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Description: In This Issue: Blood Sugar Support, Supply Innovation, Botanical Extracts, and EFAs

A VRM Media Publication December 2018 www.niemagazine.com Don t miss a single issue of NIE go online to renew your free subscription today NIEmagazine.com December18 Go to www.niemagazine.com sabinsa for info about this advertiser Go to www.niemagazine.com nowpl for info about this advertiser Proud Supporter of TableofContents VOLUME 23 NO. 9 DECEMBER2018 F E A T U R E S 30 Blood Sugar Support Consumers look for the most effective supplements to maintain healthy blood sugar levels. 36 EFA Essentials As consumers become more educated ingredient suppliers and manufacturers must create products that address their concerns. 45 Supply Innovation NIE has given companies an opportunity to highlight their latest most innovative offerings. C O L U M N S 4 First Word 39 Nutraceuticals 6 Legalities 42 Functional Food 42 30 A L S O I N S I D E 12 Industry News 18 Ingredient News 25 Association News 29 Science Update 53 Conventions & Meetings 54 Equipment & Packaging 55 Advertiser Index 55 Industry Events 56 Supplier of the Month FREE Subscription (Print Digital or BOTH) & E-newsletter Available www.niemagazine.com Copyright 2018. Nutrition Industry Executive (ISSN 2331-2602) Volume 23 Number 9 December 2018. Nutrition Industry Executive is published monthly (except for bimonthly January February and July August and October November) by VRM Media 431 Cranbury Road Suite C East Brunswick NJ 08816 USA Phone (732) 432-9600 Fax (732) 432-9288. All rights reserved including the right to reproduce in whole or in part. Not responsible for unsolicited material. Opinions expressed in by-lined articles or advertisements are not necessarily those of Nutrition Industry Executive or its owners. Publisher is not liable for advertiser product claims or representations. Advertisers assume total responsibility for the contents of their advertisements. Printed in U.S.A. Basic annual subscription rate is 50.00. Periodicals Postage Paid at East Brunswick NJ 08816 and additional mailing offices. POSTMASTER Send address changes to Nutrition Industry Executive P.O. Box 15026 North Hollywood CA 91615-5026. Subscription Customer Service Nutrition Industry Executive P.O. Box 15026 North Hollywood CA 91615-5026 USA Phone (818) 286-3170 Fax (800) 869-0040 niecs magserv.com www.niemagazine.com. Back Issues & Single Copies For order information contact (732) 432-9600 or info niemagazine.com. March issue is 25.00. All other issues are 8.00 each. 2 Nutrition Industry Executive www.niemagazine.com December 2018 Go to www.niemagazine.com gcinutrients for info about this advertiser FirstWord See Change he view outside was a sight to behold the beautiful and dramatic Laguna Niguel on the California coast with cliffs overlooking the Pacific Ocean. Inside the RitzCarlton during CRN s (Council for Responsible Nutrition) The Workshop and The Conference the discussions may have been a little less awe-inspiring but certainly noteworthy nonetheless. Held in mid-October with the theme See Change the educational programs covered substantial industry hot-button topics blockchain technology and how it might disrupt supply chain management prevention of product adulteration the status of CBD the hottest ingredient currently to hit the natural product market among others presentations by Dean Ornish MD and Jon Meacham and the keynote from Steven Tave director Office of Dietary Supplement Programs U.S. Food and Drug Administration (FDA). Regarding the latter during his talk I couldn t help but observe how much the relationship between the FDA and the natural products industry has improved over the last five to 10 years. According to an informal poll taken at the conference most other attendees (an impressive group of high-level natural industry professionals) agreed with me. It doesn t seem all that long ago that meetings with FDA at SupplySide and other conferences were somewhat tense affairs with defensive-tinged questions asked by natural industry members and some finger wagging from the FDA officer over a perceived lack of GMP (good manufacturing practice) standard preparation or some other similar offense. Time has passed things change and pressures have eased. Now it s safe to say industry and FDA are on the same page especially regarding irresponsible outliers trying to make a quick buck in the supplement T market with no regard to safety. All agree they hurt the natural products industry and outing them is a priority. Publisher Daniel McSweeney Editorial Director DanM VRMmedia.com Associate Russ Fields Publisher RussF VRMmedia.com Mandatory Listing Advertising Barry Young Another topic that created buzz amongst Sales Manager Barry VRMmedia.com attendees began with an update on the status of CRN s Supplement OWL by the trade Editor-in-Chief Janet Poveromo JanetP VRMmedia.com associtation s President and CEO Steve Mister. Companies industry-wide have subManaging Editor Shari Barbanel mitted their product information to the dataShariB VRMmedia.com base and currently more than 10 000 labels are listed. This benefits natural product retailAssociate Editor Nicholas Saraceno ers especially with the promotion of the NicoS VRMmedia.com retailer-focused Commercial Data Exchange (CDX) formerly known as Tier 2 (see news Art Director Robert Certo item on page 28) manufacturers suppliers consumers and potentially the FDA s office of Production Manager RobertC VRMmedia.com Dietary Supplements. Production Assistant Bryan Zak The discussion led to the question Graphic Designer BryanZ VRMmedia.com Should there be mandatory product listing for dietary supplements In fact Scott Bass Circulation Manager Rosie Brodsky partner with Sidley Austin and Anthony Rosie StarkServices.com Young Partner Kleinfeld Kaplan & Becker led a debate on the topic. They argued would a mandatory listing A PUBLICATION OF stop outliers Would it prevent innovation VRM MEDIA Do we need it if the Supplement OWL is working Would FDA be able to make this President meaningful to companies that don t comply Daniel McSweeney And here s what surprised me in another one of those informal polls taken at the VRM Media event the consensus was yes product list431 Cranbury Road Ste. C ings should be mandatory for dietary suppleEast Brunswick NJ 08816 ments. It seems rather than wait for possible demands by the government or other outPhone (732) 432-9600 siders many industry members prefer a Fax (732) 432-9288 strong offense. And as the theme of the event hinted we may see that change. Email info VRMmedia.com Website www.niemagazine.com Season s Greetings Back home in New Jersey the staff of VRM Media would like to wish our readers a very happy and healthy holiday season. And here s to a productive and prosperous New Year VRM Media publishes Nutrition Industry Executive Vitamin Retailer Natural Practitioner and Fitness Trainer magazines. VRM Media is a proud member of Connect With Us Proud Supporter of Vitamin Angels www.twitter.com vitaminretailer www.facebook.com vitaminretailermagazine 4 Nutrition Industry Executive www.linkedin.com company vrm-media www.instagram.com www.pinterest.com vitaminretailermagazine vrm_media go.vrmlink.com youtube www.niemagazine.com December 2018 Go to www.niemagazine.com jiaherb for info about this advertiser Legalities By Steven Shapiro Esq. t seems that we spend so much time thinking about the product that goes inside the bottle or box that we sometimes give very little thought to the package itself. There are several issues concerning product packaging that deserve your attention including the question of whether the container itself is potentially misleading. The possibility of a consumer class action alleging that your company s products are being sold in misleading containers (food companies of all types have been targeted) is real. The U.S. Food and Drug Administration (FDA) defines a misleading container as one that does not allow the consumer to fully view its contents if it contains nonfunctional slack-fill. 21 CFR 100.100(a). Slack-fill is defined as the empty space in a package that is filled to less than its capacity. Not all slack-fill however is necessarily a problem. There are per- I 6 Nutrition Industry Executive fectly legitimate reasons why a container might include some amount of empty space which is why the law recognizes a number of exemptions for the inclusion of functional packaging slack-fill. Issues arise when the slack-fill is determined to be non-functional. Under the Federal Food Drug and Cosmetic Act slack-fill is considered nonfunctional if it does not meet one of the listed exemptions set forth in 21 C.F.R. Section 100.100 these are 1) protection of the contents of the package 2) requirements of the machinery used for enclosing the contents 3) unavoidable product settling during shipping and handling 4) instances where the package performs a specific function in the preparation or consumption of the product where such function is inherent to the nature of the food and is clearly communicated to consumers 5) food packaged in a reusable container where the container is part of the presentation of the food and has value which is both significant in proportion to the value of the product and independent of its function to hold the food (e.g. a gift product with a container intended for further use after the food is consumed or durable commemorative or promotional packages) and 6) when there is an inability to increase the level of fill or further reduce package size (e.g. where some minimum package size is necessary to accommodate required food labeling excluding any vignettes or other nonmandatory designs or label information) to discourage pilfering facilitate handling or to accommodate a tamper-evident system. Enforcement Despite the existence of the regulation it appears that FDA has never actually undertaken enforcement action of any kind against any company or individual involving an allegation of non-functional www.niemagazine.com December 2018 Go to www.niemagazine.com minerallogic for info about this advertiser Legalities slack-fill. This apparent lack of FDA enforcement however has not stopped potential plaintiffs from filing numerous class action complaints in courts across the country concerning a vast array of food products. In these cases the FDA regulation is frequently at issue because even while there is no private right of action to enforce FDA regulations if the defendant can demonstrate compliance with the aforementioned FDA regulation the lawsuit would almost certainly be preempted. In addition to the FDA many states also prohibit the use of misleading containers. For example under New York state law [f]ood shall be deemed to be misbranded [i]f its container is so made formed colored or filled as to be misleading. N.Y. Agric. & Mkts. Law 201(4). On September 19 2018 California amended its own slack-fill law (A.B. 2632 Chapter 544) https leginfo.legislature.ca.gov faces b illTextClient.xhtml bill_id 201720180AB 2632 to include the following additional exemptions when the dimensions of the product or immediate product container are visible through external packaging when there is a clear and conspicuous depiction of the actual size of the product or immediate product container on the exterior package (except on the bottom) when there is a line or a graphic that represents the product or product fill showing the minimum amount of the product (fill line after maximum settling) or when the mode of commerce does not allow the consumer to view or handle the physical container or product. (This last exemption almost certainly refers to mail order situations where a consumer would not be able to physically examine the product prior to purchase). It remains to be seen how the new California exemptions will interact with the FDA regulation should the agency ever decide to commence a slack-fill enforcement action or how the new California exemptions might be referenced by companies seeking to defend consumer class actions brought in states other than California. An example of functional slack-fill would seem to be the inclusion of air in a bag of potato chips. The purpose of the air is to keep the bag fluffed so it is not crushed during shipping pulverizing the potato chips within. Of course an action was brought against a potato chip company questioning the amount of air included in the company s bags 8 Nutrition Industry Executive Alce v. Wise Foods Inc. 1 17-cv-02402NRB (S.D.N.Y.). The court ultimately granted defendant s motion to dismiss plaintiffs First Amended Class Action Complaint in a decision dated March 27 2018 which discussed the difficulty the plaintiffs faced in factually establishing that empty space in a package is truly nonfunctional. The plaintiffs arguments primarily relied on a comparison of the amount of empty space contained in packages of various brands of potato chips to demonstrate that Wise Foods had an excess amount of air (nonfunctional slack) when compared to the other brands. The court noted the Plaintiffs have not demonstrated with factual assertions that the slack-fill in the products is unnecessary to protect the chips or does not reflect the requirements of the machines used for enclosing the packages or is not the result of unavoidable product settling or is not the consequence of an inability to increase the level of fill or to further reduce the size of the package. Even though many slack-fill cases have been brought fortunately most have been dismissed on motion by the defendant companies. The following examples demonstrate some of the issues that the plaintiffs have in trying to state a viable cause of action against a company for nonfunctional slack-fill. On December 12 2016 a federal judge granted the company s motion to dismiss in Bautista v. Cytosport Inc. (15CV-9081 (S.D.N.Y.) a slack-fill case concerning containers of Muscle Milk protein powder. According to the court s decision the plaintiff had expected the opaque container to be full and was surprised and disappointed when he opened it to discover that it contained roughly 30 percent of empty space. The court ultimately dismissed the case because despite the opportunity to file an amended complaint all the plaintiff alleged as the court noted in the same conclusory fashion was that the 30 percent empty space was not used to protect product necessary for enclosing the product or because of settling. But he provides no facts rendering that conclusion plausible. So an obvious hurtle for any plaintiff in attempting to bring a slack-fill case is how he or she will be able to establish in the first instance that any slack-fill in a product container is non-functional. One must remember that it is an obligation of a plaintiff to establish a prima facie cause of action before it is the obligation of the defendant to defend the allegations. Typically accurate statements of net contents have not served as a defense to a slack-fill case but this may be in the process of changing. Although it involved a drug product a very instructive decision about slack-fill and bottles of pills tablets or capsules is Fermin v. Pfizer 1 15-cv-02133-SJ-ST (S.D.N.Y. October 18 2016). This lawsuit involved allegations of slack-fill concerning various size bottles of Advil. In its decision the court noted that while each package clearly displayed the total pill-count on the label Plaintiffs and the members of the Class did not rely on the labeling specifying the number of ibuprofen pills in the products but rather relied on the sizes of the packaging and dispensing bottles which led them to have an expectation that the entire volume of the packaging would be filled to capacity with pills. The court continued Plaintiffs provide no basis for disregarding the clearly stated pill-counts on the labels nor do they dispute the fact that the tablet-count is clearly and prominently displayed on each of the labels. Plaintiffs own exhibits show that the labels plainly negate any supposed reliance on the size of the packaging as it is impossible to view the products without also reading the total number of pills contained in each package. (Internal citations omitted). The court concluded It defies logic to accept that the reasonable consumer www.niemagazine.com December 2018 Go to www.niemagazine.com captisol for info about this advertiser Legalities would not rely upon the stated pill count. Plaintiffs cannot show that they did not receive the total number of pills listed in each package and admit as much. This court finds as a matter of law that it is not probable or even possible that Pfizer s packaging could have misled a reasonable consumer. Plaintiffs seek to be protected under packaging laws but to dispense with reading the package. The suggestion that such laws should cover their failure to read an unambiguous tablet-count does not pass the proverbial laugh test. In sum plaintiffs claims amount to non-actionable puffery and are unreasonable as a matter of law. (Internal citations omitted). Finally in a very recent decision Daniel v. Tootsie Roll Industries LLC 1 17-cv-07541-NRB (S.D.N.Y. August 1 2018) involving boxes of Junior Mints candies alleged to have significant slack-fill a federal district court judge dismissed the case because the plaintiffs did not allege reasonable reliance on the size of the packaging alone. In other words according to the Court a person of ordinary intelligence could easily ascertain the amount of candy contained in the prod- 10 Nutrition Industry Executive uct boxes by 1) inspecting the net weight printed on the front and 2) multiplying the serving size by the number of servings in the box as provided on the back. Moreover reliance is even less justified given that consumers may have come to expect significant slack-fill in [Junior Mints] and other snack products. (internal citation omitted). An appeal of this decision is pending before the Second Circuit Court of Appeals so this will be something interesting to re-visit. Avoid a Problem So what is the bottom line concern for your company Even if many of these slack-fill cases are being dismissed the cost of defending a federal court litigation can be substantial and best avoided if possible. Attempt to take an unbiased look at your packaging. Will a consumer in opening the package find something or a lack of something that may make them feel cheated Those are the people that are most likely to seek compensation. If you are using external and immediate containers such as a bottle or tube in a box does the interior container reasonably relate in size to the outer package Is the external packaging even necessary If there is a significant amount of empty space in the package is there a valid and obvious reason If a consumer understands the reason perhaps they will be less motivated to have a justification to complain. Can the package be made see through in some fashion to allow a consumer to see the contents at the point of purchase The expanse associated with applying each of these questions to your products packaging will be well worth the investment if it keeps you out of court and away from the debate over whether the consumer acted reasonably when relying solely on size of your product packaging in making a decision to purchase. NIE Steven Shapiro is of counsel to Rivkin Radler LLP (rivkin.com) and a partner of Ullman Shapiro & Ullman LLP (usulaw.com). His practice focuses on the dietary supplement natural products industries with a particular emphasis on FDA and FTC compliance issues including labels labeling and advertising claims. www.niemagazine.com December 2018 Go to www.niemagazine.com innovactiv for info about this advertiser IndustryNews New Fish Oil Vitamin D Studies Focus on Who Benefits ig studies on fish oil and vitamin D offer suggestions on who does and does not benefit from these popular nutrients. Results were revealed on November 10 at an American Heart Association conference in Chicago IL and published by the New England Journal of Medicine in a study titled The Vitamin D and Omega-3 Trial (VITAL). The Associated Press (AP) reported that the study found fish oil taken by healthy people at a dose found in many supplements showed no clear ability to lower heart or cancer risks same for vitamin D. But higher amounts of a purified prescription fish oil slashed heart problems and heartrelated deaths among people with high triglycerides a type of fat in the blood and other risks for heart disease. Doctors cheered the results and said they could suggest a new treatment B option for hundreds of thousands of patients like these the AP added. According to Duffy MacKay ND senior vice president scientific & regulatory affairs Council for Responsible Nutrition (CRN) other promising results also stood tall. While early news coverage has focused on topline results CRN is encouraged by several very positive findings showing benefits of omega-3 and vitamin D supplementation in additional analyses Almost a 30 percent reduction in heart attacks in the fish oil group compared with placebo. A 40 percent reduction of heart attacks in fish oil groups who had less than 1.5 servings of fish per week with even more dramatic impacts among African-Americans. Reduction in the rate of cancer deaths two or more years later in peo- Innovation Outpaces Regulation in FDA Probiotics Labeling Guidance n formal comments to the U.S. Food and Drug Administration (FDA) the Natural Products Association (NPA) recently said that supplement labeling regulations regarding probiotics are obsolete and ineffective and that the government s recent guidance falls short as a remedy to the problem. NPA s comments are in response to the FDA s new draft guidance titled Policy Regarding Quantitative Labeling of Dietary Supplements Containing Live Microbials Draft Guidance for Industry. This is an example of innovation outpacing regulation. The current labeling regulations for probiotics need to be updated to reflect the new innovative products consumers are demanding said Daniel Fabricant PhD president and CEO of NPA. Consumers should have access to products with clear labels that convey useful information about the product to guide their decision making. FDA s current labeling laws allow for unscrupulous companies to fly under the radar and sell probiotics with no viable microbial ingredients in the product. We look forward to working directly with the FDA towards a solution that communicates meaningful I 12 Nutrition Industry Executive information to consumers. NPA specifically took issue with the way the FDA requires live probiotic supplements to be measured in metric units instead of colony formation units or CFUs. CFUs provide a more accurate serving level for consumers because live activity is taken into account. Using metric units on probiotic supplement labels does not make regulatory sense for dietary ingredients in which activity is an essential parameter to convey to consumers said NPA. NPA noted that the reasonable consumer has an expectation that microbial ingredients in probiotics are alive and that CFUs are widely accepted in the scientific community and are consistent with international accepted definitions of probiotics as live microorganisms. For more information visit www.npanational.org. ple who took vitamin D. The study reaffirms the safety of both vitamin D and omega-3 fatty acids and does not change decades of research showing how critical vitamin D and omega-3 supplementation are for overall health Vitamin D a nutrient of public health concern plays an important role in bone health immune function and maintaining cardiovascular health in adults. Omega-3 is essential to cardiovascular health prenatal health and cognitive health. These findings are promising and CRN looks forward to ancillary studies that are expected to be published from this impressive data collected on over 25 000 participants. Passina Sells Dutch Operations to D hler Group hler Group (Germany) and Passina Group (The Netherlands) have reached an agreement on the acquisition of Concentra Europe BV with its Dutch and German subsidiaries by D hler Group. The proposed transaction has now been filed with the relevant antitrust authorities and is conditional upon their approval. This transaction marks a step where customers will benefit from a more complete offering and improved efficiency of the combined businesses in a global market that is characterized by volatility as well as the challenges and opportunities of supply and demand. D hler Group and Passina Group believe that this step has created a path toward further growth in the market while simultaneously strengthening their respective positions specifically as reliable suppliers of tropical and natural plant-based ingredients for the global food and beverage industry. Concentra Holding AG owner of the brand name Passina will focus its future activities on its core business the production and commercialization of passion fruit products including passion fruit juices concentrates and derivatives. For more information visit www.doehler.com or www.passina.com. D www.niemagazine.com December 2018 Glanbia plc to Acquire Slimfast lanbia plc (Ireland) the global nutrition group has signed an agreement with the owners of KSF Holdings LLP (Dallas TX) and HNS Intermediate Corporation (Richmond TX) who collectively own SlimFast and other brands to acquire such entities for 350 million. SlimFast is a leading weight management and health and wellness brand family distributed primarily in the food drug mass and club (FDMC) channel in the U.S. and U.K. It is a well-established and growing G brand with high levels of brand awareness in the U.S. its largest market. In 2017 SlimFast delivered 212 million net sales adjusted EBITDA (before non-recurring costs) of 24 million and after non-recurring supply chain transition costs a net loss before tax of 12 million. The gross assets of SlimFast at its 2017 financial year end were 136 million. Glanbia plans to operate SlimFast within its Performance Nutrition segment. It is anticipated that the transaction will close before the end of 2018 sub- ject to the customary completion conditions agreed closing accounts and regulatory approval. Final consideration will be dependent on the value of actual working capital at completion there is no other deferred component to the consideration. The transaction will be fully financed by Glanbia s available banking facilities and it is expected to be accretive to earnings per share from 2019 onwards. For more information visit www.glanbia.com. Cargill & Royal DSM to Establish Joint Venture to Bring Zero-calorie Cost-effective Sweeteners to Market Faster s food and beverage producers look to significantly reduce calories in their offerings to consumers they are in need of nonartificial zero-calorie great-tasting sweetener options. Cargill (Minneapolis MN) and Netherlandsbased Royal DSM recently announced a new joint venture Avansya to rise to this challenge. Together the companies will produce highly sought-after sweet-tasting molecules such as steviol glycosides Reb M and Reb D through fermentation giving food and beverage manufacturers an even more scalable sus- A tainable and low cost-in-use solution than if these same molecules were extracted from the stevia leaf. The new venture will combine both companies technologies for producing steviol glycoside products made through fermentation and will market its products under one brand name EverSweet. The joint venture will be a 50-50 partnership between the two companies. The establishment of the joint venture is subject to regulatory approvals and other customary closing conditions but expected to be finalized in the first calendar quarter of 2019. For more information visit www.dsm.com or www.cargill.com. Australians Develop Novel Microencapsulation Technique for Fish Oils ustralian researchers have developed a novel technique using a seaweed extract to significantly reduce oxidation in microencapsulated fish oils. The breakthrough is expected to revolutionize the delivery of fish oils and other dietary supplements. In the study published in the journal Powder Technology Alfred Deakin Professor Colin Barrow led researchers from Deakin University s School of Life and Environmental Sciences have developed a two-step microencapsulation system with a double shell structure using a bioactive seaweed polysaccharide known as fucoidan. The incorporation of fucoidan was found to significantly improve oxida- A December 2018 www.niemagazine.com tive stability of the encapsulated oil and induce better crosslinking of the shell material. The polyphenols present in the fucoidan extract cross-link to form a tight network of chains with gelatin which provides this powerful stability explained Barrow. A current limitation in the manufacture of fish oil is its susceptibility to oxidation during production and storage. Oxidation of the polyunsaturated fatty acids in fish oil can lead to unpleasant odor and taste as well as compromised functional benefits. However this new technique provides a solution with study results showing no oxidation or degradation of the oil during production and greater stability at high temperatures. Produced by Australian biotechnology company Marinova Pty Ltd (Australia) the fucoidan extract was included in the shell material at 7 percent. For more information visit www.marinova.com.au. Nutrition Industry Executive 13 IndustryNews SIRIO Pharma Opens New Supersized Plant for Gummy Production in China irio Pharma Co. Ltd. (SIRIO China) a global nutraceutical contract development and manufacturing organization (CDMO) has announced the opening of a gummy production plant at its new development and manufacturing facility in Ma anshan China (more than 186 miles west of Shanghai). This announcement comes 11 years after SIRIO opened its first gummy facility also in China. The new site will be built in several phases and form a Centre of Excellence covering an enormous 240 000 square meters (2 583 338.5 square feet). S Phase 1 of the site s construction has just been completed and features a gummy production plant and its associated building designed to expedite development and manufacturing of gummy formulations for global customers. In the United States and Europe in particular there is a significant growth potential in gummy formulations as they are seen as a more consumer friendly dosage form. For many of the branded firms looking to enter this market early with customized formulations we offer clear advantages said Rui Yang CSO of SIRIO. We can expedite development and even offer taste testing options during formulation. Alternatively we also offer ready-to-go formulations for companies that are looking to enter the market quickly because we have one of the largest ranges of existing gummy formulations of any global business. But as consumers become more discerning we anticipate branded companies will increasingly need specialist gummy development partners and capabilities. The gummy production plant features integrated R&D and will increase production capacity to 2.4 billion gummies per year. SIRIO also expanded its ability to make innovative products such as liquid filled center-filled swirled and multi-colored gummies. In addition SIRIO has hundreds of standard gummy formulation options suitable for market launch in the U.S. and E.U. and vegetarian options including carrageen and Sirio Pharma s new facility pectin as well as sugar free and lowsugar options. Loren Israelsen president United Natural Products Alliance (UNPA) on his recent visit to the new facility commented I have toured scores of dietary supplement factories around the world but few equal SIRIO s new gummy facility in terms of technology state-of-theart design and engineering robotics and R&D capabilities. This facility boasts world-class R&D and manufacturing and will help customers innovate new formulations for the fast-growing gummy market. For more information visit https en.siriopharm.com. FDA Announces New Final Guidances on Revised Nutrition Labeling Requirements n November 2 the U.S. Food and Drug Administration (FDA) announced two new final guidances to help companies revise nutrition labels for conventional foods and dietary supplements to comply with the new regulations. One document deals with the definition of a single-serving container reference amounts customarily consumed which are used by companies to determine serving size dual-column labeling and other related issues. Food Labeling Serving Sizes of Foods That Can Reasonably Be Consumed At One Eating Occasion Reference Amounts Customarily Consumed Serving Size-Related Issues Dual-Column Labeling and Miscellaneous Topics Guidance for O 14 Nutrition Industry Executive Industry The second final guidance document consists mainly of questions and answers to help manufacturers determine how to calculate added sugars in their juice-containing products and certain other products. Other topics include compliance label formats and the declaration of quantitative amounts of vitamins and minerals. Nutrition and Supplement Facts Labels Questions and Answers Related to the Compliance Date Added Sugars and Declaration of Quantitative Amounts of Vitamins and Minerals Guidance for Industry Importantly FDA made a clear statement that the compliance date is based on the date the label is applied to the product. If a label compliant with the old requirements is applied before the compliance date the product is compliant and remains compliant throughout distribution. Any label applied after the compliance date must comply with the new revised requirements. Virginia-based EAS Consulting Group is offering its Food Labeling and Dietary Supplement Labeling seminars in Philadelphia PA on March 12-13 (Food) and March 14-15 (Dietary Supplement). For more information visit https easconsultinggroup.com. www.niemagazine.com December 2018 Synergy Flavors Uncovers Sports Nutrition s Flavors of the Future ew research from Synergy Flavors Inc. (Wauconda IL) highlights new and inspirational flavors for the North American and Latin American sports nutrition markets. The company s Flavors of the Future research yielded a hot list of emerging growing mainstream and established flavor trends that will dominate the sports nutrition market along with expected flavor combinations utilizing Foodpairing technology which is based on using science to analyze and determine the compatibility between different ingredients. N Through the Flavors of the Future research Synergy Flavors gathered insights from industry experts and then benchmarked the input with quantitative data such as product launches and global search trends. This process identified the palette of flavors which Synergy Flavors then validated in sports nutrition applications. Finally Synergy Flavors team of flavorists and sports nutrition experts assessed and refined the list to create the Flavors of the Future hot list. Only those flavors that have true potential in the sports nutrition market made the final cut. To access the full research report and download a free Flavors of the Future booklet visit www.synergytaste.com flavorsofthefuture or email flavorsofthefuture synergytaste.com. NOW Honored by Economic Lonza Consumer Health and Nutrition Joins Clean Label Alliance Development Authority of Western Nevada onza (Greenwood SC) has announced that its Consumer L Health & Nutrition (CHN) team will be a founding member of the Clean Label Alliance a new initiative to help manufacturers develop or transition to clean labels to meet evolving consumer preferences. Bringing together five leading dietary supplement innovators and coordinated by RIBUS Inc. the Clean Label Alliance will provide manufacturers with support and problemsolving solutions. It was launched officially at this year s SupplySide West Expo in Las Vegas NV. Developed in response to the increasing demand by consumers for greater transparency and cleaner and simpler dietary supplements the Clean Label Alliance will offer expert guidance to companies bringing nutritional supplements to consumers. As supplement manufacturers transition to cleaner labels they must overcome both formulation and production challenges. The Clean Label Alliance will offer premium resources and technical solutions to help manufacturers to produce clean-label supplements more easily and efficiently. For more information visit www.cleanlabelalliance.com or www.lonza.com. he Economic Development Authority of Western Nevada (EDAWN) honored NOW (Bloomingdale IL) with the Manufacturing Excellence Large Company award in the Greater Reno-Sparks Nevada area 7th Annual Industry Awards. The Economic Development Authority of Western Nevada is a private public partnership established in 1983. EDAWN is committed to adding quality jobs to the region by recruiting new companies supporting the success of existing companies and assisting new forming companies to diversify the economy and have a positive impact on the quality of life in Greater RenoSparks. NOW received the EDAWN Leader in Sustainability Large Company award in 2017 and the Company of the Year award in the Large Company category in 2014. For more information visit www.nowfoods.com. T ISO-22000 Food Safety Management Certification Now Offered by SCS alifornia-based SCS Global Services (SCS) a third-party certification body announced that it has been accredited as a certifier under the ISO 22000 2005 international standard for food safety management. The standard provides robust food safety management requirements for growers food manufacturers processors packers retailers and other entities across the human food and animal feed supply chains. The addition of ISO 22000 to our C December 2018 www.niemagazine.com suite of certification offerings means that clients can be more responsive to their customers and stakeholders around the world while simultaneously benefitting from the efficiencies of working with one certifier to handle all of their audit needs said Heena Patel SCS technical director food safety. This is particularly important she noted given the increasing extent to which food items now cross international boundaries from farm to fork. ISO 22000 maps out the steps an organization must take to demonstrate its ability to control food safety hazards in order to ensure that food is safe. It was developed through the multistakeholder consensus ISO process involving country delegations from around the world. Given its international status it also serves as a platform upon which other standards can be benchmarked or built such as FSSC 22000. For more information visit www.scsglobalservices.com. Nutrition Industry Executive 15 IndustryNews First Dietary Fiber Verified Natural According to ISO ajor chicory root processor Sensus (The Netherlands) announced that its full range of chicory inulin and oligofructose products qualifies as natural according to the new ISO 19657 2017 standard. About a year after ISO set a new standard for food ingredients to be called natural chicory root fiber is the first dietary fiber to achieve this verification. The root of the chicory plant is the natural source of the inulin and oligofructose ingredients that Sensus produces. We are extremely pleased that we can now really call our chicory inulin natural according to the very latest and strict ISO standard explained Elaine Vaughan PhD Sensus scientific and regular affairs leader. There are many fibers available in the market and this qualification distinguishes chicory inulin from fibers that you cannot find in nature. Occurring in nature is exactly the focus of ISO when determining the naturalness of an ingredient. Inulin has been part of our daily diet historically and there are more than 36 000 M plants in the world that contain inulin fiber like banana wheat and garlic. The inulin is extracted with hot water from chicory roots which contain a high level of inulin. The inulin fiber delivered to the customer is the same as you can find it within the chicory root. To become verified as natural an ingredient must occur in nature. For this reason not many other dietary fibers will qualify for this verification simply because they do not occur in nature. For more information visit www.inspiredbyinulin.com. O 16 Nutrition Industry Executive atural products industry veteran Todd Pauli has announced the launch of a new marketing agency 24 Stories focused on building marketing conTodd Pauli tent campaigns for wellness-minded brands. The agency will work with both ingredient suppliers and finished goods manufacturers to help them strategically leverage video social content and influencer campaigns to grow customer relationships throughout the supply chain. Many wellness-minded brands have recognized that content-based marketing fits perfectly with their desire to tell genuine educational brand and product stories said Pauli. They also realize that providing consistent video social and digital content requires a lot of work specific expertise and the connections to scale that content to reach the right audience. This is where 24 Stories can assist with both onetime campaigns and the day-to-day content needs of brands looking to grow an engaged audience passionate about health and nutrition. Pauli will continue as a partner with The Shelton Group while leading operations for 24 Stories. Many brands in our industry require traditional marketing and trade PR expertise and The Shelton Group remains the agency with the experience breadth of services and long-standing industry connections to meet those needs said Pauli. With a focused team of writers designers and consumer PR experts 24 Stories is solely focused on providing content-based marketing services within the wellness industry. For more information visit www.24storiesdigital.com. N Omniactive Launches Improving Lives Foundation mniActive s (Morristown NJ) Improving Lives Foundation officially launched at this year s SupplySide West show in Las Vegas NV. As part of the foundation s commitment to bring positive change to communities customers and consumers corporate social responsibility is one of the key initiatives. OmniActive continues to support farming communities in rural India with multiple initiatives including health camps and a guaranteed buy-back program and now they are taking it to the next level said Rushva Parihar CSR consultant for the OmniActive s Improving Lives Foundation. OmniActive fosters an environment where farmers their families and communities can truly thrive. OmniActive is focused on improving the health of the small farming communities and promoting gender equality in rural India. The percentage of women who depend on agriculture for their livelihood is as high as 84 percent. New Agency 24 Stories Focuses on Content-based Marketing for Wellness Brands Through regional community-and school-level nutrition and hygiene programs OmniActive s Improving Lives Foundation focuses on several key areas including Protection and improvement of vision Improved nutrition to help farmers and their families meet their nutritional needs Improved sanitation and clean water systems as well as guidance on healthy hygiene practices Promotion of gender equality and empowering women to become agents of change within their communities through education as well as preventative and corrective health care For more information visit www.omniactives.com. www.niemagazine.com December 2018 Aker BioMarine to Build New Support Vessel in China igning a memorandum of understanding with representatives from the China Overseas Development Association (CODA) Norway-based Aker BioMarine announced that its newest support vessel will be built in the world s leading shipbuilding country China. The project with a yet undisclosed set of Norwegian suppliers and a Chinese yard includes the construction and the final fit out of the vessel by December 2020. Coinciding with the State Visit of His Majesty King Harald V and Her Majesty Queen Sonja of Norway to the People s Republic of China the memorandum of understanding between Aker BioMarine and CODA highlights the active dialogue ongo- S ing cooperation and growing economic ties between the two nations. Renowned for their expertise and capacity to deliver we are thrilled to continue modernizing and improving our operations with Chinese partners said Matts Johansen CEO Aker BioMarine. This is the beginning of a unique collaboration targeting the delivery of a custom-made Chinese built vessel equipped with truly unique Norwegian technologies. Highlighting the importance of the agreement Hu Weiping chairman of CODA shared We are delighted to see the continuous deepening relations between China and Norway providing win-win solutions and mutual benefits. Aker BioMarine s wish to build a state-of-the-art transport vessel in China embodies this spirit of cooperation between the two nations. We are pleased to be a part of supporting this process and desired to contribute to this cooperation. CODA is a national non-profit organization providing comprehensive services for the overseas development of Chinese businesses and is an important bridge between the Chinese government and businesses. Replacing their existing transportation vessel La Manche Aker BioMarine s new krill support vessel will be based on the latest energy saving and environmentally-friendly technologies. For more information visit www.akerbiomarine.com. You reHired ChromaDex Corp. (Irvine CA) has announced that it has Nutrition 21 LLC (Purchase NY) has welcomed Erika Harvey as appointed Matthew Roberts as chief scientific officer and senior the key accounts manager West Coast. Harvey brings 16 years of vice president of innovation effective immediately. He has been experience selling ingredients in the natural products space most on the ChromaDex Scientific Advisory Board since November recently with HORN Nutraceuticals (La Mirada CA). 2016. The company has also appointed Yan Chu as managing DuPont Nutrition & Health has announced the addition of a new director Asia Pacific. Based in Singapore Chu will lead the TRU member to its sustainability team with experience in sustainable NIAGEN business for the region. sourcing. Marta Maireles Gonzalez has joined the organization as Jason Brown has been named manager of the analytisustainable sourcing coordinator. Maireles work will cal chemistry department at Q Laboratories (Cincinnati focus on helping DuPont Nutrition & Health execute its OH). Brown will be responsible for the day-to-day operasustainability strategy with special focus on sourcing of tion of the Chemistry Laboratory including sample flowbio-based raw materials including palm oil soy guar through analyst training and compliance to industry seaweed LBG kernels and wood. standards. Vitamin Angels (Santa Barbara CA) a global charity Iowa-based Kemin Industries has expanded its bakery connecting at-risk pregnant women and children to applications team with the addition of Anita Srivastava essential vitamins and minerals ha announced the PhD CFS. As senior product development manager for appointment of Elizabeth Kimani-Murage PhD to its bakery applications Srivastava will be dedicated to supboard of directors. A public health specialist and Anita Srivaftava porting Kemin customers in the tortilla segment. researcher based in Kenya Kimani-Murage has focused Rupa Das BI s (Rancho Dominguez CA) vice president much of her work on finding solutions to childhood of global quality and compliance has been appointed as the inter- nutrition problems in poor urban settings throughout Africa. im chair for the American Herbal Products Association (AHPA) s Mineral Logic LLC (Kalamazoo MI) a producer of fulvic acid for Board of Trustees. Das a long-serving member of the board will human applications recently hired veteran biochemist Mark K. replace Graham Rigby until March of 2019. Williams PhD to serve as the company s chief science officer. December 2018 www.niemagazine.com Nutrition Industry Executive 17 IngredientNews Research on Curcumin s Positive Effects on Microbiome Published recently published double-blind randomized placebo-controlled clinical study investigated a new aspect of curcumin with a trial on the impact of curcuminoids on the gut microbiome in humans. Effects of Turmeric and Curcumin Dietary Supplementation on Human Gut Microbiota A Double-Blind Randomized Placebo-Controlled Pilot Study by Christine T. Peterson PhD et al published in the Journal of Evidence-Based Integrative Medicine (Volume 23 1-8) examined the effects of placebo Turmeric powder in combination with BioPerine and Curcumin C3 Complex in combination with BioPerine as actives. New Jersey-based A Sabinsa supplied Curcumin C3 Complex and BioPerine material to the research team which was affiliated with several universities in the U.S. The study found that while both turmeric and curcuminoids have similar qualitative effects on the intestinal bacterial population curcuminoids had a far larger quantitative effect indicating that curcuminoids in turmeric are the decisive components in influencing the bacterial population. Thus curcuminoids have an unique role and effect on the gut microbiome in the sense that they are not only metabolized to useful products such as reductive metabolites like tetrahydrocurcumin (by E. coli) and to demethylated curcuminoids (by Blautia sp.) as demonstrated by previous researchers but they also increase the population of several species of gut microbiome. In other news Sabinsa recently launched Shagandha USP (U.S. Pharmacopeia) grade branded ashwagandha as well as three versions of the recently introduced Nigellin Sabinsa s standardized black cumin (Nigella sativa) seed extract in Amber Onyx and Pearl editions. This emerging antioxidant ingredient has traditionally been used in the management of several health conditions with recent research beginning to validate historically reported benefits. For more information visit http journals.sagepub.com doi 10.1177 2515690X1 8790725 or www.sabinsa.com. Arjuna Natural to Supply Curcugreen Directly to the U.S. Market rjuna Natural Ltd. (India) announced it has established a direct supply chain in the U.S. for its turmeric extract Curcugreen ensuring a safe pure product. Curcugreen has the same market-leading patented bio-available composition that was sold previously through an exclusive agreement with Dolcas A Biotech (New Jersey) under the brand name BCM-95. This composition experienced record growth levels compared to all other curcumin supplements. Our priority is to ensure our customers and consumers that our patented composition the safety and therapeutic benefits of which have been validated by more than 50 scientific studies will continue to be available without any change in the composition explained P.J. Kunjachan chairman and managing director for Arjuna. Arjuna Natural will market the same patented composition under its own trademark Curcugreen. Arjuna the manufacturer and owner of 29 patents on product composition process and application will no longer supply the clinically proven composition to Dolcas Biotech (New Jersey). The BioCell Collagen Featured in Bluebonnet Targeted Choice Joint Support ioCell Technology LLC (California) announced that its flagship healthy aging ingredient BioCell Collagen is featured in a new product launch from the Bluebonnet Targeted Choice product line called Joint Support. Targeted Choice Joint Support Caplets are specially formulated with BioCell type II collagen and identity-preserved (IP) vitamin C hyaluronic acid glucosamine chon- B 18 Nutrition Industry Executive droitin and MSM as well as sustainably harvested or wildcrafted herbal extracts such as turmeric root and white willow bark. This wholesomely crafted formula is designed to help optimize joint function by maintaining healthy cartilage tendons and ligaments. It is also available in easy-to-swallow caplets for maximum assimilation and absorption. For more information visit www.biocellcollagen.com and www.bluebonnetnutrition.com. change to the new brand name will not affect the composition and quality of this curcumin. For more information visit www.arjunanatural.com. Nuherbs Co. Highlights Bespoke Extracts Made in U.S. Quality Herbs from China and Launch Mycelium Detox Ingredient alifornia-based Nuherbs Co. featured its range of organic herbs standardized extracts Pharmacopeia grade herbs and Bespoke extracts at SupplySide West in November. The company also introduced a proprietary Mycelium detox ingredient. Nuherbs Bespoke Extracts made in the U.S. offers custom ratios starting at 50 kg. This line uses a collaborative process and time-tested production methods to produce extracts from the best quality botanicals made to the customer s specifications. Every lot is fully traceable and accompanied by samples of the exact lot of herbs used to make the extract according to the company. For more information visit www.nuherbs.com. C www.niemagazine.com December 2018 Natreon Transitions to Direct Distribution of Sensoril Ashwagandha Ingredient atreon (New Jersey) announced that it has established direct sales activities of its Sensoril ingredient in the U.S. market effective immediately. Natreon will now provide direct sales service support and co-marketing to its customers that formulate with Sensoril in the supplement food beverage and personal care products industries. This transition allows us to align our product innovation clinical research and N consumer awareness programs directly with the needs of our customers said Bruce Brown president of Natreon. Furthermore we believe there is value in improving operational efficiency as well as connecting customers directly to Waitaki Biosciences Launches CytoC for Musculoskeletal Support aitaki Biosciences a New Zealand-based manufacturer of natural nutritional ingredients launched CytoC a new ingredient for complete musculoskeletal health. A product designed with the understanding that a range of nutrients work together to support a healthy musculoskeletal aging process CytoC contains both type I and type II collagen along with calcium phosphorous and glycosaminoglycans to support bone muscle and joint health the company stated. Waitaki Biosciences uses only New Zealand-grown raw materials in its ingredients. In particular fruit varieties selected such as the green kiwifruit used in digestive health product ActiPhen and Ben Ard blackcurrants in high anthocyanin blackcurrant extract CassiPure have exceptionally high levels of bioactives due to the New Zealand growing environment and the company s proprietary manufacturing processes. PernaTec Greenshell Mussel Oil Extract from sustainable New Zealand aquaculture grown Greenshell Mussels is produced by an extraction process developed by Waitaki Biosciences that very efficiently pulls high levels of phospholipids from the mussel to provide a free flowing amber oil with exceptional anti-inflammatory properties. For more information visit www.waitakibio.com or www.stimucal.com. W Sensoril and take them on a journey of how Sensoril is sourced its unique adaptogenic health benefits and organic non-GMO (genetically modified organism) attributes. Moving to a direct sales and distribution model will allow our knowledgeable world-class team to leverage its expertise and foster closer customer relationships. For more information visit www.natreoninc.com. Seniors With Sarcopenia Improve With New Astaxanthin Formulation he AstaReal Group (Sweden) announced the results of a randomized double-blind placebo-controlled study on the effectiveness of a new medical protocol to improve muscular function via Journal of Cachexia Sarcopenia and Muscle. Sarcopenia affects nearly a quarter of adults older than 60 according to Diagnostic Criteria and Clinical Outcomes in Sarcopenia Research A Literature Review. The study investigated the restoration of muscle loss and improvement of functional decline in elderly people with sarcopenia. Sarcopenia is the loss of muscle mass associated with aging. It starts at about 40 and for most people progressively accelerates after the age of 65 affecting muscle size strength and performance. It can diminish a person s ability to do everyday activities such as lifting objects and climbing stairs. The 4-month study investigated individuals aged 65 82 in two groups. The first group received AstaMed MYO a formula that contains AstaReal natural astaxanthin and an interval exercise training protocol. The control group was prescribed the exercise training protocol only. Over a four-month span treatment recipients experienced a 40 percent increase in endurance a 14 percent increase in muscle strength and an 8 percent increase in mobility. There was no muscle strength improvement in the group that undertook exercise alone. For more information visit www.astareal.com. T FutureCeuticals Launches S7 Boosts NO by 230 Percent utureCeuticals Inc. (Illinois) introduces S7 the newest addition to its sports nutrition line of branded ingredients. This revolutionary clinically researched blend of seven plant-based ingredients has been clinically shown to boost nitric oxide (NO) levels in humans by an impressive 230 percent over baseline. Intake of nitrates and dietary nitrates F December 2018 www.niemagazine.com has been heavily marketed as the best way to increase NO in the body. FutureCeuticals S7 research however proposes a better and more powerful way to increase NO production in our bodies. Supplementation with exogenous nitrates (e.g. beets leafy greens sodium nitrate) may have some value but does not show the remarkable increase in NO our bodies can produce internally with S7 supplementation. S7 is different. It is not an ingested nitrate product. Rather S7 triggers the best kind of NO production your body s own NO. Many well-known NO ingredients have large serving sizes but S7 delivers documented results with only one 50-mg dose. For more information visit www.futureceuticals.com. Nutrition Industry Executive 19 IngredientNews BGG Announces Astaxanthin Water Dispersible Emulsion for Drink Applications GG (California) and its affiliates Colorado-based Solix Algredients (Solix) and California-based Algae Health Sciences (AlgaeHealth) announced that their flagship product AstaZine Natural Astaxanthin has been released in a perfectly water dispersible emulsion form for use in drink applications. This product features a new technological platform trademarked as Dispersa that will be used for other BGG products in the future. This innovative technology resolves two key complications common in competitive water dispersible Astaxanthin products ineffective dis- B persion in water applications and residual staining of consumers mouths and packaging containers. We ve seen competitive products claiming to be water dispersible which have sedimentation and suspended particles after mixing said Lixin Ding PhD general manager of BGG North America. Astaxanthin using Dispersa technology is completely transparent and stable over time with no aggregation sedimentation or suspension of Astaxanthin. This product was developed in Switzerland under the direction of BGG Europe s CEO Christian Artaria who decided to begin with Astaxanthin due to a lack of performance in this category. We re extremely enthusiastic about this state-of-the-art development said Artaria. Astaxanthin is an ideal ingredient for several different applications that lend themselves to a drinkable delivery method such as sports drinks and anti-aging health shots. Now we can offer a truly suitable solution for pioneering brands to bring the benefits of Astaxanthin to their consumers in drinkable form. For more information visit www.bggworld.com www.solixalgredients.com and www.algaehealthsciences.com. Canadian Researchers Discover Anti-inflammatory Compound from Omega-3 ETA ast year the journal Nutrients published a novel mechanism by which consuming Ahiflower oil supports the body s natural anti-inflammatory response for example after strenuous exercise or immune challenge. Now the same team of Canadian researchers at the University of Moncton has just published a study that deepens our understanding of how Ahiflower oil s natural anti-inflammatory support may be occurring. The research is reported in the journal Prostaglandins Leukotrienes and Essential Fatty Acids 138 L (2018) 33-44. The Canadian research team has discovered that eicosatetraenoic acid (c20 4 n-3 ETA) a long-chain omega-3 molecule that is significantly elevated through Ahiflower Oil consumption can be converted into two novel compounds associated with inflammation management. Two previously published human clinical studies have shown that Ahiflower oil consumption rapidly improves tissue levels of ETA within two to four weeks. This occurs because Ahiflower oil is the richest source of omega-3 stearidonic acid (c18 4 n-3 SDA) the immediate metabolic precursor to ETA meaning that our bodies convert SDA in Ahiflower oil very efficiently to ETA in circulating cells. Prior to the current study no biologically active metabolites of ETA have ever been reported. The University of Moncton team led by Marc Surette and Kristine Gagnon confirmed the novel identity and bio-activity of these molecules as well as a specific anti-inflammatory mechanism of action for one of them. For more information visit www.naturescrops.com and www.stratumnutrition.com. Activeberry Gives Performance a Boost ctiveberry an all-natural black currant-derived performance ingredient for athletes and consumers with active lifestyles was recently launched by Frutarom Health Ltd. (Belgium). With the launch of Activeberry Frutarom Health strengthen its position in the sport nutrition market adding to its already substantial portfolio of active natural ingredients said Itay Shafat PhD product manager for Frutarom Health. The sports nutrition category showed an impressive increase in launch activity in 2017 with a year-over-year growth of 18 percent (2017 vs. 2016) according A 20 Nutrition Industry Executive to Innova Market Insights. Sportification moves toward the mainstream of food and beverage branding with a growing number of NPD (new product development) launches tracked with sport-related claims comprising 25 percent CAGR (compound annual growth rate) from 2013 to 2017. Natural claims experienced strong growth as well. Together new sport-related food and beverage launches tracked with a natural claim rose more than 20 percent CAGR from 2013 to 2017. Related claims are gaining ground in mainstream food and beverages. Activeberry is produced from blackcurrant a known source of anthocyanins and antioxidants as well as other potent bioactive molecules. Using a technology that maintains the properties of the natural berry while at the same time assuring the quality and safety of the product the ingredient is produced without solvents or other chemicals. For more information visit www.frutaromhealth.com. www.niemagazine.com December 2018 Gencor Introduces Levagen alifornia-based Gencor a supplier of clinically researched branded ingredients introduced its newest ingredient Levagen. Levagen is a branded palmitoylethanolamide (PEA) that has been clinically shown to benefit joint discomfort and support a healthy anti-inflammatory response. PEA was first identified in the 1950 s as a therapeutic substance with potent anti-inflammatory proper- C ties. It is produced in the body as a biological response and as a repair mechanism for inflammation. Levagen utilizes the endocannabinoid system for supporting joint function reducing joint stiffness and providing joint comfort. As part of this introduction Gencor also previewed Levagen a coldwa- PURIS Creates First Gelatin and Pectin-free Gummies and then Doubles Down with PURIS Fava Protein innesota-based PURIS accelerates great-tasting U.S.made organic and non-GMO (genetically modified organism) plant proteins with the completion of its newly expanded second spray dryer. PURIS President Tyler Lorenzen noted For the past couple of years we had been sold out of the best-tasting pea protein in the market but with the completion of our capacity increase of plant proteins produced in our Wisconsin production facility not only can we can handle the scale and growth of the rapidly growing plant-based protein CPG industry but also we felt it was time to introduce the newest member of our best in class tasting proteins PURIS Fava Protein. What makes PURIS Pea Proteins special also enable PURIS to make new pulse proteins such as PURIS Fava Protein the company stated. PURIS Fava Bean Protein will be available in 2019 and can be used in a variety of food applications from dry beverage blends and bars to snacks and plant-based meats. For more information visit www.purisfoods.com. M ter dispersible PEA powder specifically designed to increase bioavailability in aqueous environments such as the stomach. With more than 90 percent loading this formulation supplies the largest amount of PEA in a water dispersible formulation. For more information visit www.gencorpacific.com. TRU NIAGEN Daily Serving Strengthened Under FDA s NDI Notification alifornia-based ChromaDex Corp. announced it has strengthened its flagship TRU NIAGEN (nicotinamide riboside) nutrient to 150 mg capsules two per day. The more potent product launched on truniagen.com effective Oct. 24. We are pleased to offer Tru Niagen users a 300 mg daily serving of our revolutionary ingredient said Robert Fried ChromaDex CEO. This will provide an extra boost in NAD [nicotinamide adenine dinucleotide] levels which decline with age and the daily stressors of life. Niagen was clinically studied at 300 mg to increase NAD in 2016 published in the journal Nature Communications. Since then three additional clinical studies have published on Niagen and 18 additional clinical studies on ChromaDex s patented ingredient are planned or in progress. Niagen has received two successful New Dietary Ingredient (NDI) notifications the second reviewed at 300 mg as well as Generally Recognized as Safe (GRAS) notification to the U.S. Food and Drug Administration (FDA). For more information visit www.truniagen.com. C DuPont Nutrition & Health Debuts Pea Protein for Beverages uPont Nutrition & Health (Missouri) announced an expansion of its plant-based protein product range with TRUPRO 2000 Pea Protein from the DuPont Danisco range of ingredients. According to the company flavor and consistency are key features that differentiate TRUPRO 2000 Pea Protein from other pea proteins in the market. Specifically designed for beverage applications TRUPRO 2000 Pea Protein allows manufacturers to deliver a high quality and consistent consumer experience while maximizing operation efficiencies. Pea protein produced from yellow peas is a popular choice today D December 2018 www.niemagazine.com as it lies at the intersection of three major trends driving the food industry strong consumer demand for protein desire for plant-based alternatives and clean label. TRUPRO 2000 Pea Protein delivers superior flavor and mouth-feel performance in beverage powders compared to competitive pea protein options as demonstrated in consumer sensory panels. Seventy-seven consumers evaluated two basic protein powders reconstituted in water and containing 20 grams of plant protein from pea. One was formulated with TRUPRO 2000 Pea Protein and a similar beverage was formulated with a leading competitive pea protein. The results demonstrated that the sample containing TRUPRO 2000 Pea Protein was significantly preferred in overall liking as well as flavor thickness mouthfeel and aftertaste liking. For more information visit www.food.dupont.com and www.dow-dupont.com. Nutrition Industry Executive 21 IngredientNews EVNol SupraBio Supports Diabetic Nephropathy A Pilot Phase II Clinical Trial randomized double-blinded placebo-controlled trial was conducted by a group of researchers from the School of Medicine and Health Sciences Monash University Malaysia to investigate the effect of EVNol SupraBio on diabetic nephropathy (also known as diabetic kidney disease). The study is published in the journal Nutrients focusing on diabetic nephropathy one of the major complications for diabetes and the leading cause of end stage renal failure worldwide. In general kidney damage rarely happens in the first 10 years of diabetes. Kidney failure usually happens A 15 to 25 years after the first symptoms of diabetes. Since diabetic nephropathy takes many years to develop 45 patients with type 2 diabetes for an average of 18.5 years were selected for this study. Their microalbuminuria-positive results were ensured to be due to diabetic nephropathy alone (microalbuminuria is an early sign for kidney disease). They were randomly divided into 2 groups Placebo group and the Intervention group receiving EVNol SupraBio. The blood serum of the patients were measured at baseline and after a short 8-week supplementation of either 400 mg day EVNol SupraBio or placebo. Nutrition 21 Releases Consumer Brand Awareness Data for Nitrosigine and Velositol ew York-based Nutrition 21 LLC announced the results of a new brand awareness survey recently conducted by American Media Inc. (AMI) publisher of the popular men s fitness magazines Muscle & Fitness and Flex. For the past year Nutrition 21 has promoted its cornerstone ingredients Nitrosigine and Velositol through various print advertisements and digital programs within AMI s platform to create demand among consumers. Results from this survey yielded highly favorable data with Nitrosigine the company s nitric oxide boosting ingredient receiving an 85 percent brand awareness rating and Velositol the ingredient that enhances muscle protein N synthesis receiving an 89 percent awareness rating. Of these two results Nitrosigine also received an 81 percent favorable view from consumers with Velositol receiving an 85 percent favorable view. The Velositol AMI survey size was 311 participants while the Nitrosigine AMI survey size was 271 participants. For more information www.nitrosigine.com www.velositol.com and www.nutrition21.com. Lycored Unveils New UserFriendly Names for its Colors ycored (New Jersey) has re-named all its colors for food and beverages as part of a re-branding strategy that emphasizes simplicity and userfriendliness. The new names communicate the qualities of the colors and their benefits to customers rather than their origins. The company offers a portfolio of super-stable food and beverage colorants sourced naturally from carotenoids. Its lycopene-based range of reds derived from tomatoes and previously called Tomat-O-Red will now be L 22 Nutrition Industry Executive grouped into four new color families. Designed to be memorable the names are all simple and constructed from two words that are either alliterative or rhyme. Each communicates shade as well as product performance benefits such as stability. For more information visit www.lycored.com colorants . EVNol SupraBio bioenhanced full spectrum palm tocotrienol complex significantly reduced serum creatinine level hence potentially averting the progression of renal impairment among the diabetic nephropathy patients. For more information visit www.excelvite.com www.tocotrienol.org and www.carotene.org. The statements in the above article have not been evaluated by the Food and Drug Administration. They are not intended to diagnose treat cure or prevent any disease. Naturex TakesPlantbased Ingredients to the Next Level aturex (New Jersey) released new clinical results for ULTIMINE Iron a whole food iron obtained from fermentation by koji culture. There was also a focus on the clinically validated heart health benefits delivered by Aronox aronia extract and SWEOAT oat beta-glucan. N Developed through a partnership between Naturex and Cura Global Health Inc. ULTIMINE Iron is a whole food iron obtained from koji (Aspergilus oryzae) using a patented fungal fermentation process. Three clinical studies have shown that it is highly bioavailable and is released slowly into the blood. The latter benefit is unique and important because most iron supplements in the market are absorbed quickly potentially leading to iron overload. ULTIMINE Iron is the first generation of products within a proprietary koji fermentation platform that aims to develop whole food nutrients with better efficacy. The second generation of products ULTIMINE Multi 7 is already available on the U.S. market and provides 25 percent of the RDI for seven nutrients within a small dosage. For more information visit www.naturex.com. www.niemagazine.com December 2018 Lonza Adds Color to the Clean-label Experience DRcaps Receive NON-GMO Project Verification outh Carolina-based Lonza announced the global launch of its latest dosage form innovation with supplement manufacturers now able to choose from a range of clean label colorants when selecting its Capsugel Vcaps Plus plant-based capsules. Its premier vegetarian capsules are already popular among brands looking to achieve a variety of on-pack claims but coloring the shell has previously required an E-number. The new food colored capsules labeled as natural colorants in the United States allow customers to create bright eye-catching supplements that also appeal to consumers seeking improved supply chain transparency and a natural posi- S tioning. The first of the nextgeneration clean label solutions to be marketed worldwide is the Vcaps Plus Purple Carrot capsule following the successful introduction of the Vcaps Plus Blue Spirulina capsule in Europe earlier this year. The high-performance capsule shell is made using plant-based hypromellose (HPMC) and water only without any preservatives. A colorant derived from purple carrots is used to match the desired shade as closely as possible while maintaining a natural Lallemand Showcases Women s Health Range of Probiotics and Kid s Health Studies allemand Health Solutions (Canada) presented its newest probiotic offer for women s health and shared latest clinical studies with key formula Oralis SB in oral health and with the strain Bifidobacterium lactis LAFTI B94 in kid s health. The company also showcased its range of complete probiotic solutions for other specific areas gut health immunity stress and mood balance (brain-gut-axis) kids and teens health sports nutrition. The probiotic strain B. lactis LAFTI B94 is supported by clinical evidence for its gut health benefits in children and adolescents. As part of Lallemand Health Solutions Hearty Kids and Teens range B. lactis LAFTI B94 has been thoroughly characterized and selected for in-vitro and in-vivo documentation of its modes of action and its good synergy with prebiotics. The Canadian Health Authorities have recently recognized its beneficial usage for occasional constipation and bloating in children and teens. For more information visit www.lallemand-health-solutions.com. L appearance in the finished supplement. Lonza also announced that its Capsugel DRcaps capsules have been verified as non-GMO (genetically modified organism) by the Non-GMO Project organization. DRcaps capsules are designed to help protect sensitive ingredients such as probiotics from stomach acid as well as to provide taste and odor masking and to reduce bad aftertastes. For more information visit www.lonza.com. Blue Diamond Showcases Almond Protein Powder alifornia-based Blue Diamond Almonds Global Ingredients Division an almond processor and supplier released Almond Protein Powder. For manufacturers and formulators of functional foods and nutraceuticals Blue Diamond Almond Protein Powder fills a need for a better tasting and a more natural protein source and serves as an essential component of a protein ingredient blend. The powder s fine texture smooth mouthfeel and neutral flavor make it an ideal ingredient for nutraceutical blends protein smoothies shakes and bars. In addition to its preferable flavor and texture Blue Diamond Almond Protein Powder is an excellent source of magnesium phosphorous manganese and copper and a good source of fiber potassium and calcium according to the company. The ingredient is also non-GMO (genetically modified organism) gluten- dairy- and soy free appealing to consumers of all dietary needs. For more information visit www.almondproteinpowder.com and www.bdingredients.com. C BASF Clinical Trial Reveals Reduction in Liver Fat Content in NAFLD ASF AS (Norway) completed a randomized placebo-controlled clinical trial in the U.S. published in Nutrients evaluating the use of high concentrate omega-3 to correct the nutritional deficiency of omega-3 fatty acid in patients with non-alcoholic fatty liver disease (NAFLD). Several studies have shown that NAFLD patients have lower levels of eicosapentaenoic acid (EPA) and docosa- B December 2018 www.niemagazine.com hexaenoic acid (DHA). The study covering 176 patients demonstrates that intervention with high concentrate omega-3 for 24 weeks significantly raises the omega-3 index in adults with NAFLD compared to placebo thereby correcting the patients nutritional deficiency. Patients showed reductions of up to 44 percent in liver fat after placebo correction providing evidence that clinical man- agement of NAFLD with high concentrate omega-3 has a beneficial outcome on liver fat. This intervention study supports a recently published meta-analysis that concluded that omega-3 fatty acids are associated with significant improvements in liver fat and liver function tests with approximately 3 g of EPA and DHA daily. For more information visit www.basf.com. Nutrition Industry Executive 23 IngredientNews Arla Foods Ingredients Launches Protein Extreme Whey Shot Concept new concept from Arla Foods Ingredients (Denmark) offers manufacturers the opportunity to create the first protein shot made exclusively with whey as a protein source. The Protein Extreme concept packs 20 g of high-quality whey protein into a convenient 100 ml low-calorie serving. Despite recent growth in global launches of protein drinks no such product currently A exists according to the company. Protein Extreme is made with Lacprodan HYDRO.365 Arla Food Ingredients high-quality whey protein hydrolysate. Developed to meet the needs of athletes and gym-goers it helps speed up muscle recovery after exercise due to its superior amino acid composition and fast absorption rate. It is also pH-flexible allowing a range of application options and UHT (ultra-high temperature processing)-stable allowing easy production on a standard UHT line. Each 100 ml (3.4 oz.) ready-to-drink serving contains only 98 Kcal. Lacprodan HYDRO.365 provides four significant on-pack claim opportunities high in protein high in calcium fat-free and no added sugar. For more information visit www.arlafoodsingredients.com. WACKER Enters the Sports Nutrition Market ACKER (Germany) presented two products that are ideal for sports nutrition supplements. The first is a coenzyme Q10 complex which WACKER supplies under the new trade name CAVAQ10. The second product presented by WACKER is CAVACURMIN which contains curcumin a plant-based antioxidant. Several published human clinical trials have confirmed the ben- W efits of coenzyme Q10 and curcumin on both general performance and muscular endurance and regeneration. As both substances are sparingly soluble in water and thus difficult for the human body to absorb WACKER s approach is to convert them into cyclodextrin complexes. This boosts their bioavailability significantly and affords a way to incorporate them into various products aimed at athletes. For more information visit www.wacker.com. Protein Glutaminase Improves Solubility llinois-based Amano Enzyme has introduced Protein Glutaminase Amano 500 (PGA 500) a protein glutaminase believed to be the first food enzyme to improve the solubility of proteins at low pH levels. When proteins are added to low pH formulations they precipitate limiting flavor masking and formulation options said Ken Iritani vice president technical services. We expect this enzyme to be a break-through development for beverage companies wishing to develop fruity protein shakes as well as other products for the thriving protein market. PGA 500 converts glutamine residues in protein into glutamic acid which increases solubility at levels as low as 5.0 pH added Iritani. This will greatly expand the applications and options for our customers. While the enzyme works for all proteins it works especially well for pea protein which has been gaining in popularity for a variety of foods. For more information visit www.amano-enzyme.com. I Correction Go to www.niemagazine.com somalabs for info about this advertiser 24 Nutrition Industry Executive In the October November issue an Ingredient News item stated that BioPQQ was certified free of banned substances. The article should have stated that BioPQQ which has been certified by the Informed-Sport quality assurance program together with its sister program Informed-Choice certification ensures that the product has been manufactured to high-quality standards and is tested for WADA (World Anti-Doping Agency)-banned ingredients. www.niemagazine.com December 2018 AssociationNews AHPA Requests Pullulan be Allowed in Organic Dietary Supplement Products he American Herbal Products Association (AHPA) recently submitted comments to the National Organic Standards Board (NOSB) to request that pullulan continue to be allowed to be used in encapsulated herbs marketed as made with organic [specified ingredients or food group(s)] under the National Organic Program (NOP). AHPA s comments support a petition submitted by the Organic Trade Association (OTA) to request that pullulan be added to the National List which identifies a limited number of T non-organic substances that may be used in or on processed organic products. Many AHPA members expressed concerns that there is a lack of rea- sonably available alternatives to non-organic pullulan capsules and prohibiting this ingredient in herbal capsules that are otherwise NOP organic could cause significant business disruptions said AHPA President Michael McGuffin. Adding pullulan to the National List would avert significant disruption to the organic dietary supplement industry and encourage commercial development of certified organic pullulan. For more information visit www.ahpa.org. Tea Tree Oil Laboratory Guidance Document Issued by ABC-AHP-NCNPR Botanical Adulterants Prevention Program he ABC-AHP-NCNPR Botanical Adulterants Prevention Program (BAPP) has released a Laboratory Guidance Document (LGD) on tea tree oil the essential oil obtained from tea tree (Melaleuca alternifolia and M. linariifolia) leaves. Tea tree oil is a popular ingredient known for its antimicrobial properties. Medicinally it is widely used as a topical treatment for minor cuts and wounds other skin problems and as an inhalant or in chest rub formulations to help alleviate the symptoms of the common cold. In addition it is frequently included as an ingredient in animal care home care personal care and cosmetic products. Australia is the major producer of tea tree oil providing an estimated 80 percent of the global supply. In 2018 Australian tea tree oil exports reached a market value of 35 million (AU) which is roughly 21 million (U.S.). Due to the relatively high costs of authentic tea tree oil some unethical suppliers substitute materials labeled to contain tea tree oil with lower-cost adulterants. Tea tree oil adulterants include monoterpene-rich materials obtained from the industrial waste stream after the purification of camphor (Cinnamomum camphora) eucalyptus (Eucalyptus globulus and other Eucalyptus spp.) and pine (Pinus spp.) essential oils. Tea tree oil can also be adulterated by adding pure chemical T December 2018 www.niemagazine.com compounds that originate from other plant materials fermentation or chemical synthesis. Common analytical assays to evaluate the identity of essential oils include organoleptic (sensory) evaluations physicochemical tests and chemical methods. The main advantages and disadvantages of each analytical method and the usefulness of these methods to detect tea tree oil adulteration have been summarized by Stefan Gafner PhD chief science officer of the American Botanical Council (ABC) and technical director of BAPP and Ashley Dowell manager of the Analytical Research Laboratory at Southern Cross University (East Lismore NSW Australia). In addition to the assessment of the analytical methods the document details the chemical composition of tea tree oil potential confounding species and known adulterants. The LGD has been peer-reviewed by 13 international experts from third-party contract analytical laboratories and the herbal industry. The Tea Tree Oil LGD is the 45th peer-reviewed publication published by BAPP and the sixth in the series of LGDs. As with all publications in the program the laboratory guidance documents are freely accessible to all ABC members registered users of the ABC website and all members of the public on the program s website (registration required). For more information visit http cms.herbalgram.org BAP index.h tml ts 1539373171&signature 63b90f 08ad1fc7f43c915e09fe6446a0. Four Companies Join CRN s Membership Roster he Council for Responsible Nutrition (CRN) has announced the addition of four new companies to the association s membership roster. The four new voting members include Care of Neves Global Resources LLC Quincy Bioscience Ritual For more information visit www.crnusa.org. T Nutrition Industry Executive 25 AssociationNews AHPA Launches Sustainability Subcommittee Formalizing Ongoing Efforts he American Herbal Products Association (AHPA) Botanical Raw Materials Committee has launched a Sustainability Subcommittee to further AHPA s ongoing efforts to ensure sustainable supplies of valuable botanicals. The subcommittee will be a vehicle for increasing awareness of sustainability issues and best practices provide a forum to discuss and develop industry-wide standards and promote existing sustainability initiatives throughout the industry. AHPA s Sustainability Committee will work to increase collaboration and engagement among farmers and collectors industry academic government standard setting and conservation groups to promote the long-term success of the herbal products industry by ensuring that botanicals currently in commerce continue to be available and can be sourced sustainably said AHPA Chief Science Officer Holly Johnson PhD who will act as the staff liaison to the subcommittee. T The subcommittee brings together herbal industry leaders to create a sustainability community forum and to identify analyze and problem solve key social brand and environmental issues. The subcommittee will work to generate tools and guidance for member companies of all sizes wishing to address sustainability issues and launch sustainability programs. According to Johnson the subcommittee will build on AHPA s sustainability work by collaborating with other sustainabilityfocused organizations supporting ongoing initiatives and programs and providing educational opportunities. We will curate existing resources and explore collaborations and find ways to assist companies address sustainability and supply chain issues said Johnson. We will also highlight and showcase examples of ethical and sustainable sourcing of botanicals within the industry. Some of AHPA s recent sustainability initiatives include funding researchers at the University of Kansas from 2014-2018 for a multi-year harvest impact study on osh (Ligusticum porteri) participating in meetings convened by the German Federal Agency for Nature Conservation in 2004 and 2005 where the ISSC-MAP standard (predecessor to the FairWild standard) was created conducting tonnage surveys since 1999 of articles derived from U.S. wild harvested plants and attending CITES Plants Committee meetings since 2004. The group will focus on areas where there needs to be more leadership in sustainability and social issues within the industry developing self-assessment tools identifying gaps in certification and creating vehicles for AHPA members to engage in forums around sustainable and regenerative agriculture conservation social responsibility and the impact of climate change on the herb industry. For more information visit www.ahpa.org AboutUs Committees Botani calRawMaterialsCommittee.aspx. Botanical Adulterants Prevention Program Publishes Revised Bulletin on Saw Palmetto he ABC-AHP-NCNPR Botanical Adulterants Prevention Program (BAPP) has announced the publication of a revised Botanical Adulterants Prevention Bulletin (BAPB) on saw palmetto (Serenoa repens) berry and berry extracts. Saw palmetto extract is a popular ingredient in dietary supplements in the United States and other countries and in phytomedicinal products in Europe. The primary use is for normalizing prostate function to relieve lower urinary tract symptoms (e.g. ability to void urine) related to benign prostatic hyperplasia (BPH) in middle-aged and older men. The 2017 HerbalGram Herb Market Report ranked saw palmetto products among the 20 top-selling herbal supplements in the United States in both the natural and mainstream retail channels. As documented in the initial bulletin on saw palmetto published in February 2017 adulteration of saw palmetto by adding undeclared lower-cost vegetable oils (e.g. palm canola coconut or sunflower oils) to saw palmetto extracts for financial gain has been known since in the early 2000s. Over the past two years several saw palmetto suppliers have reported the sale of a particu- T 26 Nutrition Industry Executive larly sophisticated type of adulterated saw palmetto extracts mainly from suppliers in Asian countries. According to the suppliers these materials are partly made using fatty acids obtained from animal fats and are designed to mimic the fatty acid composition of authentic saw palmetto extracts. The revised saw palmetto bulletin has been updated to reflect this newly reported form of adulteration with animal fats. The saw palmetto bulletin is coauthored by Scott Baggett PhD an analytical methods consultant for the natural products industry and Stefan Gafner PhD chief science officer for the nonprofit American Botanical Council (ABC) and technical director of BAPP. Besides information on new forms of adulteration and how to detect them the bulletin provides updated information on the saw palmetto market by adding the latest U.S. sales data and a discussion of the new harvest permit requirements issued by the Florida Department of Agriculture and Consumer Services in July 2018. Six expert peer reviewers provided input on the revised saw palmetto bulletin. The first bulletin was peerreviewed by 10 experts. Below-average harvests of saw palmetto berries have led to a dramatic increase in berry prices. This situation combined with a consistently strong demand for saw palmetto dietary supplements and other phytomedicinal products has led to a situation where adulteration of saw palmetto extracts appears to be on the rise Gafner explained. Adulteration by mixing saw palmetto extracts with fatty acids from animal materials is particularly challenging to detect since these fraudulent mixtures are designed to pass routine laboratory chemical methods of analysis. The adulterators fraudsters criminals whatever you want to call them have reached a new low in herb ingredient and botanical extract adulteration added Mark Blumenthal founder and executive director of ABC and founder and director of BAPP. Adding undisclosed amounts of animals fats to what would otherwise be a plant-based remedy is not only illegal and ethically inappropriate but also morally abhorrent particularly for the millions of men who are vegetarians or members of a religious group that promotes or requires vegetarianism or avoidance of certain types of meats. For more information visit http cms.herbalgram.org BAP BAB SawPal mettoBulletin.html ts 1540830209&signature 58a32ad10d61ff66f9e01623748f6433. www.niemagazine.com December 2018 Streamlined and Efficient Regulatory Structure Critical to Protecting Consumers and Public Health says NPA he Natural Products Association (NPA) recently called for a streamlined and efficient regulatory structure to protect consumers and public health as the U.S. Food and Drug Administration (FDA) implements its Comprehensive Multi-Year Nutrition Innovation Strategy. NPA supports the goals of FDA in its plans for the Multi-Year Nutrition Innovation Strategy and its efforts to promote public health and foster the development of healthier food options said Daniel Fabricant PhD president and CEO of NPA. The increased demand for natural products means that a streamlined and efficient regulatory structure is critical T in order to protect consumers and public health. We are pleased to work with FDA and the Trump Administration to ensure that health conscious American consumers have access to the products they use every day. In its comments NPA commented on the following four areas from FDA s notice to stakeholders in the Federal Register Creating a more efficient review strategy for evaluating qualified health claims on food labels Discussing new or enhanced labeling statements or claims that could facilitate innovation to produce more healthful foods and more healthful consumer food choices Modernizing the standards of identity to provide more flexibility for the development of healthier products while making sure consumers have accurate information about these food products Providing opportunities to make ingredient information more helpful to consumers For more information visit www.npanational.org. New Data Reaffirm Trust and Confidence in Industry Reveal Modern Trends and Habits of American Consumers he use of dietary supplements among U.S. adults increased 10 percent over the past decade confirms new data from the 2018 CRN Consumer Survey on Dietary Supplements. Commissioned by the Council for Responsible Nutrition (CRN) and conducted by Ipsos Public Affairs the survey found that 75 percent of U.S. adults take dietary supplements as opposed to just 65 percent in 2009. Results of the 2018 survey also revealed emerging trends in both consumer behavior and product demand. This year s data provide further evidence that dietary supplements are mainstays in modern day health and wellness regimens said Brian Wommack senior vice president communications CRN. Three-quarters of Americans take dietary supplements and the steady increase in use observed over recent years speaks to society s shift toward a more holistic personalized approach to healthcare. Not only does the 2018 survey reaffirm positive data we ve seen before but the results also paint a clearer picture of a changing industry guided by the needs and wants of American con- T December 2018 www.niemagazine.com sumers today. Consumer confidence in products and trust in industry remain strong. The majority of U.S. adults 87 percent have overall confidence in the safety quality and effectiveness of dietary supplements consistent with last year s data and up from 84 percent in 2009. Additionally the 2018 survey found that 78 percent of Americans perceive the dietary supplement industry as being trustworthy. When it first appeared on CRN s Consumer Survey in 2016 the question To what extent do you perceive the dietary supplement industry as being trustworthy yielded a response of 73 percent. We re pleased to see a 5 percent increase in consumer trust in just two years. said Wommack. As the industry continues to grow and innovate we will keep working hard to be worthy of consumers trust while helping them live healthier and more fulfilling lives. As seen throughout the survey s history the 2018 results also show that dietary supplement users are more likely to engage in other healthy habits than non-users. The 2018 survey found that supplement use is diversifying across categories. While vitamin mineral supplements remain the most popular category among supplement users (98 percent) the overall use of herbals botanicals has significantly increased in the past five years. In 2018 41 percent of supplement users reported they had taken herbals botanicals in the past 12 months up 13 percentage points from 2013. Within that category the 2018 data reflect the emergence of one of industry s rising stars turmeric. Turmeric wasn t on the survey five years ago noted Wommack. Now it s the second most popular supplement in the herbal botanical category. This year s survey results show similar upticks with other categories and products not only in the greater population but especially among different generations. For more information visit www.crnusa.org. Nutrition Industry Executive 27 AssociationNews Valensa Adopts Saw Palmetto Through ABC s Adopt-an-Herb Program he American Botanical Council (ABC) announced Valensa s (Eustis FL) adoption of saw palmetto (Serenoa repens) through ABC s Adopt-an-Herb botanical education program. Valensa s adoption supports ABC s extensive HerbMedPro database ensuring that this essential educational resource remains up to date for researchers health professionals industry members students consumers and other members of the herbal and dietary supplements and natural medicine communities. HerbMedPro is a comprehensive interactive online database that provides access to important scientific and clinical research data on the uses and health effects of more than 250 herbs spices and medicinal plants. Saw palmetto is an important botanical with extensive scientific and clinical literature supporting its use wrote Umasudhan C.P. president and CEO of Valensa. Specifically the oil from the ripe saw palmetto berry is extracted to obtain a nutraceutical that has proven benefits in the management of lower urinary tract symptoms associated with an enlarged prostate. Valensa is committed to creating the highest quality effective nutraceuticals and is proud to be a world leader in producing saw palmetto extract obtained using our sustainable wild-harvest practices and clean supercritical CO2 extraction process Umasudhan T continued. ABC is providing a valuable service by helping industry and consumers access scientifically accurate and relevant information regarding the efficacy of saw palmetto and the quality differences that can exist in marketed products. Saw palmetto dietary supplements ranked 11th in total sales in natural foods stores in the United States in 2017 and 14th in the mainstream retail channel according to ABC s annual HerbalGram Herb Market Report for 2017. Retail sales for saw palmetto supplements in these two market channels totaled almost 30 million. ABC is deeply grateful to our good friends at Valensa for their adoption of saw palmetto on ABC s HerbMedPro database said Mark Blumenthal founder and executive director of ABC. Valensa s adoption allows ABC to be able to provide its members with up-to-date information on this economically important medicinal plant. For more information visit www.herbalgram.org or http valensa.com. CRN Launches Pilot Program for CDX ith more than 10 000 labels in the Council for Responsible Nutrition s (CRN) Supplement OWL the registry is quickly becoming a go-to resource for regulators and other industry stakeholders. In addition to serving regulators the Supplement OWL provides retailers with an authoritative database to examine and evaluate labels of products on the market. As the registry nears its two-year milestone CRN members have the opportunity to help the OWL soar further. Following further direction from CRN s Board of Directors CRN and its member companies are ready to define the retailer-focused CDX. The Commercial Data Exchange (CDX) formerly known as Tier 2 is a retailer-focused feature of the Supplement OWL (Online Wellness Library). CDX facilitates business-tobusiness information exchange and allows companies with product labels in the Supplement OWL to upload additional information and supporting documents about W 28 Nutrition Industry Executive quality practices for their products for a nominal fee. The product marketer controls CDX information and only entities with permission from the marketer will be able to view these documents. CDX documents demonstrate compliance adherence in the following categories Evidence of Third Party cGMP (current good manufacturing practice) Audit Inspection Finished Product Testing Certifications Product Attributes (i.e. non-GMO gluten free allergen free halal kosher etc.) Post Market Surveillance AER Letter Statement of Compliance Structure Function Claim Notification FDA Assigned SFC Notification Number CRN seeks to reevaluate and improve the functionality of the CDX through a memberdriven pilot program. For more information visit www.supplementowl.org or www.crnusa.org supplement-owl-cdx-pilotprogram. www.niemagazine.com December 2018 ScienceUpdate Scoliosis Linked to Poor Utilization of Manganese obody knows why some children s backs start to curve to one side just as they hit puberty. Most children diagnosed with scoliosis or curvature of the spine have no known risk factors. A new study published in Nature Communications suggests that the body s inability to fully utilize the essential dietary mineral manganese might be to blame for some cases of severe scoliosis. Researchers at Washington University School of Medicine in St. Louis MO have found that children with severe scoliosis are twice as likely as children without the disease to carry a gene variant that makes it hard for their cells to take in and use manganese. Manganese is required for growing bones and cartilage. Our study links a common disease scoliosis to something that s potentially modifiable in the diet said senior author Christina Gurnett MD PhD a professor of neurology of orthopedic surgery and of pediatrics. But we don t want people to go out right now and start manganese supplements because we already know that too much manganese can be harmful. Approximately 3 million new cases of scoliosis are diagnosed every year. Most are mild and require only that doctors keep a watchful eye on the condition. Children who develop a moderate bend to their spine may need to wear a back brace until they finish growing. In rare cases the curvature is so pronounced that it requires surgery to correct. Cases of scoliosis tend to cluster in families but not in a simple way which suggests that many different genes each play a small role in increasing the risk of the disease. To identify such genes Gurnett and a research team including Matthew Dobbs MD Dr. Asa C. and Dorothy W. Jones professor of orthopaedic surgery and postdoctoral researcher and first author Gabriel Haller PhD scanned all the genes in 457 children with severe scoliosis and 987 children without scoliosis. They found a variant in the gene SLC39A8 in only 6 percent of the healthy children but 12 percent of the children with severe scoliosis. A second analysis in a separate group of 1 095 healthy children and 841 children with moderate to severe scoliosis also found that children with scoliosis were about twice as likely to carry the variant. N December 2018 www.niemagazine.com When the researchers bred zebrafish with a disabled SLC39A8 gene the fish developed movement and skeletal abnormalities including curves in their spines. This gene hasn t been studied much but there are some reports that it helps cells take in minerals such as zinc iron and manganese. Haller and Gurnett found that human cells with the gene variant successfully took up zinc and iron but failed to take in manganese. They also discovered that children with the gene variant had significantly lower levels of manganese in their blood than those with the more common form although both groups were still within the normal range. Our goal in studying the genetics of this disorder was to see if there was anything we could learn that might change how we treat patients said Gurnett who is also director of the Division of Pediatric and Developmental Neurology and neurologist-in-chief at St. Louis Children s Hospital. And we came across this gene variant that affects the level of manganese in the body. That tells me maybe we should start thinking about studying nutritional treatments for some children at risk. Manganese is both an essential mineral and a toxin. High doses can cause manganism a permanent neurological condition characterized by tremors and difficulty walking as well as psychiatric symptoms such as aggression and hallucinations. The mineral also has been linked to Parkinson s disease schizophrenia and high blood pressure. Too little manganese on the other hand can cause manganese deficiency although this is rarely seen in people because the human body needs only trace amounts that are easily obtained from food. But animal studies show that lack of manganese can result in problems metabolizing fat and sugar impaired growth difficulty walking and curvature of the spine. The children with the genetic variant did not have manganese deficiency but they may be unable to use manganese as efficiently as others. The genetic variant does not stop the gene from working entirely it s just not working optimally Haller said. So maybe most people need a certain level of manganese in their blood but if you have a bad gene variant like this one you need more. Any manganese supplementation would have to be carefully measured to avoid raising the risk for other serious diseases the researchers cautioned. We ve started doing these studies in zebrafish by adding manganese to their water Gurnett said. But we still need to do human studies to figure out how much exactly is both safe and effective. For more information visit https medicine.wustl.edu. Nutrition Industry Executive 29 By Lisa Schofield upermarkets are weird in a way now more than ever. More foods and beverages are on shelves that are healthier featuring natural ingredients strong macro- and micronutrient profiles no added sugars (or other chemicals) and reasonable calories per serving. And then there are the mouthwatering junk foods high in calories high in carbs high in sugar. More of these too. For example for years there was only one type of Oreo cookie. Now this classic offering has a large extended family including mint limeade fruit punch root beer float and salted caramel among many others. It takes tremendous self-discipline to pretend all these indulgent unhealthy foods don t exist. And many people who are learning how to support healthy blood sugar while navigating the supermarket need to have a glycemic-support S 30 Nutrition Industry Executive Sherpa. More attention is being paid to how diet impacts the blood sugar insulin cycle. According to Rhonda Witwer vice president of marketing and business development International Agriculture Group (IAG) of North Carolina the CDC (Centers for Disease Control and Prevention) has intensified its focus on prediabetes within the last few years. Major campaigns are underway to help people identify if they have higher than normal blood sugar levels and are prediabetic. For example she explained there is a growing resistance to the processed carbohydrates (Atkins Paleo low-carb). The U.S. s Dietary Guidelines have encouraged high carbohydrate foods for more than 30 years without adequate scientific evidence. We are learning that continuing scientific studies have not shown disease prevention benefits from adherence to a low-fat diet (as has been promoted and promised by The Dietary Guidelines) she asserted. In short our dietary recommendations have failed and Americans are now suffering from the ill effects of high-carb lowfat diets in epidemic proportions. Insulin resistance is the underlying factor why low-carb diets would be beneficial for half of all Americans. The Nutrition Coalition founded in 2015 is endeavoring to change that by encouraging the government to develop dietary policies based on rigorous science by abandoning low-fat and promoting low-carb high fat diets. The coalition is said Witwer challenging the exclusion of approximately 70 clinical trials on low carbohydrate diets that were omitted from the Dietary Guidelines Advisory Committee Report. According to the Nutrition Coalition website (www.NutritionCoalition.us) the cumulative evidence shows that low-carb diets www.niemagazine.com December 2018 are safe and effective for combating obesity highly promising for the treatment of Type 2 diabetes and they improve most cardiovascular risk factors. Processed foods and high sugar fructose intake as common contributing factors to glucose intolerance and increased risk of type II diabetes and a 2016 paper co-authored by Mohamed Rafi PhD founder of New Jersey-based Bioactives American Corp. goes into new territory of the etiology of hyperglycemia. Hyperglycemia occurs when glucose is stranded in the blood after each meal if the body fails to store it as glycogen in muscle and liver tissue the storage tissues he explained. The review revealed a new theory that glucose uptake is not insulin dependent in most tissues and that a key role of insulin in the liver is its inhibition of gluconeogenesis and glucose production which controls postprandial glucose. Insulin is necessary but alone will not suffice in glucose control he said. The applications of more precise research technologies such as in silico molecular docking to identify and study novel applications of food components to safely improve and perhaps reverse insulin-resistance within a preventative dietary approach have been driven by two things the understanding of different issues involved with glucose homeostasis and also the clearer clustering of metabolic syndrome abnormalities caused by insulin-resistance leading to increased inflammation according to Andrea Zangara MS scientific marketing manager Euromed SA of Spain. Despite the spate of rollouts and reformulations of foods and beverages with no added sugar and grain and other slower carbs recent data shows that the typical diet still contains carbs and sugar in high proportions observed Jocelyn B rub executive vice president scientific & regulatory affairs InnoVactiv Inc Canada. Estimates show that sugar consumption is reaching slightly more than 140 pounds per person annually while simple carb consumption (including other forms like starch maltodextrins and HFCS) rose from nearly 44 percent of daily calories in 1971-75 to an average of approximately 50 percent over the last seven NHANES surveys (i.e. after the 1977 publication of Dietary Goals in the U.S. which ushered in the low-fat era). Putting those stats into current context Berube asserted High-carb intake means that every meal pushes our blood glucose to high levels triggering the December 2018 www.niemagazine.com release of large amounts of insulin and forming dangerous free radicals and glycated end products. Constantly high insulin levels also pave the way to insulin resistance. No surprise then that nearly 34 percent of U.S. adults are prediabetic He added True innovation in the category of blood sugar support should target mechanisms of action that safely support blood glucose in a broad spectrum of individuals including healthy prediabetics and diabetics alike. Category Innovations Numerous suppliers are investing in research and development of natural ingredients that are shown to help the body regain balance in blood sugar and insulin sufficiency. Ingredients range from botanical roots used in traditional medicine systems to polyphenols and antioxidants to fibers and fruit extracts. Botanical Roots LJ100 Tongka Ali (Eurycoma longifolia) long known as the king of men s health and virility supplements and long history of traditional use in Malaysia has now been shown through a new in vitro study to help manage blood glucose. Specifically researchers focused on a compound contained within the patented ingredient a 4.3kDa peptide known to provide stamina enhancement and energy release as well as to act as an antihyperglycemic on insulin secretion and glucose uptake. Specifically according to Annie Eng CEO of HP Ingredients the researchers incubated cultured cells (3T3-L1 L6 BRIN-BD-11 and Caco-2 cells) with concentrations of E. longifolia water extract or the peptide then determined their viabilities after 24 hours. After this time period higher doses of both were used to determine glucose uptake into 3T3-L1 and Caco-2 and L6 cells while insulin secretion was assessed from BRIN-BD-11 cells. After 30 minutes of incubation with the water extract and the peptide insulin secretion from BRIN-BD-11 cells increased by up to 200 percent and 2 800 percent respectively. Glucose uptake was increased by up to 23 percent (LJ100) and 31 percent (peptide) in 3T3-L1 cells and 54 percent and 68 percent also respectively in L6 cells. In both cases glucose uptake was significantly augmented in the presence of insulin. There was marginal reduction in glucose uptake in Caco-2 cells. The researchers concluded that the results suggest that LJ100 is a candidate for enhancing glycemic control. Another root botanical comes from Bioactives American Corp. Salsulin is a self-affirmed GRAS (generaly recognized as safe) ingredient from Salacia oblonga root which contains various beneficial nutraceuticals including anthocyanidins catechins phenolic acids quinones and triterpenoids according to Rafi. The primary bioactive compounds in Salacia oblonga are xanthanoid (mangiferin) and two unique sulphur compounds salacinol and kotalanol. S. oblonga has been the subject of several clinical studies since 2005 that said Rafi demonstrate its strong efficacy in supporting healthy blood glucose metabolism. One study noted that the presence of S. oblonga extract tended to lower post-prandial glycemia and significantly reduce postprandial insulin response. Another randomized doubleblind crossover study concluded that S. oblonga has the potential to support healthy blood glucose metabolism after a high-carbohydrate meal. This present-day research coupled with the ancient wisdom and documentation of ayurvedic medicine makes Salacia oblonga an emerging nutritional solution to address post-prandial glucose and insulin response especially in combination with diet and lifestyle changes he summarized. Polyphenols Horphag Research s Pycnogenol described S bastien Bornet vice president global sales and marketing is an antioxidant shown in numerous studies to support healthy blood sugar levels. Nutrition Industry Executive 31 Pycnogenol may help normalize blood sugar levels by slowing the absorption of carbohydrates which results in reduced blood glucose. It is shown to significantly delay the uptake of complex sugars and inhibit the digestive enzyme -glucosidase to help normalize post-prandial blood glucose. It has been shown to play a role in metabolic syndrome which impacts blood sugar. For example provided Bornet A 2013 study found Pycnogenol may reduce metabolic syndrome factors (waistline obesity high cholesterol high blood pressure and high blood sugar). A 2015 study found that Pycnogenol naturally improves circulatory and endothelial function while improving fasting glucose levels in individuals with borderline high glucose. Pycnogenol has also been found to reduce cardiovascular risk factors in diabetics like high blood sugar LDL cholesterol and blood pressure. One study shows that Pycnogenol naturally supports kidney function in patients with metabolic syndrome. This study showed Pycnogenol s benefits for managing blood pressure reducing blood sugar and lowering body mass index. Resveratrol is a polyphenol that is found in grapes and other plants and is mainly known for its antioxidant properties. However pointed out Sally Aaron senior vice president of health ingredients and marketing Evolva (California and Kentucky) clinical studies have revealed benefits such as efficacy in reducing blood sugar and improvement in insulin sensitivity. Studies have shown that resveratrol seems to support a healthy blood glucose homeostasis and affects prediabetic and diabetic patients but not healthy subjects. Resveratrol has also been presented to ameliorate diabetic foot syndrome and to accelerate wound healing she explained. Evolva s Veri-te resveratrol is produced through a fermentation process to create high purity trans-resveratrol ( 98 percent) according to Aaron. The ingredient is featured in a variety of products such as chewing gum to liquid shots and functional beverages. One of the latest innovative delivery technologies we have 32 Nutrition Industry Executive seen are dissolvable oral film strips she related. The oral filmstrip technology is currently being researched to determine if the uptake of resveratrol via the oral mucosa is radically different from the absorption of traditional applications that absorb via the gut. It is hypothesized that resveratrol may be more bioavailable when delivered to the lining of the mouth and exposed to plasma. This increased bioavailability of resveratrol can lead to many new applications and novel products. InnoVactiv s InSea2 B rub described is a polyphenol extract derived from two species of wildcrafted brown seaweeds. Studies have shown that resveratrol seems to support a healthy blood glucose homeostasis and affects prediabetic and diabetic patients but not healthy subjects. Sally Aaron Evolva The ingredient s polyphenols act upon digestive enzymes -amylase and -glucosidase which convert dietary starch and sugars into simple glucose allowing its uptake in the bloodstream. When these enzymes are functioning optimally they effectively convert all carbs into glucose in the 15 to 30 minutes after eating. InSea2 has been shown to help individuals across the spectrum of metabolic profiles reported B rub . In several clinical trials healthy subjects who took one dose of InSea2 saw significant improvements in their post-prandial blood glucose and insulin responses to starchy and sugary foods. In another trial with one dose of InSea2 healthy subjects felt improvement in focus and attention following a high-carb meal which is a sign of improved glucose and energy management after meal he noted. Lastly InSea2 was shown effective in improving glycemic and inflammation markers in a group of prediabetic subjects after six months. Fiber Ancient grains continue to be sought after by health-conscious consumers not only for meals but also for specific health attributes in supplements such as powders for smoothies. One such fiber is chia seed (Salvia hispanica L.) a rich source of highly viscose soluble dietary fiber. Since viscose fiber has been proven to reduce the glycemic index in food and thus postprandial glycemia recent research was targeted to show the influence of chia fiber in reducing glycemic index explained Carolina Chica ND head of nutrition and regulatory department Benexia of Chile. Chia fiber may lower postprandial plasma glucose plasma insulin while improving insulin sensitivity in healthy individuals. Chia s naturally occurring combination of functional nutrients found in large quantities including the high amounts of omega-3 magnesium polyphenols and soluble fiber may be responsible for its blood glucose-lowering response she described. According to Chica several studies have shown chia s ability to support parameters of metabolic syndrome such as reducing conventional and emerging heart disease risk factors in patients with type 2 diabetes as shown in one study. Another study showed that taking 45 grams of chia (25 g of chia fiber) daily for one month resulted in reduction in blood pressure triglycerides and smaller waist circumferences or less abdominal fat. A study on obese rats with metabolic syndrome showed chia fiber reversed insulin resistance lowered triglyceride levels and reduced abdominal fat compared to control. A newly launched product featuring Benexia combined with chromium picolinate and ginger powder is formulated to help control blood sugar response and insulin resistance Chica reported. This product was designed to help manage weight control and the prevention of metabolic disease. This product is a one sachet daily dose easily dispersed in cold water with a great taste. This product is clean label and designed for the new generation of consumers looking for natural ingredients she said. Sunfiber soluble guar fiber also PHGG from Minnesota-based Taiyo has been shown in studies to decrease glycemic index of a variety of foods decrease post-prandial glucose levels and lower www.niemagazine.com December 2018 Go to www.niemagazine.com euromed for info about this advertiser hemoglobin A1C according to Derek Timm PhD RDN Sunfiber s technical sales director. He noted that Sunfiber works in two ways by slowing the gastric emptying time which in turn slows the digestion and absorption of carbohydrates and sugars that results in decreased glycemic response and peak glucose levels and can decrease glycemic index when added in products to displace to some glycemic carbohydrates. Sunfiber resulted in significant reductions in the insulin resistance index as well he added. Not only does it helps decrease postprandial blood sugar levels over time it helps improve the body s ability to utilize insulin. intake. Research has shown that after glucose intake plasma ABA increases in healthy people but does not increase in diabetic people. In non-diabetic individuals ABA has a beneficial effect on the glycemic and insulin responses without affecting insulin release. Research has identified ABA s mechanism of action lies in the metabolic changes occurring when it binds to the receptor lanthionine synthetase C-like 2. Additionally binding to this receptor induces anti-inflammatory effects through a PPAR -dependent action. The net effect is to increase the production of the protein Glut-4 that carries glucose from the bloodstream into the cell reducing the level of glucose in the bloodstream Zangara commented. Fruits IAG s NuBana RS65 Green Banana Flour contains a minimum of 60 percent resistant starch and according to Witwer it significantly improves insulin sensitivity and helps to maintain healthy blood sugar levels especially in individuals that are insulin resistant and or prediabetic. Resistant starch feeds the beneficial bacteria in the large intestine and changes the expression of more than 200 genes some of which control insulin resistance within the large intestine. Clinical trials have shown that resistant starch s fermentation improves insulin sensitivity (reducing insulin resistance) as fast as the next day she said. It does not require exercise or weight loss for these benefits to be seen. In fact the FDA (U.S. Food and Drug Administration) approved a qualified health claim that resistant corn starch may reduce the risk of Type 2 diabetes. Thus resistant starch delivers an important new tool for individuals trying to maintain healthy blood sugar levels. Euromed s Abalife is a new patented extract from fig a fruit containing a standardized amount of abscisic acid (ABA) which is naturally produced in the human body in the vitamin A pathway according to Zangara. ABA s key role in human health has been only recently clarified It induces metabolic signals that promote glucose and inflammatory homeostasis. ABA is largely influenced by dietary 34 Nutrition Industry Executive New research presented at the 2018 meeting of the American Diabetic Association showed that 200 mg of ABAlife extract consumed by healthy individuals in a glucose solution reduced overall levels and peaks in their blood glucose and insulin after both 30 minutes and two hours after consumption. It also significantly improved glycemic index (GI) compared to a reference glucose solution without ABAlife Zangara reported. Although not a fruit fiber polyphenol or botanical root the trace mineral chromium is a powerhouse partner in many blood sugar support formulas as it has years of clinical trials demonstrating efficacy as it is essential for carbohydrate fat and protein metabolism. Insufficient chromium levels can have a negative impact on blood glucose and insulin as well as triglyceride and total cholesterol levels. As an insulin co-factor chromium increases insulin-stimulated glucose metabolism increasing the ability of excess glucose to enter cells. Because of its efficacy in lowering elevated fasting blood sugar lowering insulin levels and helping insulin to work better chromium picolinate should be considered by individuals interested in maintaining healthy blood sugar levels said James Komorowski chief science officer Nutrition 21 LLC New York. With over 60 patented uses Chromax chromium picolinate is the only form of clinically efficacious dietary chromium that has been reviewed extensively for safety and efficacy he stated. Chromax can also help improve body composition as part of a healthy diet and exercise program. More than 30 million Americans now have diabetes and while prevalence of this disease is highest among those who are 65 and older according to the National Diabetes Statistics Report for 2017 4.6 percent of U.S. adults between age 18 and 44 are also diabetic. And many are seeking natural ways and dietary changes to support the medical protocol they are on. Sugar is definitely on the radar for a growing number of consumers. Data from the Foodinsight.org 2018 Food and Health Survey shows about one-third of American consumers now see sugar as the source of calories that are most likely to cause weight gain and 77 percent said they are actively avoiding or limiting sugars in their diet reported Rafi. By formulating effective blood sugar support products you can help guide them through the alluring highsugar high-carb terrain with the occasional stop to indulge in gustatory bliss. NIE Extra Extra Visit www.niemagazine.com to learn about how alanine can help support glucose metabolism. FORMOREINFORMATION Benexia www.benexia.com Bioactives American Corp. http bioactivesamerica.com Euromed www.euromed.es Evolva www.evolva.com Horphag Research www.pycnogenol.com InnoVactiv Inc www.innovactiv.com International Agriculture Group www.iagnubana.com Nutrition 21 www.nutrition21.com Taiyo www.sunfiber.com www.niemagazine.com December 2018 THE NUTRITION INDUSTRY S NEWS & INFORMATION RESOURCE Coming in 2019 Jan. Feb 12 14 18 ad closing Heart Health Digestive Health March 2 8 19 ad closing Weight Management SupplySide East Show Issue April 3 19 19 ad closing Compliance & Improving Quality Bone Muscle & Joint Health May 4 10 19 ad closing Science of Ingredients Vision Health June 5 16 19 ad closing 2019 NIE Supplier Sourcebook Our 2019 Media Planner Is Available At NIEmagazine.com 2019-Media-Planner Contact One of Our Ad Specialists Today Russ Fields at (732) 432-9600 ext. 102 or e-Mail RussF VRMmedia.com Barry Young at (732) 432-9600 ext. 103 or e-Mail Barry VRMmedia.com EFA Essentials As consumers become more educated ingredient suppliers and manufacturers are creating products that address their concerns. By Shari Barbanel t is widely known that EFAs (essential fatty acids) are essential because they cannot be produced by the human body and must be obtained by diet or supplementation. Countless studies have been done on how EFAs benefit a number of the body s systems including heart joint immune health etc. And as consumers learn about the many benefits that EFAs offer they often add omega-3 rich foods to their daily routine. In fact a report published by Allied Market Research titled Omega-3 Market - Global Opportunity Analysis and Industry Forecast 20142022 found that the omega-3 market is expected to reach 6 955 million by 2022 with a CAGR (compound annual growth rate) of 14.9 percent from 2016 to 2022. Proprietary GOED (Global Organization for EPA and DHA Omega3s) research noted that the EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) omega-3 market in 2017 at the raw materials level was I 36 Nutrition Industry Executive 1.25 billion (U.S.) in value on a global basis up 5.0 percent from 2016 with oils going into supplements making up 58 percent of that noted Chris Gearheart director member communications & engagement for GOED in Utah. In addition the Allied Market Research report also found that global ALA (alpha-linolenic acid) market has great potential as compared to DHA and EPA as consumers constantly look for alternatives of fish oil as the world ALA omega-3 market accounted for more than 234 million in 2015. In addition North America dominated the world ALA omega-3 market in terms of revenue generating 96 million in 2015. The fatty acid market continues to be strong particularly for the omega-3 fatty acids due to the wide range of health benefits associated with them and in recent months there have been several noteworthy developments both positive and negative said Nena Dockery technical services manager for Missouri-based Stratum Nutrition. From a positive perspective not only has the number of published research studies into the health advantages of omega fatty acids increased but so has the number of health areas benefited by fatty acid supplementation. Hugh C. Welsh president and general counsel for New Jersey-based DSM North America added that there is a huge body of evidence to demonstrate the role and positive impact that essential fatty acids can have in heart brain eye and maternal health. Put simply DHA and EPA help to keep some of the body s most important organs functioning and healthy at every life stage he explained. It is the healthy benefits of DHA and EPA that perhaps offer the most potential to functional food beverage and dietary supplement manufacturers however as we have recently seen there is an increased need for transparency quality and traceability in the industry. Consumers are also www.niemagazine.com December 2018 becoming increasingly aware of the importance to source ingredients in a sustainable manner. According to Gretchen Vannice MS RDN head of global nutrition education for Ohio-based AlaskOmega a large research study that followed more than 8 000 adults for an average of approximately five years (4.9 years) was presented at the American Heart Association meeting on November 10 2018. This study called the REDUCEIT trial found that high EPA omega-3 (4 grams ethyl ester EPA day) reduced risk by approximately 25 percent for several cardiac events such as fatal and nonfatal heart attack and stroke in adults taking statin medications to lower LDL (low-density lipaprotein)-cholesterol she explained. This study adds more evidence to the existing body of scientific research that EPA omega-3 from fish and fish oil saves human lives is not only safe to take with statin medications but adds significant and measurable health benefits and a good safety profile Vannice added. Addressing Concerns Today s consumers are savvy they want to be sure that every purchase they make is a quality one that meets their criteria for quality transparency etc. And it is up to ingredient suppliers and manufacturers to deliver on these expectations. Our research suggests that there is a rising consumer concern with respect to safety quality and traceability of ingredients said Welsh. Consumers trust the brands they buy which means food manufacturers need to deliver on that trust. Safe ingredients are key to this and the ingredients manufacturers have a vital role to play. Katrin Berntsen director of communications with Aker BioMarine in Norway agreed noting that consumers want to know all of the expected benefits from products and they also want to know where the ingredients are coming from. Manufacturers should always be transparent and consistent in their messaging and make Ahiflower education a priority. Ingredients that are sustainable and traceable are becoming the norm with consumers so it s important that comDecember 2018 www.niemagazine.com panies show the credibility of their ingredients she added. Education is key and it s important across the whole supply chain. Aker BioMarine maintains a 100 percent traceable supply chain so consumers retailers and manufacturers alike can see each step in the krill production process. The company is also making it a priority to promote industry responsibility by employing effective sustainability practices through the Association of Responsible Krill Harvesting Companies (ARK). According to Berntsen this includes safeguarding the buffer zones around breeding colonies of penguins to protect Antarctic wildlife and supporting the scientific and political process for the creation of a network of large-scale marine protected areas in the Antarctic including areas in which krill companies currently operate. DSM has committed to reducing its carbon footprint through improved production processes. Welsh noted that the company put significant efforts into improving the efficacy of food ingredient production within all levels of the industry. We invest heavily in developing products that help reduce the ecofootprint and continually strive to reduce energy consumption and the environmental impact of our activities while optimizing land and resource use he said. To ensure safety and quality we have invested in robust internal auditing processes ensuring that ingredients can be tracked and found quickly. For example the company supports a renewable sustainable environment by sourcing fish for MEG-3 oils from regulated fisheries where equipment practices and procedures are in place to protect fish stocks. The fish oil we use is sourced from a variety of wild fish species and is a byproduct of either the fishmeal or edible canning industries Welsh said. No fish are caught for the exclusive production of oil. We also turn fish oil processing waste into biofuel to operate our state-of-the-art fish oil production facility in Mulgrave Nova Scotia (Canada). As for AlaskOmega Vannice explained that the company s fish oils exceed industry standards for freshness and are sourced from sustainable Marine Stewardship Council (MSC)-certified wild Alaska pollock fish. AlaskOmega fish oil is caught and manufactured in the U.S. and the company produces concentrated fish oil delivering more EPA and DHA per serving. Stratum Nutrition addresses the concerns of sustainability of marine sources as well as the dietary restrictions of vegetarians by offering Ahiflower seed oil a vegetarian omega fatty acid source that is sustainably produced by local farmers in the U.K. Most plant sources of omega-3s contain the essential fatty acid alphalinolenic acid (ALA) which converts in the body to EPA and DHA but not efficiently said Dockery. Stratum Nutrition offers an ahiflower (Buglossoides arensis) seed oil which contains not only ALA but also stearidonic acid (SDA). SDA converts much more efficiently in the body to EPA increasing serum levels of EPA after supplementation about four times higher than flaxseed oil. In addition ahiflower also contains several other fatty acids including the only other truly essential fatty acid linoleic acid (LA an omega-6) as well as the beneficial omega-6 gamma linolenic acid (GLA) and the omega-9 oleic acid. According to Welsh DSM s research indicates that there are a few strong consumer preference trends within dietary supplements including smaller capsules safety quality and an overall increased mindfulness surrounding diet choices. As consumers become Nutrition Industry Executive 37 EFA Essentials increasingly aware of the significance that healthy diet choices play in healthy aging we have seen a much higher demand for alternative sources to meet dietary requirements he said. DSM s life sDHA is a vegetarian kosher halal and major allergen-free DHA sourced from algae that is nongenetically modified (GM) and is the only DHA currently used in U.S. infant formulas. The company s life sOMEGA is produced using the same methods as life sDHA from non-GM algal source algae and is a vegetarian source of EPA and DHA omega-3s. It s produced from start to finish in an U.S. Food and Drug Administration (FDA)-inspected facility with controls in place to ensure the highest quality. Trends Within the EFA category there has been growth and change from the types of sources to advancements in research expanding the list of benefits. One of the first omega-3 products in the modern market was cod liver oil which is a legacy product that probably goes back hundreds of years said Gearheart. Modern day omega-3 supplements have traditionally come from anchovy oil currently 60 to 70 percent of fish oil for supplements come from the Peruvian anchovy fishery but there are plenty of supplement products from other fish like salmon pollock and tuna as well as krill oil. Algae oil is a growing area with many new suppliers commercializing algae products. Additional categories include green-shelled mussels squid and a micro-crustacean called calanus. Researchers have been conducting vast amounts of studies on EFAs showing their positive effects on a number of the body s systems. EPA and DHA omega-3s have more than 30 000 published papers showing their benefits noted Gearheart. The research is strongest in the heart health category particularly for lowering triglycerides and blood pressure and for reducing the risk of coronary heart disease and cardiac death. Additional areas of benefit for EPA and DHA are brain health eye health and prenatal and infant health. EFAs are also moving into the sports nutrition category as it is no longer just for body builders and hard-core athletes consumers of all ages are now living more active lifestyles. The health and wellness market is growing thanks to health conscious consumers everywhere and there is no question that sports nutrition is a subcategory that is on the move explained Berntsen. In fact the sports nutrition market is spanning well beyond traditional bodybuilders and athletes and is evolving to target active lifestyles across the board. From fitness gurus to lively seniors and everyone in between this market is on the move and krill oil is starting to make a major impact in this space. Due to its inherent advantages krill oil has great potential for the sports nutrition market. To that end Aker BioMarine s research team has set out to explore the effects that krill oil has with active lifestyles and preliminary research data is proving to be promising. Aker BioMarine is also exploring the effects that krill oil can play in ultimate performance. The company initiated a study with the Norseman Xtreme Triathletes some of the toughest athletes in the world to see what positive effects krill oil has on illness reduction during training and recovery time said Berntsen. If krill oil proves to be bene- ficial to the most extreme athletes in the world there will likely be great possibilities that it can have on active lifestyles across the board. Aker BioMarine s flagship product is Superba Krill. According to Berntsen Superba Krill has come a long way over the past decade and has opened the doors to many new opportunities for the company and industry alike including Superba2 the next generation of Superba Krill Oil as well as Superba Boost a new krill concentrate which contains higher amounts of phospholipids choline and omega-3s. And in addition to the growing list of health concerns that may benefit from EFAs Gearheart noted that the primary trend in the EPA and DHA omega3 category is the trading up of consumers moving from supplements containing a base level of omega-3s socalled 18 12 oils to more highly concentrated forms with more EPA and DHA per pill. DSM s 3C Technology for example allows the company to create a concentrated EPA DHA supplement choice that is up to three times more potent in a much smaller easier to swallow capsule allowing consumers to receive the targeted health benefit in a single daily dose according to the company. EFAs offer a number of benefits and options for consumers with different dietary concerns therefore the potential for the category seems endless. The market for omega fatty acids particularly omega-3s continues to grow as the health benefits expand concluded Dockery. This category is one that benefits everyone young and old alike so it will continue to grow and expand. NIE Extra Extra Visit www.niemagazine.com to read about a study showing fish oil supplement in pregnancy may be associated with a higher BMI in children by age 6. FORMOREINFORMATION 38 Nutrition Industry Executive Aker Biomarine Antarctic AS www.akerbiomarine.com AlaskOmega https alaskomega.com DSM www.dsm.com Global Organization for EPA and DHA Omega-3s (GOED) www.goedomega3.com Stratum Nutrition www.stratumnutrition.com www.niemagazine.com December 2018 Nutraceuticals EMBRACING One of the most BOTANICAL challenging issues with combination products is being able to include therapeutic levels of key While the popularity of ingredients while certain medicinal plants may keeping the daily ebb and flow the need for serving of tablets or research and clean ingredients capsules to a remains steady for botanical minimum extracts in finished products. EXTRACTS Marci van der Muelen National Sales Manager Nordic Naturals By Nicholas Saraceno he National Institutes of Health s Office of Dietary Supplements sums up a botanical best in its definition of the item a plant or plant part valued for its medicinal or therapeutic properties flavor and or scent. Upon being soaked in a liquid that removes chemicals that liquid can then be evaporated and made into a dry extract for capsules or tablets or used as is. Botanicals are known for their antimicrobial antioxidant and anti-allergic benefits German chamomile (Matricaria recutita) has been utilized to treat skin conditions. But this only represents a microcosm of what plant extracts can offer and extract fads and trends ebb and flow. T Popular Extracts Extracts in oil and powder form have gained a reputation especially from Botanic Innovation a Wisconsin producer of these which come from non-GMO December 2018 www.niemagazine.com (genetically modified organism) fruit grain and herb seeds. Some such as chia seed oil have been observed to have actually cooled down in popularity. Botanic Innovations has been producing Organic Black Cumin Seed Oil and Organic Black Cumin Seed NutriPowder for almost two decades (at our plant in Wisconsin) and we have supporting clinical research with Organic Black Cumin Seed Oil and NutriPowders that is pushing a decade old said Rebecca Blahosky vice president of sales and marketing. Yet the past one to two years has seen a significant jump in this ingredient and we are getting inquiries for these ingredients on a global scale. This ingredient has a long history of safe use to support a variety of wellness applications so it s very exciting to witness the explosion of interest in these ingredients. Other plant seed oils from cranberry to pomegranate to tomato etc. are gaining in popularity as well as long as they re cold pressed and unadulterated like Botanic Innovations are. Chia Seed Oil was hot about five-plus years ago but now is almost mainstream. We look at the popularity and consumer acceptance of chia seed oil as a huge opportunity for other nutritional oils (and nutritional oil blends) that can help support human wellness. Blahosky noted that the Organic Black Cumin Seed Oil has a primary use in oil blends used as dietary supplements adding that the company produces NatureFRESH Cold Press fruit vegetable and herb seed oils and nutripowders offering comprehensive benefits that help support overall human wellness this includes supporting heart brain skin health and more. California-based Ethical Naturals who individuals might recognize as being a supplier of several common standardized extracts such as milk thistle grape seed and Ginkgo biloba offers further variety according to Cal Nutrition Industry Executive 39 Nutraceuticals Bewicke CEO such as Cranberex a cranberry extract that supports urinary tract health (two clinical studies) GreenGrown a vegetable source glucosamine that supports health cartilage growth VinCare patented grape extract that supports healthy cholesterol and cardiovascular function (one clinical study) In fact this assortment of available botanical extracts has positively impacted the market for these ingredients. Market Status & Clean Label The request for botanical extract ingredients is steadily growing with factors such as consumer demand and conducted research helping to lead the charge. Demand for botanical extracts continues to grow at 7 percent to 10 percent per year and all of this is driven by consumer demand for finished products Bewicke noted. The high quality of research and the number of published clinical studies focused on botanicals continues to add more validation to the use of botanical extract supplements for maintaining long-term health. Blahosky was in complete agreement she even spoke on the importance of clean ingredients. The state of the botanicals ingredients market has never been stronger she said. Consumer interest is high and credible research on botanicals is helping support the positive reputation of many botanicals. I think that with transparency for ingredients from supply chain botanical origin etc. there is growing opportunity for clean pure ingredients. For our company where we produce ingredients in the USA without additives we are getting exposed as a great option for companies who do not wish to muddle through all the paperwork since clean is in. Although adding botanicals to finished products may be easier said than done following this Clean Label path could prove to be worthwhile. Clean label is important and being able to prove that ingredients are clean and unadulterated is important with botanical extracts Blahosky continued. For companies who can manage the paper and transparency trail to meet clean label obligations this is positive and ideal. However it s a huge commitment for finished product pro40 Nutrition Industry Executive ducers to be able to manufacture with botanical extracts due to paper trail pureness of ingredients etc. prohibitively long and expensive. That said it s worth it for proven botanical ingredients that support a wellness application Challenges Being able to ultimately get finished products containing botanical extracts in the hands of consumers is the end goal but for finished product manufacturers the use of these ingredients provides an extra challenge. From the point of view of manufacturing finished products Bewicke explained botanical extracts can create problems because of variation in both density and potency. To get a botanical extract capsule to conform exactly to specification can thus require a lot more care and attention than vitamins or minerals that are very consistent in density and potency. Being able to effectively test these products also comes at a financial cost. Additionally the identity and potency testing required to guarantee a product that fully meets cGMP [current good manufacturing practice] FSMA [Food Safety Modernization Act] and high level certification requirements today is sophisticated and expensive Bewicke added. Some suppliers do this testing in U.S. labs prior to shipment others don t. All imported botanical extracts should be fully tested in the U.S. prior to use. The importance of clean ingredients cannot be stressed enough and the same can be true for its price. Supply chain is a huge hurdle with botanicals Blahosky pointed out. Many are grown in exotic locations so finding quality vendors is difficult. Additionally the burden to ensure that products are clean and unadulterated is Research Ethical Naturals Inc. s latest research has revolved around cranberries and its standardized cranberry extract Cranberex which several companies have utilized. Our most recent research and development of clinical studies has focused on cranberry and particularly on our unique Cranberex product a 200 1 extract of Oregon cranberries said Bewicke. We accomplished two studies at Rutgers University [New Jersey] that showed exceptional bacterial AAA activity (anti-adhesion activity) in the human urinary tract. Our most successful customers for this product are Doctor s Best [California] who is now adding a second combination product using Cranberex and Her Vital Way [California] a company that focuses on high-grade supplement products for women. And for Bewicke testing of purity and potency is a requirement. Spearheaded by ABC (American Botanical Council) and a number of leading botanical extract suppliers testing and research into the purity and potencies of products has continued to grow. On the other hand there are still a number of companies supplying ingredients that go through very little testing to assure potency and identity. In turn it is apparent that ingredient suppliers and manufacturers find safety to be a critical focal point in conducted research. If possible studies and results featuring humans is preferred. The more research the better Most important is any safety data Blahosky advised. Some botanicals have been used for centuries as ingestibles for human health. That is a great start It s helpful for companies to provide nutrient profiles so that formulators can understand component nutrients in botanicals. Any human data would be the gold standard as it relates to benefits but overall clinical research helps build a body of information to support the benefit of botanicals. NIE FORMOREINFORMATION Botanic Innovations LLC www.botanicinnovations.com Ethical Naturals Inc. www.ethicalnaturals.com www.niemagazine.com December 2018 Go to www.niemagazine.com bio-botanica for info about this advertiser FunctionalFoods SUGAR REDUCTION BEST PRACTICES By Nathan Pratt PhD RD he functional food revolution has changed the way that consumers today eat as more brands are innovating products with tailored and specific functional benefits like immune digestive or heart health. Thirty percent of consumers now eat functional foods at least once a week and research shows that 85 percent of consumers globally consider food to be their preferred consumption format for health-enhancing ingredients.1 Furthermore more than half of consumers believe foods can provide the same or better benefits than non-prescription medications.2 As the move to enrich products ranging from nutritional bars to yogurts and even baked goods with functional ingredients continues to gain momentum there are key considerations related to sugar content and overall healthfulness that manufacturers must not overlook. T Make Sure Functional Foods Are Healthy In the grand scheme of things consumers are migrating toward functional 42 Nutrition Industry Executive foods because they want to be healthier. This means a couple of important things for product manufacturers. The product should deliver an effective serving of the ingredient based on scientific studies. Some products rely strongly on a health halo or will fairy dust an ingredient meaning there is not enough to provide the benefit. For example many studies on health benefits of turmeric provide at least 200 mg of curcumin the active ingredient in turmeric per day. A functional food delivering only 50 mg of curcumin likely isn t enough to deliver the health benefit a consumer would expect. Functional Ingredients can provide permissible indulgence Functional foods should easily fit into a healthy diet. Adding the health benefits of a functional ingredient to an everyday food or beverage product allows for consumers to add a bit of healthy indulgence to their diet and lifestyle. Consumers proactively seek the added health benefits of functional foods as a means to take control of their diet and health. Given this it s important for manufacturers to align product offerings accordingly. The functionality provided by a health-enhancing ingredient such as a probiotic or immune health ingredient are typically best suited to products that are already positioned to be somewhat healthy or better-for-you. Once again if consumers are expecting a product to be healthy for them manufacturers have a responsibility to make sure this is true Adding health benefits to a product like a sugar-laden soda would negate the desired benefits but fortifying a better-for-you reduced-sugar beverage with added benefits is much more appealing to today s consumers. A Focus on Sugar It seems like half of the news articles we see in the food and beverage industry are about reduced-sugar product launches or market insights about consumers wanting less sugar. For formulators these types of articles can often www.niemagazine.com December 2018 cause more questions than answers How do I actually reduce sugar How much should I reduce sugar by and what sweeteners should I use Which Sweetener Should I Use This is usually the main question any time sugar reduction comes up. The first step is to know what type of consumer you are targeting. People are almost evenly split into the following groups (Food & Health Survey 2017 International Food Information Council) Prefer low-calorie sweeteners because they want to reduce sugar intake as low as possible Avoid low-calorie sweeteners because they prefer the taste of sugar or are nervous about health implications of consuming low-calorie sweeteners Once this is known you can narrow down the solutions available. Kerry recently conducted a consumer research study titled Sensibly Sweet to better understand attitudes toward sweeteners of 760 American consumers. When it comes to sweetener choice the study showed honey and sugar were by far the most preferred sweeteners with maple syrup stevia and agave following behind. This answers the question What sweetener on the label appeals most to consumers For caloric sweeteners honey or sugar are preferred while for lowcalorie sweeteners stevia is preferred. The least preferred sweeteners were erythritol acesulfame K monk fruit sorbitol and xylitol basically any sweetener that has a difficult to pronounce name. Monk fruit stands out because consumers perceived it as a natural sweetener but it was still not preferred. Choosing a Preferred Sweetener is Not Enough An important callout though is that you should still be reducing sugar no matter which sweetener is used. Even though consumers perceive some sweeteners as more healthy than others in most cases this is not true. There can be minor differences in sweeteners like honey maple syrup sugar and high fructose corn syrup but these are often negligible compared to the impact of consuming high amounts of sugar itself. Using low-calorie sweeteners makes sugar reduction easier but there is a challenge when creating a product for consumers who don t want low-calorie sweeteners in their product. The main December 2018 www.niemagazine.com problem to solve is How can I reduce sugar without sacrificing taste One solution is to use flavor modulators which can help boost the sweet taste and mouthfeel of a reduced-sugar product without using low-calorie sweeteners. Kerry offers a natural flavor solution called TasteSense which can help manufacturers enhance the taste profile in low sugar products and aid in sugar reduction by up to 30 percent in applications without sacrificing sweetness or mouthfeel. Another solution is to use value-added sweeteners like fruit or vegetable juices and purees which still provide sugar but are also providing beneficial nutrients of the named fruit at the same time. This can help consumers accept the trade-off of having a higher sugar product. been the practice for breakfast cereals for a long time partly because it is a requirement to have low sugar content to advertise certain products to children. On the other hand sugar taxes are emerging in countries around the world which encourages reducing sugar content as low as possible. Due to many consumers wanting to avoid low-calorie sweeteners many companies are coming out with low sweetness beverages that have 5 to 10 grams of sugar rather than 30-plus grams. There are also restaurants offering customizable sweetness for beverages so consumers can choose how much sugar they are getting. There s no right way to target sugar reduction but instead there are a lot of creative solutions to reduce the amount of sugar people are getting in their diet. How Do I Tell if A Sugar Is Added vs. Natural What is the Goal for Sugar Content There are no formal guidelines for how much sugar products should contain but we can use a few different sources as guidelines. First we can look at dietary recommendations for added sugars. Both the World Health Organization and the USDA (U.S. Department of Agriculture) Dietary Guidelines recommend we consume less than 10 percent of our total calories from added sugar. This is equivalent to 200 calories on average or 50 grams of added sugar for the whole day. A can of cola may contain 35 grams of added sugar for reference. Getting sugar content of products into the single digits is a good start. Reducing sugar to 0 to 9 grams has Dietary recommendations food labeling and sugar taxes often target added sugars but the definition of an added sugar differs across the globe. The World Health Organization European Food Safety Authority and U.S. Food & Drug Administration (FDA) all word their description of added sugars slightly differently. Generally though added sugar refers to any sugar typically mono- or disacchardies not naturally occurring in a food or added to a food for sweetening or flavor purposes. This section is not meant to be a formal guidance but rather to show some key points about added sugar. Check out the article Tips to Determine if a Sugar Should be Labeled Added or Naturally Occurring on the Kerry Health and Nutrition Institute website for a more detailed dive into this topic. Sugar presents itself in many guises on food labels (e.g. dextrose lactose molasses invert sugar fructose glucose maltose saccharose glucose-fructose syrup). Naturally occurring sugars are natural sugars present in fruits and vegetables (fructose) and dairy products (lactose). However the sugars in fruits and vegetables (and their juice concentrates) have provided quite a bit of confusion with regard to labeling added sugars on the nutrition facts label when they are added to other foods such as using fruit juice to sweeten a snack bar. Here are some examples of where the sugar from these sources may or Nutrition Industry Executive 43 FunctionalFoods may not be considered added sugar according to the FDA May appear as added sugar on a nutrition label Juice concentrates that are used to sweeten other foods are considered added sugars and thus need to be included in the new nutrition facts category. If a fruit or vegetable has been processed so that it no longer contains all of the components of the whole fruit that is typically eaten the pulp for example and the sugars have been concentrated then those sugars need to be included in the addedsugar portion of the nutrition panel (such as adding raspberry puree to a snack bar). If sugars are in excess of what would be expected from an ingredient made from 100 percent fruits or vegetables those sugars 44 Nutrition Industry Executive must be declared as added sugars. May not appear as added sugar on a nutrition label Fruit or vegetable juice concentrates used toward the total juice percentage in a juice (for products claiming to contain fruit or vegetable juice). For example a blend of fruit and vegetable juice concentrates to create a 100 percent juice beverage. Sugar Has Functional Roles in Food That Must be Considered When reducing sugar taste and sweetness aren t the only consideration. This infographic shows what challenges sugar reduction poses for different applications. For most product categories best practice will be to combine several solutions to maintain flavor and functional properties. Summary In the end the secret to success when reducing sugars in functional foods and beverages is knowing the type of consumer a product is being made for choosing the appropriate sugar reduction strategy and above all making sure a product is meeting consumer expectations of both health and taste. NIE References 1 Global Data Global Consumer Surveys 2014 Q4 2017. 2 GlobalData Global Consumer Survey Q3 2016. Nathan Pratt PhD RD completed his doctoral studies at the University of Illinois at UrbanaChampaign where his research focused on weight management nutrition labeling and consumer behavior. He is a member of Kerry s nutrition science team and is responsible for managing content on the Kerry Health and Nutrition Institute and supporting Kerry s internal and external scientific communications. www.niemagazine.com December 2018 Supply Innovation F or more than a decade Nutrition Industry Executive (NIE) has strived to cultivate Following is the list of companies participating in this year s Supply Innovation section relationships between ingre- dient suppliers and finished product Bio-Botanica ...................................................46 manufacturers by providing Science of Ingredients sections to highlight Euromed USA ................................................47 the research supporting ingredients that can help finished products stand GCI Nutrients.................................................48 out. In the interest of furthering that cause and providing greater insight InnoVactiv.......................................................49 into suppliers efforts NIE offers its Supply Innovation section. NIE has given companies an oppor- Mineral Logic .................................................50 tunity to highlight their latest most innovative offerings. NIE has also pro- PLT Health Solutions ......................................51 vided ample company information to foster immediate connections with Sabinsa Corp..................................................52 parties interested in learning more. December 2018 www.niemagazine.com Nutrition Industry Executive 45 Supply Innovations Bio-Botanica Inc. 75 Commerce Dr. Hauppauge NY 11788 Phone (631) 231-5522 Email Msysler bio-botanica.com Website www.bio-botanica.com Puresterol The Miracle Root W omen often develop a myriad of health issues linked to hormone imbalance. A majority of these are believed to start in midlife with the onset of menopause. Millions of women experience dysfunctions such as PMS depression decreased libido fibrocystic breasts food and sugar cravings uterine fibroids irregular or excessive uterine bleeding and endometriosis infertility and more. Fluctuating estrogen and progesterone levels are commonplace as women age but during menopause the side effects of these fluctuations hot flashes mood swings decreased libido and memory impairment to name a few can be particularly difficult to deal with. The common use in conventional medicine of HRT (hormone replacement therapy) was once believed to be a panacea that would solve many of these problems. However there have been disappointing scientific findings concerning the safety and efficacy of HRT (JAMA March 2001). While we are losing faith in HRT as the answer menopausal women still have an interest in maintaining youthful vigor sexual function and mental capacity. Women have become more interested in finding natural means to bolster or balance hormone levels other than drug based HRT. Herbs can be a significant part of an overall wellness program that can be instituted toward this end. enhancing memory. (Wanadorn P.W. A Reputed Rejuvenator J. Siam Society Natural History Supp. 8 337 1931). Aging women around 70 to 80 years old who take this herbal medicine when healthy will be young again. So begins a 700-year-old palm leaf scroll written by a Buddhist monk espousing the benefits of a plant that only grows in northern Thailand an area with a 40 percent lower rate of breast cancer than in Japan which is acknowledged to be the lowest in the world. An Herb to Watch Further Investigation One herb that is up and coming is Pueraria mirifica (PM). PM is a plant that belongs to the family Papilionaceae (Leguminosae). The root is the part of the plant that has been used in Thailand for more than 500 years. It has also been called Kwao Krua and Thai Kudzu. This plant grows in deep forest regions in northern Thailand. Legend has touted the anti-aging properties of using this plant medicine for centuries. A paper translated from Siamese in 1931 mentions the use of the root pueraria tuberous root to make the skin smooth like a 6-year-old child and allow you to live 1 000 years and prevent suffering from parasites while also So much for folklore. Scientists are now seriously investigating the properties of the PM plant. Researchers in the U.K. have been studying PM and miroestrol its principal component since the 1940s and it was prominently featured in the December 3 1960 edition of Nature. More recently PM has been shown to be a promising hormone and support herb for menopausal women. Approximately two thirds of women will experience undesirable symptoms ranging from hot flashes and night sweats to loss of interest in sex. In a Phase III study funded by an agency of the Thai government published in the J Med 46 Nutrition Industry Executive Assoc Thai Vol. 90 No. 9 2007 PM demonstrated great promise in helping to offset the discomforts associated with menopause. One study by Wattanapitayakul et al (J Med Assoc Thai Vol 88 Supl 1 2005) reported These data demonstrate that PM is a potential source of phytoestrogens for postmenopausal women. The researchers conclusion was the same as was previously reached by Sayan Sawatsri MD working with Emory University Department of Obstetrics and Gynecology in Atlanta GA where he presented a paper on his research on PM which concluded PM may constitute a new class of treatment safe low toxicity showing natural SERMs (selective estrogen receptor modulator) properties agonist in specific tissues and antagonist in other tissues in-vitro and in-vivo models. Loosely this means that PM may support estrogen receptors found in cells and without negatively affecting other cells. Botanica s Puresterol (patent 7 658 955) was the actual product used in a recent research study. The research showed that the phyto-oestrogens in Puresterol were able to inhibit the growth of breast cancer cells in-vitro (Ramnarine S MacCallum J and Ritchie M. Phyto-oestrogens do they have a role in breast cancer therapy P Nutr Soc 68 OCE2 E93 (2009). In addition another study by Maninai et al (Menopause Vol 14 No 7) concludes PM was proven to exhibit estrogenicity on vaginal tissue to alleviate vaginal dryness symptoms and dyspareunia to improve signs of vaginal atrophy and to restore the atrophic vaginal epithelium in healthy postmenopausal women. The same 700-year-old palm leaf scroll warned The plant is very easy to find but the specification of the right plant is very difficult. There are many pretenders that call themselves PM but they are one of the dozen other species that grow in Thailand. To be certain make sure miroestrol is listed as a specific component in the PM analysis. For more information visit www.puresterolpm.com. www.niemagazine.com December 2018 Supply Innovations Euromed USA Inc. 80 Emerson Ln. Ste. 1304A Bridgeville PA 15017 Phone (877) 696-3960 Website www.euromedphytoproof.com Pomanox Whole Fruit Pomegranate Extract at the Heart of Healthy Aging M any people drink pomegranate juice for its health benefits and may be unaware of its important assets for the heart to help counteract the adverse effects of aging on the cardiovascular (CVD) system. Pomegranate s health-promoting activities include helping to offset diminished antioxidant capacity reducing elevated blood pressure (BP) and lowering oxidized blood lipids with the onset of middle age and beyond. All of these contribute to endothelial dysfunction (ED) that afflict our aging U.S. population resulting in atherosclerosis or clogging of the arteries. Pomanox a Potent Force for Vital Health Pomegranate (Punica granatum L.) has been a symbol of health and longevity in many cultures worldwide for millennia. A new Spanish patented pomegranate extract from Euromed called Pomanox has been investigated for its health promoting benefits. In research studies Pomanox improved endothelium health the inner layer of the arteries counteracting vascular inflammation and oxidative damage.1 3 8 The extract changed the expression of 12 genes that are associated with cardiovascular disease (CVD) in research conducted at La Paz University Hospital Madrid Spain. One of these genes activates the Akt endothelial nitric oxide-synthase pathway that is a key trigger point for an inflammatory process.5 Importantly normalization of BP has been reported In five published academic trials and two that have been submitted for publication.1-4 6 8 High blood pressure is the greatest contributor to CVD worldwide and one of the most common CVD risk factors. A recent meta-analysis confirms the benefits of Pomanox and pomegranate juice consumption on BP.9 A Full-spectrum Pomegranate Extract Pomanox is a whole fruit extract of pomegranate containing up to 30 percent punicalagins and a full compleDecember 2018 www.niemagazine.com Pomanox is a whole fruit extract of pomegranate containing up to 30 percent punicalagins and a full complement of antioxidant molecules. ment of antioxidant molecules. Punicalagins are among nature s most powerful antioxidants. Punicalagins are the main phenolic compounds in pomegranate peel. The pericarp or fleshy peel contains more of the healthy phytochemicals found in pomegranate than the juice provides. Pomanox is a full spectrum extract and contains phytochemicals from the juice and the peel. Not all pomegranate products provide the same health benefits. Many pomegranate extract products contain high levels of ellagic acid (EA) up to 40 percent. These products do not have the characteristic chemical profile of natural pomegranate juice and may contain EA from botanical sources other than pomegranate.10 11 There are vast groves of pomegranate trees in the sunny climate of Murcia Spain known as the breadbasket of Europe because of the widespread regional agriculture. Euromed obtains its fruit from the surrounding orchards and extracts fresh whole select pomegranate cultivars grown following good agricultural practices (GAP). The mature fruit is concentrated in its ISO 9001 and 14001 certified extraction facility using a Pure-Hydro Process producing a highly water-soluble extract. Each batch of extract produced undergoes a minimum of 20 laboratory tests from the fruit to the final extract following Euromed s Phyto-Proof Process of quality control. Pomanox is available as a certified organic extract as well. Pomanox is at the heart of healthy aging for consumers concerned about maintenance of optimal health. References 1 MartinSanchez F et al. Cell Death Differ. 2016 23(7) 1219-31. 2 Stockton A et al. Annals of Nutrition and Metabolism. 2013 63 1193. 3 Dujaili AI et al. Endocrine Abstracts. 2012 28 P313. 4 Stockton A et al. EC Nutrition 2.4. (2015) 396-411. 5 Vilahur G et al. Rev Esp Cardiol (Engl Ed). 2015 68(3) 216-25. 6 Tsang C et al. Journal of Nutritional Science (2012) vol. 1 e9 page 1-9. 7 Dujaili AI et al. EC Nutrition 4.6 (2016) 982-995. 8 Stockton A et al. J Nutr Sci. 2017 6 e39. 9 Sahebkar A et al. Pharmacol Res. 2017 115 149161. 10 Heber D et al. J. Agri. Food Chem. 2009 57 73957400. 11 Cardellina et al. Herbal Gram 112 62-69 . Nutrition Industry Executive 47 Supply Innovations GCI Nutrients USA 375 Beach Rd. Burlingame CA 94010 Phone (650) 667-5910 Fax (650) 696-6300 Email rickm gcinutrients.com Website www.gcinutrients.com Creating New Research Ventures C an the New Age of Nutraceutical Formulations creatively disrupt chemically derived pharmaceutical drugs in the race to improve and lower our health care costs This question helps outline the scientific challenge that lies ahead for the nutraceutical industry. GCI Nutrients has been working in the industry since 1970 and during that time we have been regulated by the U.S. Food and Drug Administration (FDA) which has always leaned in favor of the pharmaceutical drug companies. To state that the deck has been stacked against our industry is an understatement. Pharmaceutical companies focus has been finding treatments for health issues by spending millions of research dollars on patentable chemical drugs that might keep us alive but do not improve our long-term health by correcting the real problems. Through more scientific research nutraceutical companies are finding that some of the answers to challeng- ing health conditions might be found in Mother Nature s natural ingredients. In order to keep up with the science of nutraceuticals GCI Nutrients has expanded its research and development capabilities by partnering with NAG Research Laboratories and Dr. Jit Nag in creating a new research venture called Herbalyn Life Sciences whose mission is to develop alternative nutraceutical therapies for acute and chronic diseases. Nag has more than 150 drug patents and has spent the last 10 years of extensive R&D exploring functional botanicals and other nutritional ingredients such as minerals and amino acids. Nag has identified most of the health conditions which have been targeted by previous nutraceutical clinical research and through his R&D has shown amazing success in developing new cutting-edge nutraceutical formulations that have successfully revealed good results against each of these health conditions. This new age of nutraceutical for- A GCI Nutrients Partner tope based monoclonal antibodies ishwajit Nag PhD was recently against ribosomal proteins. He has appointed chief science officer authored more than 200 peerof both GCI Nutrients and reviewed scientific publicaHerbalyn Life Sciences Inc. tions abstracts and is an Nag s appointment proinventor with more than vides the expertise and 100 U.S. and international resources needed to optipatents in the fields of mize the science behind the biotechnology molecular individual ingredients that biology natural product GCI distributes as well as discoveries herbal formulaHerbalyn Life Sciences Inc. tions and new drug discovwhich is the collaboration eries. In addition to being between Nag Research GCI Nutrients and Labs and GCI Nutrients. Bishwajit Nag Herbalyn s chief science Nag has a PhD in molecular officer Nag is the biology biochemistry from founder president of Nag Research BHU India. He was the distinguished Laboratories (NRL) which is focused NIH (National Institutes of Health) on new drug discovery novel scientist in the Biological Chemistry biotechnology products pre-clinical Department School of Medicine research services and a unique line of University of California Davis where herbal and nutraceuticals. he was involved in developing epi- B 48 Nutrition Industry Executive mulations is just starting to develop. The main challenges are the cost of product development and the clinical trial expense to prove out the validity and effectiveness of the new formulations. In addition there are no patents to protect all of the investment required. Due to Nag s vast drug experience he knows the best ways to control all of these costs which gives Herbalyn Life Science a major leg up on the field. Because of Nag s experience in drug trials his focus is on selecting the proper group of patents and the successful completion of each clinical trial. His synergistic formulations will be testing against the leading drug for each health condition. For example with diabetes his Diabelyn formulation will be tested side-by-side against the 6 billion drug product Metformin. Due to cost factors all clinical trials all be performed at a leading hospital in India but all results will be reviewed and approved by a leading U.S. university. In addition Nag s clinical lab expertise will be utilized to assist the company s customers in developing their own product formulas to help the nutraceutical industry play a major role in keeping the world healthy. GCI Nutrients will be using science to validate the effectiveness of all of its branded ingredients. www.niemagazine.com December 2018 Supply Innovations innoVactiv inc. 265 2e rue Est Rimouski QC Canada G5L 9H3 Phone (418) 721-2308 Email info innovactiv.com Website www.innovactiv.com 84 Million Americans Should Be Concerned About Their Blood Glucose T his means that one in three adults should be taking decisive actions to maintain healthy blood glucose levels. For most people these actions will focus solely on maintaining body weight. While it may be a good start when it comes to blood glucose maintaining a healthy body weight offers at best a partial protection as 22 percent of normal weight and 35 percent of overweight individuals still face blood glucose concerns.1 Today s diet is seen as a putative culprit. In 1977 the publication of Dietary Goals in the U.S. singled out fat as the component to avoid in our food effectively kick-starting the low-fat era. But this only substituted fat calories for carbohydrates calories. Carbohydrate intake (including starch maltodextrins HFCS and sugar) rose steadily thereafter reaching a historic high from 43.9 percent of daily calories in 1971-75 (before the low-fat era) to an average of 49.5 percent over the last seven NHANES (National Health and Nutrition Examination Surveys) up to now.2 The main issue with carbohydrates is that our body is extremely effective at converting them into fat for storage mainly in the liver. Studies show that animals fed a high-carb diet saw a 54 percent increase in liver fat content compared to animals fed a high-fat diet.3 Similarly humans on a four-week highfat diet followed by a four-week highcarb diet saw their plasma triglyceride levels increase by a mean 178 percent after high-carb diet over the high-fat diet.4 The problem is that fat infiltrations in the liver and muscle affect insulin signaling in these organs leading to a gradual decrease in overall insulin function. Fatty liver is thought to affect 30 to 40 percent of the U.S. population.5 Carb restriction produces the opposite effects on liver fat content. Within two weeks of an isocaloric low-carb regimen obese subjects with a fatty liver saw a 44 percent decrease in liver fat while maintaining their body weight constant.6 There is thus an urgent need to effectively counter the negative health December 2018 www.niemagazine.com impacts of high dietary carbohydrates on our health. InSea2 The Most Effective Carb Optimizer Available Today InSea2 is a natural GRAS (generally recognized as safe) organic and genetically modified organism (GMO)-free dietary ingredient that reduces undesired aftermeal fluctuations in blood sugar and insulin. Containing purified polyphenols from two species of brown seaweeds InSea2 is clinically shown to modulate digestion and assimilation of carbohydrates through inhibition of pancreatic -amylase and intestinal -glucosidase enzymes.7-10 Because of its effects on post-meal blood glucose homeostasis it was hypothesized that InSea2 could help restore optimal glycemic health in challenged individuals. InSea2 New Human Clinical Trial Results A randomized double-blinded placebo-controlled study was undertaken at University of Pavia (Italy) examining the effects of InSea2 in 65 men and women with impaired fasting glucose (IFG) or impaired glucose tolerance (IGT) not using any medication. Subjects were instructed to adhere to a physical activity program and a calorie-restricted diet based on NCEP-ATP III recommendations containing 50 percent of calories from carbohydrates 30 percent from fat and 20 percent from proteins. Assessments were conducted at baseline and then after three and six months of treatment. The results show that HbA1c fasting plasma glucose and post-prandial glucose were significantly improved in the InSea2 group over placebo following six months of use. Most importantly 11 subjects in the InSea2 group improved from IGT to IFG stage and six patients saw a normalization of their glycemic status. On the other hand the placebo group saw seven subjects moving from IFG to IGT meaning a deterioration of their glycemic status even though subjects in both groups adhered to their diet and exercise plans.11 These findings support the efficacy of InSea2 as a safe and effective solution to support optimal blood glucose levels. Available exclusively from innoVactiv InSea2 is set to become the next breakthrough in science-based ingredients. References 1 Blumen H et al. 2014 Oct Miliman Client Report. 2 Ford ES Dietz WH. Am J Clin Nutr. 2013 Apr 97(4) 848-53. 3 da Silva-Santi LG et al. Nutrients. 2016 Oct 29 8(11). pii E682. 4 Farquhar JW et al. J Clin Invest. 1966 Oct 45(10) 1648-56. 5 Spengler EK Loomba R. Mayo Clinic Proceedings. 2015 90(9) 1233 1246. 6 Mardinoglu A et al. Cell Metab. 2018 Mar 6 27(3) 559-571.e5. 7 Paradis ME et al. Appl Physiol Nutr Metab. 2011 Dec 36(6) 913-9. 8 Roy MC et al. Food Res Intl. 2011 Nov 44(9) 3026-9 9 Gabbia D et al. Mar Drugs. 2017 Feb 15 15(2). pii E41. 10 B rub J et al. L Integratore Nutrizionale. 2014 Jun 17(2) 24-9. 11 Derosa G et al. Societa Italiana di Nutraceutica Congresso Nazionale 2018. Nutrition Industry Executive 49 Supply Innovations Mineral Logic LLC 7136 E. N Ave. Kalamazoo MI 49048 Phone (269) 552-9436 (800) 342-6960 Website www.minerallogic.com Fulvic Revolution F ulvic acid and fulvic minerals are available in different qualities and potencies depending on their origin and how they are extracted. Fulvic acid is an organic acid resulting from the natural breakdown of organic matter by microorganisms in the soil. Once coupled with minerals they are highly stable water soluble function at a broad pH range and are known as fulvic minerals. Fulvic acids can also exist in free form meaning not attached to or chelated with a mineral. The combination of fulvic acids fulvic minerals polyphenols and several other organic acids including some amino acids has potent and cumulative health benefits. The specific mixture of constituents is directly related to the source deposit and the extraction method. Fulvic in the Body Organic acids polyphenols and trace minerals are found throughout our food supply worldwide. They are essential micronutrients that empower our mitochondria1 to produce clean energy and supply the cells with abundant antioxidants which in turn prevent disease protect neurological 2-6 cardiovascular 7-8 and digestive functions 9 plus aid in recovery from illness or strenuous activity.10 Fulvic acid by itself has shown to improve the utilization of minerals and nutrients in the diet due to its covalent and ionic properties. Some fulvic acid 50 Nutrition Industry Executive extracts can possess more than 70 trace minerals as well as groups of organic acids polyphenols amino acids and electrolytes. It is the complexity of constituents in these sources of fulvic that provide the most health benefits. Trace elements are critical these days because so many are missing in our diet. Since plants convert inorganic minerals into accessible minerals for our bodies organic origin minerals are most beneficial. Polyphenols are organic compounds that we ingest from specific plant-based foods think berries spices vegetables nuts. Polyphenols have significant antioxidant properties. Fulvic acid from a prehistoric deposit will contain the highest amount of beneficial trace minerals polyphenols and electrolytes. Adding 50 to 100 mg per serving of MLG-50 120 powder to a nutraceutical adds vital micronutrients plus fulvic acid catalyzing nutrient absorption while also delivering the many other fulvic acid benefits which produce virtually instant and noticeable results for the consumer. Fulvic Innovated This year the company developed a process that yields a highly potent and palatable fulvic acid powder while retaining the abundant mineral and organic acid attributes. The result is a 100 percent soluble powder with high fulvic acid and mineral content. Its potency means that formulations typically require less of its product than competing sources of fulvic thus reducing costs inventory space and achieving a more nutritious and functional product. Mineral Logic s fulvic acid and fulvic minerals are available in powders and liquids. They are concentrated sta- ble water soluble biologically active and function within a wide pH range. Guarantee Mineral Logic operates a cGMP (current good manufacturing practice) facility certified by UL NPA (Natural Products Association) and is FSMA (Food Safety Modernization Act) and HACCP (Hazzard Analysis and Critical Control Points) compliant. The company owns its source deposit which gives it complete quality control from raw material to final product. Proprietary fulvic formulas are its specialty. References 1 Teixeira J. et al. Dietary Polyphenols and Mitochondrial Function Role in Health and Disease. Curr Med Chem 2017. www.ncbi.nlm.nih.gov pubmed 28554320. 2 Nicolson G.L. Mitochondrial Dysfunction and Chronic Disease Treatment With Natural Supplements. Integr Med (Encinitas) 2014. 13(4) p. 35-43. www.ncbi.nlm.nih.gov pubmed 26770107. 3 Wang W. G. Karamanlidis and R. Tian Novel targets for mitochondrial medicine. Sci Transl Med 2016. 8(326) p. 326rv3. www.ncbi.nlm.nih.gov pubmed 26888432. 4 Paillusson S. et al. There s Something Wrong with my MAM the ER-Mitochondria Axis and Neurodegenerative Diseases. Trends Neurosci 2016. 39(3) p. 146-157. www.ncbi.nlm.nih.gov pubmed 26899735. 5 Blesa J. et al. Oxidative stress and Parkinson s disease. Front Neuroanat 2015. 9 p. 91. www.ncbi.nlm.nih.gov pubmed 26217195. 6 Huhn S. et al. Components of a Mediterranean diet and their impact on cognitive functions in aging. Front Aging Neurosci 2015. 7 p. 132. 7 Schini-Kerth V.B. et al. Nutritional improvement of the endothelial control of vascular tone by polyphenols role of NO and EDHF. Pflugers Arch 2010. 459(6) p. 85362. www.ncbi.nlm.nih.gov pubmed 20224869. 8 Andriantsitohaina R. et al. Molecular mechanisms of the cardiovascular protective effects of polyphenols. Br J Nutr 2012. 108(9) p. 153249.www.ncbi.nlm.nih.gov pubmed 22935143. 9 Deponte M. Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes. Biochim Biophys Acta 2013. 1830(5) p. 3217-66. www.ncbi.nlm.nih.gov pubmed 23036594. 10 Simioni C. et al. Oxidative stress role of physical exercise and antioxidant nutraceuticals in adulthood and aging. Oncotarget 2018. 9(24) p. 17181-17198. www.ncbi.nlm.nih.gov pubmed 29682215. www.niemagazine.com December 2018 Supply Innovations PLT Health Solutions 119 Headquarters Plaza Morristown NJ 07960 Phone (973) 984-0900 Website www.plthealth.com ceratiq Phytoceramides Beauty From Within Clinically Studied Hydration and Wrinkle Reduction C eratiq Phytoceramides is an exciting natural ingredient developed to address the beauty-from-within market. It offers a range of benefits that are associated with youthful skin including improved overall skin health reduced appearance of wrinkles increased elasticity suppleness and a more radiant appearance. A natural vegan source of ceramides it can be a perfect added benefit in a wide range of beauty-from-within formulations. Manufacturer Robertet and PLT Health Solutions have teamed up to develop a rigorous set of scientific studies which now include five in-vitro and ex-vivo studies supporting safety efficacy and mechanism of action and five human clinical studies (two published and one awaiting publication) with 229 test subjects. In addition the companies have developed an ingredient identity and quality control program using industry best practices to understand phytoceramide content of the ingredient and dosage recommendations that are supported by clinical science. ceratiq is the only source of natural ceramides on the market with a new dietary ingredient (NDI) on file with the FDA (U.S. Food and Drug Administration) with the authorized claim helps maintain healthy skin hydration. Background ceratiq is made up of compounds known as phytoceramides which act as cement between skin cells. In the figure below you can see a cross-section of skin. There are many layers and it is the top layer called the epidermis where ceratiq works to form a moisture barrier that prevents moisture loss. While topical phytoceramides have been used for years as a method to enhance skin hydration it has been shown that topicals December 2018 www.niemagazine.com only affect the top levels of skin and instead the use of oral phytoceramides has been investigated. In-vitro and ex-vivo work with phytoceramides showed that they had anticollagenase and anti-elastase activity increased collagen in simulated aging experiments and played an antioxidant role in skin cells. wrinkle visibility in the ceratiq subjects vs PLA 2. (At 12 weeks) Corneometer measurements showed that ceratiq subjects had 273 percent greater improvement in facial hydration over PLA 3. (At 12 weeks) Expert dermatological evaluation showed 492 percent greater Exciting New Clinical Study improvement in radiance for ceratiq subjects over PLA 4. The effects on wrinkles hydration and radiance lasted two months beyond supplementation period 5. Three Lines of Evidence (experiential objective and dermatologist clinical) show efficacy A soon-to-be-published clinical featuring 64 women (average age 55.8 years old) focused on several anti-aging skin factors most notably hydration and anti-wrinkle efficacy. The subjects received either 350 mg of ceratiq oil or the placebo for 12 weeks. In ceratiq group wrinkles were significantly and visibly reduced from eight weeks (p 0.001) compared to the placebo. The wrinkle reduction was visible for 88 percent of women after 12 weeks. The results demonstrated that skin was better hydrated after just four weeks. Compared to the placebo ceratiq was shown to offer three times the improvement in wrinkle visibility 2.75 times the improvement in facial hydration and five times the improvement of radiance. The recent study also allows the development of stronger potential product claims and overall consumer messaging. Included in these are 1. (At 12 weeks) Expert dermatological evaluation showed nearly 300 percent (297 percent) greater improvement in Winner Ingredient of the Year for Healthy Aging ceratiq Phytoceramides was honored by Nutraingredients-USA as the Ingredient of the Year in the Healthy Aging Category at its first-ever Nutraingredients Awards in Chicago IL on July 17 2018. The Nutraingredients Awards aim to celebrate the best ingredients and innovations that the natural products supplements industry has to offer in key consumer categories. The broad scientific program supporting ceratiq Phytoceramides provide consumer products formulators with the ability to develop credible specific and compelling front of label messaging claims in the areas of wrinkle reduction skin hydration and improved overall skin health and appearance. Nutrition Industry Executive 51 Supply Innovations Sabinsa Corporation Corporate Office 20 Lake Dr. East Windsor NJ 08520 Phone (732) 777-1111 Fax (732) 777-1443 Email info sabinsa.com Website www.sabinsa.com Antiasthamatic Potential of Black Cumin (Nigella sativa) N igella sativa known as black seed or black cumin is an annual herb belongs to the family Ranunculaceae. In Arabic it is known as Habbat Al-Barakah The Blessed Seed. This blessed seed have been used for centuries by millions of people in Arabia Asia and Africa to support their health. It has been used in traditional medicine systems such as Unani and ayurveda (Ahmad et al. 2013). For thousands of years black seed has been used extensively as an herbal remedy and as a food condiment around the world. Hippocrates the father of modern medicine and Greek physician Pedanius Dioscorides considered black seed as a valuable remedy for a number of ailments. Records indicate that black seed was an integral part of ancient Egyptian life. Cleopatra used black cumin oil in her bath and Nefertiti as part of her skin care regimen. Black cumin seed oil was discovered in the tomb of Tutankhamun (King Tut) which dates back 3 300 years. epithelial cells (Koshak et al. 2018). The details of the samples are given in Table 1. Table 1. The details of samples black cumin seed extracts and their thymoquinone concentration Sl. No. Sample ID %w w Thymoquinone 1 Ethanol Extract 0.4 2 Water Extract 0.005 3 Nigellin BCS Amber 2.4 4 Cold Pressed Oil 0.7 Fig. 3B. Immunomodulatory activity of black cumin seed extracts Fig. 2A. Fig. 3. Effects of Black cumin seed extracts on IL-6 (Fig. 3A) and PGE2 (Fig. 3B) release by LPS-induced monocytes. (n 3) ( p 0.05 p 0.01 p 0.001) (adapted from Koshak et al. 2018). Nigellin BCS (Black Cumin Seed Extract) Sabinsa s Negellin BCS is obtained from the seeds of Nigella sativa contains thymoquinone thymohydroquinone hederagenin with added rosmarinic acid. Rosmarinic acid is a well-known antioxidant which prevents the oxidation of fatty acids. Fig. 3A. Fig. 4. Fig. 2B. Health Benefits of Black Cumin Black cumin has a wide range of health benefits and some of them are listed in Fig. 1. Fig. 2C. Fig. 1. Health benefits of black cumin In a recent study the immunomodulatory activity of black cumin seed extracts (sample 1-4) were assessed by the release of mediators (IL-2 IL-6 PGE2) in primary human T-lymphocytes monocytes and A549 human lung 52 Nutrition Industry Executive Fig. 2. Effects of Black cumin seed extracts on IL-2 (Fig. 2A) IL-6 (Fig. 2B) and PGE2 (Fig. 2C) production by SEB-induced T-lympocyte cells. (n 3) ( p 0.05 p 0.01 p 0.001) (adapted from Koshak et al. 2018). Fig. 4. Effects of Black cumin Seed extracts on PGE2 production by A549 cells. (n 3) ( p 0.05 p 0.01 p 0.001) (adapted from Koshak et al. 2018). Nigellin BCS Amber and the cold pressed oil which are characterized by the highest level of thymoquinone showed the most remarkable effect on suppressing inflammatory mediators IL-2 IL-6 and PGE2 release from human T-lymphocytes (Fig. 2A 2B and 2C). Also these two extracts showed a marked suppression of IL-6 and PGE2 release in human monocytes (Fig. 3A and 3B). On the other hand the extracts containing thymoquinone had a remarkable effect enhancing the release of PGE2 from A549 human lung epithelial cells (Fig. 4). For the list of references visit www.niemagazine.com. www.niemagazine.com December 2018 Conventions&Meetings 8th China International Nutraceutical and Functional Food Summit 2018 featuring separate forums on healthy aging and sports nutrition will provide a platform for attendees to educate themselves with market conditions for the Chinese nutraceutical and functional food industry. The summit held December 13-14 2018 at the Crowne Plaza Beijing Chaoyang U-Town in Beijing China will facilitate communication between policymakers and delegates from the private sector helping promote a better understanding of the regulatory framework for health foods and nutraceuticals. Furthermore speakers representing a wide range of institutions including government agencies industry associations and leading multinational companies will share valuable insights on this burgeoning industry. For more information visit www.duxes-foodbeverage.com functionalfood-cn index.html. T he global functional food and nutraceuticals market is expected to grow at a robust CAGR (compound arrival growth rate) of 7.39 percent from 2016-2020 culminating with a value of approximately 2.5 billion in 2020 according to a June 2015 report from Markets and Markets. Within the Asia Pacific region China offers the most promising market for functional foods and nutraceuticals. According to estimates middle-aged and elderly consumers constitute half of the market products for women account for 25 percent and children youth products are the remaining 25 percent indicating that the greatest potential for companies operating in China is in developing products for middle-aged and elderly consumers. Against this backdrop the 8th China International Nutraceutical and Functional Food Summit 2018 The Mexican Healthy Products Summit T he Sheraton Buganvilias Resort and Convention Center in Puerto Vallarta Mexico will be home to the Mexican Healthy Products Summit which will be held January 25-27 2019. This is an invitation-only business-to-business trade show and conference linking healthy products suppliers with key retail buyers and distributors. There will be a variety of networking opportunities including a welcome reception evening cocktail gatherings meals (breakfast lunch and dinner) and entertainment. Expert speaker session will be in the morning with topics ranging from the Latest Healthy Lifestyle Trends in Mexico & Research in Mexico and Globally to Best Export Practices. For more information visit www.healthyproductssummit.com. Branch Out With VRM s FAMILY OF PUBLICATIONS NIEmagazine.com VitaminRetailer.com FitnessTrainerMag.com NaturalPractitionerMag.com Our 2019 Media Planner Is Available At NIEmagazine.com 2019-Media-Planner Contact One of Our Ad Specialists Today Russ Fields at (732) 432-9600 ext. 102 or e-Mail RussF VRMmedia.com Barry Young at (732) 432-9600 ext. 103 or e-Mail Barry VRMmedia.com December 2018 www.niemagazine.com Nutrition Industry Executive 53 Equipment&Packaging Weiler Labeling Systems Introduces LP-100R Label Printer New Jersey-based Weiler Labeling Systems (WLS) a ProMach (Kentucky) product brand introduces its state-of-theart LP-100R on-demand label printer. Delivering digital flexibility the stand-alone high-speed LP-100R eliminates the need to inventory distinct labels for each product while its high resolution and excellent print wear resistance on a wide variety of substrates helps to maximize label quality and permanence. When we took our prototype LP-100 to Pack Expo Las Vegas last year prospective customers responded extremely favorably. We then launched an in-depth market study to identify the exact capabilities that were wanted. The LP-100R we re now introducing is the culmination of that activity said Ted Geiselman business development for ProMach s Digital Printing Solutions. Featuring a UV-curing drop-on-demand (DOD) printer the LP-100R can print linear barcodes serialized 2D data matrix barcodes and human readable codes as well as high-impact visual graphics in full color or black-and-white at speeds up to 4 700 inches per minute. Applications include printing variable data on pre-printed labels and on-demand printing the entire label from bright stock as needed. Achieving superior print quality and print wear resistance on most substrates without the need for a protective top coat the LP-100R is capable of producing the highest graded codes. The CE-marked and UL-certified LP-100R is ideal for manufacturers and contract packagers of over-the-counter (OTC) and regulated pharmaceuticals nutraceuticals diagnostics medical devices biotech and other products around the world. For more information visit www.weilerls.com and www.promachbuilt.com. Low-Profile Sanitary Screener Achieves High Rates A new Low-Profile FLO-THRU Sanitary Screener from New Jersey-based Kason Corporation scalps oversize particles and foreign matter from dry bulk materials and solids-laden slurries at high rates in low headroom areas as announced by Henry Alamzad president. The screener employs two unbalanced-weight gyratory motors mounted on opposing exterior sidewalls of the screening chamber instead of one motor positioned beneath it reducing minimum height requirements significantly. Mounted on suspension springs the FLO-THRU design also allows vertical alignment of the top inlet and bottom outlet allowing on-size material to rapidly descend through the screen in a straight-through path at high rates into downstream equipment or receiving vessels. Oversize material is ejected through a spout at the periphery of the screen. The unit is available in diameters from 18 to 100 in. (460 to 2540 mm) with interchangeable screens that allow sifting of on-size materials as fine as 38 microns (400 mesh). For more information visit www.kason.com. Twin Flexible Screw Conveyor With Common Hopper Mobile Base New from Pennsylvania-based Flexicon is a Twin BEV-CON Flexible Screw Conveyor system with a common hopper and mobile base constructed and finished to sanitary standards. Ready to plug-in and run the self-contained system can fill two vessels with the same material simultaneously. Mounted on a frame with locking casters for in-plant mobility it can be utilized in multiple locations and rolled to a wash-down booth. The hopper is equipped with dual discharge adapters each of which charges a BEV-CON flexible screw engineered to move free- and non-free-flowing bulk materials that pack cake smear fluidize compress or are otherwise problematic to convey. As material is conveyed rotation of the screws causes them to self-center in the polymer conveyor tubes eliminating or minimizing contact with the tube wall preserving material integrity. The rolling action of material also prevents the separation of blended products comprised of disparate sizes shapes and bulk densities. The screws are the only moving parts contacting material and are driven beyond the point at which material is discharged eliminating wear and contamination related to product contacting seals and bearings. Discharge housings of the conveyors are supported by dual booms cantilevered from the mobile base allowing discharge of material into processing equipment or storage vessels up to 12 ft. (3.7 m) above the plant floor. The hopper has a capacity of 20 cu. ft. (566 L) and is designed with a steep back wall and diametrically opposed side walls skewed to form a trapezoidal area the divergent angles causing non-free-flowing material to topple into the conveyor charging adapters. For more information visit www.flexicon.com. Continuous Processor Manufacturer Unveils Test Laboratory Offers Free Live Streaming Process equipment manufacturer Readco Kurimoto LLC has unveiled a fully equipped testing laboratory at its York PA headquarters. Featuring full-size fully operating machinery able to process up to 2 000 lbs hr the Readco test laboratory includes both the company s Continuous Processor for mixing multiple liquid powdered and or viscous materials in a single step and the SC Processor for transforming powders into slurries and or increasing the viscosity of slurries in a single step along with a host of feeders heaters and accessories. The laboratory enables the company to conduct tests that simulate actual operating conditions using customer materials and formulations to verify machinery performance meets targeted goals. Based on testing data Readco engineers may customize the continuous processing systems to achieve pinpoint control over product uniformity texture color and other criteria. To enable a variety of personnel around the world to view the laboratory testing process the company offers to present the tests on video via a secure live stream. The web-based live stream may be accessed by private login. The testing laboratory is open for free tours by appointment. For more information visit www.readco.com. 54 Nutrition Industry Executive www.niemagazine.com December 2018 Advertiser Index Bio-Botanica Inc. 41 (631) 231-5522 www.niemagazine.com bio-botanica Captisol a Ligand technology 9 (858) 550-7895 www.niemagazine.com captisol Euromed USA Inc. 33 (877) 696-3960 www.niemagazine.com euromed GCI Nutrients 3 (650) 697-4700 www.niemagazine.com gcinutrients InnoVactiv Inc. 11 (418) 721-2308 www.niemagazine.com innovactiv Jiaherb Inc. 5 (888) 542-4372 www.niemagazine.com jiaherb Mineral Logic 7 (800) 342-6960 www.niemagazine.com minerallogic Now Foods PL 1 (800) 999-8069 www.niemagazine.com nowpl Olcott Plastics C4 (630) 584-0555 www.niemagazine.com olcott PLT Health Solutions C3 (973) 984-0900 www.niemagazine.com plt Sabinsa Corporation C2 (732) 7 7 7 - 1 1 1 1 www.niemagazine.com sabinsa Soma Labs Inc. 24 (732) 271-3444 www.niemagazine.com somalabs Industry Events February 5-7 2019 West Pack Anaheim Convention Center Anaheim CA www.westpack.packagingdigest.com March 5-9 2019 Natural Products Expo West Anaheim Hilton & Marriott Anaheim Convention Center Anaheim CA www.expowest.com April 9-10 2019 SupplySide East Meadowlands Exposition Center Secaucus NJ east.supplysideshow.com May 7-9 2019 Vitafoods Europe 2019 Palexpo Geneva Swizerland www.vitafoods.eu.com Don t miss a single issue of NIE go online to renew your free subscription today NIEmagazine.com December18 December 2018 www.niemagazine.com Nutrition Industry Executive 55 SupplieroftheMonth Natreon Inc. Bruce Brown MPH MA 2D Janine Pl. New Brunswick NJ 08901 Phone (732) 296-1080 Email info natreoninc.com Website www.natreoninc.com Natreon is a leader in nutritional ingredient innovation quality and research. Trusted for more than 20 years Natreon s patented ingredients are derived from nature and founded on evidence-based ayurveNatreon da. Natreon s ingredients have been tested in multiple clinical and safety studies to ensure safety efficacy and authenticity. Natreon brings storied knowledge and expertise in botanical cultivation and extraction and its ingredients are sustainably sourced through an integrated supply chain to ensure quality and potency. Natreon has its global headquarters in New Jersey and an R&D facility in Kolkata India. Bruce Brown currently serves as president and board member of Natreon where he is responsible for all commercial activities for the company. Brown began his career in public health serving communities in West and East Africa focusing primarily on food security nutrition and communicable disease control. He served as a visiting fellow with the Centers for Disease Control and Prevention (CDC) in the Office of Global Health and as director of public health programs for Phyto-Riker Pharmaceuticals in Accra Ghana. Brown joined Market Biosciences to spearhead the commercial development of Martek s patented ingredient portfolio and upon the company s acquisition by DSM Nutritional Products he transitioned into the director of marketing role for DSM North America. He then joined Innophos to lead the commercial efforts as vice president. Brown also serves as a board member for the Council for Responsible Nutrition. President of NIE Please discuss recent studies on Natreon s ingredients. Brown Science is at the core of our business. We believe it is imperative to provide scientific backing in the way of human clinical trials to demonstrate the safety and efficacy of all of our ingredients. For example our Sensoril Ashwagandha is already backed by 12 human clinical trials and we continue to study it. These trials have demonstrated many proven benefits including Sensoril s ability to enhance focus and mental stamina support healthy cardiovascular function sleep sports performance help the body cope with stress and promote mental clarity. We are confident in making these claims only with such solid scientific backing. This year we unveiled the findings of two clinical trials in the area of sports performance. One examined the effects of Sensoril on the sports performance of 66 healthy and recreationally active male participants. The initial results found significant improvements in the Sensoril group for numerous sports performance measures and also showed an improvement in subjects perceived recovery scores. Another recent trial studied the effects of PrimaVie Shilajit compared to a placebo on fatigueinduced percent decline in maximal voluntary isometric contraction (MVIC) and the results showed that the 56 Nutrition Industry Executive PrimaVie group helped maintain more muscular strength. While other dependent variables are still being analyzed and more evaluation is to come this study is extremely encouraging. NIE In November 2017 the company expanded its global intellectual property portfolio. How will this affect the growth of the company Brown Natreon is committed to providing the highest quality and most efficacious standardized extracts available. Over 20 years of research work and science has gone into perfecting these ingredients and it is extremely important that we protect both our customers and our intellectual property. We currently have a broad portfolio of 21 U.S. and foreign patents and several registered trademarks in various countries. Sensoril Ashwagandha is a powerful adaptogen derived from a blend of both leaves and roots of the Withania somnifera plant to provide optimal efficacy and bioactive diversity. Natreon has patented this leaf and root composition to protect this unique blend. Last year Natreon was also granted U.S. Chinese and Japanese patents for a new bioactive isolated from Sensoril to cover the recent discovery of a new class of compounds Indolealkylamino-withasteroid conjugates and their significant acetylcholinesterase inhibitory activity. This year Natreon received a U.S. patent on natural bioactives (urolithins) and unique combinations of bioactive components present in shilajit. Additionally Natreon has been granted a U.S. patent for its ayuric ingredient whose claims support the use of the standardized extract of Terminalia bellirica for the treatment of gout uricemia and hyperuricemia. We also recently achieved a Canadian patent for Capros a standardized extract of Phyllanthus emblica. This patent covers a composition and method to treat or prevent endothelial dysfunction. NIE Is there anything else you would like to add Brown Another important initiative for Natreon is to help educate the market about adaptogens. This unique class of botanicals is experiencing significant growth as people recognize that supporting health and wellness involves a delicate balance of body systems. While adaptogens have been used for thousands of years they are just recently gaining attention in regions and cultures not as accustomed to these ancient traditions. Adaptogens help support the body s natural balance. It can be challenging to explain that adaptogens can both increase energy and promote relaxation. www.niemagazine.com December 2018 Go to www.niemagazine.com plt for info about this advertiser Go to www.niemagazine.com olcott for info about this advertiser