiKale per day for eight weeks typically be mixing the powder into water. We have confirmed that Q SAI kale powder (fujiKale) is effective in improving blood pressure blood glucose and lipid metabolism in study subjects said Tomomi Ide who conducted the study and serves as an instructor at the Department of Cardiovascular Medicine at Kyushu University Graduate School of Medical Sciences located in Fukuoka City Japan. Therefore it is considered to be an effective diet therapy for (these) lifestyle diseases. For more information call (866) 226-6481 or visit C A 18 Nutrition Industry Executive Celebrating 20 Years of Excellence 1995-2015 May 2015 Go to nutragenesis for info about this advertiser IngredientNews SourceOne Global Partners Reaches Agreement With Santal Solutions I llinois-based SourceOne Global Partners recently announced it has reached an agreement with Santal Solutions (Appleton WI) wherein SourceOne is awarded exclusive global distribution rights for Santal s new metabolic health and weight management product LeptiPURE a novel patented synergistic combination of GymnePURE and the botanical extract Tinospora cordifolia. Combined in this precise and patented formulation scientific studies demonstrate enhanced effectiveness impacting several important health benefits. Protected by multiple patents GymnePURE has been shown to increase insulin production at a much lower dosage level than standard Gymnema sylvestre extracts because of SourceOne s novel OSAtechnology which captures the most bio-active parts of the Gymnema sylvestre leaf and produces an isolate with a specified molecular weight which mimics a hypoglycemic agent. In addition it has been shown in initial scientific studies to increase adiponectin by 12 percent and decrease leptin levels by 25 percent. Adiponectin and leptin are key hor- mones that when functioning optimally help ensure healthy weight and metabolism. The initial clinical study results are very encouraging because the science is clear--improved ratio of leptin to adiponectin levels up to 37 percent with LeptiPURE is directly related to healthy metabolic flexibility and supporting the body s natural ability to maintain a healthy weight said Dr. Arun K. Chatterji CEO of Santal Solutions. For more information call (800) 755-4886 or visit Nutrition 21 Presents New Study on Nitrosigine utrition 21 LLC (Purchase NY) presented new clinical study results supporting the efficacy of Nitrosigine bonded arginine silicate (ASI) titled Arginine Silicate Supplementation Decreases Markers of Cardiovascular Renal and Metabolic Dysfunction and Increases Markers of Vasodilation and Cardiovascular Health in Healthy Adult Males at the Experimental Biology 2015 annual meeting and the abstract will be published in the Federation of American Societies for Experimental Biology Journal (FASEB). The demonstrated connections between Nitrosigine bonded arginine silicate supplementation and various protein levels contribute to the understanding of the ingredient s mechanism of action. The clinical study examined more than 100 proteins and demonstrated that a single dose of Nitrosigine bonded arginine silicate supplementation resulted in statistically significant changes in more than 70 key proteins measured from baseline to six hours post-dose at the first treatment visit. After 14 days of product use the levels of more than 80 proteins changed significantly from baseline. The proteins significantly affected by Nitrosigine bonded arginine silicate included biomarkers of vasodilation vascular wound-healing and cardiovascular health. The protein Kallistatin a potent vasodilator significantly increased by Nitrosigine bonded arginine silicate. Vasodilation is known to increase blood flow and vessel flexibility key factors in sports nutrition and bodybuilding. Changes in proteins like Kallistatin are indicative of possible pathways by which Nitrosigine bonded arginine silicate may influence muscular function and cardiovascular health further supporting its role as a key ingredient in sports nutrition products. These results enhance our knowledge of the positive effects of Nitrosigine in humans said James Komorowski MS CNS vice president scientific & regulatory affairs for Nutrition 21. Specifically they continue to show sports nutrition benefits associated with increased nitric oxide (NO) levels and provide further support for its impact on increased vessel flexibility and blood flow to working muscles. For more information visit N Sabinsa and Sami Labs Add Four New U.S. Patents N ew Jersey-based Sabinsa Corporation and its sister company Sami Labs Limited (Bangalore India) added to their long track record of innovative intellectual property development with four new U.S. patents bringing the company s patent portfolio total to 95. These most recent patents include U.S. Patent 8383594 was accorded to the invention titled Peptides modified with triterpenoids and small organic molecules synthesis and use in cosmeceuticals. Olepent has been shown by extensive research to be stable and capable of delivering the active principles right into the target areas of the skin with profound beneficial effects on aspect of skin aging. U.S. Patent 8394852 is for the invention titled Inotilone derivatives as coherent biological response modifier (cBMR). The invention discloses a new composition of matter an inotilone analog and also its ability to modulate biological responses. U.S. Patent 8853407 a process patent for the synthesis of 4-aryl 4-acyl piperidine its salts and analogs using indium metal. The invention is for a shorter practical scalable synthetic method for the synthesis of the 4-aryl 1 4-diacyl dihydropyridine group of compounds. The extensive applications of 4-aryl 4-acyl piperidine in the fields of investigation drugs and medicinal chemistry are well known. The earlier known synthetic methods involved lengthy processes use of hazardous chemicals and non-scalability at industrial levels. The Sami-Sabinsa process overcomes all the technical challenges by using favorable starting materials and metallic indium as a catalyst in a safe synthetic process. U.S. Patent 8987212 Sabinsa s triterpenoid peptide product Olepent received its second U.S. patent which claims therapeutic efficacy in effectively reducing skin wrinkling through anti-elastase activity. The signal peptide technology disclosed in this patent demonstrates an effective therapeutic means to counter the ill effects of serine protease enzymes on the human skin. For more information call (732) 777-1111 or visit May 2015 20 Nutrition Industry Executive Celebrating 20 Years of Excellence 1995-2015 Go to igy for info about this advertiser AssociationNews AHPA Board Opposes Federal Preemption and Natural Labeling of GMOs t its meeting in March the American Herbal Products Association (AHPA) Board of Trustees acted to adopt a position to oppose labeling of foods that contain GMO (genetically modified organism) ingredients as natural or with any similar term and to oppose inclusion of a federal preemption provision in any GMO legislation that may be offered in the U.S. Congress whether for mandatory or voluntary labeling. As more legislation is proposed to label GMO-derived foods the herbal and natural products industry must continue to advocate for provisions that benefit consumers and that are also practical in the current legislative environment said AHPA President Michael McGuffin. AHPA adopted a position over a decade ago to support consumers right to be informed on issues that affect their purchasing decisions including the use of GMO ingredients in the foods they purchase and consume. Since 2013 AHPA has advocated for establishment of a federal reg- A ulation for voluntary disclosure of absence of GMO ingredients and is currently examining the Organic Foods Production Act (OFPA) as a model for such a federal standard. The current conflict between advocates and opponents of mandatory GMO labeling has led to a standstill in the U.S. Congress said McGuffin. A federal standard modeled after OFPA--a very successful voluntary labeling law without a federal preemption clause--would meet consumer demand to be able to ensure that the products they actually use are free of GMO ingredients and would not obstruct individual states from establishing their own laws if their citizens also want information on other products. At the federal level Senator Barbara Boxer (D-CA) and Representative Peter DeFazio (D-OR) have reintroduced the Genetically Engineered Food Right-To-Know Act to create a federal mandate to label foods that contain GMO ingredients. Representative Mike Pompeo (R-KS) is expected this week to reintroduce the Safe and Accurate Food Labeling Act which when initially offered last year would have instructed FDA (U.S. Food and Drug Administration) to create a voluntary federal GMO and or non-GMO labeling standard and would have also prevented states from establishing their own labeling requirements. At the state level ballot initiatives in Oregon and Colorado to mandate labeling of products with GMO ingredients barely failed last fall. Similar legislation is reportedly under consideration in numerous states current legislative sessions. Meanwhile a lawsuit filed by the Grocery Manufacturers Association (GMA) to stop Vermont s mandatory GMO labeling initiative has not yet been adjudicated. For more information visit CRN-I Announces New Membership Dues Structure he Council for Responsible Nutrition-International (CRN-I) has announced a new dues structure associated with more member benefits making CRN-I membership more accessible to a broader range of companies. According to CRN-I Chairman Tyler Whitehead vice president and general counsel Nu Skin Enterprises Inc. The dietary supplement industry continues to rapidly expand into new markets with more consumers worldwide seeking to understand the scientifically proven benefits of dietary supplements. As more and more companies participate on a global scale it is vital that our entire industry increases its scientific educational efforts and we believe that CRN-I is poised to lead that charge. Annual membership fees begin at 1 000 (U.S.) for basic membership going to 10 000 (U.S.) for those companies who wish to have a board-level role. By creating a membership level that is very affordable CRN-I is giv- T ing more companies the opportunity to engage in its initiatives and to help increase momentum in the scientific arena said Jim Griffiths PhD vice president scientific and international affairs CRN-I. CRN-I is addressing many dietary supplement and functional food issues worldwide with a renewed energy and determination and I look forward to more companies joining our efforts. With a broader membership our platform will have increased visibility and impact globally. Companies who join CRN-I at the 1 000 level are entitled to the following benefits One complimentary registration for the annual CRN-I Scientific Symposium and additional discounted registrations to the event for others in the company access to a CRN-I quarterly newsletter use of the CRN-I membership logo on company websites and immediate access to CRN-I proceedings or other CRN-I publications. Celebrating 20 Years of Excellence 1995-2015 Companies who join at the 10 000 level receive a seat on the Managing Board. Board members elect the CRN-I officers and help shape the association s strategic direction and priorities and content for the annual scientific symposium. In addition these companies receive three complimentary registrations for the annual scientific symposium as well as the other benefits provided to all members. CRN-I is offering free membership to academicians (employed full-time by an educational institution and who are not working for companies in the industry) and regulators. Members at this level will be given consideration as speakers for CRN-I s scientific symposium and other potential events as well as all the benefits of basic CRN-I membership including complimentary registration to the scientific symposium newsletter and access to publications. For more information visit May 2015 22 Nutrition Industry Executive AHPAUpdate Leading Industry Association Speaks Directly to Nutrition Industry Executive Readers California Proposition 65 is Changing here have been a number of significant developments impacting California s Proposition 65 (the Safe Drinking Water and Toxic Enforcement Act of 1986). From lawsuits to the addition of new chemicals to proposed amendments to the regulations for clear and reasonable warnings Prop 65 is changing. The American Herbal Products Association (AHPA) has been working with California policymakers and interested parties for years in attempts to influence changes to Prop 65 to ensure consumers receive more useful and meaningful information and to make compliance for the herbal products industry as least burdensome as possible. Industry companies can learn more about these changes during AHPA s May 20 webinar Prop 65 What s Going On. T New Chemical Another issue is that a chemical that is a common naturally occurring substance has been added to the list of chemicals that require a Prop 65 warning. On April 18 2014 OEHHA added pulegone to the list of chemicals known to cause cancer. This means that beginning April 18 2015 companies selling products with pulegone in California that are not exempt must include a warning that states WARNING This product contains a chemical known to the State of California to cause cancer. However there are exemptions under Prop 65 and one of those exemptions is for naturally occurring food constituents. OEHHA has already identified pulegone as a natural constituent of various plants including mint and other herbs and of their essential oils. This can be interpreted to mean that foods dietary supplements cosmetics or other consumer products that contain pulegone due to the presence of a mint another herb or spice or an essential oil in which pulegone is known to be a natural constituent does not constitute an exposure for purposes of Prop 65 and therefore no Prop 65 warning should be required. AHPA issued a guidance document on this topic to help the herbal products industry understand this issue and their obligations under Prop 65. Lawsuits A Prop 65 lawsuit brought against Beech-Nut (Amsterdam NY) and other baby food manufacturers for the levels of lead in their products was recently dismissed and an appeal by the plaintiff was also unsuccessful. Late in 2013 the California Superior Court ruled in BeechNut s favor finding that the daily exposure to a Prop 65-listed chemical in a food could be determined by averaging consumption over 14 days. While this ruling may provide some relief for certain companies selling products in California it is unlikely to apply to products that are promoted for daily use. In another lawsuit filed while the Beech-Nut case was on appeal Mateel Environmental Justice Foundation--a prominent Prop 65 plaintiff--sued the California Office of Environmental Health Hazard Assessment (OEHHA) to challenge its current maximum allowable daily level (MADL) of 0.5 micrograms per day for lead exposures. The lawsuit alleges that OEHHA did not follow the statutorily mandated evidence and standards required when it established this MADL and requests the court to order OEHHA to vacate and rescind and not ... implement or enforce the 0.5 ug day regulatory safe harbor level for lead under Proposition 65. AHPA has joined California Chamber of Commerce (CalChamber) in a letter to OEHHA requesting the agency to vigorously defend itself against this lawsuit. The potential ramifications of this lawsuit will be discussed during the May 20 webinar. May 2015 Amending Prop 65 OEHHA is presently working to amend the regulations regarding clear and reasonable warnings for exposures to Prop 65 listed chemicals. AHPA has been actively engaged to influence these changes which are currently being negotiated in a rulemaking process that began last year. To date OEHHA incorporated one of AHPA s recommendations in its proposed rule issued on January 16 2015 that specifically includes dietary supplements in the definition of food. This is quite significant for the supplement industry as it allows dietary supplements to use the naturally-occurring exemption for certain chemicals that would otherwise require a Prop 65 warning. AHPA is also proposing optional warning language for reproductive toxins that will provide more meaningful information to the consumer. Other issues that AHPA is working to address through the rulemaking process will be discussed in-depth during the webinar. Legislation has also been introduced in the California Congress to amend the Celebrating 20 Years of Excellence 1995-2015 knowingly and intentionally provision of Prop 65. The law requires persons to provide a warning before knowingly and intentionally exposing individuals to chemicals known to cause cancer and or reproductive toxicity however in the implementation of Prop 65 even those who unknowingly accidentally or inadvertently expose individuals to Prop 65 chemicals are being penalized for not providing a warning. Thus the practical application of the provision has led to excessive warnings as companies provide warnings to preemptively defend against lawsuits. To address this issue California Assemblyman Bill Quirk (D-CA20) introduced legislation (AB 543) that would establish that a person does not knowingly and intentionally expose an individual to a chemical known to the state to cause cancer or reproductive toxicity if prior to the receipt of a 60-day notice an exposure assessment by a qualified scientist concludes that there is not an exposure at a level that requires a warning. AHPA joined a host of organizations led by the CalChamber to express support for this legislation. The organizations noted that the bill would provide a modest improvement that encourages the use of a scientific exposure assessment ... [and] will create an incentive ... for a business to use science as the predicate for a decision to warn or not ... [and] will provide businesses with greater confidence in the utility of conducting scientific exposure assessments and in doing so will restore meaning to warnings that the law actually requires to advise consumers about chemical exposures exceeding Proposition 65 warning levels. The prospects for this legislation OEHHA s proposal and the impact of recent changes on companies doing business in California will be explored in greater detail during AHPA s May 20 webinar. Michael McGuffin President and Board of Trustees American Herbal Products Association (AHPA) Nutrition Industry Executive 23 ScienceUpdate High Cholesterol Triglycerides Can Keep Vitamin E From Reaching Body Tissues n the continuing debate over how much vitamin E is enough a new study has found that high levels of blood lipids such as cholesterol and triglycerides can keep this essential micronutrient tied up in the blood stream and prevent vitamin E from reaching the tissues that need it. The research just published in the American Journal of Clinical Nutrition also suggested that measuring only blood levels may offer a distorted picture of whether or not a person has adequate amounts of this vitamin and that past methods of estimating tissue levels are flawed. Vitamin E is especially important in some places such as artery walls the brain liver eyes and skin but is essential in just about every tissue in the body. A powerful fat-soluble antioxidant it plays important roles in scavenging free radicals and neurologic function. In the diet it s most commonly obtained from cooking oils and some vegetables. Some experts have suggested that recommended levels of vitamin E should be lowered. But because of these absorption issues the recommended level of 15 milligrams per day is about right said Maret Traber the lead author of this study. I Inadequate vitamin E intake remains a significant societal problem she said. This research raises particular concern about people who are obese or have metabolic syndrome said Traber who is the Helen P. Rumbel Professor for Micronutrient Research in the College of Public Health and Human Sciences at Oregon State University (OSU) and a principal investigator in OSU s Linus Pauling Institute. People with elevated lipids in their blood plasma are facing increased inflammation as a result Traber said. Almost every tissue in their body is under oxidative attack and needs more vitamin E. But the vitamin E needed to protect these tissues is stuck on the freeway in the circulatory system. It s going round and round instead of getting to the tissues where it s needed. This research was done with 41 men and women including both younger and older adults who obtained vitamin E by eating deuterium-labeled collard greens so the nutrient could be tracked as it moved through the body. Of some interest it did not find a significant difference in absorption based solely on age or gender. But there was a marked difference in how long vitamin E stayed in blood serum based on higher level of lipids in the blood--a more common problem as many people age or gain weight. The study also incorporated a different methodology using a stable isotope instead of radioactive tracers than some previous research to arrive at the estimates of vitamin E that made it to body tissues. Using the stable isotope methodology that these researchers believe is more accurate they concluded that only 24 percent of vitamin E is absorbed into the body instead of previous estimates of 81 percent measured by the use of radioactive vitamin E. In simple terms we believe that less than one third the amount of vitamin E is actually making it to the tissues where it s most needed Traber said. Vitamin E in the blood stream is not completely wasted Traber noted. There it can help protect LDL and HDL cholesterol from oxidation which is good. But that doesn t offset the concern that not enough of this micronutrient may be reaching tissues she said. For more information visit Green Tea May Help Improve MRIs reen tea s popularity has grown quickly in recent years. Its fans can drink it enjoy its flavor in their ice cream and slather it on their skin with lotions infused with it. Now the tea could have a new unexpected role--to improve the image quality of MRIs. Scientists report in the journal ACS Applied Materials & Interfaces that they successfully used compounds from green tea to help image cancer tumors in mice. Sanjay Mathur and colleagues noted that recent research has revealed the potential usefulness of nanoparticles-- iron oxide in particular--to make biomedical imaging better. But the nanoparticles have their disadvan- G tages. They tend to cluster together easily and need help getting to their destinations in the body. To address these issues researchers have recently tried attaching natural nutrients to the nanoparticles. Mathur s team wanted to see if compounds from green tea which research suggests has anticancer and anti-inflammatory properties could play this role. Using a simple one-step process the researchers coated iron-oxide nanoparticles with green-tea compounds called catechins and administered them to mice with cancer. MRIs demonstrated that the novel imaging agents gathered in tumor cells and showed a strong contrast from surCelebrating 20 Years of Excellence 1995-2015 rounding non-tumor cells. The researchers conclude that the catechin-coated nanoparticles are promising candidates for use in MRIs and related applications. For more information visit 24 Nutrition Industry Executive May 2015 Go to fuji for info about this advertiser Conventions&Meetings 35th Expo West & Engredea Celebrate Growth N atural Products Expo West the world s largest natural organic and healthy products event celebrated its 35th anniversary in grand style in Anaheim CA in March by setting new attendance records. The annual event which brought together more than 71 000 industry members 2 700 exhibiting companies and 634 first-time exhibitors grew 7.2 percent continuing a year-by-year upward climb. Held at the Anaheim Convention Center Expo West is co-located with Engredea the event to source new ingredients packaging technologies equipment and services for cuttingedge products as well as the Fresh Ideas Organic Marketplace an innovative outdoor event that combines a traditional farmers market feel with the business-building power of a trade show. This year the conference program was extended to four days for the first time. The program offered a full array of education topics as well as keynote presentations from Mark Bittman food journalist at The New York Times and David Perlmutter MD FACN ABIHM board-certified neurologist fellow of the American College of Nutrition who spoke on The Gut of Brain Matters. and Drug Administration (FDA)acknowledged GRAS (generally recognized as safe) source. Sabinsa Corporation unveiled a new form of curcumin Curcumin C3 Reduct which seeks to solve the problem of staining and C3 Complex the most studied curcumin in the world. The Winners Circle The American Botanical Council (ABC) announced that Loren D. Israelsen president of the United Natural Products Alliance (UNPA) was selected as the recipient of its 2014 Mark Blumenthal Herbal Community Builder Award. The award is granted annually to an individual in the herbal medicine community who has played a significant role in creating a sense of community among herbalists researchers members of the herb and natural products communities and related groups who work in the area of medicinal plants. Among his many noteworthy accomplishments since 1991 Israelsen has served as the president of the United Natural Products Alliance (formerly the Utah Natural Products Alliance) a global industry trade association dedicated to supporting companies and consumers. The American Herbal Products Association (AHPA) presented the 2015 AHPA Awards to individuals and companies that have made substantive positive contributions to the herbal products industry. This year s AHPA Award winners are Dick Griffin former owner of Celebrating 20 Years of Excellence 1995-2015 Engredea Too Clean label curcumin plant protein and vitamin K were among the hottest topics of this year s wellattended Engredea as were bone and vision health. OmniActive Health Technologies celebrated the second anniversary of its education campaign--Lutein for Every Age--during the trade show. Attendees were surprised with a sponsorship that included three performances by a flash choral mob ranging from children to seniors singing about the importance of the macular carotenoids lutein RR-zeaxanthin and RS-zeaxanthin. OmniActive also introduced Gingever High Potency Ginger for the first time. Non-GMO (genetically modified organism) and allergen-free Gingever is a high-potency super-critical fluid extract with 30 percent bioactives made from an U.S. Food 26 Nutrition Industry Executive Grifcon Enterprises was awarded the AHPA Herbal Hero Award in recognition of the tremendous benefits that his insurance programs provided to the dietary supplement industry. James Prochnow a shareholder at Greenberg Traurig presented the award highlighting that Griffin is one of the pioneers of developing product liability insurance for the dietary supplement industry. Prochnow also noted that Griffin has been a generous and active supporter of AHPA. Mountain Rose Herbs was presented the AHPA Herbal Industry Leader Award for taking steps above and beyond normal business practices to advance the herbal products industry. Beth Lambert CEO of Herbalist & Alchemist presented the award to Mountain Rose Herbs copresident Shawn Donnille and other employees of the company. Tieraona Low Dog MD was awarded the AHPA Herbal Insight Award in recognition of her efforts to significantly increase and further knowledge and understanding of botanicals and their uses. Low Dog is an internationally recognized expert in the fields of dietary supplements herbal medicine women s health and natural medicine. Hold Those Dates Natural Product Expo East 2015 will return to the Baltimore Convention Center on September 16-19 2015 in Baltimore MD. Natural Products Expo West will return to Anaheim CA on March 9-13 2016. May 2015 Protein Trends & Technologies Seminar O n May 5-6 the 2015 Protein Trends & Technologies Seminar held by Global Food Forums Inc. will take place at the DoubleTreeHilton in Oak Brook IL. The seminar will include a pre-conference event on business strategies for protein vendors as well as the formulating with proteins technical program for R&D and application food scientists. The seminar invites product development teams (R&D food scientists nutrition innovation and regulatory functions) at consumer packaged goods and food service companies technical & application personnel from ingredient suppliers and personnel at analytical services companies consultants and associations that are involved in protein ingredient science. In addition certified food scientists (CFS) may choose to submit credit hours for one or more of the sessions toward re-certification. Attendees can register for either program alone or for both for cost savings. For more information call (800) 799-9671 or visit 2015protein-seminar . Sports & Performance Nutrition 2015 N etherlands-based Bridge2Food will host the 5th Sports & Performance Nutrition 2015 on June 11-12 at the Hotel Casa 400 in Amsterdam The Netherlands. By attending this year s industry event guests will be among more than 200 experts 40 speakers and 30 exhibitors and stay on top of the latest product innovations market developments and trends. For more information call 31 30 225 2060 or visit ConditionSpecific (Continued from page 6) Ginger for Migraines A double-blind randomized controlled clinical trial titled Comparison between the efficacy of ginger and sumatriptan in the ablative treatment of the common migraine published in Phytotherapy Research compared the efficacy of ginger to sumatriptan a standard conventional prescription treatment in the treatment of common migraine. Study subjects were randomly delivered either one ginger capsule of 250 mg upon onset of headache or 50 mg of sumatriptan. Questionnaires were completed for each headache attack recording time of headache onset severity timing of drug taking and response self-assessments at 30 60 90 and 120 minutes and 24 hours. Any adverse effects were also recorded. The overall study duration was one month. One hundred sufferers of common migraine headaches from a hospital in Iran were the study subjects. The average age of participants was 35.1 in the sumatriptan group and 33.9 in the ginger group. Women comprised 68 percent of the sumatriptan group vs. 74 percent of the ginger group. The average duration of a migraine diagnosis was similar in both groups at approximately seven years. The average number of headache attacks in the sumatriptan groups were 5.8 and 4.9 in the ginger treated group. Inclusion criteria for the study included a confirmed diagnosis of migraine without aura by a neurologist 18 May 2015 years and older high school diploma or higher and a frequency of two to 10 headaches month. Both sumatriptan and ginger powder decreased the mean severity of common migraine attacks within two hours of use. No significant difference existed between the two treatments. Before taking the medication 22 percent of the sumatriptan group and 20 percent of the ginger group had severe headaches. The mean headache severity at two hours after sumatriptan or ginger use demonstrated similar effectiveness for both groups. There was 4.7 unit reduction in the headache severity in the sumatriptan group and a 4.6 reduction in the ginger group. Favorable relief was achieved in 70 percent of the sumatriptan treated headache individuals and 64 percent of the ginger treated patients at two hours following intake. Both the sumatriptan and ginger significantly provided pain relief and no significant differences were achieved. There were more side effects from sumatriptan using including dizziness sedation vertigo and heartburn. The only clinical adverse effect of ginger was dyspepsia. As for krill oil it has been found to be more potent gram for gram as its absorption rate is much higher than fish oil. Krill is also a sustainable and environmentally friendly source of omega-3. Not only is krill the largest biomass in the world but krill harvesting is one of the best regulated on the planet using strict international precautionary catch limit regulations that are reviewed regularly to assure sustainability. Ishaq concluded that for managing joint pain joint supplements are in high demand and their market continues to evolve he said. Science-based ingredients are growing in popularity nowadays and consumers are becoming more aware of the science behind the products that they purchase--they want the best when it comes to their health and they demand high quality evidence-based products. NIE Sources chronicdisease resources publications aag arthritis.htm. Deutsch L. Evaluation of the effect of Neptune Krill Oil on chronic inflammation and arthritic symptoms. J Am Coll Nutr 2007 26(1) 39-48. Reference Maghbooli M Golipour F Moghimi Esfandabadi A Yousefi M. Comparison between the efficacy of ginger and sumatriptan in the ablative treatment of the common migraine. Phytother Res. 2014 Mar 28(3) 412-5. Celebrating 20 Years of Excellence 1995-2015 FORMOREINFORMATION BioCell Technology LLC (714) 632-1231 Neptune Technologies & Bioressources Inc. (450) 687-2262 Nutrition Industry Executive 27 s indicated by the tale of Ponce de Leon searching for the fountain of youth to the recent fascination with the secrets from the Blue Zones a demographic and or geographic area of the world where people live measurably longer lives the prospect of long life and vitality has extremely broad appeal. Given population projections the market for natural products that address aging offers tremendous opportunities said John Gehbauer business manager with BASF Nutrition & Health in New Jersey adding that the company prefers to say healthy aging instead of anti-aging since aging is inevitable. The Baby Boomers (those born between 1946 and 1964) started turning 65 in 2011 and the number of older people will increase dramatically during the 2010 2030 period. The older population in 2030 is projected to be twice as large as their counterparts in 2000 growing from 35 million to 72 million and representing nearly 20 percent of the total U.S. population. Gehbauer noted that seniors want products that help maintain their health appearance and mobility while their families and caregivers are also interested in pre28 Nutrition Industry Executive A serving their wellness. Brian Zapp director of marketing with Applied Food Sciences Inc. in Texas pointed out that the market for antiaging products continues at an average compound annual growth rate of 7.8 percent. Although the numbers vary between 122 B Transparency Market Research to 290 B one thing is certain the market is large and continues to grow as Boomers become more present in their quest for looking and feeling younger. (By 2030 approximately 70 million Americans will be aged 65 or older) This in turn has created a market for functional anti-aging ingredients close to 10 B. And it s not just Boomers interested in these products Zapp added. According to the NPD Group Inc. ( wps portal npd us solutions retail-tracking ) anti-aging continues to be a key motivator for purchases among woman skincare users from most age groups. Seventy-five percent of woman tells NPD they use skincare products to look the best they can for their age. Anti-aging and longevity of course not only relate to how we look said Zapp but also how we feel and how our bodies cope with the aging process. Celebrating 20 Years of Excellence 1995-2015 There are many products on the market today that can help our cells trigger youthful gene expression provide DNA protection and enhance cellular function. In addition the constant need for every age and demographic group to have more energy with our fast passed lives is a major factor in how we feel and ultimately how we age. Ingredients for Healthy Aging When it comes to ingredients for healthy aging antioxidants are here to stay noted Zapp and continue to evolve into more functional delivery vehicles for both topical applications in skincare as well as internal applications for cellular health. The added desire for more natural easy-to-understand ingredients is one of the fastest growing segments in both oral and topical applications around the world which is a good thing since by design this is where antioxidants are typically derived from he said. For anti-aging products we have noticed a great jump in the use of botanicals such as green coffee extract and tea extracts which provide some of the highest natural contents of free radical fighting antioxidants but also provide cell stimulation and even skin tone. Addressing the overall lack of energy May 2015 is probably one of the largest and most popular topics associated with aging Zapp continued. A deeper look at energy production and adrenal shows that the serum hormone DHEA is on the constant decline as we age and that by age 70 it may be reduced by as much as 75 percent to 80 percent from peak levels in our lifetimes. This may be why there is a growing population of older consumers who are seeking more caffeine which can act as a short-term solution for that quicker pick-me-up. However the experienced health-conscious consumer is not interested in the sugary market of traditional energy drinks. We have noticed a large increase in the energy category as a whole going more natural and also adopting the clean label look. Dan Lifton president of New Yorkbased Proprietary Branded Ingredient Group Maypro Industries said the common ingredients that are put forward for their anti-aging healthy aging abilities typically include vitamin D vitamin C and vitamin B12. However despite their reputation the science is divided when it comes to these ingredients he said. The Maypro anti-aging ingredient line instead features antioxidants as well as other proprietary ingredients that have been shown in numerous trials to work against the various aspects of aging. Various forms of CoQ10 have gained interest in the field as the substance has been shown to increase energy levels and improve cardiovascular health Lifton explained. Maypro offers MicroActive CoQ10 formulated for maximum bioavailability. The ingredient has a 24-hour sustained release and doubles CoQ10 levels from baseline after three weeks in 100 percent of users. A new ingredient for healthy aging Lifton added is Sirtmax a proprietary black turmeric extract that helps to stimulate enzyme Sirt1 activation to support healthy aging inhibit weight gain reduce visceral fat reduction and maintain blood glucose levels within the normal range. The Maypro patented and branded ingredient line also features an extract of lychee and green tea Oligonol that won the 2007 Best New Product Award at the 3rd International Conference on Polyphenols and Health (ICPH IFIA HFE) the NutrAward for Best New Ingredient in 2008 and the SupplySide West Scientific Excellence Award in 2011. Oligonol has been proven to counteract poor blood circulation oxidative stress and inflammation--the three most problematic symptoms of aging. In addition Maypro s BioPQQ is the only natural New Dietary Ingredient (NDI)-approved PQQ (pyrroloquinoline quinone) on the market and won the May 2015 Studying Aging Vice President of Scientific Affairs Chris Fields with Texas-based Applied Food Sciences Inc. listed several studies and reports of interest on the topic of anti-aging. Scientific research suggests that minimizing damaging free radical reactions by ensuring optimal antioxidant levels may hold the key to extending the healthy human life span. Studies have shown that people who live to be 100 years or older often demonstrate higher blood levels of antioxidants than their much younger counterparts. In addition antioxidants may help protect against mitochondrial dysfunction. One such study of 442 elderly Swiss patients directly correlated higher blood levels of two common antioxidants (beta-carotene and vitamin C) with better memory.1 An Italian study in 2000 led by Dr. Harman demonstrated that that centenarians (people aged 100 or older) had markedly higher blood levels of antioxidants.2 The importance of mitochondrial function in aging and disease was published in the Annals of the New York Academy of Sciences emphasizing how mitochondrial dysfunction caused by free radical-induced oxidative damage is a common marker in both aging and age-related diseases. According to the authors not only it is likely that increased susceptibility of mitochondrial DNA to oxidative damage and limited DNA repair capacity of the proteins involved in mitochondrial repair play a significant role in mutagenesis of aging but mitochondrial dysfunction that accompanies aging may exert a major influence on longevity and overall health.3 In addition preliminary evidence indicates antioxidants exert direct protective effects against mitochondrial damage caused by free radicals. In another article in the Annals of the New York Academy of Sciences the authors reviewed how certain antioxidants such as coenzyme Q10 Nacetylcysteine and lipoic acid may neutralize the excess production of free radicals inside the mitochondria.4 5 A study published in the Archives of Neurology in 2004 researchers examined Alzheimer s risk in people who took antioxidant supplements. The study found that use of vitamins E and C together is associated with reduced prevalence and incidence of Alzheimer s disease.6 New research is being propagated on units of our DNA to help us understand how cell growth and change impact aging. Telomeres are small units of DNA at the end of our chromosomes. As our cells divide telomeres progressively shorten until they become dysfunctional causing Celebrating 20 Years of Excellence 1995-2015 aging and age-related diseases including cancer. But if telomeres can remain intact they protect the genes inside the cell. These structures that cap the ends of chromosomes get shorter with each cell division. And they also get shorter with age. And when they get so short that the telomeres fail to function the cells become senescent. When cells become senescent they change their function so much that they can begin to alter the tissue and cause degenerative changes. Researchers believe that these senescent cells may be responsible for chronic inflammation in the body. How we change the telomeres activity is still unfolding but a radically different approach to controlling the aging process of these cells is emerging called regenerative medicine. Regenerative medicine is a technique to create living functional tissues through the use of stem cells or progenitor cells. The goal of repairing or replacing cellular function that is lost due to damage or the aging process is to restore the structure of the aged tissue to its original healthy young adulthood state. Coffee research continues to unfold around its many substances thought to offer health benefits. Along with all the polyphenols to assist with healthy blood glucose levels and healthy insulin activity we re learning more about the synergistic effects they have with the plant s natural caffeine content in healthy brain function.8 Caffeine has had much historical evidence in its role in enhancing metabolism and mental acuity. Research is teaching us more about its mechanisms and supplemental health effects when used in small amounts or through natural delivery systems such as coffee and tea.9 When caffeine is ingested it is rapidly absorbed and distributed throughout the body including the brain. Research suggests that multiple receptor sites in the brain are activated by caffeine with the adenosine as the main target. By occupying receptors and blocking other neurotransmitters caffeine can trigger events that affect dopamine another neurotransmitter that stimulates arousal pleasure and thinking. Outside of the cerebrum caffeine can help boost muscle activity balancing physiological and psychological effects of physical exertion. However we must be mindful of the negative effects demonstrated by some compounds in coffee such as the diterpenes that have been shown to harden the arteries increase levels of homocysteine insulin and possibly cholesterol. Filtering coffee to remove some of the oils becomes important to those at risk.10 Nutrition Industry Executive 29 Engredea Editors Choice Award for Ingredient with the Best Science in 2013. The substance is the first new vitamin discovered since 1948 playing a key role in increasing cell life and energy production Lifton said. The New Jersey-based Seppic Inc. supplies Ceramosides and SOD (superoxide dismutase) B that are two innovative and scientifically studied ingredients that aid in healthy aging. Ceramosides is one of the latest and trendiest ingredients in the beauty-from-inside-out segment and SOD B a powerful antioxidant according to the company. Skin youth and hydration depends on key lipids called ceramides explained Sebastien Merchet Seppic s nutrition business development manager. When aging we start losing ceramides resulting in dry and itchy skin pulling sensations and wrinkles. Phytoceramides are ceramides that come from plants they are highly concentrated in Ceramosides along with digalactosyl diglycerides (DGDG). Ceramosides brings new ceramides to the skin via the bloodstream and help restore the water barrier and replenish cracks. DGDG has been scientifically studied to have a key impact on ceramides absorption (thanks to its amphiphilic properties) the patented complex of the two lipids phytoceramides and DGDG found in Ceramosides provides a quicker and stronger effect on skin health at a low dose Merchet explained. SOD is one of the body s primary antioxidant that acts at the source of the oxidative stress reaction and slows down the aging process. Our three primary antioxidants are SOD catalase and glutathione peroxidase Merchet said. He explained that as we age we produce less primary antioxidants reducing our defense against oxidative stress. SOD B is a patented complex with a high content of SOD coming from a French melon specie. SOD B has been microencapsulated for protection from gastric acids and to be progressively released into the intestinal tract. SOD B acts possibly via an induction of Nrf2 a transcription factor known to induce primary antioxidant enzymes synthesis in the body and induces the endogenous expression of SOD (superoxide dismutase) CAT (catalase) and Gpx (glutathione peroxidase). At BASF part of the focus is on traditional ingredients with an innovative edge. The company works with its customers so they can reach their target consumers with products including carotenoids for eye health vitamins B D E and K for overall health sterols for heart health omega-3s for heart health and cognitive function and Tonalin CLA to reduce body fat and maintain lean muscle. Lutein was just recently again associated with improved outcome for people with macular degeneration Gehbauer said. Vitamin D has been studied for the maintenance of bone density and prevention of falls. Vitamin K is also recognized as a contributor to bone health. Lycopene is associated with prostate health for older men. Additionally a recent study suggested that high doses of vitamin E may help to slow cognitive decline in Alzheimer s patients. The company is innovating with new delivery formats that make it easy and convenient for seniors to take their dietary supplements. More than three quarters of the population of those aged 55 plus regularly use vitamins and Go to afs for info about this advertiser 30 Nutrition Industry Executive Celebrating 20 Years of Excellence 1995-2015 May 2015 Go to certifiednutraceuticals for info about this advertiser Parisian Anti-Aging Tetrahedron s recent self-affirmed GRAS (generally recognized as safe) status for its Ergoneine ingredient a new source of the antioxidant L-ergothioneine is allowing the Paris France-based company to move rapidly to address key issues for its broad commercialization in the U.S. market. In the spirit of transparency a recently published Tetrahedron study on the reproductive safety evaluation of ERGONEINE in Food and Chemical Toxicology was presented during the Annual Meeting of the Society of Toxicology in March in San Diego CA underscoring the safety of Ergoneine for use in nutritional products. The ingredient has been recognized as a physiological antioxidant that may play a critical role in many aspects of healthy aging by supporting the body s defenses against oxidative stress. usage of vitamins minerals and supplements increases with age. However while many seniors have difficulty swallowing pills most dietary supplements are still in traditional formats like pills and tablets Gehbauer said. BASF actively develops consumerfriendly innovations in delivery systems for every life stage. Examples of such delivery systems include a broad range from chewable tablets orally disintegrating tablets (ODT) gummies emulsions stick packs and chewable soft gel capsules. When certain ingredients are used integrated taste-masking or modified release technologies may be needed. For example fish oil soft gels with delayed release technology can bypass the stomach and release the fish oil in the small intestine to minimize a fishy aftertaste. To make it easier for seniors to swallow fish oil supplements BASF has introduced a broad range of high concentrate omega oils high in EPA or high in DHA depending upon the consumer target group and targeted health condition. By creating a smaller pill or capsule it s easier for consumers to take the product. Scientists state that chronic inflammation is a pathological condition characterized by continued active inflammation response and tissue destruction. At Washington-based Bergstrom Nutrition Tim Hammond vice president of sales and marketing pointed out that oxidative stress and recurring inflammation are associated with poor physical functioning and are believed to accelerate the aging process. Research indicates that OptiMSM supplementation may serve as an adjunct therapy to support our health as we age he said. OptiMSM is a wellresearched high-quality MSM with clinical data demonstrating that it can help minimize oxidative stress and provide nutritional support for a healthy inflammatory response within the body. Beauty From Within Looking at beauty from the inside-out has been a growing topic in anti-aging as well but this is often a difficult approach for consumers to understand said Zapp. A simpler way of looking at it is that we are what we eat and that a reflection of how we look and feel is oftentimes a mirror of our cellular health and how it has been affected over time. As we age our bodies need to help to remove the buildup of toxins and free radical damage that has occurred to otherwise healthy cells. Supplementing with agents like glucarate can help increase the body s natural pathway for detoxification removing harmful toxins pollutants and chemicals that are affecting cell health. Glucarate continues to make innovative progress in the space of nutricosmetics as it can be fortified in better-for-you foods and beverages or used more traditionally in supplements. Zapp pointed out that beauty from within is only just starting to capture a significant market share or interest in the U.S. relative to other countries. This is mainly because the U.S. consumer wants to see instant results expecting beauty products to work and have some reaffirmation of product efficacy if not the moment they are used then very shortly thereafter. It is difficult to see or feel the benefits of oral and ingestible beauty products because they have long-term cellular benefits to the dermal layers of the skin hair or even nails. Beauty encompassing the entire definition is moving away from the conventional cosmetic beauty model and becoming more intrinsic in both definition and delivery. Rod Benjamin director of research and development and technical services with Bergstrom Nutrition agreed that the beauty from within category is already significant in Europe and especially Asia. The American consumer is starting to realize that healthy skin hair and nails are difficult to achieve without May 2015 32 Nutrition Industry Executive Celebrating 20 Years of Excellence 1995-2015 proper nutritional support. While collagen is recognized in this category additional ingredients are gaining traction as new research supporting their efficacy becomes available. For instance MSM has historically been considered as a source of nutritional sulfur that can support areas like keratin and disulfide bonds within the collagen matrix of the skin. While studies have strongly suggested that MSM may play this role actual scientific substantiation of efficacy in the area of nutritional support in the personal care category is limited. Benjamin added that Bergstrom recently concluded a number of studies that are pending publication and will bring additional scientific credibility to OptiMSM s use in both the nutritional and topical personal care categories. Up-and-coming ingredients for the beauty from within field in general noted Merchet are collagen hyaluronic acid CoQ10 omegas green teas phytosterols vitamins and minerals. Seppic s Ceramosides and SOD B are most recent but are gaining a lot of attention for this category. Both ingredients have been researched separately by several in vitro and in vivo studies and human gold standard clinical studies. Ceramoside was found to improve skin moisture and elasticity. SOD B may improve skin appearance by reducing visual cellulite. ered GRAS. To obtain this status is often a tedious and costly process that many suppliers are not willing to undergo. For Applied Food Sciences Zapp added it is important that the company takes these extra steps to help manufacturers take the guesswork out of what they are offering their consumers. That is why we offer USDA (U.S. Department of Agriculture)-certified organic ingredients as well as ensuring all of our products are self-affirmed GRAS. This broadens our ability to have an answer for the diversity of solutions that manufacturers require today. NIE References Consumer Demands on Natural As with weight loss unfortunately there is no quick fix to anti-aging. Healthy aging begins with adopting a lifestyle that includes a nutrient-dense diet regular exercise appropriate sleep and stress management said Hammond. Beyond this certain nutraceuticals-- such MSM--may provide beneficial nutritional support. Additionally there are the consumers who want to stick with traditional topical cosmetics while others want to build it into their nutrition. This puts a heavy demand on ingredient suppliers said Zapp. Standardization and certification are two of the easiest ways for suppliers to meet that flexible demand from manufacturers. In addition the word natural is under growing scrutiny because it lacks regulatory definition Zapp added. For instance a naturally derived ingredient might still be processed with harmful chemicals or pesticides before it reaches consumers which could easily defeat the very purpose of its health benefits ... additionally for a botanical ingredient to make that jump into the growing world of functional foods beverages it also has to be considMay 2015 1 Perrig WJ Perrig P Stahelin HB. The relation between antioxidants and memory performance in the old and very old. J Am Geriatr Soc. 1997 Jun 45(6) 718-24. 2 Mecocci P Polidori MC Troiano L et al. Plasma antioxidants and longevity a study on healthy centenarians. Free Radic Biol Med. 2000 Apr 15 28(8) 1243-8. 3 Singh KK. Mitochondrial dysfunction is a common phenotype in aging and cancer. Ann NY Acad Sci. 2004 Jun 1019 260-4. 4 Miquel J. Can antioxidant diet supplementation protect against age-related mitochondrial damage Ann NY Acad Sci. 2002 Apr 959 508-16. 5 Liu J Atamna H Kuratsune H Ames BN. Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites. Ann NY Acad Sci. 2002 Apr 959 133-66. 6 Zandi PP Anthony JC Khachaturian AS et al. Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements the Cache County Study. Arch Neurol. 2004 Jan 61(1) 82-8. 7 8 Eskelinen MH Kivipelto M. Caffeine as a protective factor in dementia and Alzheimer s disease. J Alzheimer s Dis 2010 20 S167 174. 9 O Keefe JH Bhatti SK Patil HR DiNicolantonio JJ Lucan SC Lavie CJ. Effects of habitual coffee consumption on cardiometabolic disease cardiovascular health and all-cause mortality. J Am Coll Cardiol. 2013 62 1043 1051. 10 Bredesen DE. Reversal of cognitive decline a novel therapeutic program. Aging. 2014 6 707 717. 11 Forster et al. Reproductive safety evaluation of LErgothioneine J. Food and Chem. Tox. DOI 10.1016 j.fct.2015.02.019. Extra Extra Information on an ingredient based on telomere research as well as educational videos on some of the ingredients mentioned in this article can be found by visiting FORMOREINFORMATION Applied Food Sciences Inc. (512) 732-8300 Bergstrom Nutrition (360) 693-1883 Certified Nutraceuticals (951) 600-3899 BASF Nutrition & Health (800) 527-9881 Maypro Industries (914) 251-0701 Seppic Inc. (973) 882-5587 Tetrahedron 33 (0)1 41 83 75 00 Celebrating 20 Years of Excellence 1995-2015 Nutrition Industry Executive 33 Beyond What Meets The Eye New ingredients and today s trends help expand the variety of options to support eye health. By Cristina Goodwin ith so many people affected it is no wonder the global eye health market--comprising of OTC (over-the-counter) eye care and eye health supplements--is worth nearly 5 billion growing 15 percent from 2008 to 2013 according to Euromonitor in 2014 noted Lynda Doyle vice present of global market for OmniActive Heath Technologies in New Jersey. Moreover the number of new products launched in the eye health supplement sector accounted for 3.4 percent of total supplements introduced into the market in 2014 (Innova Market Research 2015). There are factors concerning eye health including not being able to see as well as one used to eyestrain from too much computer use and poor night vision Doyle said. She noted that electronic devices have taken a toll on our eyes whether it is computers hand-held devices televisions and video games. We are constantly bombarded with blue light and 34 Nutrition Industry Executive W although most of us understand the importance of protecting ourselves from damaging rays of the sun most adults don t realize the potential longterm damage blue light can cause to their eyes. According to Vice President of New-Jersey based LycoRed Corp. Golan Raz there is hard evidence that specific nutrition components can help reduce the risk for age-related eye disease (ARED). More than eight million Americans are at high risk to develop ARED conditions and a growing number of them are using nutrition including supplements as a component in reducing the relevant risks he explained. According to the Centers for Disease Control and Prevention (CDC) the leading causes of blindness and low vision in the United States are primarily ARED such as age-related macular degeneration (AMD) cataract diabetic retinopathy glaucoma amblyopia and strabismus. In fact AMD is associated with aging and can Celebrating 20 Years of Excellence 1995-2015 damage sharp and central vision. It comes in two forms wet and dry however the dry form is the most common and accounts for 70 to 90 percent of all AMD cases. The Benefits of Lutein Zeaxanthin & Lycopene According to the American Optometric Association (AOA) there have been many studies showing that lutein and zeaxanthin help reduce the risk of chronic eye disease. Out of 600 carotenoids in nature there are the only two deposited in high quantities in the macula. The National Eye Institute conducted its second largest human clinical trial Age-Related Eye Disease Study (AREDS2) in order to confirm whether or not supplements that contain 10 mg a day of lutein and 2 mg of zeaxanthin daily affect the risk of developing AMD. The phase III study with 2 x 2 factorial design was conducted in 2006-2012 and enrolled 4203 participants aged 50 to 85 years. The results found that lutein May 2015 plus zeaxanthin may be the right substitute to beta-carotene. According to PubMed there have been approximately 1 900 studies conducted on lutein alone between 2004 and 2013. Further it was found that lutein and zeaxanthin may improve visual acuity and visual performance reduce glare sensitivity enhance contrast sensitivity and improve vision in dim light. As research revealing the positive health benefits of the macular carotenoids continues to grow coupled with consumer awareness about the vital role of lutein and zeaxanthin isomers in health more consumers now understand the need to incorporate these important eye health nutrients into their daily supplementation regime OmniActive s Doyle said. Scientific interest in lutein and zeaxanthin isomers have grown significantly over the last three decades and Doyle expects this trend to continue. Not only are we seeing a growing number of supplements containing lutein and zeaxanthin isomers appearing on the market we are also seeing eye health supplements with higher levels of lutein and zeaxanthin isomers she said. OmniActive offers an extensive line of macular carotenoids including Lutemax 2020 Lutein with Enhanced Levels of Zeaxanthin Isomers Lutemax Free Lutein and Lutein Esters and OmniXan RR-Zeaxanthin derived from natural paprika. Lutemax 2020 delivers a 5 1 lutein to zeaxanthin isomers ratio to optimally support eye health and is available in a variety of 100 percent vegetarian beadlets oil suspensions and powder. Lutemax Free Lutein is the company s high-quality lutein extract manufactured from marigold flowers by using proprietary technology and Lutemax Lutein Esters deliver the most premium safe lutein in its natural ester form. Both Lutemax Free Lutein and Lutein Esters are available in a variety as well of 100 percent vegetarian beadlets and oil suspensions she continued. Overall the Lutemax range of products are made under a fully integrated supply chain process that begins with the cultivation of the marigold flowers and continues though the extracting and manufacturing of beadlets oils and powders for superior quality control. In addition the FDA (U.S. Food May 2015 and Drug Administration) accepted OmniActive s notification of GRAS (generally recognized as safe) and zero adverse effects were known to be reported for lutein and zeaxanthin isomers at extremely high levels for long periods of times. The company s other eye health ingredient OmniXan delivers the benefits of premium zeaxanthin--a potent quencher of singlet oxygen and lipid radicals and one of the principle carotenoids in the eye Doyle explained. Concentrated in the center of the macula zeaxanthin absorbs specific wavelengths of light which could damage the retina and plays a unique role in supporting macular health she said. The new OmniXan is available in a variety of delivery forms with the help of the company s patented OmniBead Beadlet technology which helps protect the zeaxanthin in the eye and offers greater stability during manufacturing as well as suspensions for flexibility. Also it allows manufacturers to incorporate the zeaxanthin to their existing or new combination eye health formulas. OmniActive s OmniXan RRZeaxanthin is another eye health ingredient made from paprika which is a natural whole-food and a GRAS source. In addition it is grown and extracted in the U.S. through a vertically integrated supply chain. Another ingredient that has been added to products with lutein and zeaxanthin for vision support is lycopene which decreases the serum and lipoproteins in AMD patients according to Natural Medicine Journal. It was found that the high risk ARED population are suffering from a relatively low level of lycopene in their blood Doyle noted. As lycopene is known to be important for multiple bio-chemical functions in our body scientists have been searching for explanation for this phenomenon. It was suggested that while lutein is finding its way to the eye lycopene functions as a bodyguard and sacrifices itself in order to protect the lutein from oxidation she continued. Because it is difficult finding the right balance of lutein and zeaxanthin LycoRed invested in an eye health pre-clinical and clinical program with the guidance of Dr. Alon Harris MS PhD from Indiana University and Itay Celebrating 20 Years of Excellence 1995-2015 Old English Medical Text Holds Recipe to Cure Eye Infection Bald Leechbook a 1 000-year-old English leather-bound diary found in the British Library in London England was found to contain a hand-written recipe to cure eye infections. Reported by ABC News scientists tried the stepby-step recipe in order to recreate the old world salve and discovered it killed more than 90 percent of a methicillin resistant Staphylococcus aureus aka MRSA bacteria that was grown in a petri dish of mouse cells. The 10th-century recipe contained two types of allium--garlic plus onion or leek--wine from a vineyard that has existed since the ninth century and oxgall which is the bile from a cow s stomach. As with all recipes there were specific instructions on how to make the concoction in a brass vessel straining through a cloth then letting it sit for nine days before it is mixed and ready for use. The researchers concluded it wasn t one particular ingredient that did the trick but rather the entire recipe. We thought that Bald s eye salve might show a small amount of antibiotic activity because each of the ingredients has been shown by other researchers to have some effect on bacteria in the lab Freya Harrison one of the lead Nottingham researchers said in a statement. But we were absolutely blown away by just how effective the combination of ingredients was. Nutrition Industry Executive 35 important role in vision bone growth and health of the immune system. Vitamin A also helps the surface of the eye mucous membranes and skin be effective barriers to bacteria and viruses reducing the risk of eye infections respiratory problems and other infectious diseases. Omega-3s and DHA have also been Chowers MD of Hadassah Medical known to support eye health. Center to prove the efficacy of a new According to generation of Lutein High Zeaxanthin omega-3 fatty acids include DHA Nutrient Complex. Using this new eicosapentanoic acid (EPA) and alphaLutein High Zeaxanthin Nutrient linolenic acid (ALA). As noted on the Complex the LycoRed research and website a 2009 National Eye Institute development team developed Lyc-Ostudy that used data obtained from Vision technology an optimized forthe AREDS found participants who mula that contains both bio-available reported the highest level of omega-3 and highly active nutrients for ARED fatty acids in their diet were 30 persupport Raz said. cent less likely than their peers to develop macular degeneration during Ingredients & Challenges a 12-year period. Other ingredients that benefit eyes While there are a number of ingrediinclude antioxidants vitamins C and E ents that are beneficial in regard to to prevent cataracts omega-3 long vision health there are multiple chalchain PUFAs genistein and docosalenges when developing an eye health hexaenoic acid (DHA) which are essen- product Raz explained. Bio-availabilitial for infants eyesight and vitamin A. ty is one of the most common. Also Vitamin A actually is a group of lutein extracted from marigold flowers antioxidant compounds that play an grown in uncontrolled environment is subject to the presence of heavy metals and other THE NUTRITION INDUSTRY S toxins. Another NEWS & INFORMATION RESOURCE challenge is the right mix between ting 20 Years 1995 Celebra lutein zeaxanthin 2015 of Excellence and the vitamins and minerals recommended in the AREDS 2 study he said. NIE s Upcoming Beyond Luetin for Every Age OmniActive Health Technologies first launched Lutein for Every Age an educational campaign three years ago. The campaign promotes ways to support eye brain skin and general health through healthy living diet and supplementation through educating consumers industry members and health care professionals regarding the lifelong benefits of macular carotenoids. To further spread the word the program launched a consumer website which was created to educated consumers on how to maintain eye health while only touching on lutein and zeaxanthin isomers and how they directly support healthy vision over time. There are many features on the website including a quiz to test whether his her eyes are at risk recipes supporting healthy eyes skin and brain and tips on how to enjoy being healthy throughout their lifetime. In addition the campaign sponsors educational events and publications for consumers and health and industry experts who use a variety of macular carotenoid professionals to discuss the benefits of lutein and zeaxanthin over time. For instance OmniActive has developed UltraSOL Nutrient Delivery System for functional food and beverages. New Jersey-based AstaReal is another company keeping tabs on potential trends. The company provides manufacturers with an alternative approach to the future of eye health ingredients with its AstaReal P2AF (2 percent cold water dispersible powder) AstaReal L10 (10 percent oleoresin) and AstaReal HBA (1.5 percent water soluble) which is its newest natural astaxanthin. In order to support and stay on top of this thirst for liquid dosing said Janice Brown technical support for AstaReal Inc. AstaReal has developed a water-soluble form of astaxanthin AstaReal HBA. This new version of our natural astaxanthin is ideal for functional beverages and liquid supplements and will greatly support this growing movement she concluded. NIE What Meets The Eye 2015 Issue Highlights July August 6 29 15 ad closing 8 11 15 ad closing Company Profiles Functional Food and Beverages for Eye Health While pills and capsules are the most popular delivery form in the vision health category functional food and beverages are gaining attention in this category. Although food and beverages for eye health are not yet firmly established as of yet they are set to become a trend. September Contract Manufacturing Our 2015 Media Planner Is Now Available At 2015-Media-Planner Contact One of Our Ad Specialists Today Russ Fields at 732-432-9600 ext. 102 or e-Mail RussF Roy Kieffer at 719-358-9838 or e-Mail RoyK Gary Pfaff at 732-432-9600 ext. 107 or e-Mail GaryP FORMOREINFORMATION AstaReal Inc. (609) 386-3030 LycoRed Corp. (877) LYCORED OmniActive Health Technologies (866) 588-3629 May 2015 36 Nutrition Industry Executive Celebrating 20 Years of Excellence 1995-2015 2015 ScienceofIngredients ince 2002 Nutrition section has been offered to help manufacturers gain a better understanding of the ingredients and services available that can make their products stand out. It gives the magazine s advertisers an opportunity to describe the research that substantiates the safety and efficacy of their branded ingredients products and services. These companies have responded to this opportunity with information about the health concerns their products are intended to address histories of nutrients behind their ingredients and details of research that has been carried out. In order to bridge the gap between interested parties and those participating in this section we ve also provided company addresses phone numbers email and website addresses to make obtaining additional information as easy as possible. May 2015 S Industry Executive s Science of Ingredients Following is an index of companies participating in this year s Nutrition Industry Executive Science of Ingredients section AstaReal Inc. ................................................38 Certified Nutraceuticals Inc. ........................39 HealthCo ........................................................40 IgY Nutrition LLC. ........................................41 J.G. Pizzey Inc. ..............................................42 Kyowa Hakko USA ........................................43 Natreon Inc. ..................................................44 Sabinsa Corp. ................................................45 U.S. Pharmacopeial Convention (USP) ..........46 Celebrating 20 Years of Excellence 1995-2015 Nutrition Industry Executive 37 2015 ScienceofIngredients AstaReal Inc. 3 Terri Ln. Unit 12 Burlington NJ 08016 Phone (609) 386-3030 Fax (609) 386-3033 Email contact Website AstaReal Astaxanthin An Ingredient for Better Health (Be You Just Healthier) F rom young athletes to middleaged everyday workers to senior citizens they all share the common interest of finding ways to maintain a healthy lifestyle and fight signs of aging. But how does one choose the ingredient that is right for them How do they know that what they are taking is safe unadulterated and well researched The answer is elementary you have to undertake the research yourself seek a brand that you trust and stick with it AstaReal astaxanthin is a unique carotenoid with powerful antioxidant capabilities. Its unique chemical structure allows the molecule to orient across the lipid bilayer of cellular membranes. This allows astaxanthin to protect our cells on the inside and out. More importantly it quenches reactive oxygen species through physical contact and not by donating an electron like other carotenoids. This mechanism of action keeps astaxanthin from ever becoming a pro-oxidant. In numerous studies AstaReal astaxanthin has been shown to be a safe and effective antioxidant. Eye Health With the increased development of new digital devices the average person is likely to spend about 15 hours day using one. The heavy use of devices such as smartphones tablets computers and video games has led to increased incidences of computer vision syndrome (CVS). Symptoms of CVS include eyestrain sensitivity to glare sore eyes blurred vision neck and shoulder pain. A study was conducted to determine the effect of astaxanthin supplementation on eye fatigue in individuals suffering from CVS. Taking AstaReal astaxanthin at 6 mg day for four weeks was shown to improve accommodative amplitude refocusing rate eye irritation and bleariness.3 Another study conducted in the same year validated the previous findings. Additionally subjects supplemented with 6 mg day for four weeks displayed improvement in far to near refocusing rate.4 In a separate study daily supplementation of AstaReal astaxanthin at 6 mg day for two weeks indicated a reduction of excessive micro fluctuations and micro spasms of the ciliary muscle. Results suggest that astaxanthin may work on the ciliary body directly recovering and repairing the muscle after stressful visual conditions.5 Skin Health In a single blind placebo-controlled study 4 mg day supplementation of AstaReal astaxanthin displayed visible reduction in fine lines and wrinkles after four weeks of treatment. Dermatologist assessment confirmed this observation and also showed significant improvement in skin moisture content.1 Another study was conducted to assess the impact of sun exposure on cellular DNA. UV radiation induces the production of free radicals or oxidizing agents. These free radicals cause oxidative stress which breaks down the supporting structure of the skin causing premature sagging and wrinkling. AstaReal astaxanthin supplementation significantly improved human dermal fibroblast survival rate after persistent exposure to singlet oxygen attack.2 38 Nutrition Industry Executive Physical Endurance and Muscle Recovery With every positive comes a negative. In exchange for wanting to maintain a healthy lifestyle comes a consequence. Reactive oxygen species (ROS) are a byproduct of energy (ATP) Celebrating 20 Years of Excellence 1995-2015 generated by the mitochondria found within cells. During strenuous physical activity mitochondria are working to supply muscles with energy and as a result ROS are produced. ROS are responsible for triggering the inflammation cascade that leads to muscle fatigue and soreness. In 2008 a study was conducted on young healthy male students. At the outset both groups were tested for the amount of shoulder weighted squats they could perform. For the duration of the study both the placebo group and the supplemented group took part in normal exercise. At the conclusion both groups were again tested for the amount of squats they could perform. The supplemented group (4 mg daily) performed three times the amount of squats as the placebo group.6 Another study was conducted on long-distance runners indicating that daily supplementation of AstaReal astaxanthin decreased the level of lactic acid present in the blood. Lactic acid is responsible for the soreness felt in the muscles after exercise. These results indicate the preference to burn fat as a source of energy rather than glucose.7 It is very important to know and trust your source of astaxanthin. It is especially important to confirm that you are taking a natural source and not a synthetic or otherwise adulterated source. Only the natural source of astaxanthin from Haematococcus pluvialis microalgae is FDA (U.S. Food and Drug Administration) approved for daily human consumption in dietary supplements. Furthermore trust the brand that has significant clinical research to support safety and both of its successful FDA notifications NDI (new dietary ingredient) and GRAS (generally recognized as safe). Trust AstaReal. For a full list of references visit May 2015 2015 ScienceofIngredients Certified Nutraceuticals Inc. P. O. Box 1065 Pauma Valley CA 92061 Phone (951) 600-3899 Fax (951) 600-8676 Email info Websites Healthy Aging & Science Telomeres The 2009 Nobel Prize in Medicine was awarded to three scientists who solved an essential element in biology how chromosomes replicate in a complete way during cellular division and how they are protected from degradation. Most people are not familiar with the word telomere telomerase enzyme and or telomere health. It will become a household topic in coming years. Telomeres hold remarkable information about the path of our health and may provide the single most important biomarker of aging. Telomeres are the biological clocks that are ticking from the day we are conceived until the day we die. When cells divide and replicate we lose telomere length. Cellular reproduction is required on a regular basis to repair damaged tissue and to cope with stresses both good and bad. When telomeres are reduced to approximately five thousand base pairs our cells become senescent (a retirement like state in which they no longer divide) and die. Telomeres are defined as the protective tail at the end of a chromosome structure that conveys the genetic material information of our cells. Telomeres keep our chromosomes intact and functioning to reproduce cells the key to healthy aging. Telomere length is very essential for good health. Having long telomeres is an indication of a healthy individual. they no longer have the ability to protect DNA replication causing aging cells or cell death. Much of this damage is caused by free radicals unstable molecules created when the body uses oxygen. Research shows that short telomeres are linked to the causes of many serious diseases and cause premature aging. Scientific research conducted on the anti-aging ingredient Telos95 which is a proprietary discovery and is the result of more than a decade of research initiated by the inventor Ahmad Alkayali CEO Certified Nutraceuticals Inc. a Pauma Valley CA-based company. The initial research was about SIR2 protein and telomere maintenance in relation to the aging process. After experimenting with many purified natural compounds our research finally succeeds with the perfected composition of Telos95 scientifically validated to work. Telos95 is isolated from a natural blend of organic grapevine and olive leaves. This is highly purified into active polyphenol compounds having an extremely high antioxidant profile capacity to fight free radicals and slow down the aging process of our healthy cells. Telos95 supplement mechanisms of action are to halts the shortening of healthy telomeres. This stabilization of the telomeres allows the healthy chromosomes to continue duplication. A healthy telomere is genetically programmed to duplicate 50 to 60 times before cell death. Telos95 is available in granule powder capsule form and can be easily formulated into capsules tablets beverages cereal nutrition bars yogurt ice cream chewing gum and chocolate bars. Recommended daily human adult dosage is only 65 mg capsule tablet taken daily with food. It is a safe and effective dietary supplement concentrated from a natural botanical source. Celebrating 20 Years of Excellence 1995-2015 Clinical studies and research prove that shorter telomere length is associated with osteoporosis and inflammatory diseases such as arthritis cardiovascular disease cancer stroke diabetes cognitive impairment and dementia. Most Americans over the age of 60 suffer from many of these conditions. Scientific research indicates that Telos95 active compounds regulate and produce cell energy and can lead to increased cell replication function in tissues. How to Keep Telomeres Healthy & Functional 1. Daily supplement of one small 65 mg capsule of Telos95 2. Change smoking habits 3. Control and manage weight 4. Regular exercise and activity 5. Healthy diet 6. Manage blood sugar 7. Maintain good cholesterol level 8. Check blood pressure regularly 9. Manage stress 10. Restful eight hours sleep The rising number of Baby Boomers will be more than 100 million in the 21st century. The demand for natural ingredients for prevention will surpass the demand for treatment. Certified Nutraceuticals Inc. is staying in the fore front of scientific research and currently conducting a large-scale one-year human study to demonstrate Telos95 efficacy. Telos95 is also beneficial for veterinary applications to increase performance and endurance in animals such as racehorses and dogs. For more information visit For a full list of references visit Nutrition Industry Executive 39 Why is Telomere Length Important Telomere shortening is correlated with human disease and aging. Short telomeres impair the ability of healthy cells to divide and function properly. Longer telomeres are associated with healthy cell replication and longevity. How Does Aging Affect Telomere Shortening Aging affects the telomere shortening in two ways As we age the body s ability to reproduce the key nutrient telomerase enzyme proteins slows down. These enzymes are responsible for the maintenance of telomere health and length. When the telomeres become too short May 2015 2015 ScienceofIngredients HealthCo 244 Knollwood Dr. Bloomingdale IL 60108 Phone (800) 477-3949 Fax (630) 545-9080 Email sales Website Stevia FSE A Unique and Markedly Different Stevia Sweetener D espite stevia s relatively recent arrival to the food and beverage marketplace this exceptionally sweet herb has a very rich history. The earliest known use of stevia according to documents stored at Paraguay s National Archives can be traced back to the mid-1800s when the indigenous Guarani natives used it. Known as kaa-he-e (sweet herb) it was initially used in medicinal preparations in addition to a tea-like drink known as bitter mate. In 1931 French chemists Bridel and Lavielle were the first to successfully isolate stevioside and rebaudioside A from the leaves of the stevia plant. Approximately 40 years later during the 1970s Japanese researchers successfully isolated individual steviosides from stevia leaves each one sharing the same steviol molecule nine have been discovered to date. From there the popularity of stevia evolved rapidly. Within 20 years it was universally accepted as Japan s No. 1 sweetener. In the 1980s stevia became available in the natural products marketplace but could only be sold as a dietary supplement not a sweetener.1 It wasn t until 2008 that the FDA (U.S. Food and Drug Administration) permitted stevia to be used as a food additive and that was largely due to efforts by Coca Cola and Cargill to gain approval.2 The initial stevia offerings were highly processed extractions with a somewhat bitter aftertaste. Stevia FSE is a unique and markedly different stevia sweetener. While most stevia ingredients on the market have a bitter aftertaste enzyme-treated Stevia FSE provides a betterrounded sweetening profile that is ideal for numerous food applications. Stevia FSE utilizes the whole stevia leaf and is not an isolated fraction like Reb A which is said to require additional added substances to mask its bitter aftertaste. No flavorings or masking agents are used in Stevia FSE because none are needed. The 40 Nutrition Industry Executive natural enzyme treatment enhances its organoleptic (sensory) properties. Stevia FSE is 60-100 times sweeter than sugar (sucrose). Stevia FSE is also NOP Certified Organic and kosher. Stevia FSE is a unique and markedly different stevia sweetener. While most stevia ingredients on the market have a bitter aftertaste enzyme-treated Stevia FSE provides a better-rounded sweetening profile that is ideal for numerous food applications. Since spring 2010 Stevia FSE has generally recognized as safe (GRAS) status after a comprehensive review of safety and toxicology data by an independent panel of scientists.3 Utilizing the platform of general purpose non-nutritive sweetener for foods and beverages self-affirmed GRAS status allows manufacturers additional freedom to add Stevia FSE in a variety of foods and beverages ranging from baked goods to milk products breakfast cereals cheese egg products processed vegetables soft candy soups snack foods nonalcoholic beverages imitation dairy products hard candy chewing gum granulated sugar and even seasonings and flavors. The benefits of this natural herbal extract are many. Stevia contains no calories and is therefore ideal for Celebrating 20 Years of Excellence 1995-2015 individuals that are conscious of their caloric intake. Additionally stevia ranks extremely low on the glycemic index scale a chart used to measure a food s impact on insulin release following the consumption of food. Stevia is approximately 60 to 100 times sweeter than white crystalline table sugar. Perhaps most appealing stevia is highly versatile and can be used in practically any application that calls for conventional sugar or high fructose corn syrup (HFCS). This provides both economic and health benefits when used in bulk beverage and other food production settings. No natural or artificial low-calorie sweeteners or added flavors of any kind are used during the manufacturing process nor are they added to the finished product. Erythritol is a corn-based sweetener commonly used in many Reb A stevia products but not used in Stevia FSE Sweetener. Stevia FSE is 100 percent vegetarian and vegan suitable and free of common food allergens including yeast dairy egg gluten wheat soy sugar starch salt artificial colors flavors or fragrances. In order to ensure the highest levels of purity it is tested for heavy metals pesticides bacteria and other potentially harmful contaminants. Stevia FSE sweetener is both pH and temperature stable making it ideal for use in many functional foods and beverages. References 1 McCaleb Rob (1997). Controversial Products in the Natural Foods Market. Herb Research Foundation. 2. Stevia sweetener gets US FDA go-ahead. Decision News Media SAS. 18 December 2008. 3 HealthCo Receives GRAS Status for STEVIA FSE New Hope 360 May 19 2010 http supply-news-ampanalysis healthco-receives-gras-status-stevia. May 2015 2015 ScienceofIngredients IgY Nutrition LLC Contact Evan Comer Director of Sales Phone (405) 242-5382 Email evan Website IgY HIE PL-100 I gY hyperimmune egg is an easily administered nutritional supplement that captures the immune capabilities of IgY immunoglobulins in order to deliver targeted support to the human immune system via the gastrointestinal (GI) tract. Modern life has been greatly enhanced and extended by the scientific advancements of the industrial era. Infections and injuries have receded as life threats and today s Americans suffer more frequently from diseases attributed to excess inflammation.1 2 While we are only beginning to understand how subclinical excess inflammation develops current evidence indicates a mitigating role for the enormous populations of healthy organisms that inhabit the human gut and interact with the immune system.3 4 Intestinal homeostasis is believed to play a key role in combatting the chronic subclinical inflammation that can lead to heart disease stroke cancer obesity and type 2 diabetes. The state of GI balance can be disrupted by both pathogens and the antibiotics used to try and eliminate or control them. Hyperimmune egg PL-100 (HIE PL100) is unadulterated avian egg protein in the form of a nutritional supplement that delivers comprehensive immune support. It offers a unique ability to affect the immune system in several ways eliminating 26 harmful pathogens promoting gastrointestinal balance moderating or reducing subclinical inflammation and improving the quality of life among autoimmune sufferers and those undergoing chemotherapy. Hyperimmune egg PL-100 (HIE PL-100) is unadulterated avian egg protein in the form of a nutritional supplement that delivers comprehensive immune support. Eliminating Pathogens GI pathogens cause many debilitating conditions in human patients. HIE PL100 uses targeted immunoglobulins (Ig) to eliminate 26 of these harmful pathogens and cultivate a healthy intestinal microbiome. The Ig in PL100 survives passage through the stomach and upper tract to target organisms in the hindgut and provide passive immunity against such pathogens5 6 as salmonella 7-10 enterotoxigenic E. coli 11-15 staph and many others associated with serious GI disorders. Long-term antibiotic treatment is known to fail in nearly 20 percent of cases due to antibiotic resistance 16 and antibiotics often have a negative effect on desirable intestinal bacterial populations disrupting the microbiome and causing additional problems for as long as four years after treatment.17 HIE PL-100 is a practical alternative to antibiotic therapy targeting specific harmful bacteria without disrupting the populations of desired bacteria and helping Celebrating 20 Years of Excellence 1995-2015 restore balance to the intestinal microbiome. Modulating the Immune System Chronic subclinical inflammation is a tremendous health challenge in the U.S. Studies suggest the importance of intestinal homeostasis in both protecting against common pathogens and in combatting the many diseases now believed to be connected to chronic subclinical inflammation. In addition to copious immunoglobulins IgY from hyperimmune egg contains a number of immunoregulatory compounds known as cytokines which control unhealthy immune inflammation. Because of it s proven ability to control inflammation supplementation of IgY from hyperimmune egg is a sensible approach to many of the modern conditions associated with chronic subclinical inflammation. Preliminary studies even suggest that people with chronic inflammatory issues will experience benefits regardless of where the inflammation affects the body providing relief for a range of conditions such as leaky gut joint disease arthritis irritable bowel syndrome serum cholesterol rise and cardiovascular disease. For a full list of references visit Nutrition Industry Executive 41 May 2015 2015 ScienceofIngredients J.G. Pizzey Inc. Box 550 Russell MB Canada R0J 1W0 Phone (204) 773-3532 Fax (204) 773-3522 Email julie Website Flaxseed and Hypertension H ypertension known as the silent killer represents a global health crisis contributing to 9.4 million deaths per year and affecting more than 40 percent of adults aged 25 years and older. If left uncontrolled hypertension can lead to heart attacks strokes kidney failure blindness dementia and peripheral arterial disease (PAD) which is a serious plaque build-up in the arteries of arms and legs.1 Lifestyle factors that may lead to high blood pressure include heavy alcohol consumption high salt intake and obesity. Another potential cause is inflammation which can cause endothelial dysfunction an imbalance between vasodilating and vasoconstricting substances produced by or acting on the endothelium. Enhanced constriction of the vessels can result in hypertension and further the development of atherosclerosis.2 Flaxseed (Linum usitatissimum) comprises several components that may work together to lower blood pressure. Flaxseed contains on average 41 percent fat 20 percent protein and 28 percent total dietary fiber. post-menopausal women after one year compared to baseline.8 Flaxseed (Linum usitatissimum) comprises several components that may work together to lower blood pressure. Flaxseed contains on average 41 percent fat 20 percent protein and 28 percent total dietary fiber. Further flaxseed is rich in four health-promoting components the omega-3 polyunsaturated fatty acid (PUFA) alpha-linolenic acid (ALA 20 percent of flaxseed s dry weight) the plant lignan secoisolariciresinol diglucoside (SDG 1 percent of dry weight) soluble fiber (6 percent of dry weight) and protein.3 Flaxseed appears to reduce blood pressure through altering plasma oxylipins which are highly bioactive molecules produced in the body from PUFA. Flaxseed has been shown to reduce oxylipins that cause vascular constriction by inhibiting soluble epoxide hydrolase the enzyme that produces them.9 Flaxseed ALA and lignans may contribute to blood pressure reduction through anti-inflammatory actions that improve the health of the Celebrating 20 Years of Excellence 1995-2015 Flaxseed Lowers Blood Pressure Powerful blood pressure lowering effects have been reported in humans with the consumption of flaxseed. In patients with PAD and uncontrolled hypertension 30 g d of whole ground flaxseed reduced blood pressure by 15 mmHg (systolic) and 7 mmHg (diastolic) after six months.4 This is larger than the average reduction achieved with standard doses of blood pressure lowering medications.5 A randomized controlled double-blinded clinical trial currently underway is investigating whether ground flaxseed can lower blood pressure and prevent the need for medication in people newly diagnosed with stage 1 hypertension.6 In other research in adults with metabolic syndrome 30 g d of whole ground flaxseed combined with lifestyle counseling lowered blood pressure by 8.8 5.0 mmHg in 12 weeks.7 The consumption of 40 g d of whole ground flaxseed reduced blood pressure by 5.0 4.1 mmHg in healthy 42 Nutrition Industry Executive endothelium.6 Flaxseed is also a source of the amino acid arginine (about 11.3 percent of protein). Arginine is converted to nitric oxide which has the ability to lower blood pressure through blood vessel dilation.10 Scientific research supports the potent blood pressure lowering properties of flaxseed. The ALA lignans fiber and protein content of flaxseed together may knock out this silent killer. References 1 World Health Organization. A global brief on Hypertension Silent killer global public health crisis. WHO DCO WHD 2013.2 ed. Geneva Switzerland 2013. 2 Puddu P et al. Acta Cardiol. 2000 55 221232.. 3 Adolphe JL et al. Br J Nutr. 2010 103 929. 4 Rodriguez-Leyva D et al. Hypertension. 2013 62(6) 1081. 5 Law MR et al. BMJ. 2003 326 1427. 6 Caligiuri SP et al. Trials. 2014 18(15) 232. 7 Wu H et al. J Nutr. 2010 140 1937. 8 Dodin S et al. J Clin Endocrinol Metab. 2005 90 1390. 9 Caligiuri SP et al. Hypertension. 2014 64(1) 53. 10 Marin E Sessa WC. Curr Opin Nephrol Hyper. 2007 16 105. May 2015 2015 ScienceofIngredients Kyowa Hakko USA 600 Third Ave. 19th Fl. New York NY 10016 Phone (800) 596-9252 Websites What is Glutathione G lutathione is a small peptide comprised of three common amino acids and is present in all tissues and body fluids. Often called the master antioxidant glutathione plays many roles in supporting good health including Helping the body detoxify harmful chemicals Supporting the immune system Improving the performance of other antioxidants Sources of Glutathione Glutathione is provided both through the diet and through endogenous synthesis. The best food sources are fresh fruits and vegetables and freshly prepared meats. While maintaining adequate and consistent levels of glutathione is critical to good health it can be difficult to accomplish through diet alone due to poor lifestyle choices and even the natural effects of aging. While maintaining adequate and consistent levels of glutathione is critical to good health it can be difficult to accomplish through diet alone due to poor lifestyle choices and even the natural effects of aging. randomized double-blinded placebocontrolled study puts to rest the longstanding debate on the efficacy of oral glutathione.1 The study performed on 54 healthy adults (mean age 46 years) showed that blood levels of glutathione increased after one three and six months vs. baseline at doses of both 250 mg day and 1 000 mg day. At six months mean blood glutathione levels along with various immune markers were shown to have increased 30-35 percent in the high-dose group and 17-29 percent in the low dose. Natural killer cytotoxicity increased two fold in the high-dose group versus placebo at three months. A reduction in oxidative stress in both glutathione dose groups was indicated by decreases in the oxidized to reduced glutathione ratio in whole blood. Glutathione levels were shown to return to baseline after a one-month washout period.1 Additional Research on Glutathione Shows That Glutathione production decreases with aging beginning in midlife and plunging precipitously after age 60.2 3 Healthy elders have high blood glutathione concentrations.4 Higher glutathione status in older individuals has been correlated with multiple indices of good health--better overall health and vitality higher levels of self-rated health normal cholesterol lower body mass index and normal blood pressure--as compared to older individuals with lower glutathione levels.5 Higher glutathione status has also been correlated with good cardiovascular oral and eye health.6-10 Glutathione levels fluctuate diurnally with lowest levels found in the morning which may present a window of vulnerability.11 Increasing Glutathione Blood Levels Through Oral Supplementation Setria is a clinically studied form of glutathione that when taken orally has been shown to replenish the body s reserves.1 A recently published study on Setria Glutathione in the European Journal of Nutrition May 2014 shows for the first time that daily consumption of glutathione is effective at increasing glutathione blood levels. This long-term Safety There have been no reported adverse reactions to supplemental glutathione taken orally inhaled or used intramuscularly or intravenously.12 Doses of three grams have been used experimentally with no adverse effects.13 Setria Glutathione Setria is a unique tri-peptide form of glutathione manufactured from a patented process by Kyowa Hakko Bio Co. Ltd. Kyowa is a world leader in the research and manufacturing of high-quality ingredients for use in dietary supplements functional foods and beverages. Setria Glutathione is an ultra-pure GRAS (generally recognized as safe) ingredient that is also vegetarian and allergen-free. For a full list of references visit May 2015 Celebrating 20 Years of Excellence 1995-2015 Nutrition Industry Executive 43 2015 ScienceofIngredients Natreon Inc. 2D Janine Pl. New Brunswick NJ 08901 Phone (732) 296-1080 Fax (732) 296-1075 info A Superior Vegetarian and Organic Supplement for Cardiovascular Health C ardiovascular disease is the leading cause of death amongst men and women in the United States. Major risk factors for cardiovascular disease include hypertension dyslipidemia systemic inflammation and type 2 diabetes mellitus.1 There are many supplements in the market for cardiovascular support including omega-3 fatty acids coenzyme Q10 resveratrol and niacin. Omega-3 fatty acids have shown to decrease triglycerides significantly in numerous clinical trials however several trials show increases in total cholesterol and LDL. There is controversy regarding whether or not omega-3 fatty acids decrease the risk of cardiovascular mortality.2 A superior cardiovascular health product would address all of these risk factors. Capros is a proprietary multi-patented standardized aqueous extract of Phyllanthus emblica (Indian gooseberry amla) which is an edible fruit that grows in India. Amla has been used in India for thousands of years as a general tonic. Capros is a super antioxidant with an ORAC value of 47 110 moles TE gm. Several clinical studies have shown that Capros significantly improves many of the risk factors listed above. A new patent was recently issued for the ability of Capros to improve endothelial function and cardiovascular health (U.S. Patent No. 8 962 576 B2). Several double-blind placebo controlled human clinical trials in type 2 as well as pre-diabetic subjects were conducted with Capros 250 mg and 500 mg twice daily for 12 weeks. Both treatment groups showed significantly reduced levels of malondialdehyde and hsCRP. Glutathione levels and nitric oxide levels were significantly increased compared to placebo thus suggesting an improvement in antioxidant status.3-5 Dyslipidemia was also significantly improved in Capros treated subjects.3-5 At 500 mg BID there was a significant 44 Nutrition Industry Executive Capros is a proprietary multi-patented standardized aqueous extract of Phyllanthus emblica (Indian gooseberry amla) which is an edible fruit that grows in India. decrease in LDL of 21 percent and HDL increased 15 to 18 percent in the Capros group compared to placebo.3-5 Total cholesterol and triglycerides decreased 11 and 19 percent respectively. All results were statistically significant compared to placebo.3-5 Platelet aggregation is an important risk factor which can contribute to atherosclerosis especially in diabetic patients. Inhibition of platelet aggregation is pivotal in reducing ischemic events in diabetic patients. Capros which does not have the bleeding risks associated with aspirin and clopidogrel has shown significant platelet inhibition activity.6 In one randomized open label crossover study with type 2 diabetic patients multiple dose administration of Capros 500 mg twice daily resulted in a 36 percent inhibition of platelet aggregation while a combination of Capros with aspirin and Capros with clopidogrel resulted in 56 and 53 percent inhibition of platelet aggregation respectively. There were no bleeding incidents reported in the study.6 A study completed in rats at the University of Connecticut Medical Celebrating 20 Years of Excellence 1995-2015 Center shows the protective effects of Capros treatment on myocardial ischemia reperfusion injury. For example rats in the control group experienced a significant decline in ejection fraction to approximately 40 percent whereas the ejection fraction in the Capros treated group remained at approximately 55 percent. Rats in the Capros treated group showed less fibrosis in their myocardial tissue thus suggesting that Capros has a cardioprotective effect.7 Capros is a vegan pesticide- and solvent-free and is an organic product. It is suitable for a variety of dosage formulations due to its nearly neutral taste aqueous solubility and long-term stability in solution. Capros has been proven safe and efficacious in reducing cardiovascular risk factors improving endothelial function improving biomarkers of oxidative stress and inflammation and inhibiting platelet aggregation thus making it a superior choice as a supplement with cardiovascular health promoting benefits. For a full list of references visit May 2015 2015 ScienceofIngredients Sabinsa Corp. 20 Lake Dr. East Windsor NJ 08520 Phone (732) 777-1111 Fax (732) 777-1443 Email info Website The Anti-aging Prophecy for Curcuminoids T he free radical theory of aging postulates that formation and accumulation of free radicals is responsible for aging associated progressive increase in chance of diseases and finally the death of an organism.1 Today the refined version of the free radical theory relates aging to mitochondrial dysfunction.2 The aging phenomenon involves both extrinsic and intrinsic aging. It is the intrinsic aging that is of the greatest importance and also affects the extrinsic aging. This article will focus on intrinsic aging and how we can slow down this process. Increase in life expectancy with economic growth has a very interesting relationship as described by Preston s curve.3 While increase in income at low per capita populations has significantly improved life expectancy this effect flattens out in the high per capita population. In fact there are good reasons to believe that economic growth has also negatively impacted the health and longevity at least in developed countries due to rapid uncontrolled urbanization changing food habits and lifestyle changes in developed nations. Therefore with Baby Boomers getting older and increasing the percentage of aging population and rising health costs there is a serious need for effective anti-aging support to maintain good health and longevity. There is no better example than Japan to illustrate the importance of healthy aging. Health maintenance of an aging population (estimated to be 30 percent of adult Japanese population by 2030) is a national issue in Japan and anti-aging medicines as well as supplements have taken center stage. One ingredient that has stood out in the Japanese anti-aging market as well as in U.S. market is curcuminoids. Obtained from turmeric curcuminoids have been found to be a strong antioxidant and can reduce oxidative damage a phenomenon closely related to aging.4 Its effect as seen in a clinical study on Curcumin C3 Complex on reducing the oxidative stress in people suffering from chronic health conditions such as metabolic syndrome is of special interest 5 as aging is accelerated in the presence of metabolic and CVD cardiovascular diseases (CVD).6 Another effect of aging which has been widely discussed is increase in joint related problems or reduced joint function. This market formerly dominated by glucosamine-based products has now given way to curcumin formulations. Another recent study on Curcumin C3 Complex showed that curcuminoids not only reduced inflammation but also oxidative stress in subjects with aging joints.7 One widely recognized symptom of aging involves the brain--the master controller itself. Loss of memory and reduced cognitive function are considered inevitable symptoms of aging. Recently conducted studies show that curcumin can reduce neuro-inflammation and neuro-degeneration 8 both of which can be caused by oxidative damage and are related to aging. In fact a recent study on Curcumin C3 Complex showed that it can be safely supplemented in geriatric patients suffering from Alzheimer s disease.9 Celebrating 20 Years of Excellence 1995-2015 Curcumin metabolizes in the body into several metabolites and one of the most prominent and active metabolite of curcumin is tetrahydrocurcumin (THC). Preliminary animal model studies have shown that both curcumin and THC can increase life span and THC in particular inhibited the oxidative stress response by regulating the FOXO and Sir2 genes 10 both of which play important roles in aging. Thus curcumin and its metabolites have an important role in anti-aging supplements. Thus we see that curcuminoids not only affect various processes that contribute to aging. Their role in anti-aging supplementation is not related to just increasing the life span but can improve the quality of life in the aging population. References 1 Harman D. Free radical theory of aging. Mutat Res. 1992 275 257-66. 2 Trifunovic A and Larsson NG. Mitochondrial dysfunction as a cause of ageing. Journal of Internal Medicine. 2008 263 167-178. 3 Preston SH. The changing relationship between mortality and level of economic development. Population Studies. 1975 29(2) 231-248. 4 Siddique YH. Effect of Curcumin on life span activity pattern oxidative stress and apoptosis in brains of transgenic drosophila model of parkinson s disease. Biomed Research International 2014 DOI 10.1155 2014 606928. 5 Panahi Y et al. Antioxidant and anti-inflammatory effects of curcuminoids-piperine combination in subjects with metabolic syndrome a randomized controlled trial and an updated meta analysis. Clin Nutr. 2015 doi 10.1016 j.clnu.2014.12.019. 6 Veronica G and RRM Esther. Aging metabolic syndrome and the heart. Aging Dis. 2012 3(3) 269279. 7 Panahi Y et al. Mitigation of systemic oxidative stress by curcuminoids in osteoarthritis results of a randomized controlled trial. J Diet Suppl. 2015 doi 10.3109 19390211.2015.1008611. 8 Begum AN et al. Curcumin structure-function bioavailability and efficacy in models of neuro-inflammation and alzheimer s disease. J Pharmacol Exp Ther. 2008 326(1) 196-208. 9 Ringman JM et al. Oral Curcumin for Alzheimer s disease tolerability and efficacy in a 24 week randomized double blind placebo controlled study. Alzheimer s Research and Therapy. 2012 4(5) 43 10 Shen LR et al. Curcumin and aging. BioFactors. 2013 39(1) 133-140. Nutrition Industry Executive 45 May 2015 2015 ScienceofIngredients U.S. Pharmacopeial Convention (USP) 12601 Twinbrook Pkwy. Rockville MD 20852-1790 Phone (301) 881-0666 (800) 227-8772 Email mediarelations Website The Science Behind Ingredient Integrity T here s an old adage--garbage in garbage out. If you can t verify the quality of your ingredients you can t verify the quality of your end product. As a manufacturer you likely rely on a trusted supplier to provide quality ingredients. But is trust enough Not anymore. In today s world of increasingly complex global supply chains it s okay to trust so long as you verify. Not only is this the right thing to do it is also a regulatory requirement. Establishing qualified supplier relationships is critical for success and auditing suppliers is a business best practice. Independently verifying the authenticity identity content and purity of ingredients is essential for supplement manufacturers to minimize business risk. The FDA (U.S. Food and Drug Administration) current good manufacturing practices (cGMPs) in 21CFR111.75(a)(2)(ii)(A) require supplement manufacturers to qualify their suppliers if they intend to rely on a supplier s certification of analysis (CoA). Equally if not more important is the need to establish suitable specifications for ingredients and supplements as required by the cGMPs in 21CFR111.70(b) and (e). The lack of appropriate specifications for ingredients and supplements is frequently cited as a cGMP violation by FDA. Although more closely associated with the pharmaceutical industry the United States Pharmacopeial Convention (USP) has a wealth of resources available for the nutrition industry to help ensure the quality of ingredients used in dietary supplements and foods. USP establishes sciencebased quality standards for dietary supplement ingredients and products and offers supplier qualification and verification programs for the same. News stories about tainted herbal supplements and adulterated foods have made consumers wary and have prompted them to seek reassurance that the products they use are of high quality. That s why now more than ever it s important for supplement and food manufacturers to employ USP s stringent 46 Nutrition Industry Executive quality standards to help ensure the quality of both the ingredients they purchase and the products they deliver to consumers. Dietary Supplement Standards The United States PharmacopeiaNational Formulary (USP-NF) contains quality standards for drugs and dietary supplements. The USP-NF is recognized as an official compendium in the Food Drug and Cosmetic Act (FDCA) for drugs and in 403(s)(2)(D) of FDCA as amended by DSHEA regarding misbranded dietary supplements. The Dietary Supplement Compendium (DSC) is intended as a comprehensive resource specifically for the dietary supplement industry. In this single reference the nutrition industry can find the all the unbiased scientificbased specifications and information they need to develop manufacture and test new products to qualify raw materials to prepare for cGMP audits to develop and validate test procedures and to conduct in-process and batchrelease tests. The DSC contains close to 500 monographs for dietary supplement raw materials (e.g. ginkgo) ingredients (e.g. powdered ginkgo extract) and finished products (e.g. ginkgo tablets). Monographs set forth an ingredient or product s name definition specification and other requirements related to packaging storage and labeling. The specification consists of tests test procedures and acceptance criteria that help ensure the identity strength quality purity and performance of the ingredient or product. Verification Services For supplement manufacturers that want to be reassured of the quality of the ingredients they purchase or those that want to demonstrate the quality of Celebrating 20 Years of Excellence 1995-2015 the finished products they deliver to consumers USP offers two third-party verification programs. The USP Dietary Ingredient Verification Program is offered to ingredient manufacturers who want to reassure supplement manufactures that their dietary ingredients meet USP standards and can serve as a means by which supplement manufacturers can qualify their suppliers. USP staff help ensure that quality is built into ingredients by conducting on-site facility GMP audits reviewing product documentation performing comprehensive laboratory testing and conducting annual off-the-shelf testing of randomly selected samples to confirm that USP-verified ingredients continue to meet USP standards. Similarly the USP Dietary Supplement Verification Program is offered to supplement manufacturers who want a scientific independent third-party verification of product quality to reassure retailers and consumers that their products meet USP s stringent quality standards. When consumers see the USP Verified Mark on a dietary supplement label they have assurance that the product contains the ingredients listed on its label in the declared potency and amounts it does not contain harmful levels of specified contaminants it will break down and release the ingredients into the body within a specified amount of time and it has been made according to FDA and USP cGMPs. In addition to dietary supplements consumers increasingly turn to functional foods for the health benefits they desire. USP also engages in standardssetting activities for food ingredients that help support the quality and safety of food through a variety of resources. For more on USP s offerings for the food industry visit May 2015 ProductionLine Stability Industry suppliers employ a range of sophisicated technology to provide stable active components. By Lisa Schofield nything that is unstable is downright scary. Think about it an unstable building foundation an unstable stock market an unstable individual. When we perceive something or someone as being unstable our reaction is to avoid it. Supplements are the same way. If it degrades quickly all value is lost and there is no meaning to shelf life. Further many consumers believe if the supplement has degraded it may be harmful or taste disgusting. Supplements by nature contain volatile ingredients and in a large sense botanical extracts are still alive. And you cannot achieve any duration of shelf life--maintaining potency and integrity of the ingredients in the unique constitution of its formula--without ensuring physical stability of the product proper. Retailers want a product with a minimum of two years shelf life stated Stephen Lukawski BA MEd director of global business development sales and marketing Fruit d Or Nutraceuticals Quebec Canada. We aim to protect the health and safety of the consumer prior to the product going on the shelf. Ensuring A Challenges As the very nature of nature-made ingredients (including pre- and probiotics living organisms) is one of inherent volatility it stands to reason that with the vast variety of such ingredients challenges to May 2015 impose stability are plentiful. Gil Bakal managing director of New Jersey-based A&B Ingredients Inc. said that there are four major types of challenges Oxidation which can cause reduction and degradation in nutrient value development of anti-nutritional byproducts and development of off flavors hydrolysis (in beverage applications) microbiological degradation such as yeasts molds and spoilage organisms which can develop in moisture containing products and textural changes in nutritional bars which can become hard brittle and stale over a time period. Missy Lowery senior marketing manager Capsugel Americas Region in South Carolina asserted that moisture and oxygen-sensitive ingredients provide the greatest challenges to stability. Probiotics are hydroscopic and excessive moisture coming from environment or capsule shell can prematurely activate them. Technological advances in lowmoisture capsule delivery systems have played a key role in maintaining the viability of probiotic bacteria during processing and storage of product she reported. Further probiotics are also acid-sensitive so as they transition through the stomach moisture and acid can cause early activation and degradation. Capsugel she said has concentrated on developing innovative delivery systems to help prevent that and provide for targeted release into the intestine Celebrating 20 Years of Excellence 1995-2015 where probiotics prefer to colonize. Mike Wagner PhD food processing engineer with New York-based BI Nutraceuticals also agreed that moisture is a monster. Moisture control is critical to formulation stability. Moisture content is important but often water activity (aw) or the measure of free water in the product available for chemical reaction is more telling of the stability. Microbial growth oxidative reactions enzymatic reactions and protein-protein interactions among others are affected by water activity. Physical properties like flow hardness and particle interactions can also be influenced by unbound water. Even processing that involves the addition and or removal of water like steam sterilization requires close attention and custom solutions to properly control moisture in the product. With so many characteristics linked to one parameter you may be trying to solve a water activity issue without realizing it he explained. Other ingredients that pose similar challenges added Lowery are some enzymes sports nutrition ingredients such as sAMe and ALA which are susceptible to degradation due to stomach acids while others are not. These acid sensitive ingredients--just like probiotics--are targeted to work best in the intestines. The challenge here is to create a dosage delivery form that guards against stomach acids. Nutrition Industry Executive 47 ProductionLine Peroxide can be quite pernicious said Lukawski. To provide a safe and efficacious product we must do our real-time testing (minimum one to two years) to show that we can maintain a level of peroxide value that s low enough to avoid causing stability issues. The presence of peroxide in the product gives evidence of oxygen attaching to the fat and oil molecules which can result in rancidity meaning a change in smell (fishy scent) and taste (burning feel on the tongue). The lower the peroxide level is the fresher the product he explained. RTDs (ready to drinks) have some unique challenges. Frequently observed Dan Grazaitis senior food scientist TIC Gums in Maryland nutritional beverages are fortified with various types of protein minerals and vitamins. These additional ingredients can affect the shelf stability and the amount of perceivable particulates in RTD beverages. Some protein sources utilized in nutritional beverage formulations have the ability to create strong astringency or texture defects he said. Other ingredients such as cocoa powder and minerals can settle and cause the beverage to separate. Texture and separation can both cause an inconsistent flavor throughout the beverage. dosage delivery forms soar among consumers. The company recently invested 25 million to increase its global production capacity for its clean-label vegetarian capsules because four out of 10 supplement users expect supplement delivery in vegetarian capsules Lowery cited. Three of our four capsule offerings that address stability challenges for moisture-sensitive and acid-sensitive ingredients are plant-based Vcaps capsules Vcaps Plus capsules and DRcaps capsules. According to Bakal there are many additives that can play a role in ensuring integrity and viability through shelf life antioxidants can help prevent oxidation of fats and fat-soluble nutritional components preservatives are often used to prevent mold and bacterial growth and glycerine and soluble fibers can help retard firming up of chews and bars. Many of us view excipients simply as fillers that take up space in a formula but in reality they play very specific roles and great attention is given to their selection explained Emilio Gutierrez RPh vice president of technical services BI Nutraceuticals. Excipients can help solve simple issues related to excess free water stickiness and density modification to more complex problems related to solubility compressibility disintegration and even bioavailability of active components. Formulating RTDs that contain supplement ingredients necessitate not only preserving integrity and stability but ensuring texture and taste remain attractive. For example said Grazaitis hydrocolloids are used to combat the negative effects nutritional ingredients have on texture and stability. Multifunctional in nature each type of hydrocolloid has a unique purpose to reduce the perception of particulates reduce astringency and prevent sedimentation. For example he provided colloidal microcrystalline cellulose (CMC) gives suspension in beverages without significantly altering viscosity. For proteinbased beverages carrageenan is an excellent performer providing both suspension and texture to a protein beverage. Locust bean gum guar gum and xanthan gum provide viscosity to assist with suspension help mask particulates and increase the expected sensation of appropriate mouth feel. will be efficacious and viable for up to two years. Industry suppliers employ a range of sophisticated technology to assess rates of degradation and product preservation. Industry Innovations Capsugel Vcaps and Vcaps Plus capsules for probiotics--provide a distinct advantage over a standard gelatin capsule. Probiotics are sensitive to moisture. Normal HPMC has 4 to 6 percent moisture content at 50 percent relative humidity compared to 12 to 14 percent for gelatin. Vcaps and Vcaps Plus can better protect the probiotics from activating in the package and or before reaching the intestines where they are most effective for digestive health. DRcaps--capsules are low moisture vegetarian capsules with unique acidprotective polymer properties that slow down the capsule opening after swallowing. DRcaps capsules are a highly successful dosage delivery form for probiotics and enzymes as well as acid-sensitive sports nutrition ingredients. A&B Ingredients Pisane B9--a pea protein that does not harden over time in bars and baked goods. CytoGuard YM--natural extract from flaxseed and oregano can prevent mold growth and rancidity in bars baked goods and higher moisture items. Origanox--a natural antioxidant which can retard oxidation of lipids and lipid soluble nutrients. Extras That Support Stability Consumers who enjoy reading labels often see some extra things listed and quite a few question why they are included. Savvy brand marketers explain in literature or their websites that additives are there in the appropriate amounts to secure promised activity and potency throughout a shelf-life duration. For example Fruit d Or s cranberry seed oil can be added as a stabilizer for omega-3 ingredients such as fish oil Lukawski offered. It may also be able to replace synthetic tocophenols often used in soft gels as a true antioxidant. It may also enhance bio availability he added. According to Lowery additives are often incorporated to protect and preserve ingredients in packaging and transport for targeted release or to mask unpleasant tastes and odors. To address specific stability challenges of product delivery Capsugel innovated low-moisture polymers with unique properties for its vegetarian capsules as well as innovated structural features such as air-tight sealed capsules-within-a-capsule as part of its Licaps capsule technology. Capsugel provides additive-free capsules that address stability issues especially as the demand for clean label 48 Nutrition Industry Executive Fruit d Or Cranberry oil--can be used in soft gels to promote stability of other oils or ingredients that have a limited shelf life or poor absorption. TIC Gums Ticaloid Pro 410 and Ticaloid Pro 432--suspend fortifying ingredients in neutral dairy-based systems with varying levels of protein to optimize texture by building mouth feel while decreasing negative texture attributes and preventing sedimentation. Dairyblend Acidified Beverage 120--a system providing flexibility in acidified protein beverages such as drinkable yogurt. It also allows milk and fruit juice combinations to remain stable over an extended shelf life. Dairyblend Acidified Beverage 880F--can be used to stabilize the protein and fat in the beverage. May 2015 Testing Procedures Harking to Lukawski s earlier comment retailers want to know that the product Celebrating 20 Years of Excellence 1995-2015 Fruit d Or s cranberry seed oil is subjected to peroxide tests taste and odor in real time versus accelerated tests Lukawski said. These tests are conducted on every batch on a monthly basis. Bakal said that it is important to understand the finished product and packaging and to design tests to mimic worstcase scenarios. A&B Ingredients typically uses incubators and humidity chambers to perform accelerated tests on stability. BI Nutraceuticals said Gutierrez controls product stability by reducing the microbial load of the incoming raw material through the use of its steam sterilization process. Product moisture is then closely monitored throughout manufacturing to ensure that the ideal conditions for microbes to grow back are not created. Once the finished product is complete and stored under ambient conditions the product is generally stable well beyond its expiration dating. We have an ongoing product stability program where we have discovered that an ambient real-time study is best suited for our finished products he elaborated. Accelerated stability protocols which require higher temperatures and or humidity are often not indicate of real-life situations and can affect the product in ways not seen with the real time results. The higher temperature or humidity of the accelerated study can affect inherent moisture assay and even the stability of excipients. For example maltodextrin which is commonly used as a carrier in standardized extracts is often unstable due to its low melting point which causes the powder extract to morph into a solid sticky mass at the completion of the accelerated study. At TIC Gums said Grazaitis to ensure physical stability and shelf life of RTDs products are held and inspected for visual separation over a period of time. This is quantified using various analytical techniques to determine the rate at which sedimentation and creaming occur he explained. These techniques can include a combination of rheological backscattering transmittance and particle size measurements. For preserving life and activity of acidsensitive enzymes and probiotics Capsugel s DRcaps acid-resistant hydroxypropyl methylcellulose (HPMC) capsules were found in a scintigraphic in vivo study to be viable for ensuring stability according to Lowery. Data and images empirically demonstrated the capsules effective protection from early activation caused by stomach May 2015 acids and for a majority of study subjects complete release in intestines where products such as probiotics and enzymes work best she reported. More specifically the capsules began release in a mean time of 52 minutes after ingestion and when they were about the leave the stomach--a full 45 minutes later than an immediate release capsule. The capsules completely released the ingredients in a mean time of 72 minutes after ingestion and when most of the ingredients would most likely be in the intestines. Consumers expect that the supplements and nutra-beverages they purchase will hold up through reasonable time and deliver the activity promised on the label by the use by date. Stability indeed is a good thing. NIE FORMOREINFORMATION A&B Ingredients (973) 227-1390 Bi Nutraceuticals (973) 334-1633 Capsugel Fruit d Or Nutraceuticals (819) 385-1058 TIC Gums (800) 889-3953 Go to nutraceutix for info about this advertiser Celebrating 20 Years of Excellence 1995-2015 Nutrition Industry Executive 49 MarketingInnovations Engaging Customers With Video As companies who have turned to content-based marketing strategies have learned good storytelling is the key difference between successful campaigns and those that fail to find an audience. B Y T O D D PA U L I PA R T N E R S T R AT E G I C M A R K E T I N G T H E S H E LT O N G R O U P everal elements go into creating a good story an intriguing topic the right details and an engaging voice are all necessary for success. When planning a marketing strategy the method in which a story is told is also crucially important. For instance if an ingredient supplier wants to promote its high-quality products there are several ways to communicate the details. A simple paragraph on the company s website or a photo slideshow would technically convey the information but not necessarily create the emotional connection so important to building trust. Video is the most powerful way to fully engage the viewer in the specifics of producing quality products. Video possesses the rare ability to combine emotions with facts to build customer trust in a highly engaging visual way. Apart from standing in the supplier s field full of raw materials a short video clip interviewing growers on location along with a commentary about quality-focused practices is the best way to demonstrate the process of producing quality ingredients. Video provides the ability to quickly showcase the most important details of your business while providing viewers a vantage point for inspecting the details for themselves. The ability to drive audience engagement and bring them closer to an experience is one reason video has emerged S as the must-have medium for social channels and corporate sites alike. Both Facebook and Instagram recently worked to incorporate video directly into their users news feeds recognizing that video leads to higher levels of audience engagement. Understanding what users respond to has been central to those companies success and we can learn from them. company s reason for being in an emotional engaging way demonstrates the company s commitment and passion for what they produce. Placing a mission-focused video on your website s homepage communicates what sets the company apart much more effectively than a mission statement buried somewhere in the About Us section. Video Content Ideas for the Nutrition Industry For B2B marketers in the nutrition industry video is especially useful to demonstrate product quality and ideal for demonstrating the transparency that must be built into sourcing and producing products in today s marketplace environment. Unless you are strictly selling a commoditized product and price is the only differentiating factor building genuine loyalty-based customer relationships pay dividends in the long run. Videos can play a role by highlighting aspects of your company leadership and products that are more difficult to convey with other mediums. A few options for using video within an organization include Quality & Production Transparency is instrumental in demonstrating product quality. Short informative video tours showing the quality assurance process and the production standards an organization adheres to gives potential customers piece of mind with regard to product quality. This is particularly effective when they meet the people responsible for quality which video is ideally suited for. Meet the Founder CEO One tried-and-true marketing tactic used to establish company trust is the Letter from the CEO. Often found in longer print pieces and sometimes in the About Us section of a corporate website the piece seeks to showcase the thought leadership driving the company and the products it produces. While most site visitors won t take the time to read anything that remotely approaches letter-length video offers the chance to deliver the same content May 2015 Company Mission Especially for organizations in the nutrition industry a company s mission often begins with a very personal desire to improve peoples lives. Conveying the Celebrating 20 Years of Excellence 1995-2015 50 Nutrition Industry Executive while making the experience more personal for the viewer. Product Expertise Not every potential customer has the chance to meet directly with a lead scientist or product specialist to hear the technical details of what sets your brand apart. A quick feature covering the more highly specialized aspects of a product aimed at knowledgeable buyers has the ability to answer questions and intrigue potential customers as they conduct product research long before making the move to contact your sales department. Social Content If your brand is using social media and there are many social media strategies that work for B2B brands this is the place to show the company s personality just a bit more. Creating customer loyalty is partially about them getting to know the team and their dedication. Quick videos intended for social media can capture spontaneous moments in the office small wins with customers and even highlights of company initiatives that help make the organization a good social citizen. Sharing Events Anyone who has planned a presentation tradeshow event or customer education session knows the enormous amount of planning involved. Capturing great content at these events allows the effort to live on through web content as well as featured stories intended for a company newsletter or blog. Customer Features Testimonials Possibly the Holy Grail of marketing an appeal on your behalf by a customer is always better than a company representative touting the company s accolades. Video testimonials work best when they portray a case study or tell a story from the customer s perspective by highlighting real business situations and challenges. Have your customer tell the story of how you worked with them to resolve formulation challenges for example rather than your website just saying we ll help you with formulation challenges. Genuine details go much further in telling your story and building trust. Getting Started With Video The cost of entry with video can be a lot more affordable than it used to be with today s technology but emphasis on production quality is paramount. While large-scale video production can be expensive video content to support your May 2015 brand can also be an accessible marketing tactic that most brands can employ. Not all video work has to be outsourced. Whether video is outsourced to a professional or handled in-house depends largely on the intended audience and the topic. Creating a feature piece like a company brand story or product-focused promotional video will probably be best left to the experts. Short videos that require less editing like the content you ll film for your social sites are perfect for an internal team to produce. Quick highlights from a company tradeshow or office event are often more spontaneous and best captured on a smart phone with a decent video camera built in. A basic rule of thumb to follow is if the video will have a long-life on a company website professionally shot is the way to go. If the video will become part of an ever-evolving stream of social media content start shooting on your own. When it comes to those marquee pieces that you leave to a professional it s extremely important to interview potential agencies and review past work. Especially in the nutrition industry genuinely telling an authentic story should be the goal. No one likes to watch a cheesy corporate video full of overthe-top graphics and elaborate transitions between scenes. Instead look for a videographer that tells your story in a more documentary-style format. It s also a good idea to work with someone who has an understanding of the industry s regulatory structure to weave your quality message into the story within legal guidelines. The filming environment also plays an important role. Beyond the basics like limiting background noise and providing adequate light the setting can make a big difference in a video s effectiveness. For instance videos featuring company experts often work best when they re shot on location in the individual s work environment. Chefs look best in the kitchen and scientists are most authoritative in the lab. Almost no one looks convincing sitting at a conference room table and the setting triggers an immediate impulse to snore in the viewer. One additional consideration when filming a brand video is length. Digital audiences have short attention spans and generally speaking videos approaching the three-minute mark are usually in danger of being abandoned. Keep it short and concise or most viewers won t stick around. step is to publish it. Video services like YouTube and Vimeo are popular platforms allowing businesses to host videos and embed them directly into their sites. YouTube offers detailed metrics to keep track of audience views shares and even line graphs showing at what point in a video the audience tunes out. Tracking these metrics will help refine future videos and grow your audience. In addition to embedding a new video in your company website you will want to promote it to your entire brand audience. Knowing that video is one of the most engaging types of marketing content linking to a new video from an email newsletter and social media sites will boost audience participation in those channels. Links to brand story videos are also the perfect follow-up for tradeshow leads because they will reconnect the viewer with your company while providing a more detailed overview. Also a well-produced brand video doesn t just have to live on your own website. With the recent industry focus on transparency in the supply chain and clean label initiatives there is a tremendous opportunity for sharing marketing content through the supply chain to transparently display the benefits and quality of the products you are marketing. With supplement manufacturers constantly looking for good content to keep their consumer-focused social media channels active ingredient suppliers have an opportunity to share video content with manufacturers to help illustrate ingredient purity. Particularly in today s challenging media environment speaking directly to customers via video can be a powerful tool in building and maintaining customer trust and loyalty. NIE The Shelton Group is a boutique public relations and marketing agency working exclusively in the dietary supplements and natural products industry since 1990. Todd Pauli works with clients to develop comprehensive marketing strategies that integrate social media advertising and content marketing. Prior to joining The Shelton Group Pauli led marketing communications efforts for several well-known businesses including NOW Foods one of the largest supplement manufacturers in the natural channel. Nutrition Industry Executive 51 Putting Video to Work Once you ve produced a video either internally or using an agency the next Celebrating 20 Years of Excellence 1995-2015 FunctionalFoods Health rink and bar manufacturers are becoming more conscious about health and nutrition information on their labeling and providing options for their customers with functional ingredients that are packed with antioxidants high in protein and trans-fatfree explained Elyse Lovett MS MBA marketing manager for New York-based Kyowa Hakko USA. Consumers are reaching for those products in stores that define the best health benefits. When reaching for a drink or bar option they tend to ask themselves how will this improve my health What are the benefits in this for me Consumers love to see heart-healthy energyboasting and immune-fighting ingredients in their drink and bar options she continued. With the focus on healthy ingredients it is important to consider the guidance that distinguishes liquid dietary supplements from beverages by the Food and Drug Administration (FDA) Beverages are conventional foods under the FD&C (Federal Food Drug & Cosmetic) Act. Even when the label of a product characterizes it as a dietary supplement the product may not in fact be a dietary supplement. Products in liquid form can be repre52 Nutrition Industry Executive One of the most challenging issues with combination products is being able to include therapeutic levels of key ingredients while keeping the daily serving of tablets Clear labeling and healthier ingredients or capsules to a minimum Cheers to -- Marci van are the must-haves for functional foodsder Muelen National Sales Manager Nordic Naturals and beverages. By Cristina Goodwin D sented as conventional foods as a result of factors such as their product or brand name packaging serving size and total recommended daily intake (i.e. the volume in which they are intended to be consumed) composition recommendations and directions for use statements or graphic representations in labeling or advertising and other marketing practices. In regard to labeling manufacturers are focusing on making theirs more understandable for the consumer. The move from clean to clear labeling is a key trend for 2015 reflecting a move to clearer and simpler claims and packaging for maximum transparency said Lu Ann Williams director of innovation at Innova Market Insights (The Netherlands). But it is apparent clear labels are an area that need improvement. In a 2014 poll by industry representatives--discussed at Innova Market Insights Top 10 Trends webinar-- results showed that 42 percent of respondents said that Clean to Clear Label was at the top of the 2015 totem pole. Functional beverages are currently considered unclear and need clarity and detail when describing the vitamins and minerals in the drink. Celebrating 20 Years of Excellence 1995-2015 Interest in Safety The functional beverage market continues to explore new ways to supplement ingredients that may be considered harmful or too sugary. According to Sid Hulse director of new product development for New Jersey-based PLT Health Solutions These days the blood sugar impact of foods and beverages is on everyone s mind--from the mom who avoids giving her children beverages that cause a sugar spike and wants foods that help maintain a healthy weight for herself to the athlete who wants peak performance or the person trying to manage their blood sugar health. The company gives manufacturers the option to include natural antioxidants minerals and polyphenols which make up PLT s patented ingredient Benecarb. The ingredient has been shown to reduce the glycemic index (GI) of foods and beverages up to 20 percent at additional levels of 4 to 6 percent of total carbohydrate content. The company s Benecarb Glycemic Balance Complex based on molasses phytonutrients allows beverage companies to create products that address the lifestyle and health concerns of a broad range of consumers via blood sugar management. In May 2015 tion to supporting healthy blood sugar the newly released GI ingredient helps to support the liver essential when consuming alcohol. Hulse said it is a win-win for product manufacturers and consumers. At New Jersey-based Beneo the company provides manufacturers with two condition specific ingredients for functional food and drink. Beneo s Palatinose ingredient can be used in sports and energy beverages carbonated drinks wellness drinks ice tea enhanced fruit juices enhanced water and drinkable yogurts as well as nutritional and cereal bars noted Joe O Neill president and general manager with the company. Palatinose is also a tooth-friendly carbohydrate derived from sugar beet. Beneo s Orafti high performance inulin and oligfructose prebiotic fibers are non-digestible carbohydrates derived from chicory root and can be used to enrich the fiber content of a wide range of food and drink products O Neill said. In addition to adding fiber to products it can also reduce the fat or sugar content without jeopardizing taste and or texture. Lovette agreed that performance ingredients are evolving quickly such as Kyowa Hakko Bio s combination of the amino acids l-glutamine and l-alanine. Kyowa Hakko Bio manufactures the only stable GRAS (generally recognized as safe) form of glutamine Sustamine lalanyl-l-glutamine she said. According to Lovette one trend followed by many manufacturers is incorporating proteins in beverages. Sustamine is a prime ingredient to provide the body with L-glutamine-- an important amino acid for stimulating muscle protein synthesis and Lalanine--an amino acid needed for rebuilding the body s glycogen stores. Other examples include ingredients that benefit the cognitive health area such as a personalized smart bar eaten right before a workout to stay focused. Kyowa Hakko Bio manufactures Cognizin Citicholine which has been clinically studied to provide three primary brain health benefits sustained mental energy enhanced focus and health memory function she said. alternatives. Wisconsin-based Wixon offers Mag-nifique Bitterless National Brand Single Use Energy Water Enhancer available in black cherry to improve flavor and inherent bitterness in juices. Blue California manufactures a water-soluble functional enhancer with its SolQ10Blue formulated with CoQ10--essential for efficient cellular energy metabolism and synthesized naturally by healthy individuals. This microencapsulated ingredient is soluble in cold water a super antioxidant is essential for cell energy has enhanced bioavailability and contains no emulsifiers. smoothie flavors Amazing Cacao Merry Mango Blissful Berry and Chocolately Cheer. NIE Masking Development Smoothenol 2G line of ingredients by Wisconsin-based Sensient Flavors enhances the palatability of beverages by masking undesirable off-notes and modifying the consumer sensory perception commonly associated with sweeteners caffeine alcohol vitamins and minerals nutraceutical and functional ingredients. It works by covering up the aftertaste without compromising performance or resorting to artificial additives. The company stated that this line provides formulators with an effective solution to issues ranging from chalkiness to bitterness to astringency to alcohol burn along with other negative taste attributes. The masking technology blocks multiple receptor sites and inhibits the transmission of a signal to the brain. The Smoothenol 2G line was developed using advanced knowledge of receptors and ligand design offering formulators the flexibility of customizing the optimal masking solution while simultaneously maintaining an all-natural label said David Bom technology development manager at Sensient Flavors. Yesterday s masking technologies were based on a singlecompound approach that we now know is at odds with the reality of taste receptors. Smoothenol 2G incorporates custom blended ingredients BitterFix masks the wide variety of negative flavors associate with natural and artificial sweeteners AstringentFix smooth the dry mouth feel caused by tannins in fruit tea and red wine FunctionalFix reduces metallic and chalky off-notes caused by added proteins omega-3s vitamins and minerals BurnFix technology masks the perception of alcohol burn in spirits SourFix soften sour notes associated with citric acid and acidulants in lemonade and citrus-flavored drinks. Smoothies Florida-based Agro Innova formulates its South American Cacao Pulp Fruit Smoothies with nutrient-rich pulp of the cacao plant which was once used exclusively by communities that harvest the fruit but are now of interest to health-conscious Millennials and Baby Boomers. CEO Joseph Montgomery a seventh generation cacao farmer and his production team are now able to gently and efficiently extract cacao pulp from fresh pods to create a new delicious fruity functional beverage using state-of-the-art technologies to bring this South American line of cacao pulp-based fruit smoothies to the market the company noted. Agro Innova s Suavva brand prepares beverages by separating the pulp from the seed with a unique patented process. It offers a new ingredient profile to the juice category for consumers who recognize that cold pressed juice can benefit their health when incorporated into a daily routine. According to Suavva cacao pulp contains certified antioxidant activity as well as several vitamins and magnesium all of which are maintained using high pressure processing (HPP). The naturally occurring theobromine in cacao pulp allows Suavva to live up to its tagline energizing happiness through an all-natural energy-providing compound which may also reduce blood pressure. The company referenced a study by Mintel Group which reported that the sales of ethnic products in grocery stores would grow more than 20 percent between 2012 and 2017 with fruit flavors being essential. With this in mind the company offers four juicy Celebrating 20 Years of Excellence 1995-2015 FORMOREINFORMATION Water Enhancers Water enhancers are also making their way into the functional beverage category--many of which seek to replace sugary energy drinks with healthier May 2015 Agro Innova (954) 384-3090 Beneo (973) 867-2140 Blue California (949) 635-1991 Kyowa Hakko USA (800) 596-925 PLT Health Solutions (973) 984-0900 Sensient (800) 558-9892 Wixon (800) 841-5304 Nutrition Industry Executive 53 Equipment&Packaging Process Premier ProcessPro (St. Cloud MN) announced the release of its newest version of its software Premier 10.5. Premier 10.5 features new versatile and user-friendly updates to the customer service role using increased flexibility and improved functionality in sales order management customer management and customer item management which were all designed to streamline process and save time. In addition the technology has improved reporting added flexibility and more. For more information call (800) 457-3548 or visit Pick and Place Infeed Minnesota-based Douglas Machine Inc. has eliminated more than 30 star wheel change parts and manual adjustments points with their robotic pick-and-place infeed reducing changeover by 20 minutes for single-serve cup applications. The new dual Fanuc M-3iA Delta robots integrated with Douglas Vectra cartoner require no change in capital investment while gaining valuable production time. The new technology allows for greater machine access improved sanitation and increased machine efficiency. For more information call (320) 763-6587 or visit Advertiser Index Applied Food Sciences. Inc. Biova LLC Certified Nutraceuticals Fuji Health Science Inc. Healthco Herbally Yours IgY Nutrition LLC J.G. Pizzey Inc. Jiaherb Inc. Kyowa Hakko USA Natreon Inc. Neptune Tech & Biosources Nutraceutix Inc. Nutragenesis Nutritional Engineering Inc. PLT Health Solutions Inc. Sabinsa Corporation Saybrook University Soma Labs Inc. Uckele Health & Nutrition United States Pharmaceopea 30 7 31 25 1 9 21 17 5 11 15 C3 49 19 12 3 C2 13 14 10 C4 (512) 732-8300 (877) 682-2673 (951) 600-3899 (877) 385-4777 (800) 477-3949 (480) 892-8220 (888) 998-3763 (204) 773-3532 (888) 542-4372 (212) 319-5353 (732) 269-1080 (888) 664-9166 (425) 883-9518 (802) 257-5345 (760) 599-5200 (973) 984-0900 (732) 7 7 7 - 1 1 1 1 (509) 822-4024 (732) 271-3444 (800) 248-0330 (301) 230-6361 afs biova certifiednutraceuticals fuji healthco herballyyours igy jgpizzey jiaherb kyowa natreon neptune nutraceutix nutragenesis nutritional plt sabinsa saybrook somalabs uckele usp Industry Events May 5-7 Vitafoods Europe Palexpo Geneva Switerland October 5-9 SupplySide West Mandalay Bay Expo Hall Las Vegas NV (866) 230-2311 54 Nutrition Industry Executive Celebrating 20 Years of Excellence 1995-2015 May 2015 SupplieroftheMonth Jacqueline Khayat Neptune Technologies & Bioressources Inc. Headquarters 545 Promenade de Centropolis Ste. 100 Laval QC Canada H7T 0A3 Phone (450) 687-2262 Fax (450) 687-2272 Website Founded in 1998 Neptune RD Gd Technologies & Management Bioressources Inc. oil industry creating a new generation of pioneered the krill Sales Director superior omega-3 polyunsaturated fatty acids. Based in Laval QC Canada Neptune manufactures Neptune Krill Oil (NKO) and three condition-specific blends targeting heart and circulation vision and brain health and joints and flexibility (NKO Beat NKO Focus and NKO Flex). Neptune is a Friend of the Sea for its sustainable krill harvesting practices in the Antarctic Ocean. Serving as sales director Jacqueline Khayat s role includes expanding distribution for Neptune s line of products and ingredients among its strong customer base in North America as well as identifying potential business opportunities within Asia Europe South America and the Middle East. She also oversees the sales team and related processes collaborating with marketing to enhance Neptune s customer relationships. NIE Neptune recently launched NKO Focus NKO Flex and NKO Beat. What do these introductions mean for the brand s expanding portfolio Khayat As an innovation leader Neptune realized the opportunity to create nutrient synergies by combining its proprietary krill oil NKO to other beneficial natural ingredients. After extensive research Neptune launched the three clinically proven condition specific formulations. Each formula provides NKO plus a carefully chosen blend of essential vitamins and minerals that provide additional support targeted to specific health goals. These blends are supported by clinical studies which demonstrate that NKO is capable of enhancing the uptake of nutrient powerhouses vitamin D lutein and CoQ10. Neptune has proven its strong research and development capabilities and can take this expertise further by continuing to discover unique blends and synergies backed by strong science. With these innovative offerings and a fast growing consumer base looking for targeted health and wellness products Neptune is in a solid position for growth. strong industry connections. Throughout his career working in the United States Europe he has lead the development manufacturing marketing and sales of dietary supplement food animal feed and personal care products. He is also the immediate past chairman of the Board of Directors of the Council for Responsible Nutrition (CRN) the dietary supplement industry s leading trade association. Jim has a vision of success for Neptune with a proven track record for driving business excellence he will be able to lead Neptune into its next phase of growth and development. NIE Why did Neptune decide to relaunch its website How will it help expand the company s global vision Khayat From the headquarters in Montreal Canada we are expanding Neptune s global vision for the numerous and variety of cultures that could benefit from NKO the Original Krill Oil. To accommodate various nationalities and emerging global markets the Neptune website is now available in English French Spanish and Mandarin. We are experiencing growing demand for NKO in several regions around the globe including South America Asia and Europe. One of my top goals is to educate the world distributors and their business about the potential NKO has on human health. NutraSciences to help bring a new shrimp oil to market. Why did the company decide to support BlueOcean and what benefits does shrimp oil offer Khayat Shrimp oil a new marinederived omega-3 source is coming to the market soon thanks to the cooperative efforts of--ironically--two competitors. With a mutual objective of broadening the omega-3 category Neptune agreed to license its patented composition and extraction methods to BlueOcean NutraSciences to help bring the new shrimp oil to the masses. Neptune is a true innovator above and beyond Neptune respects and supports companies wishing to produce safe and efficacious marine nutraceuticals. On the other hand BlueOcean immediately recognized the superiority of Neptune s process and the advantage of Neptune s patents. NIE Neptune rebuilt and reopened its Sherbrooke plant last June. What capabilities does it have Khayat Neptune s new state-ofthe-art plant is able to produce a minimum of 150 metric tons of krill oil annually and is equipped to be able to double its capacity. The new facility features robust safety measures and technologies for optimized manufacturing. It also benefits from equipment upgrades and new manufacturing practices. At the same time we have opened a cutting edge laboratory dedicated to research product development and internal quality analysis. May 2015 NIE Jim Hamilton has taken over as the new president and CEO of Neptune. What will he bring to the company as it moves forward Khayat Jim s vast expertise and over 30 years of industry experience allows him to have a deep understanding of the nutraceutical market and 56 Nutrition Industry Executive NIE Neptune has agreed to license its patented composition and extraction methods to BlueOcean Celebrating 20 Years of Excellence 1995-2015 Go to neptune for info about this advertiser Go to usp for info about this advertiser